| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gui-Bin Liang, Jian-Hua Wei, Hong Jiang, Ri-Zhen Huang, Jing-Ting Qin, Hui-Ling Wang, Heng-Shan Wang, Ye Zhan. Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. European journal of medicinal chemistry. vol 210. 2021-04-28. PMID:33109400. |
cell cycle arrest studies demonstrated that compounds 6b and 7b arrested the cell cycle at the s phase, accompanied by the upregulation of the expression levels of the antioncogene p21 and the down-regulation of the expression levels of cyclin e. apoptosis assays indicated that compounds 6b and 7b caused the apoptosis of tumor cells along with the upregulation of the expression of bax, caspase-3, caspase-9 and parp and the downregulation of bcl-2. |
2021-04-28 |
2023-08-13 |
mouse |
| Santa Cirmi, Alessandro Maugeri, Giovanni Enrico Lombardo, Caterina Russo, Laura Musumeci, Sebastiano Gangemi, Gioacchino Calapai, Davide Barreca, Michele Navarr. A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes. Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-04-28. PMID:33808343. |
treatment of differentiated sh-sy5y cells with 6-ohda brought cell death, and specifically, apoptosis, which was significantly inhibited by the preincubation with mje through caspase 3 blockage and the modulation of p53, bax, and bcl-2 genes. |
2021-04-28 |
2023-08-13 |
human |
| Vijayalakshmi Annamalai, Muddukrishnaiah Kotakonda, Velu Periyanna. JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation. Journal of biochemical and molecular toxicology. vol 34. issue 8. 2021-04-27. PMID:32359221. |
we demonstrated that the treatment of mg-63 cells with bcp prompted mitochondrial apoptosis via upregulation of bax and caspase-3 and downregulation of bcl-2 as well as prompted mitochondrial membrane potential. |
2021-04-27 |
2023-08-13 |
human |
| Jae-Hwan Jang, Mi-Jung Yeom, Sora Ahn, Ju-Young Oh, Suhwan Ji, Tae-Hong Kim, Hi-Joon Par. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32827699. |
acupuncture also restored the overexpression of microglia and astrocyte as well as conversion of bax and bcl-2 expression in both the striatum and the substantia nigra, indicating that inflammatory responses and apoptosis were blocked by acupuncture. |
2021-04-27 |
2023-08-13 |
mouse |
| Rui Wang, Yang Li, Wim Dehae. Antiproliferative effect of mitochondria-targeting allobetulin 1,2,3-triazolium salt derivatives and their mechanism of inducing apoptosis of cancer cells. European journal of medicinal chemistry. vol 207. 2021-04-27. PMID:32866757. |
compounds 4n and 4q acted on mitochondria to cause an increase in intracellular reactive oxygen species and a change in the level of apoptosis-related protein (bcl-2, bcl-xl and bax), which resulted in a decrease in membrane potential and activation of caspase family to induce cancer cells apoptosis. |
2021-04-27 |
2023-08-13 |
Not clear |
| Jinhong Liu, Ning Zhao, Guiling Shi, Hai Wan. Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ. Aging. vol 12. issue 22. 2021-04-27. PMID:33197894. |
we also found that geniposide significantly reduced vascular permeability and cellular apoptosis of the kidney, with increase of bcl-2 and decrease of bax and cleaved caspase-3. |
2021-04-27 |
2023-08-13 |
mouse |
| Liqiang Chen, Yaokun Wang, Haiyan Luan, Guangyu Ma, Huiming Zhang, Guang Che. DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705203. |
moreover, compared with the hg group, cell apoptosis was inhibited by dusp6 overexpression under hg conditions, which was further indicated by decreased expression levels of cleaved caspase‑3 and bax. |
2021-04-26 |
2023-08-13 |
mouse |
| Ruli Li, Jianbo Xiao, Sufan Tang, Xinjing Lin, Honglin Xu, Bin Han, Ming Yang, Fu Li. Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705204. |
apoptosis was involved in the process of cucurbitacin i‑induced cell death, with an increase observed in cleaved‑caspase 3 and bax, and a decrease in bcl‑2. |
2021-04-26 |
2023-08-13 |
Not clear |
| Peng Huang, Dongbai Yang, Lianzhi Yu, Yu Sh. Downregulation of lncRNA ZFAS1 protects H9c2 cardiomyocytes from ischemia/reperfusion‑induced apoptosis via the miR‑590‑3p/NF‑κB signaling pathway. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705215. |
in addition, tnf‑α treatment induced apoptosis of h9c2 cells, and the changes in bax, bcl‑2, cleaved‑caspase‑3 and pro‑caspase‑3 expression levels in a dose‑dependent manner. |
2021-04-26 |
2023-08-13 |
rat |
| Jian Zeng, Bin Jiang, Xia Xiao, Rou Zhan. Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705254. |
the present results also indicated that sphk2 silencing or smad7 overexpression inhibited proliferation, but promoted apoptosis of hsf, coupled with changes in the expression levels of proliferation‑associated proteins, with an increase in p21 and a decrease in cyclin d1 expression levels, and apoptosis‑associated proteins, with an increase in bax and cleaved caspase‑3, and a decrease in bcl‑2, which were reversed following transfection with both sphk2 and smad7 using small interfering rna in hsf. |
2021-04-26 |
2023-08-13 |
human |
