| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaobo Zhang, Ying Zhu, Ying Zhou, Bingru Fe. Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32931486. |
il-37 also inhibited high glucose-induced apoptosis of podocytes by inhibiting the expression of the apoptosis-related proteins bax and cleaved caspase-3/6/9, and by promoting the expression of bcl-2. |
2021-05-20 |
2023-08-13 |
Not clear |
| Bing Yang, Guobin Ma, Yang Li. Z-Ligustilide Ameliorates Diabetic Rat Retinal Dysfunction Through Anti-Apoptosis and an Antioxidation Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:33011733. |
moreover, the rate of apoptosis and expression of bcl-2- associated x protein (bax) and cleaved-caspase-3 were clearly reduced, and the expression of bcl-2 was raised by z-lig in retinas of diabetic mice. |
2021-05-20 |
2023-08-13 |
mouse |
| Xiao-Jiang Xie, Chang-Qing L. Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:33044948. |
meanwhile, chrysophanol inhibited the myocardial apoptosis along with the upregulation of bcl-2 and downregulation of bax and cleaved caspase-3. |
2021-05-20 |
2023-08-13 |
rat |
| Xueyan Chen, Chuanbo Ding, Wencong Liu, Xinglong Liu, Yingchun Zhao, Yinan Zheng, Ling Dong, Sadia Khatoon, Mingqian Hao, Xiaojuan Peng, Yue Zhang, Huiying Che. Abscisic acid ameliorates oxidative stress, inflammation, and apoptosis in thioacetamide-induced hepatic fibrosis by regulating the NF-кB signaling pathway in mice. European journal of pharmacology. vol 891. 2021-05-20. PMID:33069671. |
after the fourth week of treatment, histological changes, the serum biochemical index, inflammation, and hepatocyte apoptosis factors (e.g., caspase-3, b-cell lymphoma 2 [bcl-2], bcl-2-associated x [bax]) were detected to clarify its underlying mechanism. |
2021-05-20 |
2023-08-13 |
mouse |
| Seung Seob Son, Jeong Suk Kang, Eun Young Le. Paclitaxel Ameliorates Palmitate-Induced Injury in Mouse Podocytes. Medical science monitor basic research. vol 26. 2021-05-20. PMID:33323915. |
the paclitaxel effects were accompanied by inhibition of the inflammatory cytokines, mcp-1, tnf-alpha, tnf-r2, and tlr4, as well as attenuation of the apoptosis markers, bax, bcl-2, and caspase-3. |
2021-05-20 |
2023-08-13 |
mouse |
| Sapana Bansod, Chandraiah Godug. Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model. International immunopharmacology. vol 90. 2021-05-19. PMID:33310297. |
furthermore, nb also inhibited pancreatic apoptosis by downregulating cleaved caspase 3 and bax while upregulating bcl2 expression in cerulein-treated mice. |
2021-05-19 |
2023-08-13 |
mouse |
| Xiao-Dong Pei, Hong-Liang Yao, Li-Qun Shen, Yang Yang, Lan Lu, Jun-Song Xiao, Xin-Yu Wang, Zhi-Long He, Li-He Jian. α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway. European journal of pharmacology. vol 883. 2021-05-18. PMID:32687921. |
mechanistically, α-cyperone promoted hela cells apoptosis via a mitochondrial apoptotic pathway, which was proved by increased level of intracellular reactive oxygen species (ros) and upregulated expression of cytochrome c, cleaved caspase-3, parp, and bax. |
2021-05-18 |
2023-08-13 |
human |
| Golnaz Rashidi, Mahsa Rezaeepoor, Chiman Mohammadi, Ghasem Solgi, Rezvan Najaf. Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells. Molecular biology reports. vol 47. issue 9. 2021-05-18. PMID:32888127. |
flow cytometry and western blot were used to evaluate apoptosis rate and pro- and anti-apoptotic expression levels of proteins involved in apoptosis including bax, bcl-2, p53, and caspase-3. |
2021-05-18 |
2023-08-13 |
human |
| Golnaz Rashidi, Mahsa Rezaeepoor, Chiman Mohammadi, Ghasem Solgi, Rezvan Najaf. Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells. Molecular biology reports. vol 47. issue 9. 2021-05-18. PMID:32888127. |
our data demonstrate that sema4d silencing results in strikingly elevated apoptosis in response to 5-fu treatment and leads to down-regulation of bcl-2 and overexpression of bax, p53, and caspase-3 in protein levels. |
2021-05-18 |
2023-08-13 |
human |
| Mamdooh H Ghoneum, Nesrine S El Saye. Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways. Oxidative medicine and cellular longevity. vol 2021. 2021-05-18. PMID:33574982. |
moreover, biobran exerted a protective effect against amyloid-beta-induced apoptosis via the suppression of both cleaved caspase-3 and the proapoptotic protein bax and via the upregulation of the antiapoptotic protein bcl-2. |
2021-05-18 |
2023-08-13 |
mouse |
| Jinhang Hu, Jiangluqi Song, Zhishu Tang, Simin Wei, Lin Chen, Rui Zho. Hypericin-mediated photodynamic therapy inhibits growth of colorectal cancer cells via inducing S phase cell cycle arrest and apoptosis. European journal of pharmacology. vol 900. 2021-05-18. PMID:33811836. |
further investigation showed that hyp-pdt significantly increased bax expression and decreased bcl-2 expression, and then, upregulated the expression of cleaved caspase-9, cleaved caspase-3 and cleaved parp, thereby inducing apoptosis in hct116 and sw620 cells. |
