| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liye Zhu, Chuchu Huang, Xuan Yang, Boyang Zhang, Xiaoyun He, Wentao Xu, Kunlun Huan. Proteomics reveals the alleviation of zinc towards aflatoxin B1-induced cytotoxicity in human hepatocyes (HepG2 cells). Ecotoxicology and environmental safety. vol 198. 2020-12-15. PMID:32353602. |
moreover, zn could decrease the expression of pro-apoptotic genes (cleaved-caspase-3, caspase-9, and bax) and increase the expression of anti-apoptotic genes (bcl-2 and bcl-xl) to alleviate the cell apoptosis induced by afb1. |
2020-12-15 |
2023-08-13 |
human |
| Arnab Banerjee, Debasmita Das, Rajarshi Paul, Sandipan Roy, Ujjal Das, Samrat Saha, Sanjit Dey, Arghya Adhikary, Sandip Mukherjee, Bithin Kumar Maj. Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963259. |
furthermore, eecgl significantly inhibited hm-induced increased population of cells in sub g0/g1 phase, decreased bcl2 expression and thereby loss of mitochondrial membrane potential with over expression of bax, p53, p21, activation of caspase 3 and 9 indicated the apoptosis and suppression of cell survival. |
2020-12-15 |
2023-08-13 |
rat |
| Carla Pisani, Martina Ramella, Renzo Boldorini, Gianfranco Loi, Michele Billia, Francesca Boccafoschi, Alessandro Volpe, Marco Krengl. Apoptotic and predictive factors by Bax, Caspases 3/9, Bcl-2, p53 and Ki-67 in prostate cancer after 12 Gy single-dose. Scientific reports. vol 10. issue 1. 2020-12-14. PMID:32341393. |
radio-induced apoptosis is mediated by the activation of tumor protein p53, bax and caspases. |
2020-12-14 |
2023-08-13 |
Not clear |
| Hui Chen, Yongjun Chen, Xin Wang, Jing Yang, Congxin Huan. Edaravone attenuates myocyte apoptosis through the JAK2/STAT3 pathway in acute myocardial infarction. Free radical research. vol 54. issue 5. 2020-12-14. PMID:32543312. |
the mrna levels for bcl-2, bax, fas, and fasl were measured by rt-pcr and apoptosis was assessed by tunel. |
2020-12-14 |
2023-08-13 |
rat |
| Guoguo Jin, Mingyang Yan, Kangdong Liu, Ke Yao, Hanyong Chen, Chengjuan Zhang, Yang Yi, Kanamata Reddy, Dhilli Rao Gorja, Kyle Vaughn Laster, Zhiping Guo, Zigang Don. Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer. Oncogene. vol 39. issue 43. 2020-12-14. PMID:32963350. |
apio-ee-07 inhibited cell growth and induced apoptosis and also increased expression of bax as well as cleaved caspase-3 and -parp in colon cancer cells by downregulating rsk1 and msk2 downstream targets, including creb and atf1. |
2020-12-14 |
2023-08-13 |
mouse |
| Shun Zhang, Haoyan Tu, Jiamin Zhu, Aihong Liang, Peng Huo, Ke Shan, Junyi He, Meng Zhao, Xi Chen, Xiaocan Le. Dendrobium nobile Lindl. polysaccharides improve follicular development in PCOS rats. International journal of biological macromolecules. vol 149. 2020-12-11. PMID:31978473. |
dnlp treatment increased the pcna mrna and protein expression levels in the pcos ovarian tissues, and inhibited cell apoptosis in the pcos ovarian tissues via regulating apoptosis-related proteins including bax, bcl-2 and caspase-3. |
2020-12-11 |
2023-08-13 |
rat |
| Wenfu Xu, Zhujun Wang, Kun Li, Runming Ji. Huai Qi Huang Potentiates Dexamethasone-Mediated Lethality in Acute Lymphoblastic Leukemia Cells by Upregulating Glucocorticoid Receptor α. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-12-11. PMID:32065117. |
results the results revealed that cell survival was reduced and apoptosis was increased as the hqh concentration was increased, and this was accompanied with increases in the levels of bax, cleaved-caspase-3 and glucocorticoid receptor alpha (gralpha) and decreases in the levels of bcl-2 and phospho-erk (perk). |
