| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiujuan Chen, Xuequn Yu, Xinxiang Li, Li Li, Fang Li, Ting Guo, Cuihong Guan, Liping Miao, Guoping Ca. MiR-126 targets IL-17A to enhance proliferation and inhibit apoptosis in high-glucose-induced human retinal endothelial cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 2. 2021-02-23. PMID:31608649. |
this indicates that mir-126 enhances proliferation and inhibits apoptosis in high-glucose-induced hrecs by activating the pi3k-akt pathway, increasing survivin levels, and decreasing bax and caspase-3 expression by targeting il-17a, suggesting that mir-126 could be a novel target for preventing dr. |
2021-02-23 |
2023-08-13 |
human |
| Zhen-Hong Xia, Xue Jiang, Ke Li, Li-Xia Li, Wen-Bo Chen, Yu-Xiang Wang, Yan-Qiang Li. Curcumin inhibits alloxan-induced pancreatic islet cell damage via antioxidation and antiapoptosis. Journal of biochemical and molecular toxicology. vol 34. issue 7. 2021-02-23. PMID:32202049. |
the results showed that curcumin significantly promoted the cellular activity of axn-treated rin-m5f cells, decreased the ratio of apoptosis, downregulated the level of malondialdehyde, upregulated the levels of superoxide dismutase and reactive oxygen species, increased the expression of bcl-2, cleaved caspase-3, and cleaved parp1, and decreased the expression of bax in axn-treated cells. |
2021-02-23 |
2023-08-13 |
Not clear |
| Qi Yu, Sa Yang, Zhongqiu Li, Yonghang Zhu, Zhenkai Li, Jiatong Zhang, Chunyang Li, Feifei Feng, Wei Wang, Qiao Zhan. The relationship between endoplasmic reticulum stress and autophagy in apoptosis of BEAS-2B cells induced by cigarette smoke condensate. Toxicology research. vol 10. issue 1. 2021-02-23. PMID:33613969. |
the results showed that csc decreased cell viability, increased cell apoptosis, elevated cleaved-caspase 3/pro-caspase 3 ratio and bax expressions, but decreased bcl-2 expressions. |
2021-02-23 |
2023-08-13 |
human |
| Qi Yu, Sa Yang, Zhongqiu Li, Yonghang Zhu, Zhenkai Li, Jiatong Zhang, Chunyang Li, Feifei Feng, Wei Wang, Qiao Zhan. The relationship between endoplasmic reticulum stress and autophagy in apoptosis of BEAS-2B cells induced by cigarette smoke condensate. Toxicology research. vol 10. issue 1. 2021-02-23. PMID:33613969. |
csc-induced apoptosis was further increased, bax expressions and cleaved-caspase 3/pro-caspase 3 ratio were improved, but bcl-2 expressions were decreased after 3-ma or 4-pba treatment. |
2021-02-23 |
2023-08-13 |
human |
| Fei Peng, Weisong Cai, Jianping Li, Haohuan L. ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation. Frontiers in oncology. vol 10. 2021-02-23. PMID:33614474. |
clc-5 downregulation induces osteosarcoma cell apoptosis by promoting bax and tbid complex formation. |
2021-02-23 |
2023-08-13 |
Not clear |
| Huankai Yao, Xiuli Zhang, Nan Zhang, Jindong Li, Yan Li, Qunli We. Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway. Journal of natural medicines. vol 75. issue 1. 2021-02-22. PMID:32865667. |
further dapi staining has revealed wikstromol at 10 μm induced apoptosis of cancer cells, which was associated with the activation of caspase-3 following down-regulation of bcl-2 as well as up-regulation of bax, cleaved parp and phosphorylated p53. |
2021-02-22 |
2023-08-13 |
human |
| Yujie Tan, Hao Wang, Chan Zhan. MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells. Environmental toxicology and pharmacology. vol 81. 2021-02-22. PMID:33086148. |
overexpression of mirna-381 in cervical cancer cells significantly (p < 0.05) inhibited their proliferation through the induction of cell apoptosis which was accompanied by depletion of bcl-2 and increase in bax expression. |
2021-02-22 |
2023-08-13 |
human |
| Hongyu Zhang, Hongxia Liang, Shuhuan Wu, Yingying Zhang, Zujiang Y. MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2). Environmental toxicology and pharmacology. vol 82. 2021-02-22. PMID:33290872. |
the dapi and annexin v/pi staining assays revealed that mir-638 induces apoptosis in human liver cancer cells which was accompanied by enhancement of bax and depletion of bcl-2 expression. |
2021-02-22 |
2023-08-13 |
human |
| Mingxing Ma, Xiaonan Wang, Ning Liu, Fengping Shan, Yong Fen. Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway. International immunopharmacology. vol 83. 2021-02-19. PMID:32171145. |
ldn was able to upregulate expression of the opioid growth factor receptor (ogfr) and apoptosis-related factors bax, caspase-9, caspase-3, and parp and downregulate expression of bcl-2, survivin, and ki67 to promote tumor cell apoptosis. |
2021-02-19 |
2023-08-13 |
mouse |
| Cheng-Yi Chang, Ping-Ho Pan, Jian-Ri Li, Yen-Chuan Ou, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Che. Aspirin Induced Glioma Apoptosis through Noxa Upregulation. International journal of molecular sciences. vol 21. issue 12. 2021-02-19. PMID:32545774. |
