| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin An, Chan Wang, You-Guang Zheng, Jia-Dong Liu, Tong-Hui Huan. Design, synthesis and evaluation of calix[4]arene-based carbonyl amide derivatives with antitumor activities. European journal of medicinal chemistry. vol 210. 2021-04-22. PMID:33183867. |
further mechanism studies significantly indicated that compound 5h could block mda-mb-231 cell cycle arrest in g0/g1 phase by down regulating cyclin d1 and cdk4, and induce apoptosis by up-regulation of bax, down-regulation of caspase-3, parp and bcl-2 proteins, resulting in the reduction of dna synthesis and cell division arrest. |
2021-04-22 |
2023-08-13 |
human |
| Ying Peng, Dong Xu, Shishi Mao, Xingqin Zho. Neurotoxicity and apoptosis induced by pyrroloquinoline quinone and its ester derivative on primary cortical neurons. Neurotoxicology. vol 78. 2021-04-21. PMID:32068067. |
pqq and pqqe induced apoptosis involving increase of bax, decrease of bcl-2, release of mitochondrial cytochrome c into the cytosol, activation of caspase-3 and cleavage of parp. |
2021-04-21 |
2023-08-13 |
mouse |
| Lihua Yang, Ningning Guo, Wei Fan, Chunmin Ni, Mengbing Huang, Liping Bai, Le Zhang, Xianwen Zhang, Yunbo Wen, Ye Li, Xiaoshuang Zhou, Jie Ba. Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice. Neurotoxicology. vol 78. 2021-04-21. PMID:32203791. |
we further examined er stress-related proteins and mitochondrial apoptosis pathway in the vta and nac, and found that meth increased the expressions of glucose regulated protein 78 (grp78), c/ebp homologous protein (chop), and bax, as same time decreased the expressions of procaspase12, bcl-2, and procaspase3, while trx-1 overexpression blocked these changes. |
2021-04-21 |
2023-08-13 |
mouse |
| Chathura D Suraweera, Denis R Burton, Mark G Hinds, Marc Kvansaku. Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax. FEBS letters. vol 594. issue 12. 2021-04-21. PMID:32390192. |
crystal structures of the sheeppox virus encoded inhibitor of apoptosis sppv14 bound to the proapoptotic bh3 peptides hrk and bax. |
2021-04-21 |
2023-08-13 |
Not clear |
| Chathura D Suraweera, Denis R Burton, Mark G Hinds, Marc Kvansaku. Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax. FEBS letters. vol 594. issue 12. 2021-04-21. PMID:32390192. |
we reveal the structural basis of apoptosis inhibition by determining crystal structures of sppv14 bound to bh3 motifs of proapoptotic bax and hrk. |
2021-04-21 |
2023-08-13 |
Not clear |
| Shuting Li, Jingwen Fang, Ting Si, Ying Lu, Lei Jian. Salvianolic acid A inhibits the growth of diffuse large B-cell lymphoma through MAPK pathways. Experimental hematology. vol 94. 2021-04-21. PMID:33278489. |
in the work described here, we found that saa inhibited the viability of dlbcl cells by inducing cellular apoptosis, which was accompanied by upregulation of bax and cleavage of parp. |
2021-04-21 |
2023-08-13 |
mouse |
| Jiansheng Zhu, Chunlan Liu, Jingyu Wang, Yinyin Liang, Xing Gong, Lianghui You, Chenbo Ji, Shou-Lin Wang, Chao Wang, Xia Ch. Difenoconazole induces cardiovascular toxicity through oxidative stress-mediated apoptosis in early life stages of zebrafish (Danio rerio). Ecotoxicology and environmental safety. vol 216. 2021-04-21. PMID:33848738. |
cardiovascular apoptosis was triggered through increased expression of p53, bcl-2, bax and caspase 9, while dif suppressed the transcription of key genes involved in calcium signaling and cardiac muscle contraction. |
