| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song-Jiang Zhang, Shao-Hua Su, Jian-Feng Ga. [Electroacupuncture improves learning-memory ability possibly by suppressing apoptosis and down-regulating expression of apoptosis-related proteins in hippocampus and cerebral cortex in immature mice with Alzheimer's disease]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 8. 2020-10-09. PMID:32869569. |
to investigate the effect of electroacupuncture (ea) at "baihui"(gv20), "fengfu"(gv16) and bilateral "shenshu"(bl23) on learning-memory ability, apoptosis in the hippocampus and expression of aβ, caspase 3, bax and bcl-2 proteins in the hippocampus and cerebral cortex in immature mice with alzheimer's disease (ad), so as to explore its mechanism underlying improvement of ad. |
2020-10-09 |
2023-08-13 |
mouse |
| Zihuan Wu, Yan Zhang, Xiarong Gong, Guiguang Cheng, Shibiao Pu, Shengbao Ca. The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet. Food & function. vol 11. issue 1. 2020-10-08. PMID:31930271. |
moreover, immunohistochemistry and western blot analyses further revealed that the phenolic-rich extract can improve nafld in high-fat diet induced rats by regulating several key proteins related to lipid metabolism, inflammation and apoptosis of hepatocytes, namely upregulating the expression levels of p-ampk, ppar-α, cpt1 and bcl-2, and downregulating the levels of ppar-γ, cyp2e1, p-p38, p-nf-κb, inos, cox-2, caspase-3d and bax. |
2020-10-08 |
2023-08-13 |
rat |
| Caoshuai Dou, Hong Zhang, Guibao Ke, Li Zhang, Zhiwen Lian, Xueqin Chen, Xingchen Zhao, Yuanhan Chen, Ruizhao Li, Jianchao Ma, Zhuo Li, Ting Lin, Wenjian Wang, Zhi Ming Ye, Xinling Liang, Wei Shi, Bin Zhang, Shuangxin Li. The Krüppel-like factor 15-NFATc1 axis ameliorates podocyte injury: a novel rationale for using glucocorticoids in proteinuria diseases. Clinical science (London, England : 1979). vol 134. issue 12. 2020-10-07. PMID:32478397. |
overexpression of klf15 attenuated podocyte apoptosis induced by adr, lps or hg and resulted in decreased expression of pro-apoptotic bax and increased expression of anti-apoptotic bcl-2. |
2020-10-07 |
2023-08-13 |
Not clear |
| Yan-Yan Bai, Jun-Zhi Ni. miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. Molecular medicine reports. vol 21. issue 3. 2020-10-06. PMID:31894320. |
the results revealed that the expression of mir‑222 was significantly increased in ich, and downregulation of mir‑222 significantly reduced erythrocyte lysate‑induced cell apoptosis by decreasing the levels of cleaved caspase‑3, cleaved caspase‑9 and bax and increasing the level of bcl‑2. |
2020-10-06 |
2023-08-13 |
mouse |
| Cheng-Yi Chang, Jian-Ri Li, Chih-Cheng Wu, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Che. Endoplasmic Reticulum Stress Contributes to Indomethacin-Induced Glioma Apoptosis. International journal of molecular sciences. vol 21. issue 2. 2020-10-05. PMID:31952288. |
indomethacin-induced glioma cell apoptosis was accompanied by a series of biochemical changes, including reactive oxygen species generation, endoplasmic reticulum (er) stress, apoptosis signal-regulating kinase-1 (ask1) activation, p38 hyperphosphorylation, protein phosphatase 2a (pp2a) activation, akt dephosphorylation, mcl-1 and flice-inhibiting protein (flip) downregulation, bax mitochondrial distribution, and caspases 3/caspase 8/caspase 9 activation. |
2020-10-05 |
2023-08-13 |
human |
| Tiansheng Zheng, Guanglin Ji, Jincai Chen, Jinliang Lai, Tong Liu, Jianwen Mo, Qi Ji. MicroRNA-142 protects MC3T3-E1 cells against high glucose-induced apoptosis by targeting β-catenin. Experimental and therapeutic medicine. vol 20. issue 6. 2020-10-03. PMID:33005251. |