2020-12-11 |
2023-08-13 |
Not clear |
| Wenfu Xu, Zhujun Wang, Kun Li, Runming Ji. Huai Qi Huang Potentiates Dexamethasone-Mediated Lethality in Acute Lymphoblastic Leukemia Cells by Upregulating Glucocorticoid Receptor α. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-12-11. PMID:32065117. |
combined treatment with hqh and dex or pd98059 increased apoptosis in jurkat and nalm-6 cells, and concurrently increased bax, cleaved-caspase-3, gilz, nfkbia, and gralpha and decreased bcl-2 and perk. |
2020-12-11 |
2023-08-13 |
Not clear |
| Kinga Szymona, Ewa Dudzińska, Hanna Karakuła-Juchnowicz, Paulina Gil-Kulik, Piotr Chomik, Małgorzata Świstowska, Joanna Gałaszkiewicz, Janusz Kock. Analysis of the expression of BAX, BCL2, BIRC6, CASP3, CASP9 apoptosis genes during the first episode of schizophrenia. Psychiatria polska. vol 53. issue 6. 2020-12-10. PMID:32017818. |
analysis of the expression of bax, bcl2, birc6, casp3, casp9 apoptosis genes during the first episode of schizophrenia. |
2020-12-10 |
2023-08-13 |
Not clear |
| Kinga Szymona, Ewa Dudzińska, Hanna Karakuła-Juchnowicz, Paulina Gil-Kulik, Piotr Chomik, Małgorzata Świstowska, Joanna Gałaszkiewicz, Janusz Kock. Analysis of the expression of BAX, BCL2, BIRC6, CASP3, CASP9 apoptosis genes during the first episode of schizophrenia. Psychiatria polska. vol 53. issue 6. 2020-12-10. PMID:32017818. |
the aim of the study was the analysis of (1) the level of bax,bcl2,birc6,casp3, casp9 apoptosis genes expression in schizophrenic patients and in the control group, and (2) the relationships between the genes expression level and the morphological and biochemical parameters, as well as the severity of psychopathological symptoms. |
2020-12-10 |
2023-08-13 |
Not clear |
| Xue-Feng Li, Shu-Hua Zhang, Gui-Feng Liu, Shao-Nan Y. miR-363 Alleviates Detrusor Fibrosis via the TGF-β1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM. Molecular therapy. Nucleic acids. vol 22. 2020-12-10. PMID:33294298. |
upregulated mir-363 inhibited col1a2 expression, which led to increased expression of b-cell lymphoma 2 (bcl-2) and smad7 and accelerated cell viability, along with decreases in cell apoptosis and col3a1, bcl-2-associated x protein (bax), transforming growth factor (tgf)-β1, and smad4 expressions. |
2020-12-10 |
2023-08-13 |
rat |
| Sarah A White, Lisa S Zhang, Daniel J Pasula, Yu Hsuan Carol Yang, Dan S Lucian. Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32620813. |
although activation of canonical intrinsic apoptosis is known to require pro-apoptotic bcl-2 family proteins bax and bak, their individual and combined involvement in glucolipotoxic β-cell death are not known. |
2020-12-08 |
2023-08-13 |
mouse |
| Sarah A White, Lisa S Zhang, Daniel J Pasula, Yu Hsuan Carol Yang, Dan S Lucian. Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32620813. |
using mice with individual or combined β-cell deletion of bax and bak, we demonstrated that glucolipotoxic β-cell death in vitro occurs by both non-apoptotic and apoptotic mechanisms, and the apoptosis could be triggered by either bax or bak alone. |
2020-12-08 |
2023-08-13 |
mouse |
| Damilare D Akintade, Bhabatosh Chaudhur. The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast. Bioscience reports. vol 40. issue 9. 2020-12-08. PMID:32794578. |
bax and α-synuclein are two human proteins which play a role in the induction of neuronal apoptosis in neurodegenerative diseases like alzheimer's and parkinson's. |
