| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xueyan Zhang, Wen Liu, Shuxiang We. Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 3. 2021-01-22. PMID:32538769. |
compared with the control group, luteolin significantly reduced the keloid fibroblast activity, cyclind1, bcl-2, and frat1 protein levels, and obviously improved the cell apoptosis rate, p21 and bax protein expression (p<0.05). |
2021-01-22 |
2023-08-13 |
Not clear |
| Xueyan Zhang, Wen Liu, Shuxiang We. Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 3. 2021-01-22. PMID:32538769. |
inhibition of frat1 expression evidently decreased cell viability at 24 h, 48 h, and 72 h, cyclind1, and bcl-2 protein expression of keloid fibroblasts, while-dramatically enhanced cell apoptosis, p21, and bax protein levels (p<0.05). |
2021-01-22 |
2023-08-13 |
Not clear |
| Xueyan Zhang, Wen Liu, Shuxiang We. Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 3. 2021-01-22. PMID:32538769. |
frat1 overexpression reversed the inhibitory effect of luteolin on keloid fibroblast activity, frat1, cyclind1, and bcl-2 protein expression, and promotion of apoptosis, p21 and bax protein expression. |
2021-01-22 |
2023-08-13 |
Not clear |
| Yuanyuan Zhang, Gaohua Zhang, Yingran Liang, Hongfang Wang, Qian Wang, Ying Zhang, Xuan Zhang, Jianping Zhang, Li Ch. Potential Mechanisms Underlying the Hepatic-Protective Effects of Danshensu on Iron Overload Mice. Biological & pharmaceutical bulletin. vol 43. issue 6. 2021-01-21. PMID:32475919. |
moreover, danshensu prominently inhibited hepatocyte apoptosis through decreasing bax and caspase-3 and increasing bcl-2 expression levels. |
2021-01-21 |
2023-08-13 |
mouse |
| Jun-Rong Liang, Hui Yan. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106377. |
in addition, ga dose-dependently induced apoptosis in gastric cancer cells through activating caspase-9/-3 and poly(adp-ribose) polymerase (parp), which was along with the reduced bcl-2 and bcl-xl expression levels, and the elevated bax and bad levels. |
2021-01-19 |
2023-08-13 |
human |
| Cynthia Lebeaupin, Marina Blanc, Déborah Vallée, Harald Keller, Béatrice Bailly-Maitr. BAX inhibitor-1: between stress and survival. The FEBS journal. vol 287. issue 9. 2021-01-18. PMID:31841271. |
bcl2 associated x, apoptosis regulator (bax) inhibitor-1 (bi-1), also named transmembrane bax inhibitor motif containing-6, is a highly conserved endoplasmic reticulum (er) transmembrane protein. |
2021-01-18 |
2023-08-13 |
Not clear |
| Yousef Faridvand, Parinaz Haddadi, Vahid Vahedian, Samira Nozari, Hamid Reza Nejabati, Masoud Pezeshkian, Abbas Afrasiabi, Nasser Safaie, Ahmadreza Jodati, Mohammad Nour. Human Amnion Membrane Proteins Prevent Doxorubicin-Induced Oxidative Stress Injury and Apoptosis in Rat H9c2 Cardiomyocytes. Cardiovascular toxicology. vol 20. issue 4. 2021-01-18. PMID:32086724. |
moreover, expression profiling of apoptosis-related genes (p53, bcl-2, and bax) and annexin v by flow cytometry were used for cell apoptosis detection. |
2021-01-18 |
2023-08-13 |
human |
| Melissa Yixin Tien, Sanduni Amaya Abeydeera, Hyun-Jung Cho, Gulcan Sarila, Angelique Catubig, Emily Burton, John Hutson, Ruili L. Does the apoptosis pathway play a critical role in gonocyte transformation? Journal of pediatric surgery. vol 55. issue 9. 2021-01-15. PMID:31711746. |
