| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiajia Ma, Fan Zhang, Ping Su. miR-140-3p impedes the proliferation of human cervical cancer cells by targeting RRM2 to induce cell-cycle arrest and early apoptosis. Bioorganic & medicinal chemistry. vol 28. issue 3. 2021-02-04. PMID:31902649. |
the protein level of bcl-2 was attenuated in accompany with elevated bax and cleaved caspase-3 protein, indicating mir-140-3p overexpression induced early apoptosis. |
2021-02-04 |
2023-08-13 |
human |
| Xiangwei Lv, Pan Lu, Yisen Hu, Tongtong X. miR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats. Drug design, development and therapy. vol 14. 2021-02-04. PMID:32161448. |
mir-346 inhibited apoptosis against myocardial ischemia-reperfusion injury via targeting bax in rats. |
2021-02-04 |
2023-08-13 |
rat |
| Weiwei Zhi, Kai Li, Hongbing Wang, Ming Lei, Yingqiang Gu. Melatonin elicits protective effects on OGD/R‑insulted H9c2 cells by activating PGC‑1α/Nrf2 signaling. International journal of molecular medicine. vol 45. issue 5. 2021-02-04. PMID:32323734. |
mel also abolished the ogd/r‑induced increase in h9c2 apoptosis, as evidenced by mitochondrial membrane potential restoration and caspase‑3 and caspase‑9 inactivation, as well as the upregulation of bcl‑2 and downregulation of cleaved caspase‑3 and bax. |
2021-02-04 |
2023-08-13 |
Not clear |
| Yuanyuan Lin, Xuewen Li, Chunhui Fan, Fan Yang, Dajie Hao, Wenjia Ge, Yuping Ga. Cardioprotective effects of rat adipose‑derived stem cells differ under normoxic/physioxic conditions and are associated with paracrine factor secretion. International journal of molecular medicine. vol 45. issue 5. 2021-02-04. PMID:32323745. |
the apoptosis of nrvms was evaluated by annexin v staining and quantitating the protein levels of bcl‑2 and bax by western blotting. |
2021-02-04 |
2023-08-13 |
human |
| Junna He, Xiangjian Zhan. miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. Folia neuropathologica. vol 58. issue 1. 2021-02-04. PMID:32337954. |
these observations suggested that inhibition of mir-668 reduces neuronal apoptosis by ameliorating the expression of caspase 3, bax and bcl-2 protein in i/r stroke rats. |
2021-02-04 |
2023-08-13 |
rat |
| Xiao Ding, Bingjie Ge, Meng Wang, Hongyuan Zhou, Rui Sang, Yifan Yu, Lu Xu, Xuemei Zhan. Inonotus obliquus polysaccharide ameliorates impaired reproductive function caused by Toxoplasma gondii infection in male mice via regulating Nrf2-PI3K/AKT pathway. International journal of biological macromolecules. vol 151. 2021-02-03. PMID:32084465. |
furthermore, iop up-regulated the expressions of nuclear factor erythroid 2-related factor 2 (nrf2), heme oxygenase-1 (ho-1) and nadph quinoneoxidoreductase-1 (nqo-1), and suppressed the apoptosis of testicular cells by decreasing bcl-2 associated x protein (bax) and cleaved caspase-3 expressions. |
2021-02-03 |
2023-08-13 |
mouse |
| Min Liu, Chunyan Liu, Shenli Shen, Jianhui Liu, Fei Yi. Geniposide inhibits glucolipotoxicity and cooperates with Txnip knockdown to potentiate cell adaption to endoplasmic reticulum stress in pancreatic beta cells. Cell biology international. vol 44. issue 7. 2021-02-03. PMID:32215982. |
the results revealed that geniposide attenuated hg/pa-induced cell apoptosis and the expression of bax and caspase-3, while increasing mitochondrial membrane potential and the anti-apoptotic protein levels of heme-oxygenase-1 (ho-1) and bcl-2 in ins-1 rat pancreatic β cells. |
2021-02-03 |
2023-08-13 |
rat |
| Xuan Wang, Han Zhou, Rui Cheng, Xiaoguang Zhou, Xuewen Hou, Jun Chen, Jie Qi. Role of miR-326 in neonatal hypoxic-ischemic brain damage pathogenesis through targeting of the δ-opioid receptor. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32228617. |
mir-326 knockdown improved cell survival and decreased cell apoptosis by decreasing the expression levels of caspase-3 and bax and increasing bcl-2 expression in pc12 cells after exposure to ogd. |
2021-02-03 |
2023-08-13 |
Not clear |
| Xiangxiang Xu, Huajun Yu, Linxiao Sun, Chenlei Zheng, Yunfeng Shan, Zhenxu Zhou, Cheng Wang, Bicheng Che. Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway. Molecular medicine reports. vol 21. issue 4. 2021-02-03. PMID:32319628. |
moreover, ascs significantly decreased pancreatic cell apoptosis by regulating the expression levels of caspase‑3, bax and bcl‑2. |
2021-02-03 |
2023-08-13 |
rat |
| Nehal M Elsherbiny, Nada H Eisa, Mohamed El-Sherbiny, Eman Sai. Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways. Environmental toxicology and pharmacology. vol 80. 2021-02-03. PMID:32942000. |
moreover, hepatic expression of the apoptotic bax significantly increased and the anti-apoptotic bcl-2 significantly decreased in the liver specimen; biomarkers of intrinsic apoptosis. |