mir-142-mimics significantly protected against high glucose-induced apoptosis, upregulated the expression levels of b-cell lymphoma 2 (bcl-2) and downregulated the protein expression levels of β-catenin, bcl-2 associated x (bax) and caspase-3. |
2020-10-03 |
2023-08-13 |
Not clear |
| Tiansheng Zheng, Guanglin Ji, Jincai Chen, Jinliang Lai, Tong Liu, Jianwen Mo, Qi Ji. MicroRNA-142 protects MC3T3-E1 cells against high glucose-induced apoptosis by targeting β-catenin. Experimental and therapeutic medicine. vol 20. issue 6. 2020-10-03. PMID:33005251. |
similar to the effects of mir-142 inhibitors, overexpression of β-catenin aggravated the apoptosis of mc3t3-e1 cells, as demonstrated by the upregulation of bax and caspase-3, and the downregulation of bcl-2 expression levels. |
2020-10-03 |
2023-08-13 |
Not clear |
| Yi Zhang, Yina Shao, Zhimeng Lv, Chenghua L. MYC regulates coelomocytes apoptosis by targeting Bax expression in sea cucumber Apostichopus japonicus. Fish & shellfish immunology. vol 97. 2020-10-02. PMID:31843700. |
myc regulates coelomocytes apoptosis by targeting bax expression in sea cucumber apostichopus japonicus. |
2020-10-02 |
2023-08-13 |
Not clear |
| Yi Zhang, Yina Shao, Zhimeng Lv, Chenghua L. MYC regulates coelomocytes apoptosis by targeting Bax expression in sea cucumber Apostichopus japonicus. Fish & shellfish immunology. vol 97. 2020-10-02. PMID:31843700. |
in this study, the promoter sequence of apoptosis regulator bcl-2-associated x (bax) was cloned by genomic walking. |
2020-10-02 |
2023-08-13 |
Not clear |
| Yanhong Ma, Yahui Li, Hongzhi Zhang, Ying Wang, Caie Wu, Wuyang Huan. Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway. Food science & nutrition. vol 8. issue 9. 2020-10-02. PMID:32994970. |
high concentration of malvidin was found to significantly induce apoptosis, activate caspase-3, increase malondialdehyde, upregulate bax, but downregulate bcl-2. |
2020-10-02 |
2023-08-13 |
rat |
| Xiaodong Bai, Hai Meng, Lifeng Ma, Ai Gu. Inhibitory effects of evodiamine on human osteosarcoma cell proliferation and apoptosis. Oncology letters. vol 9. issue 2. 2020-10-01. PMID:25621054. |
evodiamine effectively inhibited proliferation and induced apoptosis of osteosarcoma cells in a dose-dependent manner via downregulation of bcl-2, caspase-3 and survivin protein expression levels and upregulation of bax protein expression levels. |
2020-10-01 |
2023-08-13 |
human |
| Sheng Li, Sheng Jiang, Wei Jiang, Yue Zhou, Xiu-Yin Shen, Tao Luo, Ling-Ping Kong, Hua-Qiao Wan. Anticancer effects of crocetin in human esophageal squamous cell carcinoma KYSE-150 cells. Oncology letters. vol 9. issue 3. 2020-10-01. PMID:25663893. |
crocetin was also found to induce morphological changes and cell apoptosis in a dose-dependent manner through increased expression of proapoptotic bax and activated caspase 3. |
2020-10-01 |
2023-08-13 |
human |
| Yunhua Tang, Xiangyang Zhang, Fan Qi, Mingfeng Chen, Yuan Li, Longfei Liu, Wei He, Zhuo Li, Xiongbing Z. Afatinib inhibits proliferation and invasion and promotes apoptosis of the T24 bladder cancer cell line. Experimental and therapeutic medicine. vol 9. issue 5. 2020-10-01. PMID:26136904. |
mtt assay was used to estimate the proliferation of the t24 cells; flow cytometric analysis was used to estimate the effect of afatinib on t24 cell apoptosis; cell invasion ability was assessed by a transwell invasion assay; and western blot analysis was used to detect the expression of bcl-2, bax, akt, extracellular-signal-regulated kinase (erk)1/2, matrix metalloproteinase (mmp)-2 and mmp-9. |
2020-10-01 |
2023-08-13 |
human |
