| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams, Grant Dewson, Ruth M Kluc. Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target. Cell death & disease. vol 11. issue 4. 2021-03-31. PMID:32327636. |
bak and bax, which drive commitment to apoptosis, are activated principally by certain bh3-only proteins that bind them and trigger major rearrangements. |
2021-03-31 |
2023-08-13 |
Not clear |
| Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams, Grant Dewson, Ruth M Kluc. Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target. Cell death & disease. vol 11. issue 4. 2021-03-31. PMID:32327636. |
the results suggest that bak-driven autoactivation may play a substantial role in apoptosis, including recruitment of bax to the mitochondria. |
2021-03-31 |
2023-08-13 |
Not clear |
| Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams, Grant Dewson, Ruth M Kluc. Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target. Cell death & disease. vol 11. issue 4. 2021-03-31. PMID:32327636. |
hence, directly targeting bak rather than bax may prove particularly effective in inhibiting unwanted apoptosis, or alternatively, inducing apoptosis in cancer cells. |
2021-03-31 |
2023-08-13 |
Not clear |
| Hui-Li Wang, Guang-Dong Xing, Yong Qian, Xue-Feng Sun, Ji-Feng Zhong, Kun-Lin Che. Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33676053. |
dmy can provide cytoprotective effects by suppressing heat stress-caused mitochondrial membrane depolarization and mitochondrial dysfunction, bax and caspase 3 activity, and modulation of oxidative enzymes, thereby preventing ros production and apoptosis in dcmecs. |
2021-03-31 |
2023-08-13 |
Not clear |
| Wenyuan Li, Wei Li, Yan Leng, Yonghong Xiong, Rui Xue, Rong Chen, Zhongyuan Xi. Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1. Bioscience reports. vol 40. issue 6. 2021-03-30. PMID:32347295. |
from the present study, it could be found that compared with high glucose (hg)-normal (n)/dm group, hypoxia/reoxygenation (h/r) or i/r injury can aggravate oxidative stress injury and apoptosis rate of myocardial cells, inhibit the expression of bcl-2, activate the bax and cleaved caspase-3 (c-caspase-3) protein and pten/akt pathway. |
2021-03-30 |
2023-08-13 |
rat |
| Wenyuan Li, Wei Li, Yan Leng, Yonghong Xiong, Rui Xue, Rong Chen, Zhongyuan Xi. Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1. Bioscience reports. vol 40. issue 6. 2021-03-30. PMID:32347295. |
however, in the groups of hg-n, dm, hg-n+i/r and dm+i/r, nac can significantly reduce oxidative stress injury and apoptosis rate of myocytes, promote the bcl-2 and dj-1 molecules, inhibit bax and c-caspase-3 protein and pten/akt pathway. |
2021-03-30 |
2023-08-13 |
rat |
| Wenyuan Li, Wei Li, Yan Leng, Yonghong Xiong, Rui Xue, Rong Chen, Zhongyuan Xi. Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1. Bioscience reports. vol 40. issue 6. 2021-03-30. PMID:32347295. |
compared with hg-n+i/r+nac and dm+i/r+nac groups, the oxidative stress injury, apoptosis rate of myocardial cells and heart tissues increased after the knockdown of dj-1, the expression of bcl-2 and dj-1 were inhibited, the bax and c-caspase-3 expression was increased, and pten/akt pathway was activated. |
2021-03-30 |
2023-08-13 |
rat |
| Avinash Chandra Kushwaha, Soni Jignesh Mohanbhai, Mohammed Nadim Sardoiwala, Ankur Sood, Surajit Karmakar, Subhasree Roy Choudhur. Epigenetic Regulation of Bmi1 by Ubiquitination and Proteasomal Degradation Inhibit Bcl-2 in Acute Myeloid Leukemia. ACS applied materials & interfaces. vol 12. issue 23. 2021-03-30. PMID:32453568. |
it enhanced the caspase 3-mediated apoptosis through the bax activation and bcl-2 inhibition. |
2021-03-30 |
2023-08-13 |
human |
| Rong Zhu Tang, Zhang Zhi Li, Dan Hu, Fariha Kanwal, Cheng Bin Yuan, Muhammad Mustaqeem, Aima Iram Batool, Muhammad Fayyaz Ur Rehma. Sanjie Yiliu Formula Inhibits Colorectal Cancer Growth by Suppression of Proliferation and Induction of Apoptosis. ACS omega. vol 6. issue 11. 2021-03-30. PMID:33778287. |
moreover, sjylf significantly suppressed proliferation and induced apoptosis in hct-8 and downregulated cyclin d1, cdk4, and bcl-2, while bax expression was upregulated at both mrna and protein expression levels. |
2021-03-30 |
2023-08-13 |
human |
| Feng Chi, Zhou Wang, Yuzhu Li, Ning Chan. Knockdown of GINS2 inhibits proliferation and promotes apoptosis through the p53/GADD45A pathway in non-small-cell lung cancer. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32181475. |
meanwhile, knockdown of gins2 significantly elevates the apoptosis rate and apoptosis-related protein bax and decreases bcl-2. |
2021-03-29 |
2023-08-13 |
Not clear |
| Zhaowei Liu, Zhanqiang Du, Kai Li, Yangguang Han, Guogang Ren, Zhuo Yan. TRPC6-Mediated Ca Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32274628. |
however, the apoptosis was not affected by nano-zno, because the protein levels of cytochrome c, caspase-3, bcl-xl, and bax were not varied by the nano-zno treatment. |
