| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiuning Zhang, Yarong Kong, Zhen Yang, Yang Liu, Ruifeng Liu, Yichao Geng, Hongtao Luo, Hong Zhang, Hongyan Li, Shuangwu Feng, Xiaohu Wan. Preliminary study on radiosensitivity to carbon ions in human breast cancer. Journal of radiation research. vol 61. issue 3. 2021-06-08. PMID:32239160. |
cell proliferation, cell colony formation, cell cycle distribution, cell apoptosis and protein expression levels [double-strand break marker γ-h2ax, cell cycle-related protein cyclin b1, apoptosis-related proteins bax and bcl-2, and the akt/mammalian target of rapamycin (mtor)/ribosomal protein s6 kinase b1 (p70s6k) pathway] were detected after irradiation with carbon ions or x-rays at doses of 0, 2, 4 and 8 gy. |
2021-06-08 |
2023-08-13 |
human |
| Jun-Nan Hu, Jing Leng, Qiong Shen, Ying Liu, Xin-Dian Li, Shi-Han Wang, Hui-Ping Li, Zi Wang, Ying-Ping Wang, Wei L. Platycodin D suppresses cisplatin-induced cytotoxicity by suppressing ROS-mediated oxidative damage, apoptosis, and inflammation in HEK-293 cells. Journal of biochemical and molecular toxicology. vol 35. issue 1. 2021-06-08. PMID:32881195. |
moreover, the elevation of apoptosis including bax, bad, cleaved caspase-3,-9, and decreased protein levels of bcl-2, bcl-xl induced by cisplatin were reversed after pd treatment. |
2021-06-08 |
2023-08-13 |
human |
| Mona A Kortam, Bassam Mohamed Ali, Nevine Fath. The deleterious effect of stress-induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway. Journal of biochemical and molecular toxicology. vol 35. issue 1. 2021-06-08. PMID:32905656. |
in addition, they inhibited hepatocyte apoptosis as evidenced by the increased expression of b-cell lymphoma 2, the decreased expression of bax, as well as the suppressed activity of caspase-3. |
2021-06-08 |
2023-08-13 |
rat |
| Zhijun Wang, Hongyan Li, Jiyuan Yan, Yang Li. Flavonoid compound breviscapine suppresses human osteosarcoma Saos-2 progression property and induces apoptosis by regulating mitochondria-dependent pathway. Journal of biochemical and molecular toxicology. vol 35. issue 1. 2021-06-08. PMID:32969555. |
mechanistically, bvp-induced apoptosis was mediated by the mitochondria-dependent pathway, as evidenced by the increased expression of bax and cyt c and the decreased expression of bcl-2, as well as activation of caspase 9 and caspase 3 in vitro and in vitro. |
2021-06-08 |
2023-08-13 |
mouse |
| Yaling Li, Maojun Liu, Jiali Yi, Xiong Song, Xia Zheng, Da Liu, Sen Wang, Chun Chu, Jun Yan. Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction. Acta biochimica et biophysica Sinica. vol 52. issue 12. 2021-06-08. PMID:33210714. |
moreover, the expressions of fibrosis indicators (col3a1 and col1a2), er stress-related proteins (chop and bip/erp78), autophagy-related proteins (beclin and atg5), apoptosis protein (bax), as well as fibrosis protein col4a3bp were all decreased after treatment with h2s. |
2021-06-08 |
2023-08-13 |
Not clear |
| Liulan Zhao, Gang Tang, Chen Xiong, Shuaishuai Han, Chunping Yang, Kuo He, Qiao Liu, Jie Luo, Wei Luo, Yan Wang, Zhiqiong Li, Song Yan. Chronic chlorpyrifos exposure induces oxidative stress, apoptosis and immune dysfunction in largemouth bass (Micropterus salmoides). Environmental pollution (Barking, Essex : 1987). vol 282. 2021-06-08. PMID:33848913. |
moreover, cpf upregulated the expression of pro-inflammatory genes such as tnf-α, il-8, il-15, downregulated anti-inflammatory genes tgf-β1, il-10, and promoted apoptosis through overexpression of caspase-3, caspase-8, caspase-9 and bax. |
2021-06-08 |
2023-08-13 |
human |
