| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Wang, Wenbin Shi, Xuewei Gao, Nagaraja SreeHarsha, Daisong Zhan. Cardioprotective role of metformin against sodium arsenite-induced oxidative stress, inflammation, and apoptosis. IUBMB life. vol 72. issue 4. 2021-06-21. PMID:31587475. |
in addition, sa provoked the apoptosis by expanding the p53 and bax levels, terminal deoxynucleotidyl transferase dutp nick end labeling, and expression of caspase-3. |
2021-06-21 |
2023-08-13 |
rat |
| Lingling Zhang, Ping Wu, Luyan Zhang, Nagaraja SreeHarsha, Anurag Mishra, Xinyou S. Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin-induced cardio toxicity via suppressing oxidative stress and apoptosis. IUBMB life. vol 72. issue 4. 2021-06-21. PMID:31660680. |
while in apoptosis parameters, rsg treatment in adm rats significantly diminished a cleaved caspase-3 and bax expression as well as expanded bcl-2 expression when contrasted with adm group of rats. |
2021-06-21 |
2023-08-13 |
rat |
| Raed S Ismail, Mohammed S El-Awady, Memy H Hassa. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 7. 2021-06-21. PMID:31950223. |
furthermore, pantoprazole mostly normalized cisplatin-induced distortion of renal levels of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10) and renal content of apoptosis regulating protein expressions (bax, bcl2, and active caspase 3). |
2021-06-21 |
2023-08-13 |
mouse |
| Raed S Ismail, Mohammed S El-Awady, Memy H Hassa. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 7. 2021-06-21. PMID:31950223. |
the protective mechanism of pantoprazole could be through diminution of cisplatin-induced inflammation, oxidative stress, and their subsequent apoptotic renal cell death via abatement of apoptosis regulating protein expressions (bax, bcl2, and active caspase3). |
2021-06-21 |
2023-08-13 |
mouse |
| Xun Xia, Hao Niu, Yuan Ma, Bo Qu, Mingjie He, Kai Yu, Enren Wang, Lie Zhang, Jianwen Gu, Gang Li. LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis. Cellular and molecular neurobiology. vol 40. issue 8. 2021-06-21. PMID:32239388. |
additionally, an abundance of ccat1 obviously amplified cell viability and restrained ogd/r-triggered apoptosis in astrocytes, as characterized by reduced levels of pro-apoptotic proteins bax and c-caspase-3, concomitant with elevated level of anti-apoptotic bcl-2 protein. |
2021-06-21 |
2023-08-13 |
Not clear |
| Md Sifat Rahi, Md Shihabul Islam, Israt Jerin, Chowdhury Arif Jahangir, Md Mahmudul Hasan, Kazi Md Faisal Hoque, Md Abu Rez. Differential expression of Bax-Bcl-2 and PARP-1 confirms apoptosis of EAC cells in Swiss albino mice by Morus laevigata. Journal of food biochemistry. vol 44. issue 8. 2021-06-21. PMID:32578902. |
fluorescent microscopy and expression of parp-1, bax, and bcl-2 through qpcr were performed to evaluate apoptosis. |
2021-06-21 |
2023-08-13 |
mouse |
| Yaxin Li, Aimin Zhou, Xusheng Cui, Yanqing Zhang, Junbo Xi. 6'"-p-Coumaroylspinosin protects PC12 neuronal cells from acrylamide-induced oxidative stress and apoptosis. Journal of food biochemistry. vol 44. issue 9. 2021-06-21. PMID:32592426. |
further investigation of the molecular mechanism underlying the effect of p-cs on cell apoptosis revealed that p-cs was able to suppress the expression of bax and bim induced by aa and inhibit the jnks pathway. |
2021-06-21 |
2023-08-13 |
Not clear |
| Maryam Pourhajibagher, Samira Gharesi, Nasim Chiniforush, Abbas Bahado. The Effect of Indocyanine Green Antimicrobial Photothermal/Photodynamic Therapy on the Expression of BCL-2 and BAX Messenger RNA Levels in Human Gingival Fibroblast Cells. Folia medica. vol 62. issue 2. 2021-06-21. PMID:32666749. |
to explore whether ptt/pdt with icg causes cell death by apoptosis in human gingival fibroblast (hgf) cells, bax and bcl-2 genes expression as key events for apoptosis were evaluated in this study. |
2021-06-21 |
2023-08-13 |
human |
| Gracy Jenifer Sahayanathan, Deepakrajasekar Padmanaban, Kavitha Raja, Arulvasu Chinnasam. Anticancer effect of purified polysaccharide from marine clam Donax variabilis on A549 cells. Journal of food biochemistry. vol 44. issue 11. 2021-06-21. PMID:32996209. |
although, f2.1 treatment exhibit the cell cycle arrest in s-phase through the downregulation of cell cycle regulators such as cyclin a and cdk2 and regulate ros-induced mitochondrial-mediated apoptosis in a549 cells by an increased level of proapoptotic molecules such as bax, cyt-c, cleaved caspase-3 and 9, and decreased the level of bcl-2. |
2021-06-21 |
2023-08-13 |
human |
| Li-Xin Cui, Ya-Qing Tian, Hai-Sheng Hao, Hui-Ying Zou, Yun-Wei Pang, Shan-Jiang Zhao, Xue-Ming Zhao, Hua-Bin Zhu, Wei-Hua D. Knockdown of ASH1L methyltransferase induced apoptosis inhibiting proliferation and H3K36 methylation in bovine cumulus cells. Theriogenology. vol 161. 2021-06-21. PMID:33296745. |
additionally, ash1l knockdown inhibited cell proliferation, increased the apoptosis rate, and upregulated the expression of apoptosis genes caspase-3, bax and bax/bcl-2 ratio (p < 0.05). |
