| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengzhu Liao, Yuming Jin, Yuchao Li, Sie Chin Tjon. Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity. International journal of molecular sciences. vol 21. issue 17. 2021-03-25. PMID:32878253. |
these ros-mediated responses induce caspase-dependent apoptosis via the activation of b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), ccaat/enhancer-binding protein homologous protein (chop), and phosphoprotein p53 gene expressions. |
2021-03-25 |
2023-08-13 |
mouse |
| Shingo Yokoyama, Yoshitaka Ohno, Tatsuro Egawa, Kazuya Ohashi, Rika Ito, Huascar Pedro Ortuste Quiroga, Tomohiro Yamashita, Katsumasa Got. MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle. International journal of molecular sciences. vol 21. issue 17. 2021-03-25. PMID:32887414. |
we explored the interrelationship between a tissue-specific alternative splicing factor muscleblind-like 1 (mbnl1) and peroxisome proliferator-activated receptor-γ coactivator 1-α (pgc-1α), b-cell lymphoma 2 (bcl-2) or bcl-2-associated x protein (bax) in c2c12 myotubes and mouse skeletal muscle to investigate a possible physiological role of mbnl1 in mitochondrial-associated apoptosis of skeletal muscle. |
2021-03-25 |
2023-08-13 |
mouse |
| Daniel T Cohen, Thomas E Wales, Matthew W McHenry, John R Engen, Loren D Walensk. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell reports. vol 30. issue 10. 2021-03-23. PMID:32160532. |
here, we find that trans-2-hexadecenal (t-2-hex), previously implicated in regulating bax-mediated apoptosis, does so by direct covalent reaction with c126, which is located on the surface of bax at the junction of its α5/α6 core hydrophobic hairpin. |
2021-03-23 |
2023-08-13 |
Not clear |
| Daniel T Cohen, Thomas E Wales, Matthew W McHenry, John R Engen, Loren D Walensk. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell reports. vol 30. issue 10. 2021-03-23. PMID:32160532. |
the functional role of bax lipidation as a control point of mitochondrial apoptosis could provide a therapeutic strategy for bax modulation by chemical modification of c126. |
2021-03-23 |
2023-08-13 |
Not clear |
| Guijun Cao, Xianqing Meng, Xiaodong Han, Jinhua L. Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-α-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a. Bioscience reports. vol 40. issue 5. 2021-03-23. PMID:32400849. |
results showed that tumor necrosis factor-α (tnf-α) dose-dependently increased mir-146a expression, inhibited cell viability, and promoted cell apoptosis, as indicated by increased caspase-3, cleaved caspase-3, and bcl-2-associated x protein (bax) expression as well as caspase-3 activity. |
2021-03-23 |
2023-08-13 |
Not clear |
| Guijun Cao, Xianqing Meng, Xiaodong Han, Jinhua L. Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-α-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a. Bioscience reports. vol 40. issue 5. 2021-03-23. PMID:32400849. |
moreover, co-culture with exosomes-derived from circ-rtn4-modified bmscs (rtn4-exos) attenuated tnf-α-induced cytotoxicity and apoptosis in mc3t3-e1 cells, as evidenced by the decrease in caspase-3, cleaved caspase-3, and bax protein expression and caspase-3 activity. |
2021-03-23 |
2023-08-13 |
Not clear |
| Hany Elsawy, Abdulmohsen I Algefare, Manal Alfwuaires, Mahmoud Khalil, Omar M Elmenshawy, Azza Sedky, Ashraf M Abdel-Monei. Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. Bioscience reports. vol 40. issue 6. 2021-03-23. PMID:32458964. |
also, our data introduce mtx and nar as promising antiproliferative agents with a distinctive mode of action, inducing apoptosis in hepg2 tumor cells through activation of bax and down-regulation of bcl-2 protein expression. |
2021-03-23 |
2023-08-13 |
rat |
| Shuyu Xiong, Mingming Ma, Yupeng Xu, Fang Wei, Qing Gu, Xiangui He, Xun X. Protective effects of peptide FK18 against neuro-excitotoxicity in SH-SY5Y cells. Experimental and therapeutic medicine. vol 21. issue 5. 2021-03-23. PMID:33747186. |
for this purpose, cell viability was determined by the mts assay, cell apoptosis was assessed by flow cytometry and the tunel assay; expression of antiapoptotic proteins bcl-2, proapoptotic protein bax and caspase-3 as well as the phosphorylation of akt and erk was estimated by western blotting. |
2021-03-23 |
2023-08-13 |
Not clear |
| Lixia Shi, Qing Chen, Xiaofen G. Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-22. PMID:32654289. |
downregulation of linc00337 results in increased bax level, decreased fscn1, bcl-2, vegf, and p53 levels, in addition to diminished cell proliferation, migration, invasion and tumor growth, with accelerated cell apoptosis by upregulating mir-145. |
2021-03-22 |
2023-08-13 |
Not clear |
| Suxia Zheng, Maolei Gong, Jing Che. Extracellular vesicles enriched with miR-150 released by macrophages regulates the TP53-IGF-1 axis to alleviate myocardial infarction. American journal of physiology. Heart and circulatory physiology. vol 320. issue 3. 2021-03-22. PMID:33164579. |
furthermore, increased expression of ev-derived mir-150 prevented cardiomyocyte apoptosis in vitro, as evidenced by downregulated bax and cleaved-caspase 3 and upregulated bcl2 and alleviated mi in vivo. |
2021-03-22 |
2023-08-13 |
mouse |
