| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Nasehi, Sepehr Torabinejad, Mehrdad Hashemi, Salar Vaseghi, Mohammad-Reza Zarrindas. Effect of cholestasis and NeuroAid treatment on the expression of Bax, Bcl-2, Pgc-1α and Tfam genes involved in apoptosis and mitochondrial biogenesis in the striatum of male rats. Metabolic brain disease. vol 35. issue 1. 2021-01-29. PMID:31773435. |
effect of cholestasis and neuroaid treatment on the expression of bax, bcl-2, pgc-1α and tfam genes involved in apoptosis and mitochondrial biogenesis in the striatum of male rats. |
2021-01-29 |
2023-08-13 |
rat |
| Xu Jing, Lutao Du, Aijun Niu, Yunshan Wang, Yuli Wang, Chuanxin Wan. Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells. BioMed research international. vol 2020. 2021-01-29. PMID:32337219. |
additionally, the decrease in prdx2 expression significantly promoted apoptosis in nsclc cells by downregulating expression of bcl-2 and upregulating the expression of bax, cleaved caspase 3 and cleaved caspase 9, but had no significant effect on the apoptosis of normal lung epithelial cells beas-2b. |
2021-01-29 |
2023-08-13 |
Not clear |
| Rajendran Harishkumar, Chinnadurai Immanuel Selvara. Lotusine, an alkaloid from Nelumbo nucifera (Gaertn.), attenuates doxorubicin-induced toxicity in embryonically derived H9c2 cells. In vitro cellular & developmental biology. Animal. vol 56. issue 5. 2021-01-29. PMID:32468412. |
in qpcr analysis, the lotusine-pretreated cells have mitigated doxorubicin-mediated apoptosis by downregulating the pro-apoptotic gene bax and apoptotic executor caspase-3. |
2021-01-29 |
2023-08-13 |
rat |
| Alexander V Sirotkin, Martina Macejková, Adam Tarko, Zuzana Fabova, Saleh Alwasel, Abdel Halim Harrat. Buckwheat, rooibos, and vitex extracts can mitigate adverse effects of xylene on ovarian cells in vitro. Environmental science and pollution research international. vol 28. issue 6. 2021-01-29. PMID:33033927. |
cell viability, proliferation (pcna accumulation), apoptosis (accumulation of bax), and release of progesterone (p4) and estradiol (e2) were analyzed by the trypan blue tests, quantitative immunocytochemistry, and enzyme-linked immunosorbent assays, respectively. |
2021-01-29 |
2023-08-13 |
Not clear |
| Ying Wang, Chun-Ping Yin, Yan-Lei Tai, Zi-Jun Zhao, Zhi-Yong Hou, Qiu-Jun Wan. Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-29. PMID:33500697. |
normobaric hyperoxia preconditioning improved prolonged escape latency and raised the number of platform crossings induced by sevoflurane in the morris water maze test, increased the level of bcl-2 protein, and decreased the level of bax and active caspase-3 protein, the apoptosis rate and cytosolic calcium concentration in the hippocampus 24 h after sevoflurane exposure. |
2021-01-29 |
2023-08-13 |
rat |
| Gayathri Karanam, Madan Kumar Arumuga. Reactive oxygen species generation and mitochondrial dysfunction for the initiation of apoptotic cell death in human hepatocellular carcinoma HepG2 cells by a cyclic dipeptide Cyclo(-Pro-Tyr). Molecular biology reports. vol 47. issue 5. 2021-01-28. PMID:32248385. |
initially, apoptosis inducing activity of dp was identified using propidium iodide (pi) and acridine orange/ethidium bromide (ao/eb) dual staining, then it was confirmed by dna fragmentation assay and western blotting analysis of apoptosis related markers bax, bcl-2, cytochrome c, caspase-3 and cleaved poly (adp-ribose) polymerase (parp). |
2021-01-28 |
2023-08-13 |
mouse |
