| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sei Kuriyama, Tadahiro Tsuji, Tetsushi Sakuma, Takashi Yamamoto, Masamistu Tanak. PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. Cell death discovery. vol 4. 2020-10-01. PMID:29531808. |
fluorescent time-lapse imaging revealed that plekhn1 aggregated with bid during thapsigargin- or hydrogen peroxide-induced apoptosis prior to bax aggregation. |
2020-10-01 |
2023-08-13 |
human |
| Bibi Kulsoom, Tahir Sultan Shamsi, Nasir Ali Afsar, Zahida Memon, Nikhat Ahmed, Syed Nazrul Hasnai. Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy? Cancer management and research. vol 10. 2020-10-01. PMID:29535553. |
two cytoplasmic proteins, b-cell lymphoma protein 2 (bcl-2)-associated x (bax) and bcl-2, act as a promoter and an inhibitor of apoptosis, respectively. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bo Diao, Ying Liu, Guo-Zheng Xu, Yi Zhang, Jun Xie, Jie Gon. The role of galectin-3 in the tumorigenesis and progression of pituitary tumors. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29545898. |
meanwhile, bcl2 associated x, apoptosis regulator (bax), caspase-3 and matrix metalloproteinase 7 (mmp7) protein expression levels were analyzed by western blotting. |
2020-10-01 |
2023-08-13 |
rat |
| Shuo Tu, Xia-Li Zhang, Hui-Fang Wan, Yan-Qin Xia, Zhuo-Qi Liu, Xiao-Hong Yang, Fu-Sheng Wa. Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552188. |
western blot analysis was performed to examine the levels of p53 upregulated modulator of apoptosis (puma), bcl2, apoptosis regulator (bcl-2) and bcl2-associated x, apoptosis regulator (bax) in a549 cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Shuo Tu, Xia-Li Zhang, Hui-Fang Wan, Yan-Qin Xia, Zhuo-Qi Liu, Xiao-Hong Yang, Fu-Sheng Wa. Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552188. |
the level of puma, bax and bcl-2 proteins in the mouse xenograft tumors treated with taurine and/or exogenous puma were assessed by immunohistochemistry, with taurine suppressing the proliferation of the human lung cancer a549 cell line in a concentration-dependent manner, and it significantly enhanced the apoptosis rate at all concentrations. |
2020-10-01 |
2023-08-13 |
mouse |
| Ge Li-Sha, Liu Li, Zhou De-Pu, Shi Zhe-Wei, Gu Xiaohong, Chen Guang-Yi, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chu. Ivabradine Treatment Reduces Cardiomyocyte Apoptosis in a Murine Model of Chronic Viral Myocarditis. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29556195. |
these results indicate that ivabradine could attenuate the expression of caspase-3 by downregulation of bax and upregulation of bcl-2 to prevent the deterioration of cardiac function resulting from ventricular myocyte loss by cardiomyocyte apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Ai-Jiao Xiao, Lin He, Xin Ouyang, Jie-Min Liu, Ming-Ren Che. Comparison of the anti-apoptotic effects of 15- and 35-minute suspended moxibustion after focal cerebral ischemia/reperfusion injury. Neural regeneration research. vol 13. issue 2. 2020-10-01. PMID:29557375. |
in the 35-minute moxibustion group, infarct volume was decreased, neuronal apoptosis was reduced, caspase-9, caspase-3 and bax expression was lower, and bcl-2 expression was increased, compared with the 15-minute moxibustion group. |
2020-10-01 |
2023-08-13 |
rat |
| Muxing Kang, Yaoyi Zhang, Xiaoli Jin, Guofeng Chen, Yi Huang, Dan Wu, Guogang Li, Jianzhen Shan, Pintong Huang, Jian Che. Concurrent Treatment with Anti-DLL4 Enhances Antitumor and Proapoptotic Efficacy of a γ-Secretase Inhibitor in Gastric Cancer. Translational oncology. vol 11. issue 3. 2020-10-01. PMID:29571073. |
following in vivo treatments, apoptosis of tumor cells and the expression of apoptosis-related genes bax, bcl-2, and p53 were detected by tunel and immunohistochemical staining. |
2020-10-01 |
2023-08-13 |
mouse |
| Abdullah A AlKahtane, Saud Alarifi, Ahmed A Al-Qahtani, Daoud Ali, Suliman Y Alomar, Mohammed S Aleissia, Saad Alkahtan. Cytotoxicity and Genotoxicity of Cypermethrin in Hepatocarcinoma Cells: A Dose- and Time-Dependent Study. Dose-response : a publication of International Hormesis Society. vol 16. issue 2. 2020-10-01. PMID:29686591. |
an increase in ros generation with a concomitant increase in expression of the proapoptotic protein bcl-2 and cytochrome c and decrease in the antiapoptosis protein bax suggested that a mitochondria-mediated pathway was involved in cypermethrin-induced apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Ismail Ahmed Ismail, Hanan A El-Bakry, Safaa S Solima. Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation. International journal of physiology, pathophysiology and pharmacology. vol 10. issue 2. 2020-10-01. PMID:29755640. |
we also found that aging induced apoptosis promoting genes p53 and bax mrna in thymus tissues. |
2020-10-01 |
2023-08-13 |
Not clear |
| b' Tamara Krajnovi\\xc4\\x87, Danijela Maksimovi\\xc4\\x87-Ivani\\xc4\\x87, Sanja Mijatovi\\xc4\\x87, Dijana Dra\\xc4\\x8da, Katharina Wolf, David Edeler, Ludger A Wessjohann, Goran N Kalu\\xc4\\x91erovi\\xc4\\x8. Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15. Nanomaterials (Basel, Switzerland). vol 8. issue 5. 2020-10-01. PMID:29757198.' |
