| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunpeng Jia, Yu Gao, Jianguo Do. Effects of miR-129-3p on biological functions of prostate cancer cells through targeted regulation of Smad3. Oncology letters. vol 19. issue 2. 2020-09-28. PMID:31966049. |
cell detection confirmed that the overexpression of mir-129-3p or the inhibition of smad3 expression inhibited the proliferation and invasion of prostate cancer cells, promoting apoptosis, and increased the expression level of pro-apoptotic protein bax, as well as decreased the expression level of anti-apoptotic protein bcl-2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rui Gong, Lin He, HongZhong Zhou, ShengTao Cheng, Fang Ren, Juan Chen, JiHua Re. Down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating Bax signaling pathway. Genes & diseases. vol 6. issue 3. 2020-09-28. PMID:32042869. |
down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating bax signaling pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rui Gong, Lin He, HongZhong Zhou, ShengTao Cheng, Fang Ren, Juan Chen, JiHua Re. Down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating Bax signaling pathway. Genes & diseases. vol 6. issue 3. 2020-09-28. PMID:32042869. |
mechanistic studies revealed the bcl2-associated x protein (bax) signaling pathway which determines cancer cell apoptosis was regulated by asl. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rui Gong, Lin He, HongZhong Zhou, ShengTao Cheng, Fang Ren, Juan Chen, JiHua Re. Down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating Bax signaling pathway. Genes & diseases. vol 6. issue 3. 2020-09-28. PMID:32042869. |
moreover, the depletion of bax restored the inhibition of cell growth and reduced apoptosis initiated by asl silencing. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rui Gong, Lin He, HongZhong Zhou, ShengTao Cheng, Fang Ren, Juan Chen, JiHua Re. Down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating Bax signaling pathway. Genes & diseases. vol 6. issue 3. 2020-09-28. PMID:32042869. |
together, the study demonstrated that asl regulated hcc cell growth and apoptosis by modulating bax signaling. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yonghong Luo, Chuanchuan Fang, Lan Jin, Huafeng Ding, Yuanyuan Lyu, Guantai N. The microRNA212 regulated PEA15 promotes ovarian cancer progression by inhibiting of apoptosis. Journal of Cancer. vol 11. issue 6. 2020-09-28. PMID:32047549. |
in addition, we proved knockdown of pea15 inhibits oc cell proliferation and induces cell apoptosis by bcl2 downregulation and bax and cleaved caspase-3 upregulation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Su Liu, Yunzong Huang, Shoujing Tian, Wei Zhang, Youjia Xu, Jianfei G. Hyperhomocysteinemia inhibits tibial fracture healing in rats through PI3K/AKT signaling pathway. Experimental and therapeutic medicine. vol 19. issue 3. 2020-09-28. PMID:32104269. |
moreover, the protein expressions of pi3k and phosphorylated (p)-akt in tibial tissues were detected using western blotting, the messenger ribonucleic acid (mrna) levels of bcl-2 associated x protein (bax) and caspase-3 were detected using quantitative polymerase chain reaction (qpcr), the apoptosis was detected via terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) staining, and the expressions of inflammatory factors were detected via immunohistochemistry. |
2020-09-28 |
2023-08-13 |
rat |
| Su Liu, Yunzong Huang, Shoujing Tian, Wei Zhang, Youjia Xu, Jianfei G. Hyperhomocysteinemia inhibits tibial fracture healing in rats through PI3K/AKT signaling pathway. Experimental and therapeutic medicine. vol 19. issue 3. 2020-09-28. PMID:32104269. |
compared with tibial fracture group, hhcys + fracture group had a higher level of plasma hcy, lower ultimate bending strength and torque, lower relative protein expressions of pi3k and p-akt, higher mrna levels of bax and caspase-3, a higher apoptosis rate and a higher expression of tnf-α. |
2020-09-28 |
2023-08-13 |
rat |
| Jie Zhang, Yiyi Li, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, Zhaohui Zhan. Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32116549. |
lpa elicits the activation of erk1/2, p38, and jnk pathways, decreases the expression of bcl2, promotes the translocation of bax, and enhances the activation of caspase-3, resulting in mitochondrial dysfunction and cell apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Tram Thi Ngoc Nguyen, Hojung Choi, Hee-Sook Ju. Preventive Effects of Dulaglutide on Disuse Muscle Atrophy Through Inhibition of Inflammation and Apoptosis by Induction of Hsp72 Expression. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32153405. |
dulaglutide suppressed the expression of apoptotic markers such as caspase-3, cleaved poly-adp ribose polymerase, and bax under immobilization condition and increased the expression of heat shock protein 72 (hsp72), which is related to the amelioration of inflammation and apoptosis during disuse time. |