2021-03-29 |
2023-08-13 |
Not clear |
| Chenyang Duan, Lei Kuang, Xinming Xiang, Jie Zhang, Yu Zhu, Yue Wu, Qingguang Yan, Liangming Liu, Tao L. Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways. Cell death & disease. vol 11. issue 4. 2021-03-29. PMID:32312970. |
moreover, ischemia-induced drp1 activation enhanced apoptosis through inducing mitochondrial translocation of bax and thereby increasing release of cytochrome c to activate caspase-3/-9 signalling. |
2021-03-29 |
2023-08-13 |
Not clear |
| Meng Jin, Xiuna Ji, Rostyslav Stoika, Kechun Liu, Lizhen Wang, Yang Son. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32629278. |
it was shown that the synthesized fluorescent derivative could penetrate into human breast carcinoma mcf7 cells, and then induced apoptosis detected by the western blot analysis as changed expression of apoptosis-related proteins, including bax, bcl2, and cyto c released from mitochondria, cleaved caspase 9, cleaved parp, pro-caspase 3, and cleaved caspase 3. |
2021-03-29 |
2023-08-13 |
human |
| Guo-Feng Zhang, Jia-Cheng Wu, Hong-Yong Wang, Wei-Dong Jiang, Ling Qi. Overexpression of microRNA-205-5p exerts suppressive effects on stem cell drug resistance in gallbladder cancer by down-regulating PRKCE. Bioscience reports. vol 40. issue 9. 2021-03-29. PMID:32869841. |
after isolating the gbc stem cells, ectopic expression and depletion experiments were conducted to analyze the effect of mir-205-5p and prkce on cell proliferation, drug resistance, apoptosis, and colony formation rate as well as the expression of apoptotic factors (bcl-2-associated x protein (bax), b-cell lymphoma 2 (bcl-2), and cleaved caspase 3). |
2021-03-29 |
2023-08-13 |
mouse |
| Jie Yang, Wen-Wen Mu, Yu-Xin Cao, Guo-Yun Li. Synthesis and biological evaluation of β-ionone oriented proapoptosis agents by enhancing the ROS generation. Bioorganic chemistry. vol 104. 2021-03-29. PMID:32956875. |
importantly, the cytotoxicity of the β-ionone derivatives (1a, 1d and 1g) were relationship with their reactive oxygen species (ros)-generation abilities, which could lead to the redox imbalance, lipid peroxidation, the loss of mitochondrial membrane potential (mmp), the activation of bax and caspase 3, followed by cell apoptosis. |
2021-03-29 |
2023-08-13 |
Not clear |
| Wanxin Shi, Ying Huang, Xingchen Zhao, Zhiyong Xie, Wei Dong, Ruizhao Li, Yuanhan Chen, Zhuo Li, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Li Zhang, Xinling Lian. Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin. Biochemical and biophysical research communications. vol 533. issue 4. 2021-03-26. PMID:33019979. |
meanwhile, hg-induced podocyte apoptosis was abrogated by hdac4-knockdown with subsequent decreased bax expression and increased bcl-2 expression. |
2021-03-26 |
2023-08-13 |
Not clear |
| Wanxin Shi, Ying Huang, Xingchen Zhao, Zhiyong Xie, Wei Dong, Ruizhao Li, Yuanhan Chen, Zhuo Li, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Li Zhang, Xinling Lian. Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin. Biochemical and biophysical research communications. vol 533. issue 4. 2021-03-26. PMID:33019979. |
in contrast, overexpression of hdac4 increased podocyte apoptosis and bax expression, as well as decreased bcl-2 expression. |
2021-03-26 |
2023-08-13 |
Not clear |
| Wanxin Shi, Ying Huang, Xingchen Zhao, Zhiyong Xie, Wei Dong, Ruizhao Li, Yuanhan Chen, Zhuo Li, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Li Zhang, Xinling Lian. Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin. Biochemical and biophysical research communications. vol 533. issue 4. 2021-03-26. PMID:33019979. |
in addition, podocyte apoptosis induced by hdac4 overexpression was effectively rescued by fk506, a pharmacological inhibitor of can, which was accompanied by decreased bax and increased bcl-2 expression. |
2021-03-26 |
2023-08-13 |
Not clear |
| Yongli Han, Song Chen, Hua Wang, Xing-Ming Pen. Electroacupuncture Pretreatment Regulates Apoptosis of Myocardial Ischemia-Reperfusion Injury in Rats Through RhoA/p38MAPK Pathway Mediated by miR-133a-5p. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-03-26. PMID:33763149. |
ea pretreatment protect miri rats from apoptosis by down regulating the expression of mkk3, mkk6, and p38mapk, thereby reducing the expression of bax, caspase-3 and up regulating the expression of bcl-2, which mechanism is closely related to the rhoa/p38mapk pathway mediated by mir-133a-5p. |
2021-03-26 |
2023-08-13 |
rat |
| Bin Feng, Lei Meng, Liming Luan, Zhihao Fang, Peng Zhao, Guangyu Zha. Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway Frontiers in cell and developmental biology. vol 8. 2021-03-26. PMID:33763412. |
acvr2b silencing or upregulation of mir-132 led to an elevation in neuronal activity, decreased neuronal apoptosis, reduced expression of bax, and cleaved-caspase 3, as well as increased bcl-2 expression. |
2021-03-26 |
2023-08-13 |
mouse |