| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin He, Wei Yuan, Fei Liu, Juan Feng, Yanxia Gu. Acylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux. Frontiers in pharmacology. vol 11. 2021-02-16. PMID:33584263. |
it could upregulate the expression of autophagy related proteins like atg7 and lc3-ii and downregulate p62, and downregulate apoptosis related proteins like bax and cleaved caspase 3. |
2021-02-16 |
2023-08-13 |
rat |
| Guangdong Zhang, Fangli Zhong, Lei Chen, Peipei Qin, Junmei Li, Feijie Zhi, Lulu Tian, Dong Zhou, Pengfei Lin, Huatao Chen, Keqiong Tang, Wei Liu, Yaping Jin, Aihua Wan. Integrated Proteomic and Transcriptomic Analyses Reveal the Roles of Frontiers in microbiology. vol 12. 2021-02-16. PMID:33584633. |
integrated proteomic and transcriptomic analyses reveal the roles of bax inhibitor 1 (bi-1) is an evolutionarily conserved transmembrane protein first identified in a screening process for human proteins that suppress bax-induced apoptosis in yeast cells. |
2021-02-16 |
2023-08-13 |
human |
| Viviane L Brair, Ana Lucia R S Maia, Lucas Francisco L Correia, Nathalia O Barbosa, Juliana D R Santos, Felipe Z Brandão, Jeferson F Fonseca, Ribrio Ivan T P Batista, Joanna M G Souza-Fabja. Gene expression patterns of in vivo-derived sheep blastocysts is more affected by vitrification than slow freezing technique. Cryobiology. vol 95. 2021-02-15. PMID:32554154. |
thus, this study assessed the effect of sheep embryo cryopreservation (slow freezing or vitrification) on embryo survival rate and expression of genes related to trophectoderm differentiation (cdx2), pluripotency maintenance (nanog), cell proliferation (tgfb1), mitochondrial activity (nrf1) and apoptosis (bax and bcl2). |
2021-02-15 |
2023-08-13 |
Not clear |
| Linlin Zhang, Tiantian Ma, Qibing Tao, Wushuang Tan, Huatao Chen, Wei Liu, Pengfei Lin, Dong Zhou, Aihua Wang, Yaping Jin, Keqiong Tan. Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cells. Journal of animal science. vol 98. issue 10. 2021-02-15. PMID:32954430. |
microrna-34b overexpression also leads to increased cell apoptosis, with proapoptotic genes p53 and bax upregulated, while antiapoptotic gene bcl2 decreased. |
2021-02-15 |
2023-08-13 |
cattle |
| Xiaomeng Li, Mengmei Ni, Zhirui Yang, Xuxi Chen, Lishi Zhang, Jinyao Che. Bioinformatics analysis and quantitative weight of evidence assessment to map the potential mode of actions of bisphenol A. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-02-15. PMID:33460868. |
the ctd-based bioinformatics analysis results showed that estrogen receptor 1, estrogen receptor 2, mitogen-activated protein kinase (mapk) 1, mapk3, bcl2 apoptosis regulator, caspase 3, bax, androgen receptor, and akt serine/threonine kinase 1 could be the common target genes, and the apoptotic process, cell proliferation, testosterone biosynthetic process, and estrogen biosynthetic process might be the shared phenotypes for different target organs. |
2021-02-15 |
2023-08-13 |
human |
| Atilla Engi. Bile Acid Toxicity and Protein Kinases. Advances in experimental medicine and biology. vol 1275. 2021-02-15. PMID:33539018. |
at mitochondria, the expression of b-cell leukemia/lymphoma-2 (bcl-2) family proteins contribute to apoptosis by regulating mitochondrial cytochrome c release via bcl-2, bcl-2 homology 3 (bh3) interacting domain death agonist (bid), or bcl-2 associated protein x (bax). |
2021-02-15 |
