| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sun Jiaxin, Wang Shengchen, Cao Yirong, Wang Shuting, Li Sh. Cadmium exposure induces apoptosis, inflammation and immunosuppression through CYPs activation and antioxidant dysfunction in common carp neutrophils. Fish & shellfish immunology. vol 99. 2020-11-30. PMID:32058096. |
in addition, cd activated cysteinyl aspartate specific proteinases (caspase-3) and induced apoptosis by altering the expression of major genes including mitochondrial pathway factors such as b-cell lymphoma-2 (bcl-2), pro-apoptosis factors bcl-2-associated x (bax), and caspase-9 and death receptor pathways such as fas/fas ligand (fas/fasl), tumour necrosis factor alpha/tumor necrosis factor receptor 1 (tnf-α/tnfr1) and caspase-8. |
2020-11-30 |
2023-08-13 |
Not clear |
| Yeong-Seon Won, Kwon-Il Se. Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 138. 2020-11-30. PMID:32084496. |
we also showed that sanggenol l treatment induced caspase-dependent apoptosis (up-regulation of bax and cleaved-parp or down-regulation of bid, bcl-2, procaspse-3, -8, and -9), induction of caspase-independent apoptosis (up-regulation of aif and endo g on cytosol) in melanoma skin cancer cells. |
2020-11-30 |
2023-08-13 |
mouse |
| Tianxu Zhang, Zhenguang Yan, Xin Zheng, Shuping Wang, Juntao Fan, Zhengtao Li. Effects of acute ammonia toxicity on oxidative stress, DNA damage and apoptosis in digestive gland and gill of Asian clam (Corbicula fluminea). Fish & shellfish immunology. vol 99. 2020-11-30. PMID:32092406. |
the results showed that ammonia poisoning could increase the activity of oxidative stress enzyme (sod and cat), inducing differentially expressed genes (dram2, gadd45, p53, bax, bcl2, casp8, casp9, casp3, hsp70 and hsp90) and different cytokines (il-1 beta, il-8, il-17 and tnf-alpha) of dna damage and apoptosis. |
2020-11-30 |
2023-08-13 |
cat |
| Jie Yang, Yafan Gong, Jingzeng Cai, Yingying Zheng, Ziwei Zhan. Chlorpyrifos induces apoptosis and autophagy in common carp lymphocytes by influencing the TCR γ-dependent PI3K/AKT/JNK pathway. Fish & shellfish immunology. vol 99. 2020-11-30. PMID:32112891. |
our results demonstrated that chlorpyrifos significantly decreased the expression of tcr γ, tcr γ suppression thereby induced increased mrna expression of tnf-α, bax, caspase-3, caspase-8, caspase-9 and significantly inhibited the expression of bcl-2, which indicated that apoptosis was triggered. |
2020-11-30 |
2023-08-13 |
Not clear |
| Lei Wu, Cao Jiang, Ying Kang, Yaji Dai, Wei Fang, Peng Huan. Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH‑SY5Y cells: Involvement of the PI3K/AKT pathway. International journal of molecular medicine. vol 45. issue 4. 2020-11-30. PMID:32124937. |
the results revealed that curcumin increased cell viability, decreased ldh activity, reduced apoptosis and caspase‑3 activity, downregulated the pro‑apoptotic protein bax expression and upregulated the anti‑apoptotic protein bcl‑2 expression in sh‑sy5y cells subjected to ogd/r. |
2020-11-30 |
2023-08-13 |
Not clear |
| Chunyang Yi, Xiaolong Li, Si Chen, Mingyao Liu, Weiqiang Lu, Xiyun Y. Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress. Phytotherapy research : PTR. vol 34. issue 10. 2020-11-30. PMID:32430958. |
furthermore, corynoline triggers apoptosis of melanoma cells, which is associated with increased expression of bax and cleaved caspase-3. |
2020-11-30 |
2023-08-13 |
Not clear |
| Kyung-Phil Ko, Seong-In Jeong, Ji-Sun Lim, Kyung-Woo Lee, Min-Goo Lee, Sung-Gil Ch. NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX. Oncogene. vol 39. issue 34. 2020-11-30. PMID:32690868. |
