| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guofu Yi, He Li, You Li, Fen Zhao, Zhiwei Ying, Menglan Liu, Jian Zhang, Xinqi Li. The protective effect of soybean protein-derived peptides on apoptosis via the activation of PI3K-AKT and inhibition on apoptosis pathway. Food science & nutrition. vol 8. issue 8. 2020-09-28. PMID:32884739. |
to further study its molecular mechanisms, western blot analysis demonstrated that sbp could activate the pi3k-akt pathway by increasing the phosphorylation of pi3k and akt and inhibiting apoptosis pathway by downregulating the expressions of pro-apoptotic proteins of bim, bax, fas, and fasl and promoting the expressions of anti-apoptotic proteins of bcl-xl and bcl-2. |
2020-09-28 |
2023-08-13 |
human |
| Yi Luo, Lei Song, Xinyu Wang, Yujie Huang, Yongqiang Liu, Qi Wang, Ming Hong, Zhongyu Yua. Uncovering the Mechanisms of Cryptotanshinone as a Therapeutic Agent Against Hepatocellular Carcinoma. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32903546. |
in addition, we found that cpt induced apoptosis in huh7 and mhcc97-h ells due to increased levels of cleaved parp, bax, and cleaved caspase-3 and decreased bcl-2 expression. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jiarui Yu, Wei Wang, Weinan Yao, Zhao Yang, Peng Gao, Meiyue Liu, Huan Wang, Siyuan Chen, Dan Wang, Weixi Wang, Guogui Su. Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway. Journal of Cancer. vol 11. issue 19. 2020-09-28. PMID:32913452. |
meanwhile, ga induced dose-dependent apoptosis of escc cells, repressed the expression of bcl2 and up-regulated the levels of bax protein, cleaved-parp1 and cleaved-caspase 3/9. |
2020-09-28 |
2023-08-13 |
Not clear |
| Cuihua Liu, Kaoru Tanaka, Takanori Katsube, Guillaume Varès, Kouichi Maruyama, Yasuharu Ninomiya, Zeenath Fardous, Chao Sun, Akira Fujimori, Stéphanie G Moreno, Mitsuru Nenoi, Bing Wan. Altered Response to Total Body Irradiation of C57BL/6-Tg (CAG-EGFP) Mice. Dose-response : a publication of International Hormesis Society. vol 18. issue 3. 2020-09-28. PMID:32922229. |
while in wild type cells, lower expression of pro-apoptotic gene bax and higher expression of anti-apoptotic gene bcl-2, and significant lower induction of apoptosis were observed compared to gfp transgenic cells. |
2020-09-28 |
2023-08-13 |
mouse |
| Yi-Jun Xu, Yu Mei, Xue-Qing Shi, Yi-Fang Zhang, Xin-Yue Wang, Li Guan, Qi Wang, Hua-Feng Pa. Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction. Brain research. vol 1719. 2020-09-25. PMID:31150651. |
albiflorin inhibited the mitochondrial pathway of apoptosis by increasing the levels of bcl-2 and bcl-xl and decreasing the levels of bax, caspase-3 and cytochrome c in both the hippocampus and the cortex and by reducing the number of apoptotic cells in the anterior parietal cortex of the app/ps1 mice. |
2020-09-25 |
2023-08-13 |
mouse |
| b' Sibel \\xc3\\x96zda\\xc5\\x9f, Bora Ta\\xc5\\x9ftekin, Seren G G\\xc3\\xbcrgen, Talih \\xc3\\x96zda\\xc5\\x9f, Aykut Pelit, Sanem O Erkan, Birg\\xc3\\xbcl Tuhanio\\xc4\\x9flu, Birg\\xc3\\xbcl G\\xc3\\xbclnar, Orhan G\\xc3\\xb6rg\\xc3\\xbcl\\xc3\\xb. Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting\\xc2\\xa0apoptosis. PloS one. vol 15. issue 7. 2020-09-24. PMID:32722679.' |
pts treatment also reduced cell apoptosis in a dose-dependent manner by increasing the mrna expression of the anti-apoptosis bcl2 gene and by decreasing the mrna expressions of both the pro-apoptosis bax gene and its effector casp-3 and the ratio of bax/bcl-2 in a dose-dependent manner (p < 0.05 compared to dm for all). |
2020-09-24 |
2023-08-13 |
rat |
| Hartmut Jaeschke, Anup Ramachandran, Xiaojuan Chao, Wen-Xing Din. Emerging and established modes of cell death during acetaminophen-induced liver injury. Archives of toxicology. vol 93. issue 12. 2020-09-23. PMID:31641808. |