2023-08-13 |
Not clear |
| Wenqi Huang, Hang Sun, Ting Hu, Dongju Zhu, Xianli Long, Hui Guo, Qi Li. Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway. Oncology letters. vol 21. issue 3. 2021-02-13. PMID:33574936. |
however, the results of flow cytometry revealed no changes in apoptosis, and the expression levels of bax, bcl-2, caspase-3 and cleaved caspase-3 were not affected. |
2021-02-13 |
2023-08-13 |
human |
| Yao Sh. MEG3 regulates apoptosis of adipose‑derived stem cells. Molecular medicine reports. vol 21. issue 6. 2021-02-12. PMID:32323784. |
meg3 was overexpressed in adscs and these cells were evaluated for viability, tp53 expression, apoptosis, morphology, and bax and bcl‑2 expression by performing mtt assays, reverse transcription‑quantitative pcr, flow cytometry analysis and western blotting. |
2021-02-12 |
2023-08-13 |
Not clear |
| Yanlei Xiong, Yueming Wang, Yanlian Xiong, Wei Gao, Lianghong Ten. Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1α/JNK pathway. Biochemical and biophysical research communications. vol 529. issue 2. 2021-02-12. PMID:32703432. |
high altitude hypoxia led to significant liver injury and apoptosis, increased the expression levels of p-jnk, bax and er stress markers. |
2021-02-12 |
2023-08-13 |
rat |
| Shaohong Wu, Xiaoping Huang, Wei Sun, Li Chen, Yan Huang, Yan Wang, Erping Luo, Ailan Qin, Weifeng Zhao, Jianhe Ga. Role of the microRNA‑214/Bax axis in the progression of acute liver failure. Molecular medicine reports. vol 22. issue 1. 2021-02-10. PMID:32377732. |
moreover, in d‑galn/tnf‑α‑stimulated bnlcl2 cells, mir‑214 overexpression suppressed apoptosis and decreased tnf‑α and il‑6 levels, and these effects were reversed by the bax plasmid. |
2021-02-10 |
2023-08-13 |
mouse |
| Shaohong Wu, Xiaoping Huang, Wei Sun, Li Chen, Yan Huang, Yan Wang, Erping Luo, Ailan Qin, Weifeng Zhao, Jianhe Ga. Role of the microRNA‑214/Bax axis in the progression of acute liver failure. Molecular medicine reports. vol 22. issue 1. 2021-02-10. PMID:32377732. |
collectively, the present results suggested that mir‑214 inhibited hepatocyte apoptosis during alf development via targeting bax, thus indicating that mir‑214 may be a potential target for alf treatment. |
2021-02-10 |
2023-08-13 |
mouse |
| Tingting Yi, Xiaoxiao Wu, Hong L. Ubiquinol-cytochrome c reductase core protein 1 overexpression protects H9c2 cardiac cells against mimic ischemia/reperfusion injury through PI3K/Akt/GSK-3β pathway. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-10. PMID:32819597. |
finally, uqcrc1 overexpression upregulated the expression of antiapoptotic protein bcl-2, downregulated the expression of proapoptotic protein bax, decreased active caspase 3 expression and cell apoptosis, which were completely abolished by inhibition of pi3k. |
2021-02-10 |
2023-08-13 |
Not clear |
| Jia Huang, Tian Tu, Wenbo Wang, Guangdong Zhou, Wenjie Zhang, Xiaoli Wu, Wei Li. Asiatic Acid Glucosamine Salt Alleviates Ultraviolet B-induced Photoaging of Human Dermal Fibroblasts and Nude Mouse Skin. Photochemistry and photobiology. vol 96. issue 1. 2021-02-08. PMID:31483870. |
the results showed that aags alleviated uvb-induced cell proliferation inhibition by reducing g2 phase arrest and cell apoptosis rate as well as the gene expressions of p53, bax, caspase 3 and caspase 9, but enhancing bcl-2 expression. |
2021-02-08 |
2023-08-13 |
mouse |
