| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiu-Ying Qin, Ya-Nan Wang, Han-Fu Liu, Zhao-Hui Luo, Pei-Lu Zhang, Huang Li-Fang, Mei-Rong Li. Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis. Metallomics : integrated biometal science. vol 12. issue 1. 2020-11-02. PMID:31750487. |
moreover, cu-1 dramatically inhibited the expression of the anti-apoptotic protein bcl-2 and up-regulated the expressions of the proapoptotic proteins caspase-9 and bax to induce the apoptosis of tumor cells, simultaneously decreasing the density of endothelial cells to inhibit tumor angiogenesis in cisplatin-resistant tumors. |
2020-11-02 |
2023-08-13 |
Not clear |
| Bingqiong Yu, Yanhong Liu, Xian Peng, Siyu Hua, Gangcheng Zhou, Kun Yan, Yi Li. Synthesis, characterization, and antitumor properties of Au(i)-thiourea complexes. Metallomics : integrated biometal science. vol 12. issue 1. 2020-11-02. PMID:31755504. |
mechanism experiments manifested that au(i)(3c)2otf induced the down-regulation of bcl-2 and up-regulation of bax, which further indicated that au(i)(3c)2otf triggered mitochondria-mediated apoptosis. |
2020-11-02 |
2023-08-13 |
Not clear |
| B Luzón-Toro, R M Fernández, J M Martos-Martínez, M Rubio-Manzanares-Dorado, G Antiñolo, S Borreg. LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31591432. |
our study reveals the involvement of lucat1 in ptc development, through acting in cell-cycle regulation, proliferation, epigenetic modifications through lucat1/ cdk1/ ezh2/ p57/ p21/ hdac1/ dnmt1/ p53/ bax axis and apoptosis, via extrinsic pathway activating caspases. |
2020-10-29 |
2023-08-13 |
Not clear |
| M E Maes, J A Grosser, R L Fehrman, C L Schlamp, R W Nickell. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31719602. |
completion of bax recruitment correlates with mitochondrial fission during apoptosis. |
2020-10-29 |
2023-08-13 |
Not clear |
| M E Maes, J A Grosser, R L Fehrman, C L Schlamp, R W Nickell. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31719602. |
bax has consistently been associated with mitochondrial fission, yet how bax participates in the process of mitochondrial fragmentation during apoptosis remains to be tested. |
2020-10-29 |
2023-08-13 |
Not clear |
| M E Maes, J A Grosser, R L Fehrman, C L Schlamp, R W Nickell. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31719602. |
time-lapse imaging of bax recruitment and mitochondrial fragmentation demonstrates that rapid mitochondrial fragmentation during apoptosis occurs after the complete recruitment of bax to the mitochondrial outer membrane (mom). |
2020-10-29 |
2023-08-13 |
Not clear |
| Xu Luo, Katelyn L O'Neill, Kai Huan. The third model of Bax/Bak activation: a Bcl-2 family feud finally resolved? F1000Research. vol 9. 2020-10-29. PMID:32802314. |
bax and bak, two functionally similar, pro-apoptotic proteins of the bcl-2 family, are known as the gateway to apoptosis because of their requisite roles as effectors of mitochondrial outer membrane permeabilization (momp), a major step during mitochondria-dependent apoptosis. |
2020-10-29 |
2023-08-13 |
Not clear |
| Subramanyam Dasari, Velavan Bakthavachalam, Somaiah Chinnapaka, Reshmii Venkatesan, Angela L P A Samy, Gnanasekar Munirathina. Neferine, an alkaloid from lotus seed embryo targets HeLa and SiHa cervical cancer cells via pro-oxidant anticancer mechanism. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-28. PMID:32364634. |
nef induces mitochondrial apoptosis by increasing pro-apoptotic protein bax, cytochrome-c, cleaved caspase-3 and caspase-9, poly-adp ribose polymerase (parp) cleavage, dna damage (ph |
2020-10-28 |
2023-08-13 |
Not clear |
| Meijuan Zhang, Ying Chen, Xiangjun Cheng, Zhenzhen Cai, Shengfeng Qi. GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells. Archives of virology. vol 165. issue 11. 2020-10-28. PMID:32851429. |
gzmb knockdown decreased cell apoptosis and prevented ev71-induced changes in the expression of bax, cleaved caspase 3, and bcl2 in jurkat cells, highlighting the role of gzmb as a key factor in ev71-induced apoptosis. |
2020-10-28 |
2023-08-13 |
human |
| Meijuan Zhang, Ying Chen, Xiangjun Cheng, Zhenzhen Cai, Shengfeng Qi. GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells. Archives of virology. vol 165. issue 11. 2020-10-28. PMID:32851429. |
gata1/sp1 overexpression induced cell apoptosis, increased the expression of bax and cleaved caspase 3, and decreased the expression of bcl2. |
2020-10-28 |
2023-08-13 |
human |