| Haiquan Zhu, Shaobo Zhu, Xiuchao Shang, Xiangsheng Meng, Sheng Jing, Li Yu, Yu Den. Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A. Frontiers in genetics. vol 12. 2021-06-08. PMID:34093648. |
functionally, both blocking circ_0136474 and upregulating mir-766-3p could rescue cell viability and levels of pcna, bcl-2, reduced glutathione (gsh), and total superoxide dismutase (sod), and attenuate apoptosis rate and levels of bax, reactive oxygen species (ros), and lipid peroxidation malondialdehyde (mda). |
2021-06-08 |
2023-08-13 |
human |
| Sara Shamekhi, Jalal Abdolalizadeh, Alireza Ostadrahimi, Seyyed Abolghasem Mohammadi, Abolfazl Barzegari, Hajie Lotfi, Esat Bonabi, Nosratollah Zargham. Apoptotic Effect of Saccharomyces cerevisiae on Human Colon Cancer SW480 Cells by Regulation of Akt/NF-ĸB Signaling Pathway. Probiotics and antimicrobial proteins. vol 12. issue 1. 2021-06-07. PMID:30788662. |
the results showed that hky could induce apoptosis in colon cancer cell line through downregulation of p-akt1, rel a, bcl-xl, pro-caspase 3, and pro-caspase 9 expressions, and upregulation of bax, cleaved caspase-3, and cleaved caspase-9. |
2021-06-07 |
2023-08-13 |
human |
| Sajad Sahab-Negah, Fatemeh Ariakia, Mohammad Jalili-Nik, Amir R Afshari, Sahar Salehi, Fariborz Samini, Ghadir Rajabzadeh, Ali Gorj. Curcumin Loaded in Niosomal Nanoparticles Improved the Anti-tumor Effects of Free Curcumin on Glioblastoma Stem-like Cells: an In Vitro Study. Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32430842. |
cm-np exerted significantly higher effects on gsc viability, apoptosis, cell cycle arrest, and the expression of bax, a pro-apoptotic marker, compared with cm. |
2021-06-07 |
2023-08-13 |
human |
| Jihui Wang, Nazim Muhammad, Tongtong Li, Han Wang, Yujia Liu, Bingnan Liu, Honglei Zha. Hyaluronic Acid-Coated Camptothecin Nanocrystals for Targeted Drug Delivery to Enhance Anticancer Efficacy. Molecular pharmaceutics. vol 17. issue 7. 2021-06-07. PMID:32437163. |
the possible molecular mechanism regarding this novel drug formulation might be linked to intrinsic mitochondria-mediated apoptosis by an increase of bax to bcl-2 ratio and upregulation of p53. |
2021-06-07 |
2023-08-13 |
Not clear |
| Huiyuan Zhang, Xi Lu, Yuehan Hao, Ling Tang, Zhiyi H. MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9. Acta histochemica. vol 122. issue 5. 2021-06-07. PMID:32622424. |
apoptosis-related proteins bax, bcl-2 and cleaved caspase-3 in perihematomal region were also measured to further confirm the inhibitory effect of mir-26a-5p on neuronal apoptosis. |
2021-06-07 |
2023-08-13 |
rat |
| Fatemeh Jamshidi-Adegani, Saeid Vakilian, Najeeb Ur Rehman, Mohammed Al-Broumi, Juhaina Al-Kindi, Khurshid Alam, Parisa Mozafarinahavandi, Anwarul Hasan, Hamad Al-Riyami, Javid Hussain, Solomon White, Ahmed Al-Harrasi, Sulaiman Al-Hashm. Secondary metabolites from acridocarpus orientalis inhibits 4T1 cells and promotes mesenchymal stem cells (MSCs) proliferation. Molecular biology reports. vol 47. issue 7. 2021-06-07. PMID:32623616. |
followed by the induction of cell cycle arrest in g0/g1-phase, the real-time pcr demonstrated apoptosis properties in 4t1 cells through overexpression of bax and down-regulation of bcl2 genes. |
2021-06-07 |
2023-08-13 |
Not clear |
| Shipeng Ren, Song Qin. Effects of ethyl acetate extract of peony (Paeonia suffruticosa) seed coat on the proliferation and apoptosis of oral squamous carcinoma cells through miR-424-3p/STAT3/Survivin pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 6. 2021-06-07. PMID:33040785. |
results showed that ethyl acetate extract of peony seed coat could reduce cell proliferation rate and the protein levels of pcna, bcl-2, p-stat3, survivin and the expression level of mir-424-3p (p<0.05), increase apoptosis rate and the protein level of bax (p<0.05). |
