| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liya Ma, Yongchong Cheng, Jingjie Zen. MLK3 silence induces cervical cancer cell apoptosis via the Notch-1/autophagy network. Clinical and experimental pharmacology & physiology. vol 46. issue 9. 2020-08-25. PMID:31192472. |
in hela and siha cell, mlk3 knockdown using sirna remarkably suppressed cell survival and promoted cell apoptosis, with increased expression of the apoptosis-related protein bax and reduced bcl-2. |
2020-08-25 |
2023-08-13 |
Not clear |
| Yujie Hou, Feiling Feng, Ronghua Yan. Effect of miR‑449a‑mediated Notch signaling pathway on the proliferation, apoptosis and invasion of papillary thyroid carcinoma cells. Oncology reports. vol 43. issue 2. 2020-08-21. PMID:31894345. |
compared with the control group, there was significantly increased mir‑449a expression in the mir‑449a mimic group, and there was significantly decreased expression of notch1, jagged1, pcna, mmp‑2, mmp‑9 and bcl‑2, increased bax, reduced cell proliferation, increased g1‑phase cell fraction, decreased s‑phase cell fraction, an increased apoptosis rate, and decreased invasion ability in the mir‑449a mimic group and dapt group (all p<0.05). |
2020-08-21 |
2023-08-13 |
human |
| Chuntuan Li, Yahong Xu, Pengliang Xin, Yan Zheng, Xiongpeng Zh. Role and mechanism of PTEN in Burkitt's lymphoma. Oncology reports. vol 43. issue 2. 2020-08-21. PMID:31922234. |
the results revealed that pten inhibited the proliferation of ca46 and raji cells by downregulating the expression of p‑akt, it was indicated that the upregulation of proapoptotic proteins (including bad and bax) induced apoptosis, regulated cyclin (including p53, p21, cdk4, cdk6, cyclin d3 and cyclin h) to inhibit cell cycle progression, and mediated epithelial‑mesenchymal transition‑like cell markers (including e‑cadherin, n‑cadherin, β‑catenin, tcf‑8, vimentin, slug and snail) to inhibit cell migration and invasion. |
2020-08-21 |
2023-08-13 |
Not clear |
| Yi Gong, Tongtong Kong, Xin Ren, Jiao Chen, Shanmeng Lin, Yueling Zhang, Shengkang L. Exosome-mediated apoptosis pathway during WSSV infection in crustacean mud crab. PLoS pathogens. vol 16. issue 5. 2020-08-21. PMID:32433716. |
our data also revealed that aif translocated to the nucleus to induce dna fragmentation, and could competitively bind to hsp70 to disintegrate the hsp70-bax (bcl-2-associated x protein) complex, thereby activating the mitochondria apoptosis pathway by freeing bax. |
2020-08-21 |
2023-08-13 |
Not clear |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
in order to evaluate the cleaved caspase-3, bax, and bcl2 protein expression (as biochemical markers of apoptosis) in ca1 area of hippocampus tissue, the western blot test was used. |
2020-08-20 |
2023-08-13 |
rat |
| Liang Chen, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majora. Metal-based phosphorus dendrimers as novel nanotherapeutic strategies to tackle cancers: A concise overview. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. vol 11. issue 6. 2020-08-20. PMID:31392836. |
to our knowledge, it is the first example of nanoparticles displaying bax protein activation and then cell death through apoptosis process. |
2020-08-20 |
2023-08-13 |
Not clear |
| Qing Wang, Liqiong Zhang, Meifang Huang, Yuanyuan Zheng, Kai Zhen. Immunomodulatory Effect of Eriocitrin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 39. issue 2. 2020-08-20. PMID:32749123. |
moreover, the status of apoptosis proteins (bax, caspase-9, and caspase-3) and cell proliferative protein (cyclin d1 and cyclin a) expression was determined by western blot and pcna by immunohistochemical analysis. |
2020-08-20 |
2023-08-13 |
mouse |
| Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping M. Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behavioural brain research. vol 372. 2020-08-19. PMID:31238056. |
moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tbccao-treated mice, and esc treatment regulated the expression of mitophagy-related factors, including bnip3, beclin1, pink1, and parkin, the lc-3 ii/i ratio, and apoptosis-related factors, including p53, bax, and caspase 3. |
2020-08-19 |
2023-08-13 |
mouse |
| Bei Li, Yuan Zhao, ManYu Song, HaiLin Cui, XiuJing Feng, TianYuan Yang, Hong-Gang Fa. Role of c-Myc/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases. Toxicology. vol 429. 2020-08-17. PMID:31693917. |
in an in vivo experiment, the results of he staining, transmission electron microscopic, immunofluorescence microscopy of cleaved caspase-3 and bax and the increasing expression of apoptotic pathway related proteins in mitochondria showed that lps (10 mg/kg) administration damaged mitochondrial and induced hippocampal neuron apoptosis. |