| Angus D Cowan, Nicholas A Smith, Jarrod J Sandow, Eugene A Kapp, Yepy H Rustam, James M Murphy, Jason M Brouwer, Jonathan P Bernardini, Michael J Roy, Ahmad Z Wardak, Iris K Tan, Andrew I Webb, Jacqueline M Gulbis, Brian J Smith, Gavin E Reid, Grant Dewson, Peter M Colman, Peter E Czabota. BAK core dimers bind lipids and can be bridged by them. Nature structural & molecular biology. vol 27. issue 11. 2021-01-28. PMID:32929280. |
bak and bax are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. |
2021-01-28 |
2023-08-13 |
human |
| Marco Túlio C Pessôa, Jéssica M M Valadares, Sayonarah C Rocha, Simone C Silva, Jeff P McDermott, Gladis Sánchez, Fernando P Varotti, Cristóforo Scavone, Rosy I M A Ribeiro, José A F P Villar, Gustavo Blanco, Leandro A Barbos. 21-Benzylidene digoxin decreases proliferation by inhibiting the EGFR/ERK signaling pathway and induces apoptosis in HeLa cells. Steroids. vol 155. 2021-01-27. PMID:31812624. |
in addition, 21-bd promotes apoptosis, which is mediated by the translocation of bax from the cytosol to mitochondria and the release of mitochondrial cytochrome c to the cytosol. |
2021-01-27 |
2023-08-13 |
Not clear |
| Sharareh Sharifi, Pargol Ghavam Mostafavi, Roghayeh Tarasi, Ali Mashinchian Moradi, Mohammad Hadi Givianrad, Mahdi Moridi Farimani, Samad Nejad Ebrahimi, Matthias Hamburger, Hassan Nikneja. Purified compounds from marine organism sea pen induce apoptosis in human breast cancer cell MDA-MB-231 and cervical cancer cell Hela. European journal of pharmacology. vol 877. 2021-01-27. PMID:32222494. |
immunocytochemistry and western blot analyses were used to evaluate the expression of apoptosis related markers caspase 3, caspase 8, bax and bcl2 in cancer cells after treating with three compounds. |
2021-01-27 |
2023-08-13 |
human |
| Sharareh Sharifi, Pargol Ghavam Mostafavi, Roghayeh Tarasi, Ali Mashinchian Moradi, Mohammad Hadi Givianrad, Mahdi Moridi Farimani, Samad Nejad Ebrahimi, Matthias Hamburger, Hassan Nikneja. Purified compounds from marine organism sea pen induce apoptosis in human breast cancer cell MDA-MB-231 and cervical cancer cell Hela. European journal of pharmacology. vol 877. 2021-01-27. PMID:32222494. |
treatment of cancer cells with the three purified compounds increased the expression of caspase-3, caspase-8 and bax proteins and decreased the relative bcl-2/bax ratio, demonstrating induction of apoptosis as possible mechanism of action. |
2021-01-27 |
2023-08-13 |
human |
| Jingjing Ma, Yunting Zhang, Huan Deng, Yinghui Liu, Xiaofei Lei, Pengzhan He, Weiguo Don. Thymoquinone inhibits the proliferation and invasion of esophageal cancer cells by disrupting the AKT/GSK-3β/Wnt signaling pathway via PTEN upregulation. Phytotherapy research : PTR. vol 34. issue 12. 2021-01-27. PMID:32901987. |
further investigation of the potential mechanism revealed that tq increased the levels of p53 and p21 but significantly reduced the expression of cyclin b1, cyclin a, and cyclin e. moreover, tq led to a decrease in bcl-2 and an increase in cleaved caspase-3, cleaved caspase-7, cleaved caspase-9, and bax, indicating that tq induced apoptosis by activating the intrinsic mitochondrial apoptosis pathway. |
2021-01-27 |
2023-08-13 |
mouse |
| Shahin Asadi, Alireza Khabbazi, Shahriar Alipour, Somayeh Abolhasani, Jafar Haji, Hossein Amjadi, Ebrahim Sakhini. Promoter methylation of Bax and Bcl2 genes and their expression in patients with Behcet's disease. International journal of immunogenetics. vol 47. issue 3. 2021-01-26. PMID:31916399. |
bcl2 and bax genes are a group of signalling inducer and inhibitor genes playing a key role in the process of cellular physiological death (apoptosis). |
2021-01-26 |
2023-08-13 |
human |
