| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chaitenya Verma, Kumar Rana Ankush, Vandana Anang, Brijendra K Tiwari, Aayushi Singh, Shakuntala Surender Kumar Saraswati, Malini Shariff, Krishnamurthy Nataraja. Calcium Dynamics Regulate Protective Responses and Growth of Staphylococcus aureus in Macrophages. Biomolecular concepts. vol 11. issue 1. 2021-03-17. PMID:33726488. |
while vgcc regulated the expression of apoptosis protein bax, extracellular calcium-regulated the expression of cytochrome-c. |
2021-03-17 |
2023-08-13 |
Not clear |
| Junzhi Li, Ruining Cheng, Hong Wa. Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway. Bioscience reports. vol 40. issue 1. 2021-03-16. PMID:31909787. |
overexpression of tgr5 significantly improved cell proliferation, alleviated apoptosis rate, the activities of caspase-3, cleaved caspases-3 and bax protein expression levels, and increased bcl-2 level. |
2021-03-16 |
2023-08-13 |
human |
| Yingshu Cao, Xin Di, Qinghua Zhang, Ranwei Li, Ke Wan. RBM10 Regulates Tumor Apoptosis, Proliferation, and Metastasis. Frontiers in oncology. vol 11. 2021-03-16. PMID:33718153. |
rbm10 has long been considered a tumor suppressor because it promotes apoptosis through the regulation of the mdm2-p53 negative feedback loop, bcl-2, bax, and other apoptotic proteins and inhibits proliferation through the notch signaling and rap1a/akt/creb pathways. |
2021-03-16 |
2023-08-13 |
Not clear |
| Xiaojian Zhu, Chen Luo, Kang Lin, Fanqin Bu, Fan Ye, Chao Huang, Hongliang Luo, Jun Huang, Zhengming Zh. Overexpression of DJ-1 enhances colorectal cancer cell proliferation through the cyclin-D1/MDM2-p53 signaling pathway. Bioscience trends. vol 14. issue 2. 2021-03-15. PMID:32132307. |
mechanistic studies indicated that dj-1 increased in crc cell lines, activated specific protein cyclin-d1, and modulated the mdm2/p53 signaling pathway by regulating the levels of the downstream factors bax, caspase-3, and bcl-2, which are related to the cell cycle and apoptosis. |
2021-03-15 |
2023-08-13 |
Not clear |
| Yujia Xu, Kun Zeng, Xiaoge Wang, Jieyu Zhang, Biyin Cao, Zubin Zhang, Chunhua Qiao, Xiaofeng Xu, Qi Wang, Yuanying Zeng, Xinliang Ma. Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway. Bioscience trends. vol 14. issue 2. 2021-03-15. PMID:32173687. |
further studies showed that these agents such as 4061 and 4065b displayed potent activity to induce mm cell apoptosis by upregulating pro-apoptotic p53 and bax while downregulating pro-survival bcl-2. |
2021-03-15 |
2023-08-13 |
Not clear |
| Patrycja Kurowska, Ewa Mlyczyńska, Joelle Dupont, Agnieszka Ra. Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3/1 Kinase Pathways. International journal of molecular sciences. vol 21. issue 18. 2021-03-15. PMID:32957618. |
porcine luteal cells were incubated with vaspin (0.1-10 ng/ml) for 24 h to 72 h and then mrna and protein expression of angiogenesis: vascular endothelial growth factor (vegfa), fibroblast growth factor 2 (fgf2), angiopoietin 1 (angpt1), vegfa receptors (vegfr1, vegfr2), apoptosis: caspase 3, bcl-2-like protein 4 (bax), b-cell lymphoma (bcl2), and proliferation: proliferating cells nuclear antigen (pcna), cyclin a factors as well as secretion of vegfa, fgf2, angt1 were measured by real-time polymerase chain reaction (pcr), immunoblotting and enzyme-linked immunosorbent assay (elisa), respectively. |
2021-03-15 |
2023-08-13 |
Not clear |