| Yuqing Kang, Yuebing Li, Heng Wen, Junfeng Zhu, Jiangbo Zheng, Zhaoming Fen. Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation. Molecular medicine reports. vol 21. issue 5. 2021-02-08. PMID:32186764. |
furthermore, phc and rapa inhibited apoptosis in the cellular h/r model through increasing bcl‑2 expression levels, and suppressing bax and caspase‑3 expression levels; the opposite effect was induced by 3‑ma. |
2021-02-08 |
2023-08-13 |
rat |
| Jianjun Wang, Yunchun Li, Qianfeng Ma, Jiaxin Huan. miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth. Molecular medicine reports. vol 21. issue 6. 2021-02-08. PMID:32236628. |
moreover, mir‑378 increased the rate of apoptosis and upregulated the expression of bax and p53, and suppressed the cell cycle and downregulated the expression of cyclin d1, bcl‑2, akt, β‑catenin and survivin much more effectively in the hcc cell line by applying the combined method. |
2021-02-08 |
2023-08-13 |
Not clear |
| Jiaji Hu, Zhoujie Zhu, Hanglu Ying, Jie Yao, Huabin Ma, Long Li, Yufen Zha. Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice. Frontiers in pharmacology. vol 11. 2021-02-06. PMID:33536915. |
additionally, oea markedly reduced the expression levels of bax, bcl-2 and cleaved caspase-3 to suppress hepatocyte apoptosis. |
2021-02-06 |
2023-08-13 |
mouse |
| Zhongfu Zhang, Jieqing Chen, Zhongshuang Zhu, Zhongqing Zhu, Xinhui Liao, Jianting Wu, Jianli Cheng, Xintao Zhang, Hongbing Mei, Guosheng Yan. CRISPR-Cas13-Mediated Knockdown of lncRNA-GACAT3 Inhibited Cell Proliferation and Motility, and Induced Apoptosis by Increasing p21, Bax, and E-Cadherin Expression in Bladder Cancer. Frontiers in molecular biosciences. vol 7. 2021-02-06. PMID:33537343. |
crispr-cas13-mediated knockdown of lncrna-gacat3 inhibited cell proliferation and motility, and induced apoptosis by increasing p21, bax, and e-cadherin expression in bladder cancer. |
2021-02-06 |
2023-08-13 |
human |
| Jianqin Yan, Jun Chen, Nan Zhang, Yidi Yang, Wangwei Zhu, Li Li, Bin H. Mitochondria-targeted tetrahedral DNA nanostructures for doxorubicin delivery and enhancement of apoptosis. Journal of materials chemistry. B. vol 8. issue 3. 2021-02-05. PMID:31840727. |
meanwhile, 3kla-tdns/dox elevated the pro-apoptotic bax, reduced the anti-apoptotic bcl-2 protein expression and increased the bax/bcl-2 ratio, which finally activated the mitochondria-mediated, programmed apoptosis pathway to enhance the anticancer efficacy in vitro. |
2021-02-05 |
2023-08-13 |
Not clear |
| Yu Yang, Xiaoxia Xu, Qi Liu, Hai Huang, Xuewen Huang, Hongbin L. Myricetin Prevents Cataract Formation by Inhibiting the Apoptotic Cell Death Mediated Cataractogenesis. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-05. PMID:32335580. |
the induction of apoptosis was associated with upregulation of bax and downregulation of bcl-2. |
2021-02-05 |
2023-08-13 |
human |
| Weipeng Zhou, Xianjun Zeng, Xiaoping W. Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-05. PMID:32424110. |
after inhibiting autophagy with 3-ma or cq, compared with oa alone, cell mitochondrial membrane potential and atp concentration were significantly reduced, cell p62 expression was reduced, and lc3-ii expression was increased, apoptosis-related protein bax protein was increased, and bcl-2 protein was decreased, which suggested that 3-ma or cq treatment increased oa-induced apoptosis of smmc-7721 cells. |
2021-02-05 |
2023-08-13 |
Not clear |