2020-09-28 |
2023-08-13 |
mouse |
| Bibo Yuan, Juan Hao, Qian Zhang, Yan Wang, Yu Zh. Role of Bcl-2 on drug resistance in breast cancer polyploidy-induced spindle poisons. Oncology letters. vol 19. issue 3. 2020-09-28. PMID:32194662. |
the expression of f-box and wd repeat domain containing 7 (fbw7) was decreased, while the expression of mcl1 apoptosis regulator bcl2 family member (mcl-1) and bcl-2 was increased, and caspase-3/9 and bax were not expressed in mda-mb-231 cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xinyan Li, Cuicui Liu, Xiumei Zhao, Rui Wang, Na Gu, Hongsheng Shen, Xijing Li, Luyao Wang, Chao L. Effects of CDK6 regulated by miR-298 on proliferation and apoptosis of thyroid cancer cells. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218846. |
cell experiments revealed that overexpression of mir-298 or inhibition of cdk6 expression could suppress cell proliferation, promote apoptosis, and significantly increase the expression levels of bax and caspase-3 proteins, decrease bcl-2 protein expression, which was contrary to the biological phenotype of cells after inhibition of mir-298 or further overexpression of cdk6. |
2020-09-28 |
2023-08-13 |
human |
| Hongyun Cheng, Xue Jiang, Qian Zhang, Jun Ma, Ronghui Cheng, Hongmei Yong, Huichang Shi, Xueyi Zhou, Liyue Ge, Guangyi Ga. Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway. Experimental and therapeutic medicine. vol 19. issue 6. 2020-09-28. PMID:32346444. |
the degree of apoptosis and the expression of apoptosis-related proteins (bcl-2 and bax) in crc cells stimulated by naringin was detected using flow cytometry and western blot assays, respectively. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yuxiao Zhao, Pan Shang, Meijian Wang, Min Xie, Jian Li. Neuroprotective Effects of Fluoxetine Against Chronic Stress-Induced Neural Inflammation and Apoptosis: Involvement of the p38 Activity. Frontiers in physiology. vol 11. 2020-09-28. PMID:32477152. |
meanwhile, cums rats treated with fluoxetine showed reductions in neuronal apoptosis and a downregulation of the apoptotic protein bax, cleaved caspase 3, and caspase 9 levels. |
2020-09-28 |
2023-08-13 |
rat |
| Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyon. Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway. EXCLI journal. vol 19. 2020-09-28. PMID:32483405. |
in addition, p53, bax and bcl2 could be involved in the apoptosis pathway of these leukemic cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Kathrin Funk, Carolin Czauderna, Ramona Klesse, Diana Becker, Jovana Hajduk, Aline Oelgeklaus, Frank Reichenbach, Franziska Fimm-Todt, Joachim Lauterwasser, Peter R Galle, Jens U Marquardt, Frank Edlic. BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC. Cancers. vol 12. issue 6. 2020-09-28. PMID:32486514. |
bax redistribution induces apoptosis resistance and selective stress sensitivity in human hcc. |
2020-09-28 |
2023-08-13 |
human |
| Kathrin Funk, Carolin Czauderna, Ramona Klesse, Diana Becker, Jovana Hajduk, Aline Oelgeklaus, Frank Reichenbach, Franziska Fimm-Todt, Joachim Lauterwasser, Peter R Galle, Jens U Marquardt, Frank Edlic. BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC. Cancers. vol 12. issue 6. 2020-09-28. PMID:32486514. |
the bcl-2 proteins bax and bak govern the cellular decision between survival and mitochondrial apoptosis. |
2020-09-28 |
2023-08-13 |
human |
| Sanjay Kumar, Paul B Tchounwo. Trisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia. Journal of Cancer. vol 11. issue 15. 2020-09-28. PMID:32489456. |
it also caused apoptosis through upregulation of caspase 3 and bax expression, and down-regulation of bcl2 expression. |
2020-09-28 |
2023-08-13 |
mouse |
| Yang Liu, Jie Zhang, Jingwei Zan, Fengxian Zhang, Guokai Liu, Anshi W. Lidocaine improves cerebral ischemia-reperfusion injury in rats through cAMP/PKA signaling pathway. Experimental and therapeutic medicine. vol 20. issue 1. 2020-09-28. PMID:32509019. |
compared with those in the control group, the rats in the model group had an elevated neurological function score, a raised level of bcl-2, but a reduced level of bax in the serum, an obviously increased rate of neuronal apoptosis in the brain and decreased mrna and protein levels of camp and pka in cerebral tissues. |
2020-09-28 |
2023-08-13 |
rat |
| Yang Liu, Jie Zhang, Jingwei Zan, Fengxian Zhang, Guokai Liu, Anshi W. Lidocaine improves cerebral ischemia-reperfusion injury in rats through cAMP/PKA signaling pathway. Experimental and therapeutic medicine. vol 20. issue 1. 2020-09-28. PMID:32509019. |
the rats in lidocaine group had a lower neurological function score, a lower level of bcl-2, but a higher level of bax in the serum, an evidently lower rate of neuronal apoptosis in the brain and higher mrna and protein levels of camp and pka in cerebral tissues than those in the model group. |
2020-09-28 |
2023-08-13 |
rat |