additional features like mitochondrial bax translocation and cytochrome c release, mobilization of lysosomal iron and the activation of receptor-interacting protein kinases and the inflammasome raised the question whether other emerging modes of cell death such as apoptosis, necroptosis, ferroptosis and pyroptosis could also play a role. |
2020-09-23 |
2023-08-13 |
Not clear |
| Chen Zhang, Chengshun Yang, Na Li, Xueqing Liu, Junlin He, Xuemei Chen, Yubin Ding, Chao Tong, Chuan Peng, Hubin Yin, Yingxiong Wang, Rufei Ga. Elevated insulin levels compromise endometrial decidualization in mice with decrease in uterine apoptosis in early-stage pregnancy. Archives of toxicology. vol 93. issue 12. 2020-09-23. PMID:31642978. |
all these results on flow cytometry, transmission electron microscopy and western blotting of bax, bcl2, cleaved caspase3, cleaved parp proteins level showed that decidual cells apoptosis was significantly decreased. |
2020-09-23 |
2023-08-13 |
mouse |
| Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang, Bin Liu, Weijun Yang, Luyang Yu, Zhi-Xiong Xiao, Xin-Hua Feng, Haihe Wang, Zhi-Min Yuan, Jinrong Peng, Wei-Qiang Tan, Jun Che. p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell reports. vol 29. issue 11. 2020-09-23. PMID:31825845. |
under hyperthermia conditions, atm is activated to phosphorylate p53 at s37, which increases bax expression to induce apoptosis. |
2020-09-23 |
2023-08-13 |
human |
| Bo Zhang, Haijun Zhang, Hao Luo, Chao Yang, Yi Yua. Sinomenine can promote the proliferation and differentiation of osteoblasts by regulating the Akt/Runx2 signaling pathway in MC3T3-E1 cells. Die Pharmazie. vol 74. issue 12. 2020-09-23. PMID:31907116. |
the proliferation and apoptosis of the cells were determined by mtt assay at 0, 24, 48 and 72 h, and flow cytometry method was used to determine the effect of sinomenine on the apoptosis of mc3t3-e1 cells at 72 h; furthermore, after 72 h, the cell culture supernatants were collected, and the levels of alkaline phosphatase and osteocalcin were examined by enzyme-linked immunosorbent assay (elisa); next, cells were collected, and the expression of type i collagen (col1a1), osteopontin (opn), protein kinase b (akt), runt-related transcription factor 2 (runx2), b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) were examined by rt-qpcr and western blot methods. |
2020-09-23 |
2023-08-13 |
mouse |
| Min Ma, Xia-Hui Lin, Hua-Hua Liu, Rui Zhang, Rong-Xin Che. Suppression of DRP1‑mediated mitophagy increases the apoptosis of hepatocellular carcinoma cells in the setting of chemotherapy. Oncology reports. vol 43. issue 3. 2020-09-23. PMID:32020220. |
mechanistically, mdivi‑1 upregulated bax and downregulated bcl‑xl, leading to an increase in mitochondrial membrane permeability and subsequent release of cytochrome c from mitochondria into the cytosol, thereby aggravating cisplatin‑induced apoptosis in hcc cells. |
2020-09-23 |
2023-08-13 |
Not clear |
| Md Shiblur Rahaman, Mahmuda Akter, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism. Environmental toxicology and pharmacology. vol 74. 2020-09-22. PMID:31786496. |
protein expression of western blot analysis showed that co-exposure of d-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regulation of survival factors; mtor, p-mtor, akt, p-akt, nf-кb, nrf2, erk1, gr, bcl-x and down-regulation of death factors; p53, bax, cytochrome c, lc3, although arsenic regulated those factors negatively. |
2020-09-22 |
2023-08-13 |
human |
| Xiaoshu Zhou, Rui Zhou, Qianwen Li, Xiaohua Jie, Jiaxin Hong, Yan Zong, Xiaorong Dong, Sheng Zhang, Zhenyu Li, Gang W. Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway. Anti-cancer drugs. vol 30. issue 3. 2020-09-21. PMID:30640793. |
