| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunfang Han, Haiying Yu, Qingxia Zho. Calcitriol Attenuates HRV-Induced Respiratory Injury through the AMPK-mTOR-ER Stress Signaling Pathway. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 40. issue 2. 2021-04-08. PMID:33822515. |
additionally, hrv increased levels of apoptosis and er stress markers (including cleaved-caspase3, bax, chop, natf6, and bip), while calcitriol significantly reversed these effects. |
2021-04-08 |
2023-08-13 |
human |
| Xu-Shun Jiang, Xing-Yang Xiang, Xue-Mei Chen, Jun-Ling He, Ting Liu, Hua Gan, Xiao-Gang D. Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32439839. |
furthermore, dysfunctional mitochondria accumulated in the cytoplasm, which resulted in excessive reactive oxygen species (ros) generation, bax translocation, cytochrome c release, and apoptosis. |
2021-04-07 |
2023-08-13 |
mouse |
| Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayaram. Musa acuminata lectin exerts anti-cancer effects on HeLa and EAC cells via activation of caspase and inhibitions of Akt, Erk, and Jnk pathway expression and suppresses the neoangiogenesis in in-vivo models. International journal of biological macromolecules. vol 166. 2021-04-07. PMID:33159939. |
mal mitigates the cell proliferation, colony formation, cell migration, arrest the cell cycle in the g2/m phase, and induce apoptosis by altering the expression of apoptotic proteins/mrna level (bax and bcl-2) via caspase 8/9, 3 dependent pathway in both in-vitro and in-vivo. |
2021-04-07 |
2023-08-13 |
mouse |
| Pengzhan Liu, Zhao Yin, Min Chen, Caihuan Huang, Zhihui Wu, Junqing Huang, Shiyi Ou, Jie Zhen. Cytotoxicity of adducts formed between quercetin and methylglyoxal in PC-12 cells. Food chemistry. vol 352. 2021-04-07. PMID:33706136. |
they elevated apoptosis via upregulation of expression of apoptotic markers, including p-p38, cleaved caspase-9 and -3, and pro-apoptotic bax. |
2021-04-07 |
2023-08-13 |
Not clear |
| Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Che. Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke. International journal of environmental health research. 2021-04-07. PMID:33825597. |
the results showed that cell apoptosis, lung structural damage, and the activity of mda, as well as the expression of apoptosis-related proteins bax, total caspase-3, and cleaved caspase-3 were increased in cs-treated mice. |
2021-04-07 |
2023-08-13 |
mouse |
| Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Che. Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke. International journal of environmental health research. 2021-04-07. PMID:33825597. |
however, pifithrin-α (p53 inhibitor) and n-acetylcysteine (nac) could reduce cell apoptosis, lung structural damage and oxidative stress, accelerate the expression of bcl-2, while suppressing the expression of bax, total caspase-3 and cleaved caspase-3. |
2021-04-07 |
2023-08-13 |
mouse |
| Nahla E El-Ashmawy, Eman G Khedr, Hoda A El-Bahrawy, Nada N Helm. Modulatory Effect of Silymarin on Apoptosis in Testosterone -Induced Benign Prostatic Hyperplasia in Rats. Pathology oncology research : POR. vol 26. issue 3. 2021-04-06. PMID:31902118. |
silymarin induced caspase-dependent apoptosis in bph as sil significantly reduced prostatic bcl-2 protein and increased bax protein concentration. |
2021-04-06 |
2023-08-13 |
rat |
| Kan Shao, Liuqing Xi, Zhen Cang, Cheng Chen, Shan Huan. Knockdown of NEAT1 exerts suppressive effects on diabetic retinopathy progression via inactivating TGF-β1 and VEGF signaling pathways. Journal of cellular physiology. vol 235. issue 12. 2021-04-06. PMID:32356340. |
moreover, the loss of neat1 enhanced hrecs proliferation and repressed hg-induced apoptosis, which was accompanied by an upregulation of bcl-2 and a downregulation of bax. |
2021-04-06 |
2023-08-13 |
mouse |
| Bingxian Liu, Qiwen Zeng, Hanming Chen, Jianzhao Liao, Yuman Bai, Qingyue Han, Na Qiao, Shuzhou Wang, Khalid Mehmood, Riaz Hussain, Bhutto Zohaib Ahmed, Zhaoxin Tang, Hui Zhang, Ying L. The hepatotoxicity of altrazine exposure in mice involves the intestinal microbiota. Chemosphere. vol 272. 2021-04-06. PMID:33485040. |
moreover, results also revealed that atr induced apoptosis via disruption of apoptotic (bax, bcl2, and casp3) and autophagy (lc3/map1lc3a, beclin 1/becn1 and p62/sqstm1) genes. |
2021-04-06 |
2023-08-13 |
mouse |
| G Pkhakadze, Z Bokhua, T Asatiani, T Muzashvili, G Burkadz. LOSS OF CAS3 AND INCREASE OF BAX EXPRESSION ASSOCIATED WITH PROGRESSION OF CERVICAL INTRAEPITHELIAL NEOPLASIA. Georgian medical news. issue 311. 2021-04-06. PMID:33814409. |
the results indicate that the deregulated apoptosis measured as increased expression of bax and cas3 loss, as well as the increase in proliferation index measured as ki67 expression is significantly related to the progression of cin into cervical carcinoma. |
2021-04-06 |
2023-08-13 |
human |
