| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Yan Wang, Yun-Xia Cao, Xiao Zhou, Bing Wei, Lei Zhan, Liu-Tao F. HMGA2 gene silencing reduces epithelial-mesenchymal transition and lymph node metastasis in cervical cancer through inhibiting the ATR/Chk1 signaling pathway. American journal of translational research. vol 10. issue 10. 2020-09-30. PMID:30416649. |
notably, hmga2 silencing or inhibition of the atr/chk1 signaling pathway inhibited epithelial mesenchymal transition (emt), cc cell proliferation, invasion, migration, tumorigenicity and lymph node metastasis while promoting apoptosis, indicated by reduced expression of bcl-2, mmp-2, mmp-9 and n-cadherin, with increased expression of e-cadherin and bax. |
2020-09-30 |
2023-08-13 |
mouse |
| Fangping Bao, Xianhui Kang, Qing Xie, Jian W. HIF-α/PKM2 and PI3K-AKT pathways involved in the protection by dexmedetomidine against isoflurane or bupivacaine-induced apoptosis in hippocampal neuronal HT22 cells. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651766. |
the levels of apoptosis were examined by flow cytometry utilizing annexin v-fluorescein isothiocyanate/propidium iodide double staining, and the protein expression levels of cleaved caspase-3, phosphorylated phosphoinositide 3'-kinase (p-pi3k), p-protein kinase b (p-akt), hypoxia inducible factor (hif-α), pyruvate kinase m2 (pkm2), b-cell lymphoma (bcl-2)-associated x protein (bax), bcl-2 and cytochrome c were detected by western blot analysis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jiaxin Miao, Zijun Huang, Shuang Liu, Xuying Li, Pengyu Jia, Yuxuan Guo, Nan Wu, Dalin Ji. Hydroxytyrosol protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651849. |
it was further revealed that ht decreased the b cell lymphoma-2 (bcl-2)-like protein 4 (bax)/bcl-2 ratio, suppressed mptp opening and subsequently decreased the expression of cytochrome c, cleaved caspase-9 and -3, thereby inhibiting apoptosis. |
2020-09-30 |
2023-08-13 |
rat |
| Guomei Ye, Shifeng Kan, Jianfeng Chen, Xin L. Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655755. |
compared with those in the control group, the apoptosis rate of t24 cells was remarkably increased after treatment with different doses of puerarin or ex527, and the expression level of apoptosis-related protein bcl-2-associated x protein (bax) was also significantly increased, but the expression level of b-cell lymphoma 2 (bcl-2) was decreased, and both the protein and mrna expression levels of sirt1 and p53 also significantly declined. |
2020-09-30 |
2023-08-13 |
human |
| Guomei Ye, Shifeng Kan, Jianfeng Chen, Xin L. Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655755. |
compared with those in the puerarin group, the apoptosis rate in the combination group was decreased, and the expression level of apoptosis-related protein bax was also significantly decreased, but the expression level of bcl-2 was increased, and sirt1 and p53 protein expression levels were also remarkably increased. |
2020-09-30 |
2023-08-13 |
human |
| Bo Zhang, Yuan Liu, Jiangnan Zhan. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655782. |
mir-19a-3p inhibitor transfection also promoted apoptotic rate, increased the expression of bcl-2 associated x, apoptosis regulator (bax) and markedly decreased the expression of bcl-2 compared with the cisplatin treatment group. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hong-Ying Zhao, Yun-Hui Ren, Xiu-Bao Ren, Yu Wan. Diprophylline inhibits non-small cell lung cancer A549 cell proliferation and migration, and promotes apoptosis, by downregulating PI3K signaling pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655839. |
furthermore, the percentage of apoptotic cells was detected by flow cytometric analysis, and proteins associated with apoptosis, including apoptosis regulator bcl-2, apoptosis regulator bax and active caspase-3, were examined by western blotting. |
2020-09-30 |
2023-08-13 |
Not clear |
| Guolong Sui, Yingna Qiu, Haijuan Yu, Qingbin Kong, Baowen Zhe. Interleukin-17 promotes the development of cisplatin resistance in colorectal cancer. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655852. |
il-17 was also shown to regulate the expression of several apoptosis-related proteins, including phosphorylated-protein kinase b (p-akt), apoptosis regulator bax (bax), apoptosis regulator bcl-2 (bcl-2) and serine/threonine-protein kinase mtor (mtor). |
2020-09-30 |
2023-08-13 |
Not clear |
| Guolong Sui, Yingna Qiu, Haijuan Yu, Qingbin Kong, Baowen Zhe. Interleukin-17 promotes the development of cisplatin resistance in colorectal cancer. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655852. |
these findings indicated that il-17 facilitates the development of ddp resistance in colorectal cancer by inhibiting cancer cell apoptosis through targeting p-akt, bax, bcl-2 and mtor. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ming-Zi Zhang, Yi-Fang Liu, Ning Ding, Peng-Xiang Zhao, Xin Zhang, Meng-Yu Liu, Yao Mawulikplimi Adzavon, Jian-Nan Huang, Xiao Long, Xiao-Jun Wang, You-Bin Wang, Zheng Q. 2-Methoxyestradiol improves the apoptosis level in keloid fibroblasts through caspase-dependent mechanisms American journal of translational research. vol 10. issue 12. 2020-09-30. PMID:30662647. |