in a549 and h460 cells, cardamonin induced apoptosis by activating caspase-3, upregulating bax, and downregulating bcl-2. |
2020-09-21 |
2023-08-13 |
human |
| Xiang Xiao, Juan Bai, Jiayan Zhang, Jing Wu, Ying Don. Inhibitory effect of fermented selected barley extracts with Lactobacillus plantarum dy-1 on the proliferation of human HT-29 Cells. Journal of food biochemistry. vol 43. issue 11. 2020-09-21. PMID:31364183. |
western-blotting results indicated that lfbe promoted apoptosis was relevant to the regulation of apoptosis-related proteins, such as b-cell lymphoma-2 (bcl-2), bcl-2-associated x protein (bax), and the release of cytochrome-c from mitochondria. |
2020-09-21 |
2023-08-13 |
human |
| Ahad Banagozar Mohammadi, Mohammadali Torbati, Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Seyyed Mohammad Bagher Fazljou, Seyed Mehdi Vatandoust, Samad E J Golzari, Javad Mahmoud. Sericin alleviates restraint stress induced depressive- and anxiety-like behaviors via modulation of oxidative stress, neuroinflammation and apoptosis in the prefrontal cortex and hippocampus. Brain research. vol 1715. 2020-09-18. PMID:30898675. |
finally, sericin inhibited mitochondrial-dependent apoptosis pathway through down-regulation of bax, cytochrome c, caspase-9 and -3, and up-regulation of bcl-2 protein. |
2020-09-18 |
2023-08-13 |
mouse |
| Qiang Duan, Erwang S. MicroRNA-25 aggravates Aβ1-42-induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-18. PMID:31144355. |
when the mice were induced by aβ1-42, proliferation was suppressed while apoptosis was promoted in hippocampal neurons as evidenced by lower levels of klf2, nrf2, haem oxygenase, glutathione s transferase α1, glutathione, thioredoxin, and b-cell lymphoma-2 along with higher bax level. |
2020-09-18 |
2023-08-13 |
mouse |
| Jiliang Yan, Dongya Zhang, Yanjie Han, Zhongjie Wang, Chunyan M. Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-17. PMID:31106485. |
apoptosis was assessed by flow cytometry and western blot analysis of apoptosis-associated proteins including b-cell lymphoma 2 (bcl-2), bax, and cytochrome c (cyt c). |
2020-09-17 |
2023-08-13 |
Not clear |
| Lili Xu, Jianjun Shen, Shaobing Dai, Lihong Sun, Xinzhong Che. Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells. The American journal of Chinese medicine. vol 48. issue 4. 2020-09-17. PMID:32476431. |
we measured the expression levels of the apoptosis protein markers bax and bcl-2, autophagy protein markers atg5 and lc3-ii, bace1, and a[formula: see text] in sh-sy5y cells after sevoflurane treatment and determined the effects of tetramethylpyrazine on sevoflurane-induced expression of these proteins after silencing gpr50 or atg5 with sirna |
2020-09-17 |
2023-08-13 |
rat |
| Yaqiu Wang, Zhihui Xie, Hong L. Significance of halofuginone in esophageal squamous carcinoma cell apoptosis through HIF-1α-FOXO3a pathway. Life sciences. vol 257. 2020-09-17. PMID:32679143. |
apoptosis related protein bax expression was dramatically increased, whereas bcl-2 levels were reduced in kyse-30 and te-1 cells, after hf exposure. |
2020-09-17 |
2023-08-13 |
Not clear |
| Li-Ping Wang, Yan-Qi Liu, Jie Cui, Li W. [Study on mechanism of curcumin in treatment of acute pancreatitis based on regulation of PI3K-Akt signaling pathway by miR-198]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 15. 2020-09-17. PMID:32893562. |
the apoptosis was detected by tunel staining; the levels of serum amylase, lipase, bcl-2 and bax were detected by elisa, and the levels of pi3 k, akt and p-akt in pancreatic tissue were measured by western blot. |
2020-09-17 |
2023-08-13 |
rat |