| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Chen, Tailang Yin, Baozhen Zhang, Beini Sun, Jie Chen, Tianxia Xiao, Baobei Wang, Mengxia Li, Jing Yang, Xiujun Fa. Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626948. |
further studies demonstrated that the plcsa‑bnps promoted the apoptosis of cancer cells more effectively and inhibited their proliferation, invasion and migration, accompanied by downregulation of matrix metalloproteinase (mmp)‑2, mmp‑9 and b‑cell cll/lymphoma 2 (bcl2) levels, but upregulation of bcl2‑associated x protein bax and cleaved caspase‑3 levels. |
2021-03-08 |
2023-08-13 |
Not clear |
| Li-Fang Zhu, Xiao-Yang Wu, Xue Liu, Liang Ma, Qi Zhang, Zi Yu, Zhi-Jiao He, Yue Ying, Zhu-Tian Zhang, Xiao-Yu Pan, Yu-Qi Cai, Ling Gong, Miao H. [Absence of BAX differentially affects astrocyte density in the mouse cortex and hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665654. |
previous studies suggest that the b-cell lymphoma-2 associated x protein (bax)-dependent apoptosis plays essential roles in regulating neuronal number and achieving optimal excitation/inhibition ratio. |
2021-03-08 |
2023-08-13 |
mouse |
| Yi-Feng Yuan, Wen-Xiong Zhu, Tao Liu, Ju-Qiao He, Qing Zhou, Xing Zhou, Xi Zhang, Jing Yan. Cyclopamine functions as a suppressor of benign prostatic hyperplasia by inhibiting epithelial and stromal cell proliferation via suppression of the Hedgehog signaling pathway. International journal of molecular medicine. vol 46. issue 1. 2021-03-05. PMID:32319534. |
on the other hand, epithelial cell apoptosis was enhanced, which was associated with increased bax and reduced bcl‑2 expression. |
2021-03-05 |
2023-08-13 |
rat |
| Han-A Park, Mary Margaret Hayden, Sydni Bannerman, Joseph Jansen, Kristi M Crowe-Whit. Anti-Apoptotic Effects of Carotenoids in Neurodegeneration. Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-05. PMID:32751250. |
apoptosis begins with activation of pro-death proteins bax and bak, release of cytochrome c and activation of caspases, loss of membrane integrity of intracellular organelles, and ultimately cell death. |
2021-03-05 |
2023-08-13 |
Not clear |
| Liang Ding, Yalei Wen, Xin Zhang, Fang Zhao, Kenao Lv, Jian-Hong Shi, Shigang Shen, Xuefeng Pa. Transcriptional network constituted of CBP, Ku70, NOX2, and BAX prevents the cell death of necrosis, paraptosis, and apoptosis in human melanoma. Cell death discovery. vol 7. issue 1. 2021-03-05. PMID:33637687. |
transcriptional network constituted of cbp, ku70, nox2, and bax prevents the cell death of necrosis, paraptosis, and apoptosis in human melanoma. |
2021-03-05 |
2023-08-13 |
human |
| Liang Ding, Yalei Wen, Xin Zhang, Fang Zhao, Kenao Lv, Jian-Hong Shi, Shigang Shen, Xuefeng Pa. Transcriptional network constituted of CBP, Ku70, NOX2, and BAX prevents the cell death of necrosis, paraptosis, and apoptosis in human melanoma. Cell death discovery. vol 7. issue 1. 2021-03-05. PMID:33637687. |
our results, therefore, supported the idea that cbp, ku70, bax, and nox2 have formed a transcriptional network in the prevention of cell death of necrosis, paraptosis, and apoptosis in human melanoma. |
2021-03-05 |
2023-08-13 |
human |
| Haitao Yuan, Qin Yang, Bo Yang, Hong Xu, Omaima Nasif, Sankareswaran Muruganantham, Jing Che. Phyllanthin Averts Oxidative Stress and Neuroinflammation in Cerebral Ischemic-Reperfusion Injury through Modulation of the NF-κB and AMPK/Nrf2 Pathways. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 40. issue 1. 2021-03-04. PMID:33639076. |