sba-15|eo3 causes inhibition of tumor cell proliferation and triggers apoptosis, connected with caspase activation, upregulation of bax, as well as bcl-2 and bim downregulation along with amplification of poly-(adp-ribose)-polymerase (parp) cleavage fragment. |
2020-10-01 |
2023-08-13 |
Not clear |
| Haobin Zhao, Lu Yan, Xiaoguang Xu, Chunmei Jiang, Junling Shi, Yawen Zhang, Li Liu, Shuzhen Lei, Dongyan Shao, Qingsheng Huan. Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells. AMB Express. vol 8. issue 1. 2020-10-01. PMID:29777449. |
the lipopeptides inhibited the profile of k562 via three pathways: (1) induction of paraptosis indicated by the occurrence of cytoplasmic vacuoles, and swelling of the mitochondria and endoplasmic reticulum (er) without membrane blebbing in the presence of a caspase inhibitor; (2) inhibition of autophagy progress illustrated by the upregulated expression of lcii and p62; and (3) induction of apoptosis by causing ros burst, and induction of the intrinsic pathway indicated by the upregulated expression of cytochrome c (cyto-c), bax, and bad, together with downregulated expression of bcl-2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yi-Pu Fan, Pei Liu, Wei-Kang Xue, Wei-Jiang Zhao, Hong-Chao Pa. Trimebutine Promotes Glioma Cell Apoptosis as a Potential Anti-tumor Agent. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29977208. |
in addition, trimebutine promoted cell apoptosis and induced bcl-2 downregulation, accompanied with bax upregulation. |
2020-10-01 |
2023-08-13 |
mouse |
| Yangyang Ji, Hui Li, Fang Wang, Linglan G. PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma in C666-1 Cells by Promoting Apoptosis. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30002625. |
moreover, gw501516 induced c666-1 cell apoptosis in a caspase and bax dependent manner. |
2020-10-01 |
2023-08-13 |
human |
| Yibiao Ye, Yanshan Li, Yunping Wei, Yunxiuxiu Xu, Ruomei Wang, Zhiqiang Fu, Shangyou Zheng, Quanbo Zhou, Yu Zhou, Rufu Chen, Tao Che. Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway. Oncology letters. vol 16. issue 2. 2020-10-01. PMID:30008887. |
however, downregulation of hottip expression was revealed to significantly reduce cell viability, induce apoptosis, promote caspase-3 and caspase-8 activities and increase bax expression in pancreatic cancer cells. |
2020-10-01 |
2023-08-13 |
human |
| Juling Lv, Yiqiao Xin. Effects of UV on apoptotic factors in lens epithelial cells of an animal model. Experimental and therapeutic medicine. vol 16. issue 3. 2020-10-01. PMID:30186472. |
expression levels of p53, bax, and bcl-2 in lec of rats are positively correlated with the time after uv irradiation, suggesting that uv could induce apoptosis of lec by promoting p53, bax and bcl-2 expression. |
2020-10-01 |
2023-08-13 |
rat |
| Wanliang Dong, Yuankun Zhan. Retinoic acid receptor α expression exerts an anti-apoptosis effect on PC12 cells following oxygen-glucose deprivation. Experimental and therapeutic medicine. vol 16. issue 4. 2020-10-01. PMID:30233705. |
this suggests that the expression of bax and bcl-2 in the mitochondrial apoptosis signaling pathway is, at least in part, mediated by rar-α expression, thereby indicating that rar-α expression exerts an anti-apoptotic effect on ogd-damaged pc12 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wenzhong Que, Huili Liu, Qinqin Yang, Shanghua X. Antiproliferation activities of NK4 on multiple myeloma. Experimental and therapeutic medicine. vol 16. issue 4. 2020-10-01. PMID:30233724. |
in addition, nk4 altered the expression of cell cycle and apoptosis-associated proteins in rpmi 8226, including cyclin-dependent kinase 4, cyclin d1, cyclin-dependent kinase inhibitor 1b, apoptosis regulator bcl-2, apoptosis regulator bax, cleaved caspase-9 and caspase-3. |
2020-10-01 |
2023-08-13 |
human |
| Jay R Radke, Iris Figueroa, John M Routes, James L Coo. PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis. Cell death discovery. vol 4. 2020-10-01. PMID:30245858. |
no-induced apoptosis in e1a-expressing cells did not require expression bak or bax, indicating that no-induced caspase-2-mediated mitochondrial injury does not proceed through the activities of typical, proapoptotic bcl-2 family members that induce mitochondrial cytochrome c release. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lauren C Fogarty, Robert T Flemmer, Brittany A Geizer, Maria Licursi, Ahila Karunanithy, Joseph T Opferman, Kensuke Hirasawa, Jacqueline L Vanderlui. Mcl-1 and Bcl-xL are essential for survival of the developing nervous system. Cell death and differentiation. vol 26. issue 8. 2020-10-01. PMID:30361616. |
cells were rescued from apoptosis in both the mko and bko embryos by breeding with the bax null mouse line indicating that mcl-1 and bcl-xl have a common pro-apoptotic target during developmental neurogenesis. |
2020-10-01 |
2023-08-13 |
mouse |