we aim to investigate the role of bax in gonocyte apoptosis. |
2021-01-15 |
2023-08-13 |
Not clear |
| Honglei Xu, Kun He, Yi Li, Yulong Tao, Chunfang Xu, Zhenlin Hu, Tingfang Wang, Chuan Zhan. Cytoprotective Effects Evaluation of a Novel Danshensu Derivative DEX-018 against Oxidative Stress Injury in HUVECs. Biological & pharmaceutical bulletin. vol 43. issue 5. 2021-01-15. PMID:32132313. |
in addition, dex-018 inhibited cell apoptosis and reversed the expression of apoptosis-related proteins (bcl-2, bax, and caspase-3) in huvecs stimulated by t-bhp. |
2021-01-15 |
2023-08-13 |
human |
| Lindan Sun, V Sarath Babu, Zhendong Qin, Youlu Su, Chun Liu, Fei Shi, Lijuan Zhao, Jun Li, Keping Chen, Li Li. Snakehead vesiculovirus (SHVV) infection alters striped snakehead (Ophicephalus striatus) cells (SSN-1) glutamine metabolism and apoptosis pathways. Fish & shellfish immunology. vol 102. 2021-01-15. PMID:32289513. |
by contrast, they were significantly increased in shvv infected cells with gls silence by sirna, indicating that shvv infection activated the bax and caspase-3 pathways to induce apoptosis independent of glutamine. |
2021-01-15 |
2023-08-13 |
Not clear |
| Qingqing Liu, Wei Wang, Yiming Zhang, Yuan Cui, Shiwen Xu, Shu L. Bisphenol A regulates cytochrome P450 1B1 through miR-27b-3p and induces carp lymphocyte oxidative stress leading to apoptosis. Fish & shellfish immunology. vol 102. 2021-01-15. PMID:32430284. |
at the same time, bpa activated the mitochondrial apoptosis pathway, inhibited the expression of bcl-2, and promoted the expression of cytc, bax, caspase-9 and caspase-3. |
2021-01-15 |
2023-08-13 |
cat |
| Racheal O Ogbodu, Bianca Nitzsche, Andi Ma, Devrim Atilla, Ayşe Gül Gürek, Michael Höpfne. Photodynamic therapy of hepatocellular carcinoma using tetra-triethyleneoxysulfonyl zinc phthalocyanine as photosensitizer. Journal of photochemistry and photobiology. B, Biology. vol 208. 2021-01-14. PMID:32480203. |
moreover, an up-regulation of proapoptotic bax and a down-regulation of antiapoptotic b-cell lymphoma 2 (bcl-2) expressions were observed with both proteins implicated in mitochondria-driven apoptosis. |
2021-01-14 |
2023-08-13 |
chicken |
| C R Chen, H L Bi, X Li, Z M L. Remifentanil protects neurological function of rats with cerebral ischemia-reperfusion injury via NR2B/CaMKIIα signaling pathway. Journal of biological regulators and homeostatic agents. vol 34. issue 5. 2021-01-14. PMID:33103411. |
remifentanil preconditioning substantially decreased the neurological score of rats (p<0.01), cerebral infarct size (p<0.01), neuronal apoptosis level (p<0.01), ros level in neurons (p<0.01), mda content (p<0.01) and expression levels of cysteinyl aspartate specific proteinase-3 (caspase-3), nr2b, phosphorylated camkiiα (p-camkiiα) and p-camp responsive element binding protein (p-creb) (p<0.01), but it increased the mitochondrial membrane potential (p<0.01) and b-cell lymphoma 2 (bcl-2)/bcl-2-associated x protein (bax) ratio (p<0.01). |
2021-01-14 |
2023-08-13 |
rat |
| Le Thi Nhu Ngoc, Se-Myo Park, Jung-Hwa Oh, Ho Yun Shin, Moon Il Kim, Hyun Uk Lee, Kyung-Bok Lee, Kug-Seung Lee, Ju-Young Moon, Oh-Hyeok Kwon, Hee Young Yang, Young-Chul Le. Cerium Aminoclay-A Potential Hybrid Biomaterial for Anticancer Therapy. ACS biomaterials science & engineering. vol 5. issue 11. 2021-01-14. PMID:33405676. |