2021-05-18 |
2023-08-13 |
Not clear |
| A V Sirotkin, R Alexa, S Alwasel, A H Harrat. Fennel affects ovarian cell proliferation, apoptosis, and response to ghrelin. Physiological research. vol 70. issue 2. 2021-05-18. PMID:33992047. |
expression of the proliferation marker, pcna, and the apoptosis marker, bax, were analyzed via quantitative immunocytochemical methods. |
2021-05-18 |
2023-08-13 |
Not clear |
| Wei Xie, Hade Wulin, Guo Shao, Liqin Wei, Ruifang Qi, Baohui Ma, Naihong Chen, Ruili Sh. Polygalasaponin F inhibits neuronal apoptosis induced by oxygen-glucose deprivation and reoxygenation through the PI3K/Akt pathway. Basic & clinical pharmacology & toxicology. vol 127. issue 3. 2021-05-17. PMID:32237267. |
the ability of pgsf to block the effects of ogd/r appears to involve regulation of bcl-2, bax and caspase-3, which are related to apoptosis. |
2021-05-17 |
2023-08-13 |
rat |
| Haijin Huang, Cuicui Hu, Lin Xu, Xiaoping Zhu, Lili Zhao, Jia Mi. The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) Signaling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-17. PMID:32296010. |
results hpd significantly reduced sevoflurane-induced neuronal apoptosis and protein expression of cleaved caspase-3, bad, bax, nf-kappab, tnf-alpha, il-6, and il-1ß (p<0.05). |
2021-05-17 |
2023-08-13 |
rat |
| Huan Hu, Yang Fu, Meng Li, Huasong Xia, Yue Liu, Xiaopei Sun, Yang Hu, Fulin Song, Xiaoshu Cheng, Ping Li, Yanqing W. Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrotic reactions. International immunopharmacology. vol 86. 2021-05-17. PMID:32679538. |
furthermore, decreased number of apoptotic myocardial cells, increased bcl-2 levels and decreased bax levels inhibited apoptosis, and lps-induced upregulation of the expression of cardiac pro-fibrotic genes (mmp2 and mmp9) and fibrotic factor (collagen type i) was inhibited. |
2021-05-17 |
2023-08-13 |
mouse |
| Jiasheng Wang, Yong Chen, Ze Tang, Dabi Hu, Caoyuan Yao, Lei Yan. LncRNA NEAT1 regulated inflammation and apoptosis in a rat model of sepsis-induced acute kidney injury via MiR-27a-3p/TAB3 axis. Bioscience, biotechnology, and biochemistry. vol 84. issue 11. 2021-05-17. PMID:32698679. |
sineat1 reversed the promotive effect of clp on kidney histopathological injury, and bun, scr, ngal, kim-1, tnf-α, il-1β, il-6, mda, and bax levels and apoptosis, but raised clp-downregulated sod and bcl-2 levels. |
2021-05-17 |
2023-08-13 |
rat |
| Jie Yang, Wen-Wen Mu, Guo-Yun Li. Synthesis and evaluation of the anticancer activity of bischalcone analogs in human lung carcinoma (A549) cell line. European journal of pharmacology. vol 888. 2021-05-17. PMID:32798508. |
in this study, we synthesized a series of bischalcone analogs via aldol condensation reaction; mtt method was used to evaluate the antiproliferation effects; the 2',7'-dichlorofluorescein fluorescence assay was used to determine the intracellular reactive oxygen species levels; the glutathione reductase-dtnb recycling assay was used to detect the redox imbalance; determination of thiobarbituric acid-reactive substance was used to evaluate the lipid peroxidation; rhodamine 123 was used to test the mitochondrial membrane potential (mmp); the fitc/pi kit was used to detect the apoptosis; western blotting was used to detect the expression of bax and caspase 3. |
2021-05-17 |
2023-08-13 |
human |
| Jie Yang, Wen-Wen Mu, Guo-Yun Li. Synthesis and evaluation of the anticancer activity of bischalcone analogs in human lung carcinoma (A549) cell line. European journal of pharmacology. vol 888. 2021-05-17. PMID:32798508. |
further mechanism of action studies revealed that 1d and 1g exhibited more stronger reactive oxygen species production abilities than curcumin and accompanied by the redox imbalance, lipid peroxidation, the loss of mmp, the activition of bax and caspase 3, and ultimately resulted in apoptosis of a549 cell. |
2021-05-17 |
2023-08-13 |
human |
| XinYong Cai, Chunli Yang, Liang Shao, HongMin Zhu, YunXia Wang, Xiao Huang, Shu Wang, Lang Hon. Targeting NOX 4 by petunidin improves anoxia/reoxygenation-induced myocardium injury. European journal of pharmacology. vol 888. 2021-05-17. PMID:32828742. |
the results showed that petunidin could significantly improve isolated heart function, reduce oxidative stress, inhibit cardiomyocyte apoptosis, up-regulate bcl-2 protein expression, down-regulate nox4 and bax expression, and reduce the level of cytoplasmic cytochrome c after a/r. |
2021-05-17 |
2023-08-13 |
rat |
| Han Li, Xiaoqing Xu, Yudi Zhang, Xianying Tang, Wenhua L. Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner. European journal of pharmacology. vol 888. 2021-05-17. PMID:32950498. |
moreover, molecular assays indicated that bax and p53 were the key regulators of ms-275/tetrandrine induced apoptosis. |
2021-05-17 |
2023-08-13 |
human |