| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mario Pérez-Sayáns, Alejandro I Lorenzo-Pouso, Cintia M Chamorro-Petronacci, José M Suárez-Peñaranda, Elena Padín-Iruegas, Miguel A González-Moles, Xabier Marichalar-Mendía, Abel García-García, Andrés Blanco-Carrió. Immunoexpression of Apoptosis and Cell-cycle Arrest Markers in Oral Lichen Planus. Applied immunohistochemistry & molecular morphology : AIMM. vol 29. issue 5. 2021-05-17. PMID:33044228. |
the expression pattern of a panel of 5 molecular markers (p53, cyclin d1, ki-67, bcl-2, and bax) was studied in samples from patients with oral lichen planus (olp) and normal oral mucosa (nom) of healthy controls to investigate the implications of cell cycle and apoptosis in olp. |
2021-05-17 |
2023-08-13 |
Not clear |
| Nan-Qian Zhou, Zhi-Xin Fang, Ning Huang, Yue Zuo, Yue Qiu, Li-Juan Guo, Ping Song, Jian Xu, Guang-Rui Wan, Xin-Qiao Tian, Ya-Ling Yin, Peng L. aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis. Frontiers in pharmacology. vol 12. 2021-05-16. PMID:33986662. |
in contrast, afgf-np + cpmbs combined with utmd therapy (3ug/kg, caudal vein injection, twice a week, 6weeks)prominently ameliorated left ventricular dysfunction by increased ejection fraction (ef) and fractional shortening (fs), decreased brain natriuretic peptide (bnp); strengthened the ability of antioxidant stress confirmed by increasing the activity of sod and reducing the production of mda; exerted the effect of anti-cardiomyocyte apoptosis and promotion angiogenesis by inhibited bax expression and increased bcl-2 expression and platelet endothelial cell adhesion molecule (cd31) expression. |
2021-05-16 |
2023-08-13 |
rat |
| Wan-Jun Zhao, Yang-Ping Bian, Qiu-Hui Wang, Fei Yin, Li Yin, Yong-Lan Zhang, Jian-Hui Li. Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. Acta pharmacologica Sinica. 2021-05-15. PMID:33990765. |
preincubation with belns decreased the level of reactive oxygen species (ros), increased the mitochondrial membrane potential, and prevented cell apoptosis by inducing the expression of bcl-2 and heme oxygenase-1 (ho-1) and decreasing the content of bax in rotenone-treated hepg2 cells. |
2021-05-15 |
2023-08-13 |
mouse |
| Saba Hajazimian, Masoud Maleki, Shahla Danaei Mehrabad, Alireza Isazade. Human Wharton's jelly stem cells inhibit endometriosis through apoptosis induction. Reproduction (Cambridge, England). vol 159. issue 5. 2021-05-14. PMID:32155128. |
moreover, induction of apoptosis in treated endometriosis cells can be due to regulation of apoptosis-related genes expression, including bax, bcl-2, smac, and survivin. |
2021-05-14 |
2023-08-13 |
human |
| Hannah L Morgan, Isaac Ampong, Nader Eid, Charlène Rouillon, Helen R Griffiths, Adam J Watkin. Low protein diet and methyl-donor supplements modify testicular physiology in mice. Reproduction (Cambridge, England). vol 159. issue 5. 2021-05-14. PMID:32163913. |
furthermore, tunnel staining revealed lpd males possessed a reduced number of tubules positive for apoptosis, while gene expression analysis showed md-lpd testes displayed decreased expression of the pro-apoptotic genes bax, csap1 and fas when compared to npd males. |
2021-05-14 |
2023-08-13 |
mouse |
| Mingxu Qi, Li He, Xiaofeng Ma, Zili L. MiR-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia-reoxygenation through regulating SIRT1. Bioscience, biotechnology, and biochemistry. vol 84. issue 7. 2021-05-14. PMID:32290769. |
cell viability, apoptosis, levels of released lactate dehydrogenase (ldh), malondialdehyde (mda), and superoxide dismutase (sod), as well as the bcl-2, bax, and caspase 3 levels in treated cells were tested. |
2021-05-14 |
2023-08-13 |
Not clear |
| Mingxu Qi, Li He, Xiaofeng Ma, Zili L. MiR-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia-reoxygenation through regulating SIRT1. Bioscience, biotechnology, and biochemistry. vol 84. issue 7. 2021-05-14. PMID:32290769. |