2021-04-21 |
2023-08-13 |
zebrafish |
| Kuijing Wang, Bo Li, Yuanyuan Xie, Nan Xia, Minghui Li, Guang Ga. Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway. Molecular medicine reports. vol 22. issue 3. 2021-04-20. PMID:32582964. |
the results showed that rosuvastatin treatment decreased apoptosis of hcaecs induced by cocl2 by increasing anti‑apoptosis bcl‑xl and bcl‑2 expression, and decreasing pro‑apoptosis bax, bad, caspase‑3 and caspase‑9 expression. |
2021-04-20 |
2023-08-13 |
human |
| E M Domsa, G A Filip, D Olteanu, I Baldea, S Clichici, A Muresan, L David, B Moldovan, I Para, M Suciu, M Achim, V Negrean, V Andreic. Gold nanoparticles phytoreduced with Cornus mas extract mitigate some of gliadin effects on Caco-2 cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 71. issue 2. 2021-04-20. PMID:32633238. |
measured cellular outcomes included oxidative stress markers (malondialdehyde level, catalase and superoxide dismutase activities), inflammatory response and cellular signaling and transcription factors involved in apoptosis (nfκb, pnfκb, nos2, tnf-α, trail, bax, bcl-2, p53). |
2021-04-20 |
2023-08-13 |
Not clear |
| Alina Muenchow, Sandra Weller, Clemens Hinterleitner, Elke Malenke, Stefanie Bugl, Stefan Wirths, Martin R Müller, Klaus Schulze-Osthoff, Walter E Aulitzky, Hans-Georg Kopp, Frank Essman. The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA. Cell death & disease. vol 11. issue 8. 2021-04-20. PMID:32839432. |
this synergistic mechanism of action was verified by crispr/cas9 knock-out, showing that both bax and noxa are crucial for abt-199/bzb-induced apoptosis. |
2021-04-20 |
2023-08-13 |
Not clear |
| V Sudhakar Reddy, S Pandarinath, M Archana, G Bhanuprakash Redd. Impact of chronic hyperglycemia on Small Heat Shock Proteins in diabetic rat brain. Archives of biochemistry and biophysics. vol 701. 2021-04-20. PMID:33631184. |
furthermore, diabetes reduced the interaction of αbc with bax, which may possibly contribute to neuronal apoptosis. |
2021-04-20 |
2023-08-13 |
rat |
| Zijing Yang, Li Wang, Yingjun Hu, Feixiang Wan. Butorphanol protects PC12 cells against OGD/R-induced inflammation and apoptosis. Molecular medicine reports. vol 22. issue 3. 2021-04-19. PMID:32705179. |
in addition, butorphanol treatment resulted in a significant upregulation of bax, and downregulation of bcl‑2, activated caspase‑3, caspase‑9 and poly adp‑ribose polymerase, increased the expression of x‑linked inhibitor of apoptosis protein and enhanced atp activity. |
2021-04-19 |
2023-08-13 |
Not clear |
| Hylde Zirpoli, Sergey A Sosunov, Zoya V Niatsetskaya, Korapat Mayurasakorn, Denny Joseph Manual Kollareth, Charles N Serhan, Vadim S Ten, Richard J Deckelbau. NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury. Experimental neurology. vol 335. 2021-04-19. PMID:33038416. |
to confirm whether npd1 acts as bax inhibitor, we evaluated npd1 action co-administrated with a pro-apoptotic agent, staurosporine, using mouse embryonic fibroblasts as in vitro model of apoptosis. |
2021-04-19 |
2023-08-13 |
mouse |
| Hylde Zirpoli, Sergey A Sosunov, Zoya V Niatsetskaya, Korapat Mayurasakorn, Denny Joseph Manual Kollareth, Charles N Serhan, Vadim S Ten, Richard J Deckelbau. NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury. Experimental neurology. vol 335. 2021-04-19. PMID:33038416. |