2021-02-03 |
2023-08-13 |
rat |
| Nehal M Elsherbiny, Nada H Eisa, Mohamed El-Sherbiny, Eman Sai. Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways. Environmental toxicology and pharmacology. vol 80. 2021-02-03. PMID:32942000. |
namely, crocin induced hepatic expression of nrf2 with downstream modulation of endogenous ho-1 and keap-1 signaling with modulation of various key players of apoptosis including; c-jnk, p53, trail, caspase-8, bax, and bcl-2. |
2021-02-03 |
2023-08-13 |
rat |
| Daniel A Luedtke, Xiaojia Niu, Yihang Pan, Jianyun Zhao, Shuang Liu, Holly Edwards, Kang Chen, Hai Lin, Jeffrey W Taub, Yubin G. Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Signal transduction and targeted therapy. vol 2. 2021-02-02. PMID:29263915. |
the synergistic induction of apoptosis was decreased upon bak, bax and bim knockdown. |
2021-02-02 |
2023-08-13 |
Not clear |
| Hong Zhang, Jing Zhao, Peng Sha. Long noncoding RNA MIAT2 alleviates lipopolysaccharide-induced inflammatory damage in WI-38 cells by sponging microRNA-15. Journal of cellular physiology. vol 235. issue 4. 2021-02-02. PMID:31566734. |
we found that lps declined cell viability and heightened apoptosis and levels of bax, cleaved-caspase-3, il-6, and mcp-1. |
2021-02-02 |
2023-08-13 |
Not clear |
| Lili Ji, Xing Fan, Feng Zhou, Jun Gu, Xuedong Den. lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer. Journal of cellular physiology. vol 235. issue 4. 2021-02-02. PMID:31587286. |
western blot analysis was used to assess the apoptosis proteins bax and bcl-2. |
2021-02-02 |
2023-08-13 |
Not clear |
| Rehab F Abdel-Rahman, Sally A El Awdan, Rehab R Hegazy, Dina F Mansour, H A Ogaly, Marwan Abdelbase. Neuroprotective effect of Crocus sativus against cerebral ischemia in rats. Metabolic brain disease. vol 35. issue 3. 2021-02-02. PMID:31728890. |
moreover, saffron treatment evidently reduced apoptosis as revealed by a decrease in caspase-3 and bax protein expression with a marked decrease in the apoptotic neuronal cells compared to i/r group. |
2021-02-02 |
2023-08-13 |
rat |
| Junhua Yang, Wenbo Guo, Jianhua Wang, Xianli Yang, Zhiqi Zhang, Zhihui Zha. T-2 Toxin-Induced Oxidative Stress Leads to Imbalance of Mitochondrial Fission and Fusion to Activate Cellular Apoptosis in the Human Liver 7702 Cell Line. Toxins. vol 12. issue 1. 2021-02-02. PMID:31936883. |
furthermore, the t-2 toxin promoted the release of cytochrome c from mitochondria to cytoplasm and induced cell apoptosis triggered by upregulation of bax and bax/bcl-2 ratios, and further activated the caspase pathways. |
2021-02-02 |
2023-08-13 |
human |
| Syed Saad Hussain, Shaheen Faizi, Kinza Rafi, Shabana U Simje. Novel Mannich base 3FB3FA8H induces apoptosis by upregulating P53 pathway in neuroblastoma cells. Molecular and cellular biochemistry. vol 471. issue 1-2. 2021-02-02. PMID:32472321. |
inclining bax/bcl2 ratio towards apoptotic bax leads to cleavage of caspase 3, ultimately, causing apoptosis. |
2021-02-02 |
2023-08-13 |
Not clear |
| Yahong Liu, Hui Chen, Li Zhang, Tao Zhang, Xuan Re. The Association Between Thyroid Injury and Apoptosis, and Alterations of Bax, Bcl-2, and Caspase-3 mRNA/Protein Expression Induced by Nickel Sulfate in Wistar Rats. Biological trace element research. vol 195. issue 1. 2021-02-01. PMID:31392545. |
the association between thyroid injury and apoptosis, and alterations of bax, bcl-2, and caspase-3 mrna/protein expression induced by nickel sulfate in wistar rats. |
2021-02-01 |
2023-08-13 |
rat |
| Mitu Sharma, Mani Ganeshpandian, Munmi Majumder, Ajaykamal Tamilarasan, Mukesh Sharma, Rupak Mukhopadhyay, Nashreen S Islam, Mallayan Palaniandava. Octahedral copper(ii)-diimine complexes of triethylenetetramine: effect of stereochemical fluxionality and ligand hydrophobicity on Cu Dalton transactions (Cambridge, England : 2003). vol 49. issue 24. 2021-02-01. PMID:32510543. |
the finding of the up-regulation of the pro-apoptotic bax protein and down-regulation of parp protein in western blot analysis confirms the induction of apoptosis by these complexes. |
2021-02-01 |
2023-08-13 |
human |
| Chao Lin, Yien Xiang, Jiyao Sheng, Shui Liu, Mengying Cui, Xuewen Zhan. Long non-coding RNA CRNDE promotes malignant progression of hepatocellular carcinoma through the miR-33a-5p/CDK6 axis. Journal of physiology and biochemistry. vol 76. issue 3. 2021-02-01. PMID:32621257. |
inhibition of crnde suppressed the invasion, migration, and proliferation of hcc cells and enhanced apoptosis by modulating proteins associated with mitochondrial apoptosis (caspase 3, bax, cytochrome-c, bcl-2), which were the same as the function of mir-33a-5p overexpression. |
2021-02-01 |
2023-08-13 |
mouse |