| Wenzhen Huang, Chi Liu, Fengen Liu, Zhiyong Liu, Guie Lai, Jian Y. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway. Cell biochemistry and function. vol 38. issue 3. 2021-01-26. PMID:32107809. |
hinokiflavone exhibited a time- and dose-dependent manner apoptosis induction by upregulating expression of bax and downregulating bcl-2 in breast cancer cells. |
2021-01-26 |
2023-08-13 |
mouse |
| Alexander V Sirotkin, Alexander V Makarevich, Elena Kubovicova, Marina Medvedova, Adriana Kolesarova, Abdel Halim Harrat. Relationship between body conditions and environmental contaminants in bovine ovarian cells. Theriogenology. vol 147. 2021-01-26. PMID:32120185. |
the accumulation of nuclear and cytoplasmic markers of apoptosis (p53 and bax, respectively), a proliferation marker (pcna), progesterone (p4), and insulin-like growth factor i (igf-i) was evaluated by western blot and radioimmunoassay (ria) experiments. |
2021-01-26 |
2023-08-13 |
cattle |
| Alexander V Sirotkin, Alexander V Makarevich, Elena Kubovicova, Marina Medvedova, Adriana Kolesarova, Abdel Halim Harrat. Relationship between body conditions and environmental contaminants in bovine ovarian cells. Theriogenology. vol 147. 2021-01-26. PMID:32120185. |
however, in cells from bcs3 animals, all environmental pollutants inhibited p53, toluene inhibited pcna but not bax, and xylene did not affect the expression of proliferation or apoptosis markers. |
2021-01-26 |
2023-08-13 |
cattle |
| Qifei Xie, Suiji Li, Yun Gao, Ling Jin, Cuilian Dai, Juan Son. Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity. Cardiovascular toxicology. vol 20. issue 5. 2021-01-25. PMID:32361914. |
in addition, er restored nrf2 and ho-1 expression and inhibited apoptosis through upregulating bcl-2 and downregulating bax, cytochrome c, cleaved caspase-3, caspase-9, and parp in rat hearts. |
2021-01-25 |
2023-08-13 |
rat |
| Xiao-Dan Guo, Nan Zhang, Lei Sh. miR-877-5p antagonizes the promoting effect of SP on the gastric cancer progression. Neoplasma. vol 67. issue 6. 2021-01-25. PMID:32853022. |
mir-877-5p negatively regulated gastric cancer development via inhibiting cell proliferation and promoting apoptosis accompanied by increased cleaved caspase-3, cleaved caspase-9, and bax protein levels and decreased bcl-2 level. |
2021-01-25 |
2023-08-13 |
Not clear |
| Hojat Anbara, Mohammad Taghi Sheibani, Mazdak Razi, Mehdi Kia. Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model. Environmental toxicology. vol 36. issue 2. 2021-01-25. PMID:32951320. |
also, it decreased attenuated testicular histomorphometric indices (tubular differentiation index, spermiogenesis index, and repopulation index), and steroidogenic foci, while increased mrna damages and apoptosis rate, downregulated antiapoptotic (bcl-2) and upregulated proapoptotic (p53, bax, and caspase-3) mediators respectively in testis. |
2021-01-25 |
2023-08-13 |
mouse |
| Han-A Park, Katheryn Broman, Elizabeth A Jona. Oxidative stress battles neuronal Bcl-xL in a fight to the death. Neural regeneration research. vol 16. issue 1. 2021-01-23. PMID:32788441. |
during apoptosis, pro-apoptotic bcl2 proteins such as bax and bak translocate to and oligomerize in the mitochondrial membrane. |
2021-01-23 |
2023-08-13 |
Not clear |
| Xueyan Zhang, Wen Liu, Shuxiang We. Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 3. 2021-01-22. PMID:32538769. |
mtt method, western blot, flow cytometry, and real-time quantitative pcr (qpcr) were used to detect cell proliferation, cyclin d1 (cyclind1), p21, b-cell lymphoma / leukemia-2 (bcl-2), bcl-2 related x protein (bax), frat1 protein expression, apoptosis and arhi mrna expression. |
2021-01-22 |
2023-08-13 |
Not clear |