moreover, the expression of apoptosis markers such as bax, b-cell lymphoma (bcl-2), caspase-3, cox-2, pge2, and lox-1 abruptly increased. |
2021-03-04 |
2023-08-13 |
rat |
| Qin Sun, Tingxin Li, Yamei Li, Lingling Wei, Min Zhang, Shaoping Den. Bactericidal/Permeability-Increasing Protein Improves Cognitive Impairment in Diabetic Mice Frontiers in physiology. vol 11. 2021-03-03. PMID:33643054. |
hfd mice following lps treatment showed significantly increased serum levels of tumor necrosis factor-α (tnf-α), interleukin (il)-1β, and il-6, and expressions of bcl-2-associated x protein (bax) and aβ but decreased expression of bcl-2 in hippocampal tissues, as well as enhanced fasting blood glucose, plasma insulin, glucose tolerance, insulin tolerance, cell apoptosis, aggravated hippocampal tissue injury and, ultimately, cognitive impairment. |
2021-03-03 |
2023-08-13 |
mouse |
| Kang Chen, Chen Jin, Yu-Yao Cheng, Qing-Xi Zhang, Xun-Xun Li, Ling Zhan. [Molecular mechanism of Spatholobi Caulis in treatment of lung cancer based on network pharmacology and molecular docking]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 4. 2021-03-02. PMID:33645088. |
western blot showed that luteolin, licochalcone a and spatholobi caulis extract could induce cell apoptosis by increasing the expressions of pro-apoptotic factors caspase-3 and bax. |
2021-03-02 |
2023-08-13 |
human |
| Lei Zhao, Muyang Li, Kecheng Sun, Shuai Su, Tingting Geng, Hui Su. Hippophae rhamnoides polysaccharides protect IPEC-J2 cells from LPS-induced inflammation, apoptosis and barrier dysfunction in vitro via inhibiting TLR4/NF-κB signaling pathway. International journal of biological macromolecules. vol 155. 2021-03-01. PMID:31730993. |
inflammatory factors (interleukin-1beta (il-1β), interleukin-6 (il-6), interleukin-8 (il-8) and tumor necrosis factor-alpha (tnf-α)) and apoptosis (bcl-2, bax, caspase-3, caspase-8 and caspase-9) were increased. |
2021-03-01 |
2023-08-13 |
Not clear |
| Bei-Chen Hu, Yang Liu, Meng-Zhu Zheng, Ruo-Yu Zhang, Ming-Xue Li, Feng-Yan Bao, Hua Li, Li-Xia Che. Triterpenoids from Anchusa italica and their protective effects on hypoxia/reoxygenation induced cardiomyocytes injury. Bioorganic chemistry. vol 97. 2021-03-01. PMID:32146181. |
further, the representative new compound 6 significantly suppressed the levels of h/r-induced apoptosis and autophagy in neonatal rat cardiomyocytes, with the reversing of the downregulated expression of bcl-2 and upregulated expression of bax and beclin-1 by compound 6 treatment in neonatal rat cardiomyocytes following h/r injury. |
2021-03-01 |
2023-08-13 |
rat |
| Mohamed Mohamed Soliman, Adil Aldhahrani, Adel Alkhedaide, Mohamed Abdo Nassan, Fayez Althobaiti, Wafaa Abdou Mohame. The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-02-26. PMID:32485567. |
quantitative real time pcr (qrt-pcr) was used to examine nrf2, ho-1, bax, timp, xiap, and nfkb, which are associated with apoptosis, anti-apoptosis and oxidative stress. |
2021-02-26 |
2023-08-13 |
mouse |
| Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Min-Hee Kang, Jin-Hoi Ki. Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer. International journal of molecular sciences. vol 21. issue 18. 2021-02-26. PMID:32947930. |
endoplasmic reticulum-mediated stress and apoptosis were confirmed by upregulation of protein kinase rna-like endoplasmic reticulum kinase (perk), inositol-requiring enzyme 1 (ire1), activating transcription factor 6 (atf6), activating transcription factor 4 (atf4), p53, bax, and caspase-3 and down regulation of b-cell lymphoma 2 (bcl-2). |
