| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hector Flores-Romero, Uris Ros, Ana J García-Sáe. A lipid perspective on regulated cell death. International review of cell and molecular biology. vol 351. 2020-10-01. PMID:32247580. |
lipids and lipid membranes are important accessory molecules required for the activation of protein executors of cell death such as bax in apoptosis and mlkl in necroptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Reyhane Vardiyan, Daniyal Ezati, Morteza Anvari, Nasrin Ghasemi, Alireza Taleb. Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax. Clinical and experimental reproductive medicine. vol 47. issue 3. 2020-10-01. PMID:32911587. |
the genes bcl-2 and bax play important roles in apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| P Wareski, T Motyl, Z Ryniewicz, A Orzechowski, B Gajkowska, U Wojewodzka, T Plosza. Expression of apoptosis-related proteins in mammary gland of goat. Small ruminant research : the journal of the International Goat Association. vol 40. issue 3. 2020-09-30. PMID:11323213. |
the expression of apoptosis-related proteins: tgf-beta1 (auto/paracrine inducer) and its receptor (tgf-betariii), bax (promoter), bcl-2 (inhibitor) and cpp-32 (executor of apoptosis) as well as the apoptotic cell number in mammary glands of 11 polish white improved goats in the course of the lactation cycle (peak of lactation: days 40-70, late lactation: days 208-256, drying off: days 267-340) was investigated. |
2020-09-30 |
2023-08-12 |
mouse |
| Gordon W. Moe, George Naik, Andrea Konig, Xiangru Lu, Qingping Fen. Early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 8. issue 3. 2020-09-30. PMID:12039650. |
early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure. |
2020-09-30 |
2023-08-12 |
Not clear |
| Gordon W. Moe, George Naik, Andrea Konig, Xiangru Lu, Qingping Fen. Early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 8. issue 3. 2020-09-30. PMID:12039650. |
myocardial apoptosis was assessed by multiple methods including dna fragmentation and in situ terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) staining, bax and bcl-2 protein expression, and caspase activity. |
2020-09-30 |
2023-08-12 |
Not clear |
| Gordon W. Moe, George Naik, Andrea Konig, Xiangru Lu, Qingping Fen. Early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 8. issue 3. 2020-09-30. PMID:12039650. |
the increase in apoptosis was associated with bax protein expression and caspase activation while there was no detectable changes in bcl-2 protein expression. |
2020-09-30 |
2023-08-12 |
Not clear |
| Masayuki Murota, Seishiro Watanabe, Jiro Fujita, Yuji Ohtsuki, Fei Wu, Shuhei Yoshida, Yuko Kita, Fumi Funakoshi, Tsutomu Masaki, Kazutaka Kurokohchi, Naohito Uchida, Toshihiko Ishida, Shigeki Kuriyam. Aberrant cytokeratin expression and high susceptibility to apoptosis in autoimmune hepatitis. Hepatology research : the official journal of the Japan Society of Hepatology. vol 25. issue 3. 2020-09-30. PMID:12697248. |
furthermore, to evaluate the immune surveillance system and the susceptibility to apoptosis, immunohistochemical staining of human leukocyte antigen (hla)-dralpha, cathepsin d, b cell leukemia-2 (bcl-2), bcl-2-associated x protein (bax) and caspase 3 was also performed. |
2020-09-30 |
2023-08-12 |
human |
| Xiaohong Jin, Y I Sh. Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. Experimental and therapeutic medicine. vol 11. issue 2. 2020-09-30. PMID:26893622. |
during the ibc-induced apoptosis of mgc803 cells, transient activation of phosphorylated (p)-akt and p-erk inhibited the activation of akt and erk, upregulated bax expression, downregulated bcl-2 expression and activated caspase-3. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yang Li, Jinhui Li, Hui Huang, Mingfeng Yang, Donggang Zhuang, Xuemin Cheng, Huizhen Zhang, Xiaoli F. Microcystin-LR induces mitochondria-mediated apoptosis in human bronchial epithelial cells. Experimental and therapeutic medicine. vol 12. issue 2. 2020-09-30. PMID:27446254. |
mc-lr induced cell apoptosis, excess reactive oxygen species production and mitochondrial membrane potential collapse, upregulated bax expression and downregulated b-cell lymphoma-2 expression in hbe cells. |
2020-09-30 |
2023-08-13 |
human |
| Mahbobeh Bohloli, Amir Atashi, Masoud Soleimani, Saeid Kaviani, Azadeh Anbarlo. Investigating Effects of Acidic pH on Proliferation, Invasion and Drug-Induced Apoptosis in Lymphoblastic Leukemia. Cancer microenvironment : official journal of the International Cancer Microenvironment Society. vol 9. issue 2-3. 2020-09-30. PMID:27457339. |
drug-induced apoptosis was evaluated after exposure to doxorubicin for 24 hours by annexin v/pi staining and gene expression analysis of bax pro-apoptotic protein. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hui Wang, Yihua Bei, Peipei Huang, Qiulian Zhou, Jing Shi, Qi Sun, Jiuchang Zhong, Xinli Li, Xiangqing Kong, Junjie Xia. Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice. Molecular therapy. Nucleic acids. vol 5. issue 10. 2020-09-30. PMID:27727247. |