its anticancer mechanism has been fully demonstrated through apoptosis assays; herein ceac induced high-level apoptosis (16%), which promoted the expression of proapoptotic proteins (bax, p53, and caspase 9) in tumor cells. |
2021-01-14 |
2023-08-13 |
mouse |
| Chuang Yang, Minghua Wang, Junde Zhou, Qiang Ch. MicroRNA-335 targets the MEK/ERK pathway to regulate the proliferation and metastasis of colon cancer. American journal of translational research. vol 12. issue 12. 2021-01-14. PMID:33437368. |
the tunnel assay showed mir-335 promotes apoptosis in the ht-29 and sw948 colon cancer cells and is also associated with increase in bax and decrease in bcl-2 expression. |
2021-01-14 |
2023-08-13 |
Not clear |
| Chenchen Li, Wei Zhao, Xuan Pan, Xiaoyou Li, Fei Yan, Siwen Liu, Jifeng Feng, Jianwei L. LncRNA KTN1-AS1 promotes the progression of non-small cell lung cancer via sponging of miR-130a-5p and activation of PDPK1. Oncogene. vol 39. issue 39. 2021-01-13. PMID:32820252. |
ktn1-as1 knockdown inhibited cell growth and proliferation, increased apoptosis, and modulated the expression of cell cycle- and apoptosis-related proteins (cyclin a1, cyclin-dependent kinase 2, bcl2, and bax) in nsclc cell lines and tumour xenografts in nude mice. |
2021-01-13 |
2023-08-13 |
mouse |
| Hartmut Jaeschke, Anup Ramachandra. Acetaminophen-induced apoptosis: Facts versus fiction. Journal of clinical and translational research. vol 6. issue 2. 2021-01-12. PMID:33426354. |
these papers broadly measure "apoptotic markers" with questionable specificity such as bax, bcl-2 and caspase-3 protein expression, or use the terminal deoxynucleotidyl transferase dutp nick end labeling assay as basis for the conclusion that there is apoptosis after apap overdose. |
2021-01-12 |
2023-08-13 |
Not clear |
| Chao Huang, Xiu-Lian Wang, Fang-Fang Qi, Zuo-Liang Pan. Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-β signalling. Journal of cell communication and signaling. vol 14. issue 1. 2021-01-10. PMID:31399854. |
in addition, bbr induced apoptosis in emt-like hcoepic cells in a concentration-dependent manner with upregulation of bax and downregulation of bcl-2. |
2021-01-10 |
2023-08-13 |
Not clear |
| Keman Liao, Yingying Lin, Weizhen Gao, Zhipeng Xiao, Rogelio Medina, Pauline Dmitriev, Jing Cui, Zhengping Zhuang, Xiaochun Zhao, Yongming Qiu, Xiaohua Zhang, Jianwei Ge, Liemei Gu. Blocking lncRNA MALAT1/miR-199a/ZHX1 Axis Inhibits Glioblastoma Proliferation and Progression. Molecular therapy. Nucleic acids. vol 18. 2021-01-10. PMID:31648104. |
elevated zhx1 expression correlated with poor prognosis in gbm patients, and in vitro studies demonstrated that zhx1 attenuated gbm cell apoptosis by downregulation of pro-apoptotic protein (bax) and upregulation of anti-apoptotic protein (bcl-2). |
2021-01-10 |
2023-08-13 |
Not clear |
| Yingchao Wang, Gaoxiong Wang, Xionghong Tan, Kun Ke, Bixing Zhao, Niangmei Cheng, Yuan Dang, Naishun Liao, Fei Wang, Xiaoyuan Zheng, Qin Li, Xiaolong Liu, Jingfeng Li. MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53. Oncogenesis. vol 8. issue 12. 2021-01-10. PMID:31732712. |
the modulation of mt1g on p53 resulted in upregulation of p21 and bax, which leads cell cycle arrest and apoptosis, respectively. |
2021-01-10 |
2023-08-13 |
mouse |