2021-06-07 |
2023-08-13 |
Not clear |
| Shipeng Ren, Song Qin. Effects of ethyl acetate extract of peony (Paeonia suffruticosa) seed coat on the proliferation and apoptosis of oral squamous carcinoma cells through miR-424-3p/STAT3/Survivin pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 6. 2021-06-07. PMID:33040785. |
after transfection with anti-mir-424-3p, the cell proliferation rate, the protein levels of pcna and bcl-2 were significantly reduced (p<0.05), the apoptosis rate and the protein level of bax were significantly increased (p<0.05), while the effect of mir-424-3p mimics was the opposite. |
2021-06-07 |
2023-08-13 |
Not clear |
| Wenning Cao, Lan M. Effect and mechanism of rapamycin on proliferation and apoptosis of human lung cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 6. 2021-06-07. PMID:33040787. |
in conclusion, rapa can induce apoptosis of nci-h446 cells by down-regulating bcl-2 gene expression, up-regulating p53 and bax gene expression, and increasing intracellular ca2+ concentration and its apoptosis induction effect have timeliness and dose-effect. |
2021-06-07 |
2023-08-13 |
human |
| Yu-Rong Mu, Li Cai, Meng-Yuan Zhou, Ming-Ming Liu, Zeng Li, Rong L. Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/β-catenin pathway. International immunopharmacology. vol 90. 2021-06-07. PMID:33278748. |
az could reduce ki67 expression and increase apoptosis index in cia synovial tissues by reducing bcl-2 protein level, increasing bax and caspase 3 protein levels and normalizing bcl-2/bax ratio. |
2021-06-07 |
2023-08-13 |
rat |
| Zhonghui Ling, Min Chen, Ting Li, Yating Qian, Chanjuan L. MiR-141-3p downregulation promotes tube formation, migration, invasion and inhibits apoptosis in hypoxia-induced human umbilical vein endothelial cells by targeting Notch2. Reproductive biology. vol 21. issue 2. 2021-06-07. PMID:33631423. |
hypoxia treatment inhibited viability, tube formation, migration, and invasion, and promoted apoptosis in huvecs, as well as increased bax and cleaved caspase-3 expressions and decreased bcl-2 expression. |
2021-06-07 |
2023-08-13 |
human |
| Wan-Long Xu, Dilimulati Aikeremu, Jun-Gang Sun, Yan-Jun Zhang, Jiang-Bo Xu, Wen-Zheng Zhou, Xi-Bin Zhao, Hao Wang, Hong Yua. Effect of intensity-modulated radiation therapy on sciatic nerve injury caused by echinococcosis. Neural regeneration research. vol 16. issue 3. 2021-06-04. PMID:32985491. |
additionally, apoptosis of neurons was examined using a terminal-deoxynucleotidyl transferase-mediated dutp nick end labeling assay, and expression of bcl-2 and bax in sciatic nerve tissue was detected by immunohistochemical staining and western blot assay. |
2021-06-04 |
2023-08-13 |
Not clear |
| X Gao, S Zhang, D Wang, Y Cheng, Y Jiang, Y Li. (Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway. Physiological research. vol 69. issue 3. 2021-06-03. PMID:32469229. |
after 24 h of hypoxia followed by 2 h of reoxygenation, the expression levels of prr, lc3b-i/ii, beclin1, cleaved caspase-3, cleaved caspase-9 and bax were upregulated, suggesting that apoptosis and autophagy were increased in h9c2 cells. |
2021-06-03 |
2023-08-13 |
Not clear |
| Damilare D Akintade, Bhabatosh Chaudhur. Identification of proteins involved in transcription/translation (eEF 1A1) as an inhibitor of Bax induced apoptosis. Molecular biology reports. vol 47. issue 9. 2021-06-03. PMID:32875432. |
identification of proteins involved in transcription/translation (eef 1a1) as an inhibitor of bax induced apoptosis. |
2021-06-03 |
2023-08-13 |
human |