pharmacological inhibition of mir-155 using antagomir improved cardiac function and suppressed cardiac apoptosis induced by lps in mice as determined by echocardiography, terminal deoxynucleotidyl transferase nick-end labeling (tunel) assay, and western blot for bax and bcl-2, while overexpression of mir-155 using agomir had inverse effects. |
2020-09-30 |
2023-08-13 |
mouse |
| Yohei Murakami, Shoji Takad. Rigor of cell fate decision by variable p53 pulses and roles of cooperative gene expression by p53. Biophysics (Nagoya-shi, Japan). vol 8. 2020-09-30. PMID:27857606. |
(2009) modeled the bax activation switch in the apoptosis signal transduction pathway that can rigorously "count" the number of uniform p53 pulses. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaomei Lv, Zhenhong Cai, Su L. Increased apoptosis rate of human decidual cells and cytotrophoblasts in patients with recurrent spontaneous abortion as a result of abnormal expression of CDKN1A and Bax. Experimental and therapeutic medicine. vol 12. issue 5. 2020-09-30. PMID:27882087. |
increased apoptosis rate of human decidual cells and cytotrophoblasts in patients with recurrent spontaneous abortion as a result of abnormal expression of cdkn1a and bax. |
2020-09-30 |
2023-08-13 |
human |
| Xiaomei Lv, Zhenhong Cai, Su L. Increased apoptosis rate of human decidual cells and cytotrophoblasts in patients with recurrent spontaneous abortion as a result of abnormal expression of CDKN1A and Bax. Experimental and therapeutic medicine. vol 12. issue 5. 2020-09-30. PMID:27882087. |
it was found that the cell apoptosis rate in the recurrent miscarriage group was significantly increased and the expression levels of tp53 protein, cdkn1a and bax mrna were also significantly increased (p<0.05). |
2020-09-30 |
2023-08-13 |
human |
| Wenxian Zheng, Shuyan Han, Shantong Jiang, Lina Pang, Xiaohong Li, Xijuan Liu, Minhua Cao, Pingping L. Multiple effects of Xihuang pill aqueous extract on the Hs578T triple-negative breast cancer cell line. Biomedical reports. vol 5. issue 5. 2020-09-30. PMID:27882217. |
apoptosis and mitochondrial membrane potential loss were detected, and after treatment with 4, 8 and 12 mg/ml aexhp for 24 h, cleaved caspase-3 was 1.70-, 1.81- and 1.84-fold of that of the control, while procaspase-3, procaspase-8, cleaved caspase-8, b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein (bax) and the bcl-2/bax ratio were not significantly affected. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zheng Liu, Feng Wang, Zhi-Wei Zhou, He-Chun Xia, Xin-Yu Wang, Yin-Xue Yang, Zhi-Xu He, Tao Sun, Shu-Feng Zho. Alisertib induces G American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386317. |
als also bound key regulating proteins of cell cycle, apoptosis and autophagy, such as cyclin-dependent kinase 1 (cdk1/cdc2), cdk2, cyclin b1, p27 kip1, p53, cytochrome c, cleaved caspase 3, bax, bcl-2, bcl-xl, phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), mammalian target of rapamycin (mtor), 5'-adenosine monophosphate-activated protein kinase (ampk), p38 mitogen-activated protein kinase (mapk), beclin 1, phosphatase and tensin homolog (pten), and microtubule-associated protein light chain 3 (lc3). |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaowen Yu, Yunwen Yang, Hui Yuan, Meng Wu, Shuzhen Li, Wei Gong, Jing Yu, Weiwei Xia, Yue Zhang, Guixia Ding, Songming Huang, Zhanjun Jia, Aihua Zhan. Inhibition of COX-2/PGE2 cascade ameliorates cisplatin-induced mesangial cell apoptosis. American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386348. |
firstly, we found cisplatin induced cell apoptosis in mesangial cells shown by increased number of apoptotic cells in parallel with the upregulation of bax and the downregulation of bcl-2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaowen Yu, Yunwen Yang, Hui Yuan, Meng Wu, Shuzhen Li, Wei Gong, Jing Yu, Weiwei Xia, Yue Zhang, Guixia Ding, Songming Huang, Zhanjun Jia, Aihua Zhan. Inhibition of COX-2/PGE2 cascade ameliorates cisplatin-induced mesangial cell apoptosis. American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386348. |
importantly, inhibition of cox-2 via a specific cox-2 inhibitor celecoxib markedly blocked cisplatin-induced mesangial cell apoptosis as evidenced by the decreased number of apoptotic cells, blocked increments of cleaved caspase-3 and bax, and reversed bcl-2 downregulation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jung Hoo Hwang, Soo Jung Park, Won Gyu Ko, Seong-Mun Kang, Da Bin Lee, Junho Bang, Byung-Joo Park, Chung-Beum Wee, Dae Joon Kim, Ik-Soon Jang, Jae-Hong K. Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway. American journal of cancer research. vol 7. issue 3. 2020-09-30. PMID:28401001. |
inhibition of slug by sirna induced bax and caspase-3, leading to cordycepin-induced apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Jung Hoo Hwang, Soo Jung Park, Won Gyu Ko, Seong-Mun Kang, Da Bin Lee, Junho Bang, Byung-Joo Park, Chung-Beum Wee, Dae Joon Kim, Ik-Soon Jang, Jae-Hong K. Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway. American journal of cancer research. vol 7. issue 3. 2020-09-30. PMID:28401001. |
overall, the results obtained indicate that cordycepin inhibits the erk/slug signaling pathway through the activation of gsk3β which, in turn, upregulates bax, leading to apoptosis of the lung cancer cells. |
2020-09-30 |
2023-08-13 |
human |