npd1 exposure markedly decreased mitochondria-mediated apoptosis, blocking bax translocation from cytosol to mitochondria and subsequently reducing caspase-3 activation. |
2021-04-19 |
2023-08-13 |
mouse |
| Wanjuan Xue, Yongcheng Liu, Ningning Xin, Jiyu Miao, Juan Du, Yu Wang, Haiyan Shi, Yameng Wei, Huahua Zhang, Yani Chen, Yi Gao, Dan Li, Yun Feng, Jing Yan, Jing Zhang, Ni Hou, Chen Huang, Jiming Ha. Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells. BioMed research international. vol 2020. 2021-04-16. PMID:32685496. |
it also increased the bax expression levels, while it decreased the bcl-2 expression levels in human crc cells, leading the bax/bcl-2 balance toward apoptosis. |
2021-04-16 |
2023-08-13 |
human |
| Xiangye Bu, Wenqing Xia, Xiaonan Wang, Shan Lu, Yue Ga. Butylphthalide inhibits nerve cell apoptosis in cerebral infarction rats via the JNK/p38 MAPK signaling pathway. Experimental and therapeutic medicine. vol 21. issue 6. 2021-04-16. PMID:33850537. |
additionally, qpcr was performed to measure the mrna expression of bax and bcl-2, and a tunel assay was conducted to investigate the cell apoptosis. |
2021-04-16 |
2023-08-13 |
rat |
| Lianglong Pang, Keshi Yang, Zhi Zhan. High-glucose environment accelerates annulus fibrosus cell apoptosis by regulating endoplasmic reticulum stress. Bioscience reports. vol 40. issue 7. 2021-04-15. PMID:32515472. |
compared with the control cells, high glucose significantly increased cell apoptosis ratio and caspase-3/9 activity, up-regulated mrna/protein expression of bax and caspase-3/cleaved caspase-3, but down-regulated mrna/protein expression of bcl-2. |
2021-04-15 |
2023-08-13 |
rat |
| Lianglong Pang, Keshi Yang, Zhi Zhan. High-glucose environment accelerates annulus fibrosus cell apoptosis by regulating endoplasmic reticulum stress. Bioscience reports. vol 40. issue 7. 2021-04-15. PMID:32515472. |
however, once er stress was inhibited by the inhibitor 4-pba in the high glucose group, cell apoptosis ratio and caspase-3/9 activity were decreased, mrna/protein expression of bax and caspase-3/cleaved caspase-3 was down-regulated, but mrna/protein expression of bcl-2 was up-regulated. |
2021-04-15 |
2023-08-13 |
rat |
| Xiaona Zhang, Xiushuang Fan, Fan Li, Jinpeng Qiu, Yang Zhan. Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. Molecular medicine reports. vol 22. issue 2. 2021-04-15. PMID:32626997. |
moreover, isoflurane exposure induced neuronal apoptosis, elevated the levels of bax and cleaved caspase‑3, and inhibited the expression of bcl‑2; all of these effects were partially abrogated following pypaf1 silencing. |
2021-04-15 |
2023-08-13 |
rat |
| Dulguun Amgalan, Thomas P Garner, Ryan Pekson, Xiaotong F Jia, Mounica Yanamandala, Victor Paulino, Felix G Liang, J Jose Corbalan, Jaehoon Lee, Yun Chen, George S Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T Peterson, Rachel B Hazan, John S Condeelis, Maja H Oktay, Ulrich Steidl, Lorrie A Kirshenbaum, Evripidis Gavathiotis, Richard N Kitsi. A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy. Nature cancer. vol 1. issue 3. 2021-04-15. PMID:32776015. |
here we show that bax is rate-limiting in doxorubicin-induced cardiomyopathy and identify a small-molecule bax inhibitor that blocks both apoptosis and necrosis to prevent this syndrome. |
2021-04-15 |
2023-08-13 |
mouse |