the key apoptosis factors (caspase-3, caspase-8, caspase-9, bcl-2, bax, and cytochrome-c) and pcna expression levels were detected by immunofluorescence analysis and western blotting. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bufei Zhao, Ting H. JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway. Oncology letters. vol 17. issue 2. 2020-09-30. PMID:30675258. |
furthermore, the expression of anti-apoptotic protein b-cell lymphoma 2 decreased and the expression of the pro-apoptotic proteins active caspase-3 and apoptosis regulator bax increased in the hep g2 cells following jtc-801 treatment. |
2020-09-30 |
2023-08-13 |
Not clear |
| Li Zhao, Xue Rong Yang, Xu Ha. MicroRNA-146b induces the PI3K/Akt/NF-κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Experimental and therapeutic medicine. vol 17. issue 2. 2020-09-30. PMID:30679990. |
an mtt assay, annexin v/propidium iodide (pi) apoptosis assay, elisa kits, western blot analysis and a caspase-3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory factors, and the b-cell lymphoma 2-associated x protein (bax), phosphatase and tensin homolog (pten), phosphoinositide 3-kinase (pi3k)/akt/nuclear factor (nf)-κb signaling pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Natalia Girola, Pedro T Resende-Lara, Carlos R Figueiredo, Mariana H Massaoka, Ricardo A Azevedo, Rodrigo L O R Cunha, Luciano Polonelli, Luiz R Travasso. Molecular, Biological and Structural Features of V Frontiers in oncology. vol 9. 2020-09-30. PMID:30740361. |
we found that, the anti-lewis b mab light-chain cdr1 synthetic peptide rb44, interacted with microtubules and induced depolymerization, with subsequent degradation of actin filaments, leading to depolarization of mitochondrial membrane-potential, increase of ros, cell cycle arrest at g2/m, cleavage of caspase-9, caspase-3 and parp, upregulation of bax and downregulation of bcl-2, altogether resulting in intrinsic apoptosis of melanoma cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hong Zhang, Xin Zhao, Hongbo Liu, Hui Jin, Youbo J. Trichostatin A inhibits proliferation of PC3 prostate cancer cells by disrupting the EGFR pathway. Oncology letters. vol 18. issue 1. 2020-09-30. PMID:31289542. |
apoptosis of pc3 cells treated with tsa was also investigated, and it was revealed that tsa induced apoptosis by upregulating bax and downregulating bcl-2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Liang Zhang, Yuwen Pang, Xiaobin Cui, Wei Jia, Wenwen Cui, Yang Liu, Chunxia Liu, Feng L. MicroRNA-410-3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells. Oncology letters. vol 18. issue 1. 2020-09-30. PMID:31289572. |
exogenous expression of mir-410-3p inhibited rms cell invasion, migration and proliferation, induced apoptosis, suppressed the expression of snail, slug, n-cadherin and bcl-2, and increased the expression of e-cadherin, bax, cleaved-caspase 3, cleaved parp and p53. |
2020-09-30 |
2023-08-13 |
Not clear |
| Wenwen Zhou, Xiaoyu Wang, Duanduan Yin, Lei Xue, Zhongfeng Ma, Zhenzhen Wang, Qianyi Zhang, Zishu Zhao, Haixia Wang, Yan Sun, Yanhong Yan. Effect of miR-140-5p on the regulation of proliferation and apoptosis in NSCLC and its underlying mechanism. Experimental and therapeutic medicine. vol 18. issue 2. 2020-09-30. PMID:31363375. |
in conclusion, mir-140-5p may induce apoptosis in a549 cells by targeting yes1 and regulating the expression of apoptosis-associated proteins bcl-2, bax and caspase-3. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jia-Wen Shou, Chun-Kai Cheung, Jian Gao, Wei-Wei Shi, Pang-Chui Sha. Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31551713. |
it also down-regulated the apoptotic factors-caspase 3 and bcl2 associated x (bax) and upregulated the anti-apoptotic factor-bcl2 to reduce cell apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yu Han, Yuan Qing Qu, Simon Wing Fai Mok, Juan Chen, Cheng Lai Xia, Hu Qiang He, Zheng Li, Wei Zhang, Cong Ling Qiu, Liang Liu, Betty Yuen Kwan Law, Vincent Kam Wai Won. A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C ( Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31551763. |
a novel drug resistance mechanism: genetic loss of xeroderma pigmentosum complementation group c ( the pro-apoptotic proteins bax and bak are critical regulatory factors constituting the apoptosis machinery. |
2020-09-30 |
2023-08-13 |
human |
| Megan Stevens, Sebastian Oltea. Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing. Frontiers in genetics. vol 10. 2020-09-30. PMID:31552099. |
bcl-xl is the most abundant bcl-x protein and functions to inhibit apoptosis by a number of different mechanisms including inhibition of bax. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lingzhen Wu, Jun Fang, Xun Yuan, Chang Xiong, Lianglong Che. Adropin reduces hypoxia/reoxygenation-induced myocardial injury via the reperfusion injury salvage kinase pathway. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31602203. |
the results of the current study revealed that moderate-dose adropin increased cell viability, reduced early apoptosis and caspase-3 activity, promoted bcl-2 expression, inhibited bax and increased the bcl-2/bax ratio. |
2020-09-30 |
2023-08-13 |
Not clear |