| Min Zhang, Sumei Zhao, Chen Xu, Yang Shen, Jing Huang, Shen Shen, Yanchun Li, Xiangmei Che. Ablation of lncRNA MIAT mitigates high glucose-stimulated inflammation and apoptosis of podocyte via miR-130a-3p/TLR4 signaling axis. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-15. PMID:32972755. |
moreover, depletion of miat evidently amplified cell viability and alleviated hg-triggered apoptosis, reflected as the downregulation of bax expression concomitant with the enhancement of bcl-2 expression in hg-exposed podocytes. |
2021-03-15 |
2023-08-13 |
Not clear |
| Pradip Kumar Jaiswara, Vishal Kumar Gupta, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Chandramani Pathak, Santosh Kumar, Ajay Kuma. Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism. Environmental toxicology. vol 36. issue 4. 2021-03-11. PMID:33274819. |
nimbolide-induced apoptosis in t lymphoma cells by altering the level of reactive oxygen species, p53, bcl2, bax, and cytochrome c, with subsequent cleavage of caspase 3. |
2021-03-11 |
2023-08-13 |
Not clear |
| Dandan Zhao, Hongxia Zhao, Yang He, Yang Yang, Yan Du, Meixia Zhan. The inhibitive effects of proteasome inhibitor MG-132 on pterygium fibroblasts in vitro and the potential key regulators involved. Life sciences. vol 270. 2021-03-11. PMID:33482188. |
mg-132 dose-dependently inhibited the growth of hpfs, induced g2/m phase arrest of cell cycle at a certain dose, and also caused cell apoptosis, with the levels of cleaved caspase3, cleaved parp, bax and p21 increased. |
2021-03-11 |
2023-08-13 |
human |
| Ruisan Zhang, Yongcai Zheng, Fengrui Hu, Xin Meng, Bosen Lv, Kejing Lao, Xingchun Gao, Xiaohua Zhang, Xingchun Go. Effect of (m)VD-hemopressin against Aβ1-42-induced oxidative stress and apoptosis in mouse hippocampal neurons. Peptides. vol 124. 2021-03-10. PMID:31730791. |
we also found that vd restored the decrease in cell growth and viability induced by aβ1-42 and reversed aβ1-42-induced apoptosis mediated by the apoptosis-associated proteins bcl-2 and bax. |
2021-03-10 |
2023-08-13 |
mouse |
| Hung-Ju Chien, Tsung-Ho Ying, Shu-Ching Hsieh, Chia-Liang Lin, Yung-Luen Yu, Shao-Hsuan Kao, Yi-Hsien Hsie. α-Mangostin attenuates stemness and enhances cisplatin-induced cell death in cervical cancer stem-like cells through induction of mitochondrial-mediated apoptosis. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31960449. |
further investigation showed that α-mangostin induced mitochondrial depolarization and mitochondrial apoptosis signaling, including upregulation of bax, downregulation of mcl-1 and bcl-2, and activation of caspase-9/3. |
2021-03-10 |
2023-08-13 |
Not clear |
| Ting Yang, Ting-Jun Fan, Bin X. Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 66. 2021-03-10. PMID:32320760. |
moreover, 0.75 mg/ml nor induced chromatin condensation, s phase arrest, phosphatidylserine externalization, and formation of apoptotic body through activation of caspase-2/-8/-9/-3, downregulation of bcl-2 and bcl-xl, upregulation of bad and bax, mitochondrial transmembrane potential disruption and release of cytochrome c and apoptosis inducing factor into cytosol, whereas 1.5 mg/ml and 3.0 mg/ml nor upregulated the expressions of receptor-interacting protein kinase 1 (ripk1), ripk3 and mixed lineage kinase domain-like (mlkl) together with inactivation of caspase-2/-8. |
2021-03-10 |
2023-08-13 |
human |
| Jing Huang, Dian Bao, Chun-Tao Lei, Hui Tang, Chun-Yun Zhang, Hua Su, Chun Zhan. Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-10. PMID:32686857. |