while nore1a suppresses tnf receptor-mediated apoptosis, it activates tnf-induced apoptosis through bax activation by protecting bax from itch binding and ubiquitination. |
2020-11-30 |
2023-08-13 |
human |
| Kyung-Phil Ko, Seong-In Jeong, Ji-Sun Lim, Kyung-Woo Lee, Min-Goo Lee, Sung-Gil Ch. NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX. Oncogene. vol 39. issue 34. 2020-11-30. PMID:32690868. |
collectively, this study uncovers that nore1a directs a substrate switch of itch favoring tnfri over bax to terminate tnf signaling and accelerate apoptosis, illuminating the mechanistic consequence of nore1a inactivation in tumorigenesis. |
2020-11-30 |
2023-08-13 |
human |
| Victor S Lin, Zhuo-Fan Xu, David C S Huang, Rachel Thijsse. BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic. Cancers. vol 12. issue 11. 2020-11-29. PMID:33198338. |
the pro-survival bcl2 proteins prevent apoptosis by keeping the pro-apoptotic effector proteins bcl2-associated x protein (bax) and bcl2 homologous antagonist/killer (bak) in check, while the bh3-only proteins initiate apoptosis by either neutralizing the pro-survival bcl2 proteins or directly activating the pro-apoptotic effector proteins. |
2020-11-29 |
2023-08-13 |
Not clear |
| Kaviyarasi Renu, Anusha Saravanan, Anushree Elangovan, Sineka Ramesh, Sivakumar Annamalai, Arunraj Namachivayam, Praveena Abel, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Vellingiri Balachandar, Abilash Valsala Gopalakrishna. An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity. Life sciences. vol 260. 2020-11-27. PMID:32949585. |
along with that, arsenic activates caspases and bax, decreases bcl2 through mitochondrial dysfunction, and induces apoptosis regulatory mechanism. |
2020-11-27 |
2023-08-13 |
Not clear |
| Chao Zhou, Jie Ma, Yuanhua Lu, Wan Zhao, Bingxue Xu, Jian Lin, Yongjun Ma, Yafei Tian, Qi Zhang, Wei Wang, Weiqun Yan, Ping Jia. TERT promoter regulating melittin expression induces apoptosis and G Oncology letters. vol 21. issue 1. 2020-11-27. PMID:33240422. |
the upregulation of cleaved caspase-9, cleaved caspase-3, bax and poly(adp-ribose) polymerase 1 in pctert-melittin transfected te1 cells, suggested that pctert-melittin-induced apoptosis was associated with the mitochondrial pathway. |
2020-11-27 |
2023-08-13 |
human |
| Ryan J Donahue, Margaret E Maes, Joshua A Grosser, Robert W Nickell. BAX-Depleted Retinal Ganglion Cells Survive and Become Quiescent Following Optic Nerve Damage. Molecular neurobiology. vol 57. issue 2. 2020-11-25. PMID:31673950. |
removal of the bax gene from mice completely protects the somas of retinal ganglion cells (rgcs) from apoptosis following optic nerve injury. |
2020-11-25 |
2023-08-13 |
mouse |
| Ling Zhang, Qiao-Yan Cai, Shan Lin, Bei-Bei Jia, Ren-Zhi Ye, Huai Wang, Li-Ya Bao, You-Qin Chen, Jian-Feng Chu, Jun Pen. Prevention of systemic inflammation and neuroprotective effects of Qingda granules against angiotensin II-mediated hypertension. Pakistan journal of pharmaceutical sciences. vol 33. issue 1(Spec). 2020-11-25. PMID:32173645. |
additionally, qdgs inhibited neuronal apoptosis by down-regulation of bax expression and up-regulation of bcl-2 expression. |
2020-11-25 |
2023-08-13 |
mouse |
| Zhihua Ren, Xuchu Gu, Jing Fang, Dongjie Cai, Zhicai Zuo, Shuang Liang, Hengmin Cui, Junliang Deng, Xiaoping Ma, Yi Geng, Ming Zhang, Yue Xie, Gang Ye, Liping Gou, Yanchun H. Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice. Scientific reports. vol 10. issue 1. 2020-11-25. PMID:32198370. |