we found that the human h4 glioma cell-killing effects of aspirin involved mitochondria-mediated apoptosis accompanied by endoplasmic reticulum (er) stress, noxa upregulation, mcl-1 downregulation, bax mitochondrial distribution and oligomerization, and caspase 3/caspase 8/caspase 9 activation. |
2021-02-19 |
2023-08-13 |
mouse |
| Cheng-Yi Chang, Ping-Ho Pan, Jian-Ri Li, Yen-Chuan Ou, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Che. Aspirin Induced Glioma Apoptosis through Noxa Upregulation. International journal of molecular sciences. vol 21. issue 12. 2021-02-19. PMID:32545774. |
genetic silencing of noxa or bax attenuated aspirin-induced viability loss and apoptosis, while silencing mcl-1 augmented the effects of aspirin. |
2021-02-19 |
2023-08-13 |
mouse |
| E M El Morsy, Mae Ahme. Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats. Human & experimental toxicology. vol 39. issue 8. 2021-02-18. PMID:32153214. |
furthermore, concurrent treatment of lycopene with bpa prevented apoptosis by marked decrease in bcl-2 associated x protein (bax) gene expression and caspase 3 activity while restoring b-cell leukemia/lymphoma-2 (bcl-2) gene expression. |
2021-02-18 |
2023-08-13 |
rat |
| F Shabani, M Mahdavi, M Imani, M A Hosseinpour-Feizi, N Gheib. Calprotectin (S100A8/S100A9)-induced cytotoxicity and apoptosis in human gastric cancer AGS cells: Alteration in expression levels of Bax, Bcl-2, and ERK2. Human & experimental toxicology. vol 39. issue 8. 2021-02-18. PMID:32167384. |
calprotectin (s100a8/s100a9)-induced cytotoxicity and apoptosis in human gastric cancer ags cells: alteration in expression levels of bax, bcl-2, and erk2. |
2021-02-18 |
2023-08-13 |
human |
| Małgorzata Zielińska-Przyjemska, Mariusz Kaczmarek, Violetta Krajka-Kuźniak, Marcin Wierzchowski, Wanda Baer-Dubowsk. Effect of methoxy stilbenes-analogs of resveratrol-on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells. Molecular and cellular biochemistry. vol 474. issue 1-2. 2021-02-18. PMID:32737773. |
moreover, treatment with these derivatives increased the ratio of the proapoptotic bax protein to the antiapoptotic bcl-xl protein, suggesting the induction of apoptosis through the intrinsic mitochondrial pathway in both cell lines. |
2021-02-18 |
2023-08-13 |
human |
| Damilare D Akintade, Bhabatosh Chaudhur. Human VAMP3 Suppresses or Negatively Regulates Bax Induced Apoptosis in Yeast. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33478086. |
human vamp3 suppresses or negatively regulates bax induced apoptosis in yeast. |
2021-02-18 |
2023-08-13 |
human |
| Damilare D Akintade, Bhabatosh Chaudhur. Human VAMP3 Suppresses or Negatively Regulates Bax Induced Apoptosis in Yeast. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33478086. |
it has been suggested that bax induced apoptosis in yeast could be obstructed by enhancing vesicular membrane trafficking. |
2021-02-18 |
2023-08-13 |
human |
| Jieming Ni. UNC0321 inhibits high glucose induced apoptosis in HUVEC by targeting Rab4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32877824. |
in this study, we treated huvec with unc0321 in vitro, and found that unc0321 inhibit the level of cleaved-caspase3 and bax, thus inhibiting the apoptosis caused by high glucose. |
2021-02-17 |
2023-08-13 |
Not clear |
| Mohamed E Abdraboh, Zaidoon Shaker Essa, Abdelrazek B Abdelrazzak, Yousra M El-Far, Yasser Elsherbini, Mustafa M El-Zayat, Doaa A Al. Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32892028. |
the combined treatment stimulated p53-dependent apoptosis which was indicated by the significant increase of early apoptosis marker (annexin v) expression, dna fragmentation, expression of p53 & bax and downregulation of bcl2 expression. |
2021-02-17 |
2023-08-13 |
Not clear |
| Sameena Bano, Faheem Ahmed, Farha Khan, Sandeep Chand Chaudhary, M Sami. Enhancement of the cancer inhibitory effect of the bioactive food component resveratrol by nanoparticle based delivery. Food & function. vol 11. issue 4. 2021-02-16. PMID:32215382. |
moreover, at all doses nrv altered bax and bcl2 expressions which lead to the induction of apoptosis. |
2021-02-16 |
2023-08-13 |
mouse |
| Liangjun Zhong, Jinxiang Yan, Haitao Li, Lei Men. HDAC9 Silencing Exerts Neuroprotection Against Ischemic Brain Injury Frontiers in cellular neuroscience. vol 14. 2021-02-16. PMID:33584204. |
next, primary neuronal apoptosis, expression of apoptosis-related factors (bax, cleaved caspase3 and bcl-2), ldh leakage rate, as well as the release of inflammatory factors (tnf-α, il-1β, and il-6) were evaluated by assays of tunel, western blot, and elisa. |
2021-02-16 |
2023-08-13 |
mouse |