on the other hand, mir-181a-5p inhibited apoptosis and elevated bcl-2 expression while decreasing the expressions of bax and caspase 3 in treated cells, but the effects of mir-181a-5p could be rescued by sirt1. |
2021-05-14 |
2023-08-13 |
Not clear |
| Brian T Bennett, Junaith S Mohamed, Stephen E Alwa. The Effects of Calcium- Oxidative medicine and cellular longevity. vol 2020. 2021-05-14. PMID:32774671. |
the animals' body weights were significantly reduced by ~18% after 14 days of hs and continued to decline by ~22% during r as compared to control conditions; however, despite unloading, edl did not atrophy by hs, nor did it increase in mass after r. no changes were observed in edl twitch contraction time, force production, fatigue resistance, fiber cross-sectional area, or markers of nuclear apoptosis (myonuclei + satellite cells) after hs or r. while hs and r increased the proapoptotic bax protein abundance, bcl-2 abundance was also increased as was the frequency of tunel-positive myonuclei and satellite cells, yet muscle mass and fiber cross-sectional area did not change and ca-hmb treatment had no effect reducing apoptotic signaling. |
2021-05-14 |
2023-08-13 |
rat |
| Hoomin Lee, Suji Kim, Cheolwoo Oh, Imran Khan, Shruti Shukla, Vivek K Bajpai, Young-Kyu Han, Yun Suk Hu. Folic acid-modified bovine serum albumin nanoparticles with doxorubicin and chlorin e6 for effective combinational chemo-photodynamic therapy. Materials science & engineering. C, Materials for biological applications. vol 117. 2021-05-14. PMID:32919690. |
moreover, fa-ce6/dox/bnps potentiated mitochondrial reactive oxygen species (ros) production in hela cells under 671-nm laser exposure, leading to activation of key regulator proteins of apoptosis such as bh3 interacting-domain death agonist (bid), b-cell lymphoma 2 (bcl-2), and bcl-2-associated x (bax), as well as induction of the caspase cascade and mitochondrial ros-mediated cell death. |
2021-05-14 |
2023-08-13 |
cattle |
| Guohong Shi, Zhen Zhang, Yi Fang, Donglin Bian, Zhiqun Ba. Curcumin combined with low-intensity ultrasound suppresses the growth of glioma cells via inhibition of the AKT pathway. Neoplasma. vol 68. issue 2. 2021-05-14. PMID:33231085. |
and cell apoptosis was promoted after lius-curcumin combination treatment, characterized by the occurrence of more apoptotic cells and a significant increase in bax level and attenuated bcl-2 expression. |
2021-05-14 |
2023-08-13 |
Not clear |
| Hanyu Chen, Hongqing Sheng, Yushuo Zhao, Guanghui Zh. Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-14. PMID:33382670. |
flow cytometry and western blot were used to determine cell apoptosis and the expression level of protein (cyto c, cleaved parp, cleaved caspase-3, bax, bcl-2, bad, bcl-xl, pi3k, ppi3k, akt, and pakt), respectively. |
2021-05-14 |
2023-08-13 |
mouse |
| Siqi Luo, Xiuli Sun, Meng Huang, Qianhui Ma, Libo Du, Yan Cu. Enhanced Neuroprotective Effects of Epicatechin Gallate Encapsulated by Bovine Milk-Derived Exosomes against Parkinson's Disease through Antiapoptosis and Antimitophagy. Journal of agricultural and food chemistry. vol 69. issue 17. 2021-05-14. PMID:33890462. |
cell viability, cellular reactive oxygen species, apoptosis rate, and the expressions of caspase-3, bax, bcl-2, parkin, pink1, and atg5 were determined. |
2021-05-14 |
2023-08-13 |
cattle |
| Hai Su, Xia Xiaohui, Xuenong He, Chang Liu, Guanyu Wang, Changlong Zho. The miR-455-5p/ERα36 axis regulates mammalian neuronal viability and axonal regeneration. Neuroscience letters. vol 735. 2021-05-13. PMID:32574796. |
mir-455-5p inhibition increased cell viability, pcna, cyclin d1, and bcl-2 levels and decreased apoptosis and bax levels in sh-sy5y neuroblastoma cells. |
2021-05-13 |
2023-08-13 |
Not clear |