then the rates of spleen cell (sc) apoptosis, and expression of the genes and proteins of bcl-2, bax, caspase-3 and caspase-9 were quantified in each group at 0 h (uninfected), 12 h, 24 h, and 72 h postinfection. |
2020-11-25 |
2023-08-13 |
mouse |
| Islam M Saadeldin, Fariba Moulavi, Ayman Abdel-Aziz Swelum, Sokhangouy Saiede Khorshid, Hossini-Fahraji Hamid, Sayyed Morteza Hossein. Vitrification of camel oocytes transiently impacts mitochondrial functions without affecting the developmental potential after intracytoplasmic sperm injection and parthenogenetic activation. Environmental science and pollution research international. vol 27. issue 35. 2020-11-25. PMID:33029771. |
at the molecular level, vitrification reduced mrna expression of many genes, including those related to mitochondrial function (tfam, mt-co1, mfn1, atp1a1, nrf1), pluripotency (sox2 and pou5f1), and apoptosis (p53 and bax). |
2020-11-25 |
2023-08-13 |
Not clear |
| Victoria Cluzet, Marie M Devillers, Florence Petit, Stéphanie Chauvin, Charlotte M François, Frank Giton, Catherine Genestie, Nathalie di Clemente, Joëlle Cohen-Tannoudji, Céline J Guigo. Aberrant granulosa cell-fate related to inactivated p53/Rb signaling contributes to granulosa cell tumors and to FOXL2 downregulation in the mouse ovary. Oncogene. vol 39. issue 9. 2020-11-24. PMID:31745296. |
tumorigenesis was associated with the combined inactivation of p53 and rb pathways, as shown by the impaired expression of respective downstream targets regulating cell apoptosis and proliferation, i.e., bax, bak, gadd45a, ccna2, ccne1, e2f1, and orc1. |
2020-11-24 |
2023-08-13 |
mouse |
| Jongbeom Song, Sang-Suk Lee, Sabina Lim, Sujung Ye. Mechanism of the neuroprotective effect of injecting brain cells on ST36 in an animal model of Parkinson's disease. Neuroscience letters. vol 717. 2020-11-24. PMID:31857129. |
apoptosis factors cytochrome c and bcl2 associated x, apoptosis regulator (bax) levels were decreased and b-cell cll/lymphoma 2 (bcl2) levels were increased. |
2020-11-24 |
2023-08-13 |
mouse |
| Zhan Gao, Qiang Gao, Xiaodong L. MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:31997826. |
protein and mrna levels of sdf-1, cxcr4, bcl2, bax, cleaved caspase-3, endothelial nitric oxide synthase (enos), and phosphorylated endothelial nitric oxide synthase (p-enos) were analyzed by western blot and quantitative reverse transcription-polymerase chain reaction (rt-qpcr), and apoptosis were assessed by flow cytometry. |
2020-11-24 |
2023-08-13 |
rat |
| Qin Chen, Ming Wang, Chengji She. Bauerane Induces S-Phase Cell Cycle Arrest, Apoptosis, and Inhibition of Proliferation of A549 Human Lung Cancer Cells Through the Phosphoinositide 3-Kinase (PI3K)/AKT and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:32005795. |
bauerane treatment induced apoptosis of a549 cells, which was associated with the upregulation of bax and down-regulation of bcl-2. |
2020-11-24 |
2023-08-13 |
human |
| Zhengzhong Zeng, Jiling Liang, Liangwen Wu, Hu Zhang, Jun Lv, Ning Che. Exercise-Induced Autophagy Suppresses Sarcopenia Through Akt/mTOR and Akt/FoxO3a Signal Pathways and AMPK-Mediated Mitochondrial Quality Control. Frontiers in physiology. vol 11. 2020-11-24. PMID:33224037. |
results showed the declined mass of gastrocnemius muscle with deficient autophagy and excessive apoptosis as a result of up-regulated atrogin-1 and murf1, declined beclin1 level and lc3-ii/lc3-i ratio, accumulated p62, increased bax, and reduced bcl-2 levels, and also exhibited a defective mitochondrial quality control due to declined pgc-1α, mfn2, drp1, and pink1 levels. |
2020-11-24 |
2023-08-13 |
rat |