| Chao Wang, Wen-Bo Wan. Telmisartan Induces Osteosarcoma Cells Growth Inhibition and Apoptosis Via Suppressing mTOR Pathway. Open life sciences. vol 13. 2021-04-06. PMID:33817089. |
the percentage of apoptotic cells were detected by flow cytometric analysis and proteins related to apoptosis including bax, bcl-2 and cleaved caspase-3 were examined by western blotting. |
2021-04-06 |
2023-08-13 |
human |
| Qi Wang, Shaofeng Liu, Zhen Ha. miR-339-3p regulated acute pancreatitis induced by caerulein through targeting TNF receptor-associated factor 3 in AR42J cells. Open life sciences. vol 15. issue 1. 2021-04-06. PMID:33817278. |
mir-399-3p transfection inhibited the levels of tnf-α, il-1β, and il-6 and c-caspase 3 and bax protein expression as well as suppressed cell apoptosis, while increased bcl-2 protein expression in caerulein-induced ap. |
2021-04-06 |
2023-08-13 |
rat |
| Yu Fan, Yu Wang, Shaozhi Fu, Duan Liu, Sheng Li. Methylation-regulated ZNF545 inhibits growth of the p53-mutant KYSE150 cell line by inducing p21 and Bax. Experimental and therapeutic medicine. vol 18. issue 3. 2021-04-05. PMID:31410110. |
ectopic expression of znf545 activated p53 transcription and upregulated the protein expression levels of pivotal effectors p21 and bax, which are associated with cell proliferation and apoptosis, respectively, in p53-mutant kyse150 cells; while suppressing colony formation and inducing apoptosis. |
2021-04-05 |
2023-08-13 |
Not clear |
| Xiaoqing Zhang, Juan Li, Li Ma, Hui Xu, Yun Cao, Wei Liang, Jia Ma, Z Peter Wang, Yuyun L. BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease. Cell death discovery. vol 7. issue 1. 2021-04-02. PMID:33723239. |
consistent with these results, bmp4 modulation affected cell apoptosis via the regulation of bax and bcl-2 expression in cells. |
2021-04-02 |
2023-08-13 |
mouse |
| Bing-Fan Wu, Liu-Ji Zhang, Kai-Yan Li, Jian-Xia Wang, Wan-Qian Tu, Yu Zhan. [Protective effect of serum containing ginseng and Moutan Cortex on HUVEC injured by H_2O_2]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 6. 2021-04-02. PMID:33787145. |
the expressions of mitochondrial apoptosis pathway-related proteins bax, bcl-2, cytochrome c, caspase-3 and caspase-9 were detected by western blot. |
2021-04-02 |
2023-08-13 |
human |
| Jun Xue, Yadong Liu, Sichong Zhang, Liucheng Ding, Baixin Shen, Yunpeng Shao, Zhongqing We. Caffeine improves bladder function in diabetic rats via a neuroprotective effect. Experimental and therapeutic medicine. vol 21. issue 5. 2021-04-02. PMID:33791010. |
relative to that in the dm group, the expression levels of ngf, bdnf and cgrp in the bladder tissue of dm + caffeine rats increased; cellular apoptosis in the drg of dm + caffeine rates decreased; and the expression levels of bcl-2, bax, cleaved caspase-3 and cleaved caspase-9 proteins in the drg of dm + caffeine rats were restored to a certain extent. |
2021-04-02 |
2023-08-13 |
rat |
| Chenguang Hao, Shibao Che. Knockdown of lncRNA TTTY15 alleviates ischemia/reperfusion-induced inflammation and apoptosis of PC12 cells by targeting miR-766-5p. Experimental and therapeutic medicine. vol 21. issue 5. 2021-04-02. PMID:33791020. |
the effects of the knockdown of ttty15 expression on the levels of the inflammatory cytokines tnf-α, il-1β, il-18 and il-10, cell apoptosis and the expression levels of the apoptosis-associated proteins bcl-2, bax, cleaved caspase-3, caspase-3, cleaved caspase-9 and caspase-9, were subsequently analyzed in ogd/r-treated pc12 cells using elisa, flow cytometry and western blotting, respectively. |
2021-04-02 |
2023-08-13 |
Not clear |
| Dong-Ru Ho, Pey-Jium Chang, Wei-Yu Lin, Yun-Ching Huang, Jian-Hui Lin, Kuo-Tsai Huang, Wai-Nga Chan, Chih-Shou Che. Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis. International journal of molecular sciences. vol 21. issue 11. 2021-04-01. PMID:32486412. |
apoptosis markers, b-cell lymphoma 2-associated x protein (bax) and caspase-3, were elevated in icta-treated chronic pelvic pain syndrome (cpps) rats. |
2021-04-01 |
2023-08-13 |
rat |
| Yuping Zhou, Di Zhang, Genghan He, Chuang Liu, Yinuo Tu, Xiang Li, Qianbing Zhang, Xu Wu, Ruiyuan Li. A lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescence imaging. Journal of materials chemistry. B. vol 9. issue 4. 2021-04-01. PMID:33427275. |
furthermore, ttrh-cn can efficiently produce ros in conjunction with lysosomes in situ upon light irradiation, which can damage lysosomes, up-regulate lc3 and beclin1, increase bax release, and induce cell apoptosis. |
2021-04-01 |
2023-08-13 |
Not clear |
| Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams, Grant Dewson, Ruth M Kluc. Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target. Cell death & disease. vol 11. issue 4. 2021-03-31. PMID:32327636. |
robust autoactivation for apoptosis by bak but not bax highlights bak as an important therapeutic target. |
2021-03-31 |
2023-08-13 |
Not clear |