2020-12-08 |
2023-08-13 |
human |
| Saiedeh Ganbarjeddi, Ako Azimi, Milad Zadi Heydarabad, Maryam Hemmatzadeh, Shahin Mohammadi, Reza Mousavi Ardehaie, Majid Zamani, Sina Baharaghdam, Sajjad Esmaeili, Amin Ghasem. Apoptosis Induced by Prednisolone Occurs without Altering the Promoter Methylation of BAX and BCL-2 Genes in Acute Lymphoblastic Leukemia Cells CCRF-CEM. Asian Pacific journal of cancer prevention : APJCP. vol 21. issue 2. 2020-12-04. PMID:32102534. |
apoptosis induced by prednisolone occurs without altering the promoter methylation of bax and bcl-2 genes in acute lymphoblastic leukemia cells ccrf-cem. |
2020-12-04 |
2023-08-13 |
Not clear |
| Ling Chen, Qingxiang Hou, Li Feng, Ling Li Xin, Li M. Inhibitory and protective effect of obovatol against uterine fibroid (leiomyoma) cells. Pakistan journal of pharmaceutical sciences. vol 33. issue 1(Supplementary). 2020-12-04. PMID:32122859. |
in addition, apoptosis regulatory proteins like bcl2 and bax were substantially down and up-regulated respectively, by ob in a dose-dependent fashion. |
2020-12-04 |
2023-08-13 |
human |
| Min-Yi Huang, Ren-Yan Duan, Jia-Wei Yin, Qiang Zhao, Yu-Yue Wan, Yang Li. Individual and mixture toxicity of chromium and copper in development, oxidative stress, lipid metabolism and apoptosis of Bufo gargarizans embryos. Aquatic toxicology (Amsterdam, Netherlands). vol 229. 2020-12-04. PMID:33166901. |
the treatments showed significant effects on the expression of apoptosis genes (bcl-1 and bax), with bcl-1 mrna expression increasing and bax mrna expression decreasing. |
2020-12-04 |
2023-08-13 |
Not clear |
| Baoyuan Jin, Hyehyun Kim, Jeong-Il Choi, Hong-Beom Bae, Seongtae Jeon. Avenanthramide C Prevents Neuronal Apoptosis via PI3K/Akt/GSK3β Signaling Pathway Following Middle Cerebral Artery Occlusion. Brain sciences. vol 10. issue 11. 2020-12-01. PMID:33233587. |
we evaluated the blood brain barrier (bbb) integrity (zo-1, ve-cadherin and occludin) and apoptosis (bax, bcl2, caspase3, cytochrome c, and poly adp ribose polymerase(parp)-1). |
2020-12-01 |
2023-08-13 |
mouse |
| Yuwan Zhao, Dongcai Ye, Qiuming Luo, Jianwei Li, Jianjun Li. Pterostilbene Inhibits Human Renal Cell Carcinoma Cells Growth and Induces DNA Damage. Biological & pharmaceutical bulletin. vol 43. issue 2. 2020-11-30. PMID:32009115. |
flow cytometry assay revealed that pte potently induced the apoptosis of rcc cells in a concentration-dependent manner, which was also testified by up-regulation of the pro-apoptosis-related protein (cyto c, bad, bak, bax, cleaved-caspase 3, cleaved-caspase 9, cleaved-poly(adp-ribose)polymerase (parp)) and down-regulation of the anti-apoptosis-related protein bcl-2. |
2020-11-30 |
2023-08-13 |
human |
| María-Aránzazu Martínez, Bernardo Lopez-Torres, José-Luis Rodríguez, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, Irma Are. Toxicologic evidence of developmental neurotoxicity of Type II pyrethroids cyfluthrin and alpha-cypermethrin in SH-SY5Y cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 137. 2020-11-30. PMID:32028016. |
we examine, in sh-sy5y cells, whether apoptosis and oxidative stress via reactive oxygen species (ros) generation, caspase 3/7 activation, gene expression (bax, bcl-2, casp-3, bnip3, p53 and nrf2) alterations and necrosis by release of cytosolic adenylate kinase (ak), underlie direct effects of the pyrethroids cyfluthrin and alpha-cypermethrin. |
2020-11-30 |
2023-08-13 |
Not clear |