| Yang Li, Feifei Ma, Zengqiang Li, Yige Yu, Haoni Yan, Anam Tahir, Wenwen Zheng, Xiaoheng Li, Tongliang Huang, Ren-Shan G. Exposure to 4-bromodiphenyl ether during pregnancy blocks testis development in male rat fetuses. Toxicology letters. vol 342. 2021-03-22. PMID:33582287. |
in utero exposure to bde3 can promote autophagy and apoptosis of fetal leydig cells via increasing the levels of beclin1, lc3-ii, bax, and by decreasing the levels of p62 and bcl2. |
2021-03-22 |
2023-08-13 |
rat |
| Peng Li, Weiwei Mao, Shuai Zhang, Liang Zhang, Zhirong Chen, Zhidong L. MicroRNA-22 contributes to dexamethasone-induced osteoblast differentiation inhibition and dysfunction through targeting caveolin-3 expression in osteoblastic cells. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-20. PMID:33732309. |
the results also demonstrated that silencing of cav3 blocked the beneficial effects of mir-22 inhibitor against dex-induced cell damage and apoptosis in osteoblasts, as evidenced by the increased expression levels of cleaved caspase-3, bax and alkaline phosphatase activity as well as decreased cell viability and bcl-2 levels. |
2021-03-20 |
2023-08-13 |
Not clear |
| Juan Yu, Chao Liu, Hai-Yu Ji, An-Jun Li. The caspases-dependent apoptosis of hepatoma cells induced by an acid-soluble polysaccharide from Grifola frondosa. International journal of biological macromolecules. vol 159. 2021-03-19. PMID:32422265. |
rh123, jc-1 staining and western blotting results suggested that gfap could significantly increase the permeability of mitochondrial membrane of hcc cells, and upregulated the expressions of bax, cytochrome c, cleaved-caspase-3 and cleaved-caspase-9, which indicated that gfap could trigger apoptosis of hcc cells through mitochondria apoptotic pathway in a caspases-dependent pattern. |
2021-03-19 |
2023-08-13 |
Not clear |
| Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin, Mushfera Zamila, Faisal Parvez, Md Mizanur Rahman, Ferdous Khan, Nusrat Subhan, Md Ashraful Ala. Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK-Akt-eNOS pathway in the isoprenaline-induced oxidative stress model. Scientific reports. vol 10. issue 1. 2021-03-19. PMID:32887916. |
further, canagliflozin prevents iso-induced apoptosis of kidney cells by inhibiting bax protein upregulation and caspase-3 activation. |
2021-03-19 |
2023-08-13 |
rat |
| Yongjie Xiong, Jing Li, Shaojun H. Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells. Biological trace element research. 2021-03-19. PMID:33738683. |
hs treatment inhibited cell viability and induced apoptosis, which was accompanied by the induction of the activity of caspase 3, an executioner of apoptosis, involved in the expression of pro-apoptotic protein b cell lymphoma 2-associated x protein (bax), and in the reduction of the expression of anti-apoptotic protein b cell lymphoma 2 (bcl-2), thereby activating er stress marker protein expression (glucose-regulated protein 78 (grp78) and ccaat/enhancer-binding protein homologous protein (chop)). |
2021-03-19 |
2023-08-13 |
Not clear |
| Yongjie Xiong, Jing Li, Shaojun H. Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells. Biological trace element research. 2021-03-19. PMID:33738683. |
however, zinc sulfate led to the attenuation of deleterious effects, including increases in apoptosis, caspase-3 activity, bax, grp78, and chop expression, and decreases in cell viability and bcl-2 protein expression in cells treated with hs or thapsigargin (an er stress activator). |
2021-03-19 |
2023-08-13 |
Not clear |
| Ying Zhou, Xiujuan Cha. Protective effect of bicyclol against pulmonary fibrosis via regulation of microRNA-455-3p in rats. Journal of cellular biochemistry. vol 121. issue 1. 2021-03-18. PMID:31407409. |
bicyclol inhibited fibrosis-induced apoptosis of hpaepic in alveolar epithelial cells through promoting mir-455-3p, which inhibited bax expression in ipf. |
2021-03-18 |
2023-08-13 |
rat |
| Muhammad Fakhar-E-Alam Kulyar, Wangyuan Yao, Yanmei Ding, Haitao Du, Kun Li, Lihong Zhang, Aoyun Li, Pan Huachun, Muhammad Waqas, Khalid Mehmood, Jiakui L. Cluster of differentiation 147 (CD147) expression is linked with thiram induced chondrocyte's apoptosis via Bcl-2/Bax/Caspase-3 signalling in tibial growth plate under chlorogenic acid repercussion. Ecotoxicology and environmental safety. vol 213. 2021-03-18. PMID:33647747. |
the current study investigates the imperceptible insight of cga on chondrocyte's apoptosis via b-cell lymphoma 2 (bcl-2), bcl-2 associated x-protein (bax), and caspase-3 with cd147 signalling. |
2021-03-18 |
2023-08-13 |
Not clear |
| Haili Tang, Ping Yang, Xiaojun Yang, Shujia Peng, Xi'e Hu, Guoqiang Ba. Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling. Molecular and cellular biochemistry. vol 472. issue 1-2. 2021-03-17. PMID:32577949. |
we also demonstrated that grb7 downregulation increased the levels of bax and caspase 3, and inhibited the expression of bcl-2, suggesting the induced mitochondrial apoptosis. |
2021-03-17 |
2023-08-13 |
Not clear |
| Ž Frangež, S M Seyed Jafari, R E Hunger, H-U Simo. Loss of Concurrent Regulation of the Expression of BIF-1, BAX, and Beclin-1 in Primary and Metastatic Melanoma. Biochemistry. Biokhimiia. vol 85. issue 10. 2021-03-17. PMID:33202207. |
bif-1 promotes apoptosis through binding to bax and its translocation to the mitochondrial outer membrane. |
2021-03-17 |
2023-08-13 |
Not clear |