2021-02-26 |
2023-08-13 |
human |
| Ting-Ting Xu, Han Li, Zhao Dai, George K Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi-Jie Zhan. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging. vol 12. issue 7. 2021-02-25. PMID:32268299. |
in addition, western blot results (bcl-2, bax and caspase-3, nlrp3, il-18, il-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including ngf, psd95and psd93 and bdnf in neurons of samp8 mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Xiang-Xue Kong, Shuai Jiang, Tong Liu, Gao-Feng Liu, Mei Don. Paclitaxel increases sensitivity of SKOV3 cells to hyperthermia by inhibiting heat shock protein 27. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 132. 2021-02-25. PMID:33113434. |
to further examine the role of hsp27 in the apoptosis, bcl-2, bax and caspase-3 protein expression were additionally determined after reducing hsp27 levels using an sirna strategy, and apoptosis was detected using the annexin v/pi assay. |
2021-02-25 |
2023-08-13 |
Not clear |
| Xiang-Xue Kong, Shuai Jiang, Tong Liu, Gao-Feng Liu, Mei Don. Paclitaxel increases sensitivity of SKOV3 cells to hyperthermia by inhibiting heat shock protein 27. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 132. 2021-02-25. PMID:33113434. |
furthermore, paclitaxel could upregulate the bax / bcl-2 ratio by inhibiting hsp27 expression, and in turn, promoting apoptosis due to hyperthermia. |
2021-02-25 |
2023-08-13 |
Not clear |
| Shangjie Liu, Jude Juventus Aweya, Liyuan Zheng, Zhou Zheng, He Huang, Fan Wang, Defu Yao, Tong Ou, Yueling Zhan. LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1. Cell biology and toxicology. 2021-02-25. PMID:33630204. |
moreover, lvhemb1 causes loss in mitochondrial membrane potential and increases levels of reactive oxygen species (ros) and apoptotic proteins (caspase-9, caspase-3, and bax (bcl-2-associated x)), which results in mitochondrial-mediated apoptosis. |
2021-02-25 |
2023-08-13 |
human |
| Hongbo Luo, Wei Sun, Jin Shao, Huiping Ma, Zhengping Jia, Linlin Jin. Protective effect of nitronyl nitroxide against hypoxia-induced damage in PC12 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 3. 2021-02-24. PMID:31689131. |
hpn also inhibited hypoxia-induced cell apoptosis via suppressing the expression of bax, cytochrome |
2021-02-24 |
2023-08-13 |
cat |
| Zhen Liu, Qingshan Fu, Yu Wang, Li Cui, Wenqiang Zhang, Yuou Teng, Peng Y. Synergy between vinorelbine and afatinib in the inhibition of non-small cell lung cancer progression by EGFR and p53 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-02-24. PMID:33360044. |
the anti-apoptotic proteins bcl-xl and bcl-2 showed significant reduction after the drug combination treatment, while the pro-apoptotic protein bax as well as apoptosis indicators cytochrome c and cleaved parp were observed a notable increasing. |
2021-02-24 |
2023-08-13 |
Not clear |
| Jin Sun, Ying Guo, Beibei Bie, Mengchen Zhu, Hongwei Tian, Jing Tian, Jun Li, Yi Yang, Fanpu Ji, Guangyao Kong, Zongfang L. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-23. PMID:31231887. |
in vitro loss-of-function experiments revealed that silencing of hoxd-as1 could dramatically suppress the proliferation, migration, and invasion, and induce s or/and g2/m phase cell cycle arrest as well as apoptosis of bel-7402 and mhcc97h cells accompanying the changes in expression levels of cyclin b1, cyclin d1, bcl-2, bax, and mmp2. |
2021-02-23 |
2023-08-13 |
Not clear |