| Naijia Liu, Yintao Li, Wu Nan, Wenbai Zhou, Jinya Huang, Rumei Li, Linuo Zhou, Renming H. Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species. Oxidative medicine and cellular longevity. vol 2020. 2021-05-13. PMID:33082910. |
tppp3 silencing inhibited pa overload-induced apoptosis and production of ros, along with the alteration of apoptosis-related key proteins such as bcl-2 and bax. |
2021-05-13 |
2023-08-13 |
human |
| Xuefeng Qu, Zhouyi Zhang, Wenli Hu, Minhan Lou, Bingzhong Zhai, Song Mei, Zhihang Hu, Lijing Zhang, Dongying Liu, Zhen Liu, Jianguo Chen, Yin Wan. Attenuation of the Na/K‑ATPase/Src/ROS amplification signaling pathway by astaxanthin ameliorates myocardial cell oxidative stress injury. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33173978. |
the protein expression levels of bax, bcl‑2, caspase‑3 and cleaved caspase‑3 were analyzed using western blotting to determine cardiomyocyte apoptosis. |
2021-05-13 |
2023-08-13 |
Not clear |
| Xingwang Chen, Zhijun Yao, Xian Peng, Long Wu, Huachu Wu, Yuantong Ou, Jianbo La. Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF‑κB signaling pathway. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33173992. |
eupafolin also attenuated oxidative stress, neuronal apoptosis and inflammation, with decreases in lactate dehydrogenase, malondialdehyde, tunel‑positive cells, bax and caspase‑3, along with tnf‑α, il‑1β and il‑6, but increases in superoxide dismutase and bcl‑2 levels. |
2021-05-13 |
2023-08-13 |
rat |
| Xinyong Cai, Ping Zhang, Shu Wang, Lang Hong, Songping Yu, Bin Li, Hong Zeng, Xu Yang, Liang Sha. lncRNA FGD5 antisense RNA 1 upregulates RORA to suppress hypoxic injury of human cardiomyocyte cells by inhibiting oxidative stress and apoptosis via miR‑195. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174051. |
in response to hypoxia, superoxide dismutase (sod) activity was inhibited, but apoptosis rate and levels of reactive oxygen species and malondialdehyde were promoted in ac16 cells, accompanied by increased bax and cleaved caspase‑3 expression levels, and decreased sod2 and glutathione peroxidase 1 expression levels. |
2021-05-13 |
2023-08-13 |
human |
| Jian Zhou, Zaijia Yang, Ruiming Shen, Wangwang Zhong, Huiduan Zheng, Zhenggang Chen, Jianjian Tang, Juan Zh. Resveratrol Improves Mitochondrial Biogenesis Function and Activates PGC-1α Pathway in a Preclinical Model of Early Brain Injury Following Subarachnoid Hemorrhage. Frontiers in molecular biosciences. vol 8. 2021-05-13. PMID:33968980. |
rsv significantly ameliorated the release of apoptosis-related cytokines, namely p53, cleaved caspase-3, cytochrome c, and bax, leading to the amelioration of neuronal apoptosis, brain edema, and neurological impairment 24 h after sah. |
2021-05-13 |
2023-08-13 |
Not clear |
| Hafiza Khatun, Yasuhiko Wada, Toshihiro Konno, Hideki Tatemoto, Ken-Ichi Yamanak. Endoplasmic reticulum stress attenuation promotes bovine oocyte maturation in vitro. Reproduction (Cambridge, England). vol 159. issue 4. 2021-05-12. PMID:31990669. |
subsequently, treatment of tudca (100 µm) decreased the localization and amount of grp78/bip protein level as well as er stress (grp78/bip, perk, ier1, atf4, and xbp1) and apoptosis (chop and bax)-related gene expression, while it increased the anti-apoptotic gene bcl2 level in matured cocs. |
2021-05-12 |
2023-08-13 |
cattle |
| Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li She. Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A. Toxicology. vol 450. 2021-05-12. PMID:33465424. |
results indicated that a 24 h-treatment of 1-5 μm ota could notably induce mitochondrial-mediated and er stress (ers)-excitated apoptosis via inhibiting trap1, thereby activating cypd, bax, cyt-c, cleaved caspase-9, cleaved caspase-3, grp78, p-perk, p-eif2α, atf4, and chop and inhibiting bcl-2 (p < 0.05). |
2021-05-12 |
2023-08-13 |
human |