| Wenna Li, Nan Wu, Wenqi Shu, Dalin Jia, Pengyu Ji. Pharmacological preconditioning and postconditioning with nicorandil attenuates ischemia/reperfusion-induced myocardial necrosis and apoptosis in hypercholesterolemic rats. Experimental and therapeutic medicine. vol 10. issue 6. 2020-10-01. PMID:26668616. |
the results of the present study suggest that pharmacological preconditioning and postconditioning with nicorandil may protect hypercholesterolemic hearts against i/r-induced necrosis and apoptosis; and the cardioprotective effects of nicorandil may be due to the dual pharmacological mechanisms of opening the mitokatp channels and a nitric oxide/sgc-dependent mechanism, and regulation of the expression of caspase-3, bax and bcl-2. |
2020-10-01 |
2023-08-13 |
rat |
| Limin Zhou, Yanjie Bai, Yanxi Li, Xueliang Liu, Tao Tan, Shasha Meng, Wenting He, Xiaobin Wu, Zhifang Don. Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells. Oncology letters. vol 11. issue 1. 2020-10-01. PMID:26870219. |
in addition, mcph1 overexpression promoted cell apoptosis, in association with a significant increase in the quantities of bax and active caspase-3, as well as a decrease in the level of bcl-2. |
2020-10-01 |
2023-08-13 |
human |
| Peiyan Hua, Guangxin Zhang, Yifan Zhang, Mei Sun, Ranji Cui, Xin Li, Bingjin Li, Xingyi Zhan. Costunolide induces G1/S phase arrest and activates mitochondrial-mediated apoptotic pathways in SK-MES 1 human lung squamous carcinoma cells. Oncology letters. vol 11. issue 4. 2020-10-01. PMID:27073552. |
through upregulation in the expression of p53 and bax, and downregulation in the expression of bcl-2 and activation of caspase-3, costunolide-induced apoptosis was confirmed by western blot analysis. |
2020-10-01 |
2023-08-13 |
human |
| Giovanni Vanni Frajese, Monica Benvenuto, Massimo Fantini, Elena Ambrosin, Pamela Sacchetti, Laura Masuelli, Maria Gabriella Giganti, Andrea Modesti, Roberto Be. Potassium increases the antitumor effects of ascorbic acid in breast cancer cell lines Oncology letters. vol 11. issue 6. 2020-10-01. PMID:27313770. |
in the breast cancer cell line mcf-7, a+k induced the appearance of the 18 kda isoform of b-cell lymphoma-2-associated x protein (bax), which is a more potent inducer of apoptosis than the full-length bax-p21. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiao-Juan Yu, Kun Sun, Xiao-He Tang, Cun-Jin Zhou, Hui Sun, Zhe Yan, Ling Fang, Hong-Wen Wu, Yi-Kui Xie, Bin G. Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. Oncology letters. vol 12. issue 2. 2020-10-01. PMID:27446381. |
the combination of hm and ptx exerted synergistic effects on proliferation inhibition and apoptosis induction in sgc-7901 cells, with down-regulation of cox-2, pcna and bcl-2 and up-regulation of bax expression. |
2020-10-01 |
2023-08-13 |
human |
| Chih-Jung Yao, Jyh-Ming Chow, Pei-Chun Lin, Tsai-Shu Hu, Hui-Ching Kuo, Jhy-Shrian Huang, Kuan-Jen Bai, Gi-Ming La. Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2020-10-01. PMID:28074102. |
treatment with jp-1 induces p53 and its downstream p21 and bax proteins as well as the mir-34a, resulting in growth inhibition, colony formation reduction, migration repression, and apoptosis induction. |
2020-10-01 |
2023-08-13 |
human |
| Liang Yu, Zhendong Zhong, Hongbin Sun, Linxia Yan, Baomin He, Supin Li, Shuai Ma, Lili Yang, Yulan Huan. Effect of pterostilbene on glioma cells and related mechanisms. American journal of translational research. vol 8. issue 12. 2020-10-01. PMID:28077996. |
it can also enhance cell apoptosis, decrease mrna and protein of bcl-2 expression, and increase mrna and protein expressions of bax (p<0.05 compared to control group) in a dose-dependent manner. |
2020-10-01 |
2023-08-13 |
Not clear |