2021-06-21 |
2023-08-13 |
cattle |
| Lei Wang, Longning Wang, Qingfen Wang, Bahman Yosefi, Sen Wei, Xiaodong Wang, Daqing She. The function of long noncoding RNA HOTAIRM1 in the progression of prostate cancer cells. Andrologia. vol 53. issue 2. 2021-06-21. PMID:33368390. |
reducing hotairm1 alleviated cell proliferation and increased apoptosis of pc3 cells so that the expression of pro-apoptotic agents such as bad and bax was significantly increased, while that of bid and bcl-2 (anti-apoptotic) was decreased. |
2021-06-21 |
2023-08-13 |
Not clear |
| Yaschilal Muche Belayneh, Gedefew Getnet Amare, Birhanu Geta Mehari. Updates on the molecular mechanisms of aspirin in the prevention of colorectal cancer: Review. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. vol 27. issue 4. 2021-06-21. PMID:33427041. |
cox-independent mechanisms of anticancer effects of aspirin include down-regulation of nuclear factor kappa b activity and akt activation, modulation of bcl-2 and bax family proteins, suppression of vascular endothelial growth factor, induction of apoptosis, disruption of dna repair mechanisms, and induction of spermidine/spermine |
2021-06-21 |
2023-08-13 |
Not clear |
| Yalin Guan, Xia Zhao, Nuan Song, Yuan Cui, Ying Chan. Albicanol antagonizes Cd-induced apoptosis through a NO/iNOS-regulated mitochondrial pathway in chicken liver cells. Food & function. vol 12. issue 4. 2021-06-21. PMID:33502412. |
in addition, the inos activity and no content increased significantly, which promoted the expressions of genes associated with the mitochondrial apoptosis pathway (bax, cytc, caspase-3 and caspase-9) and inhibited the expression of bcl-2 in this pathway. |
2021-06-21 |
2023-08-13 |
chicken |
| Yalin Guan, Xia Zhao, Nuan Song, Yuan Cui, Ying Chan. Albicanol antagonizes Cd-induced apoptosis through a NO/iNOS-regulated mitochondrial pathway in chicken liver cells. Food & function. vol 12. issue 4. 2021-06-21. PMID:33502412. |
however, cd + albicanol co-treatment significantly reduced the apoptosis rate and the expressions of inos and genes associated with the mitochondrial apoptosis pathway (bax, cytc, caspase-3 and caspase-9), and promoted the expression of bcl-2 in this pathway. |
2021-06-21 |
2023-08-13 |
chicken |
| Guo-Jian Jiang, Bei-Bei Li, Ting-Jun Fa. Timolol induces necroptosis, apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro. Life sciences. vol 277. 2021-06-21. PMID:33798551. |
the apoptotic mechanism in the median-concentration timolol-treated rlscs is probably via extrinsic apoptosis pathway by activating caspase-2, caspase-8 and caspase-3 and intrinsic apoptosis pathway triggered by excessive generation of ros and subsequent dna damage to upregulate bax and bad, downregulate bcl-2 and bcl-xl, subsequently disrupt mitochondrial membrane potential, cytosolically translocate cytochrome c and apoptosis-inducing factor, and activate caspase-9. |
2021-06-21 |
2023-08-13 |
rabbit |
| Dandan Shao, Jiayong Zhang, Le Tang, Qiuli Yu, Xiaoxiao Hu, Qin Ruan, Wei Ouyang, Zigui Zhan. Effects and Molecular Mechanism of L-Type Calcium Channel on Fluoride-Induced Kidney Injury. Biological trace element research. vol 197. issue 1. 2021-06-18. PMID:31792773. |
the apoptosis of kidney cell was observed by tunel, and the protein expression levels of cav1.2 and cam, camkii, bcl-2, and bax were detected by western blot. |
2021-06-18 |
2023-08-13 |
mouse |
| Rui Ma, Shuang Liu, Tingting Qiao, Demin Li, Ruixue Zhang, Xiaoying Gu. Fluoride Inhibits Longitudinal Bone Growth by Acting Directly at the Growth Plate in Cultured Neonatal Rat Metatarsal Bones. Biological trace element research. vol 197. issue 2. 2021-06-18. PMID:31838736. |
the apoptosis was detected by flow cytometry, and the expression of apoptosis-related proteins bax, bcl-2, and caspase-3 were detected by western blotting in sw1353 cells. |
2021-06-18 |
2023-08-13 |
rat |
| Yu-Shan Ren, Hong-Hua Li, Jing-Chun Yao, Yu-Jun Tan, Li-Hong Pan, Tao Peng, Li-Li Zhao, Gui-Min Zhang, Jiang Yue, Xue-Mei Hu, Zhong Liu, Jie L. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Journal of proteomics. vol 222. 2021-06-18. PMID:32068187. |
bax, cox2, and gsk3β are involved in modulating cardiomyocyte apoptosis, and rhoa and dsc2 are directly associated with myocardial function. |
2021-06-18 |
2023-08-13 |
rat |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
administration of saikosaponin a significantly ameliorated depressive-like behavior, and inhibited neuronal apoptosis, enhanced the level of p-creb, bdnf and bcl-2, reduced the level of bax, caspase-3 in the hippocampus of psd rats. |
2021-06-18 |
2023-08-13 |
rat |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
these results revealed that saikosaponin a improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia, presumably through increasing the expression of bdnf, p-creb and bcl-2, as well as decreasing the level of bax, caspase-3. |
2021-06-18 |
2023-08-13 |
rat |