| Chengni Jin, Xin Miao, Yujie Zhong, Jiahui Han, Qi Liu, Jiachang Zhu, Xiaodong Xia, Xiaoli Pen. The renoprotective effect of diosgenin on aristolochic acid I-induced renal injury in rats: impact on apoptosis, mitochondrial dynamics and autophagy. Food & function. vol 11. issue 9. 2021-04-26. PMID:32789347. |
moreover, diosgenin up-regulated the expression of bcl-2 and down-regulated bax, and subsequently inhibited aif expression and the cleaved form of caspase-3, thereby alleviating apoptosis triggered by aa-i. |
2021-04-26 |
2023-08-13 |
rat |
| Xinyi Sun, Yuman Sun, Sitong Lin, Yan Xu, Dongming Zha. Histone deacetylase inhibitor valproic acid attenuates high glucose‑induced endoplasmic reticulum stress and apoptosis in NRK‑52E cells. Molecular medicine reports. vol 22. issue 5. 2021-04-26. PMID:32901855. |
notably, hg markedly promoted apoptosis of nrk‑52e cells by regulating the protein levels of bax, cleaved caspase‑3 and bcl‑2, which was attenuated by simultaneous vpa treatment. |
2021-04-26 |
2023-08-13 |
rat |
| Yan Zhao, Jianghui Liu, Liang Li. Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis. Molecular medicine reports. vol 22. issue 4. 2021-04-26. PMID:32945409. |
the inhibitory effect of art on the growth of a549 lung cancer cells was detected by the mtt assay, and flow cytometry was utilized to determine cell cycle progression, apoptosis, mitochondrial membrane potential, as well as the expression of bcl‑2 and bax proteins in a549 cells after art treatment for 24 h. |
2021-04-26 |
2023-08-13 |
human |
| Yan Zhao, Jianghui Liu, Liang Li. Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis. Molecular medicine reports. vol 22. issue 4. 2021-04-26. PMID:32945409. |
art inhibited the growth of a549 cells in a dose‑dependent manner, induced cell apoptosis and cell cycle arrest, decreased the expression of bcl‑2 protein and mitochondrial membrane potential, and increased the expression of bax protein. |
2021-04-26 |
2023-08-13 |
human |
| Hui Sun, Qianqian Jiang, Li Sheng, Kai Cu. Downregulation of lncRNA H19 alleviates atherosclerosis through inducing the apoptosis of vascular smooth muscle cells. Molecular medicine reports. vol 22. issue 4. 2021-04-26. PMID:32945413. |
knockdown of h19 reduced the proliferation and induced apoptosis of vsmcs, and increased the expression of p53, cleaved caspase3 (c‑caspase3) and p53 upregulated modulator of apoptosis, as well as enhancing the interaction between bax and p53 proteins. |
2021-04-26 |
2023-08-13 |
mouse |
| Qianya Su, Fei Wang, Zhengbang Dong, Mei Chen, Rong Ca. IFN‑γ induces apoptosis in human melanocytes by activating the JAK1/STAT1 signaling pathway. Molecular medicine reports. vol 22. issue 4. 2021-04-26. PMID:32945463. |
in conclusion, the findings of the present study suggested that ifn‑γ may induce the apoptosis of human melanocytes by activating the jak1/stat1 signaling pathway, alongside increasing the expression levels of bax, bak and cleaved caspase‑3, and decreasing the expression levels of bcl‑2. |
2021-04-26 |
2023-08-13 |
human |
| Long Yang, Xiujuan Dong, Wei Zhan. Astragaloside IV alleviates the brain damage induced by subarachnoid hemorrhage via PI3K/Akt signaling pathway. Neuroscience letters. vol 735. 2021-04-23. PMID:32619654. |
several apoptosis associated genes including foxo1, bim, bax and a typical apoptosis marker cleaved-caspase-3 were all downregulated by as-iv. |
2021-04-23 |
2023-08-13 |
rat |
| Piyush Joshi, Caroline Bodnya, Megan L Rasmussen, Alejandra I Romero-Morales, Anna Bright, Vivian Gam. Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems. Cell death & disease. vol 11. issue 9. 2021-04-23. PMID:32978370. |
previous studies have shown that both bax and bak are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for bax and bak in mitochondrial fission during apoptosis. |
2021-04-23 |
2023-08-13 |
human |
| Zhikun Liu, Bin Zhang, Shengjin Xia, Lei Fang, Shaohua Go. ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker. European journal of medicinal chemistry. vol 212. 2021-04-23. PMID:33189440. |
besides, 22 hinted a therapeutic clue in ad-treatment by regulating proinflammatory factors (il-1β and tnf-α) and apoptosis related proteins (bax, bcl-2 and cleaved caspase-3). |
2021-04-23 |
2023-08-13 |
Not clear |
| Yang Tan, Wei Zhang, Hai-Ying Wu, Jing Xia, Huang-Bo Zhang, Ming-Wei Liu, Chuan-Yun Qia. Effects of emodin on intestinal mucosal barrier by the upregulation of miR-218a-5p expression in rats with acute necrotizing pancreatitis. International journal of immunopathology and pharmacology. vol 34. 2021-04-22. PMID:32664763. |
after 24 h of acute severe pancreatitis induced by taurocholate, emodin reduced the expression of mir-218a-5p in the intestinal tract; increased the expression of notch1 and bcl-2; decreased the expression levels of rhoa, rock1, akt, bax, fas, fasl, caspase-3, and caspase-9; inhibited the intestinal cell apoptosis caused by acute severe pancreatitis; increased the protein expression levels of occludin, zonula occludens-1 (zo-1), and e-cadherin in the intestinal tract; and alleviated intestinal dysfunction caused by acute severe pancreatitis. |
2021-04-22 |
2023-08-13 |
rat |