importantly, knocking down of selt expression in kidney cells in vitro resulted in cisplatin-induced cell apoptosis, as indicated by the elevation of cleaved-parp and bax expression, caspase-3 activity, and number of tunel-positive cells. |
2021-03-10 |
2023-08-13 |
cat |
| Hua Hu, Xiaofei Jia. The protective mechanism of action of plantamajoside on a rat model of acute spinal cord injury. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680100. |
it was observed that pms could reverse the decrease in the bbb score after asci, improve the morphological characteristics of the spinal cord, reduce the degree apoptosis and affect the expression of caspase-3, caspase-9, parp, bax and bcl-2 in a concentration dependent manner. |
2021-03-10 |
2023-08-13 |
rat |
| Anna Kleczka, Robert Kubina, Radosław Dzik, Krzysztof Jasik, Jerzy Stojko, Krzysztof Cholewa, Agata Kabała-Dzi. Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes. Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-09. PMID:32752091. |
in ov7 cells cape induced apoptosis via dysregulation of bax/bcl2 balance, while activated proapoptotic bax gene expression level was 10 times higher than bcl2. |
2021-03-09 |
2023-08-13 |
Not clear |
| Hongguang Jia, Zhan Yu, Xiaohui Ge, Zhiting Chen, Xiaobing Huang, Yongxiang We. Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats. Medical molecular morphology. vol 53. issue 2. 2021-03-08. PMID:31485805. |
noise exposure increased abr threshold shifts and cochlear apoptosis in parallel with downregulation of bcl-xl and upregulation of grp78, chop, bax and cleaved caspase-3. |
2021-03-08 |
2023-08-13 |
rat |
| Zhiyan Wu, Yudan Liang, Shangzhen Y. Downregulation of microRNA-103a reduces microvascular endothelial cell injury in a rat model of cerebral ischemia by targeting AXIN2. Journal of cellular physiology. vol 235. issue 5. 2021-03-08. PMID:31650542. |
in response to the treatment of mir-103a inhibitors, the bmecs apoptosis was suppressed and angiogenesis was restored, corresponding to upregulated bcl-2, vegf, and ang-1, in addition to downregulated caspase-3 and bax. |
2021-03-08 |
2023-08-13 |
rat |
| Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J van den Oord, William M Gallagher, Markus Reh. Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. Cell death & disease. vol 11. issue 2. 2021-03-08. PMID:32054850. |
as chemotherapy primarily eliminates cancer cells by apoptosis, we here evaluated if the expression of key apoptosis regulators (bax, bak, bcl-2, bcl-xl, smac, procaspase-9, apaf-1, procaspase-3 and xiap) allows prognosticating pfs in stage iii/iv melanoma patients. |
2021-03-08 |
2023-08-13 |
Not clear |
| Cunzhi Lin, Xinhong Zhu, Qing Jin, Aihua Sui, Jinfeng Li, Liyan She. Effects of Holothurian Glycosaminoglycan on the Sensitivity of Lung Cancer to Chemotherapy. Integrative cancer therapies. vol 19. 2021-03-08. PMID:32202167. |
the mechanism of apoptosis may be related to the reduction of bcl-2 and survivin, as well as the ascension of bax and caspase-3. |
2021-03-08 |
2023-08-13 |
Not clear |
| b' Long-An Zhou, Tong-Bo Liu, Hong-Na L\\xc3\\xb. Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo. Anti-cancer drugs. vol 31. issue 6. 2021-03-08. PMID:32427739.' |
additionally, geraniin remarkably induced apoptosis of sw480 and ht-29 cells in a dose-dependent way by hoechst 33342 staining, flow cytometric analysis, and tdt-mediated dutp nick-end labeling assays and increased the expressions of bax, caspase-3, and caspase-9, while decreased the level of bcl-2. |
2021-03-08 |
2023-08-13 |
human |