| Qingqing Dai, Song Han, Ting Liu, Jiayin Zheng, Cui Liu, Junfa Li, Shujuan L. IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis. Frontiers in aging neuroscience. vol 12. 2020-10-28. PMID:33101005. |
the il-17a neutralization could also significantly inhibit the increase of pro-caspase-3 cleavage through caspase-12-dependent cell apoptosis, as well as preventing the decrease of antiapoptotic factor b-cell lymphoma 2 (bcl-2) and the increase of proapoptotic bcl-2-associated x protein (bax) in the peri-infarct region of mice following ischemic stroke. |
2020-10-28 |
2023-08-13 |
mouse |
| Edan Elovic, Sharon Etzion, Smadar Cohe. MiR-499 Responsive Lethal Construct for Removal of Human Embryonic Stem Cells after Cardiac Differentiation. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31601830. |
in this work, we generated a mirna-responsive lethal mrna construct that selectively induces rapid apoptosis in hescs by expressing a mutant (s184del) bax variant. |
2020-10-27 |
2023-08-13 |
mouse |
| Shuangbo Fan, Qian Xu, Liang Wang, Yulin Wan, Sheng Qi. SMBA1, a Bax Activator, Induces Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells. Pharmacology. vol 105. issue 3-4. 2020-10-27. PMID:31865327. |
smba1, a bax activator, induces cell cycle arrest and apoptosis in malignant glioma cells. |
2020-10-27 |
2023-08-13 |
Not clear |
| Shuangbo Fan, Qian Xu, Liang Wang, Yulin Wan, Sheng Qi. SMBA1, a Bax Activator, Induces Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells. Pharmacology. vol 105. issue 3-4. 2020-10-27. PMID:31865327. |
silencing of bax or ectopic expression of bcl-2 significantly inhibited smba1-induced apoptosis. |
2020-10-27 |
2023-08-13 |
Not clear |
| Ruili Li, Shengde Wu, Manpreet Kaur, Shan Zong, Sanduni A Abeydeera, Tuya Bao, Shaista Arif, John M Hutso. Bcl2-Associated X (BAX) Knockout in Mice Resulted in Persistence of Neonatal Testicular Germ Cells (Gonocytes). Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. vol 13. issue 5-6. 2020-10-27. PMID:32544920. |
in conclusion, knockout of bax in mouse leads to gonocytes persisting at the centre of the tubules after minipuberty, which failed to migrate and transform into ssc, indicating the important role of apoptosis is to eliminate undifferentiated gonocytes during transformation. |
2020-10-27 |
2023-08-13 |
mouse |
| Shizong Li, Xianglu Li, Xuehua Xing, Lin Wan. miR-597-5p inhibits cell growth and promotes cell apoptosis by targeting ELK1 in pancreatic cancer. Human cell. vol 33. issue 4. 2020-10-27. PMID:32613573. |
meanwhile, it increased pancreatic cancer cell apoptosis and the expression of e-cad, cleaved caspase 3, and bax. |
2020-10-27 |
2023-08-13 |
mouse |
| Ummugulsum Tukenmez, Busra Aktas, Belma Aslim, Serkan Yavu. The relationship between the structural characteristics of lactobacilli-EPS and its ability to induce apoptosis in colon cancer cells in vitro. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31164685. |
epss were capable of inhibiting proliferation in a time-dependent manner and induced apoptosis via increasing the expression of bax, caspase 3 and 9 while decreasing bcl-2 and survivin. |
2020-10-26 |
2023-08-13 |
Not clear |
| Hongyu Liu, Qingshan Fu, Yao Lu, Wenqiang Zhang, Peng Yu, Zhen Liu, Xiaosheng Su. Anti-tubulin agent vinorelbine inhibits metastasis of cancer cells by regulating epithelial-mesenchymal transition. European journal of medicinal chemistry. vol 200. 2020-10-23. PMID:32473523. |
vinorelbine inhibited the cancer cell proliferation by mtt and colony formation assays and inducing g2/m arrest and cell apoptosis via regulation of bax, bcl-2, and bcl-xl. |
2020-10-23 |
2023-08-13 |
Not clear |
| Xin Guan, Jiali Lu, Feng Sun, Qingwei Li, Yue Pan. The Molecular Evolution and Functional Divergence of Lamprey Programmed Cell Death Genes. Frontiers in immunology. vol 10. 2020-10-22. PMID:31281315. |
our studies showed that the recombinant lamprey pdcd5 protein and transfection of the l-pdcd5 gene induced cell apoptosis, upregulated the expression of the associated x protein (bax) and tp53 and downregulated the expression of b cell lymphoma 2 (bcl-2) independent of caspase 3. |
2020-10-22 |
2023-08-13 |
Not clear |
| Yong Yin, Yang Zhou, Shao Sha, Xun Wu, She-Feng Wang, Fang Qiao, Zhong-Cheng Song, Hai-Liang Zh. Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3Kα. Bioorganic chemistry. vol 92. 2020-10-22. PMID:31499259. |
in addition, compound 4p was found to induce cell apoptosis via upregulation of bax and cleaved-caspase 3/9, and downregulation of bcl-2. |
2020-10-22 |
2023-08-13 |
Not clear |