2020-08-17 |
2023-08-13 |
Not clear |
| Sonia Abou Najem, Ghada Khawaja, Mohammad Hassan Hodroj, Patil Babikian, Sandra Riz. Adjuvant Epigenetic Therapy of Decitabine and Suberoylanilide Hydroxamic Acid Exerts Anti-Neoplastic Effects in Acute Myeloid Leukemia Cells. Cells. vol 8. issue 12. 2020-08-17. PMID:31766421. |
this effect was featured by the upregulated expression of bax, cytochrome c1, p21, and cleaved caspases 8, 9, and 3, signifying the activation of both the intrinsic and extrinsic pathways of apoptosis. |
2020-08-17 |
2023-08-13 |
Not clear |
| Danping Shen, Ruiyao Chen, Lijing Zhang, Zhiheng Rao, Yongxue Ruan, Lei Li, Maoping Chu, Yuanhai Zhan. Sulodexide attenuates endoplasmic reticulum stress induced by myocardial ischaemia/reperfusion by activating the PI3K/Akt pathway. Journal of cellular and molecular medicine. vol 23. issue 8. 2020-08-14. PMID:31120192. |
we found that sdx decreases cardiac injury during ischaemia reperfusion and decreased myocardial apoptosis and infarct area, which was paralleled by increased superoxide dismutase and reduced malondialdehyde in mice plasm, increased bcl-2 expression, decreased bax expression in a mouse model of mi/r. |
2020-08-14 |
2023-08-13 |
mouse |
| Fei Ren, Yujie Huang, Yizhou Tao, Cheng Ji, Stanley Aniagu, Yan Jiang, Tao Che. Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist. Toxicology and applied pharmacology. vol 398. 2020-08-14. PMID:32376357. |
furthermore, rsv attenuated eom-induced changes in the expression of genes involved in cardiac development (nkx2.5, sox9b, axin2), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod1, sod2, cat) and apoptosis (p53, bax). |
2020-08-14 |
2023-08-13 |
cat |
| Jie-Qiong Peng, Shu-Mei Han, Ze-Hao Chen, Jing Yang, Yan-Qing Pei, Cong Bao, Lei Qiao, Wen-Qiang Chen, Bo Li. Chaperone-mediated autophagy regulates apoptosis and the proliferation of colon carcinoma cells. Biochemical and biophysical research communications. vol 522. issue 2. 2020-08-12. PMID:31761324. |
inhibition of cma in ct26 cells facilitated apoptosis, as evidenced by increased tunel immunolabeling, increased expression of bax and bnip3, and decreased expression of bcl-2. |
2020-08-12 |
2023-08-13 |
mouse |
| Lianhua Zhao, John H Zhang, Prativa Sherchan, Paul R Krafft, Wei Zhao, Sa Wang, Shengpan Chen, Zaiyu Guo, Jiping Tan. Administration of rCTRP9 Attenuates Neuronal Apoptosis Through AdipoR1/PI3K/Akt Signaling Pathway after ICH in Mice. Cell transplantation. vol 28. issue 6. 2020-08-10. PMID:30642187. |
rctrp9 treatment significantly increased the expression of adipor1, pi3 k, p-akt, and bcl-2, while at the same time was found to decrease the expression of bax in the brain, which was reversed by inhibition of adipor1 and pi3 k. the neuroprotective effect of rctrp9 after ich was mediated by attenuation of neuronal apoptosis via the adipor1/pi3k/akt signaling pathway; therefore, rctrp9 should be further evaluated as a potential therapeutic agent for ich patients. |
2020-08-10 |
2023-08-13 |
mouse |
| Seong-Hyun Park, Wooseok Ko, Hyun Soo Lee, Injae Shi. Analysis of Protein-Protein Interaction in a Single Live Cell by Using a FRET System Based on Genetic Code Expansion Technology. Journal of the American Chemical Society. vol 141. issue 10. 2020-08-10. PMID:30707019. |
hsp70 is known to directly bind to bax for suppression of apoptosis. |
2020-08-10 |
2023-08-13 |
Not clear |
| Seong-Hyun Park, Wooseok Ko, Hyun Soo Lee, Injae Shi. Analysis of Protein-Protein Interaction in a Single Live Cell by Using a FRET System Based on Genetic Code Expansion Technology. Journal of the American Chemical Society. vol 141. issue 10. 2020-08-10. PMID:30707019. |
however, mechanisms on how bax is dissociated from its complex with hsp70 during apoptosis remain largely unknown. |
2020-08-10 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Andrej Benco, Jan Kotwica, Saleh H Alwasel, Abdel H Harrat. Apoptosis signal-regulating kinase (ASK-1) controls ovarian cell functions. Reproduction, fertility, and development. vol 31. issue 11. 2020-08-10. PMID:31217073. |
we compared the accumulation of ask-1, proliferation marker proliferating cell nuclear antigen (pcna), apoptosis marker bax and apoptosis and proliferation regulating transcription factor p53 and the release of progesterone (p4), oxytocin (ot), insulin-like growth factor i (igf-i) and prostaglandins f (pgf) and e (pge) using cultured porcine ovarian granulosa cells transfected with ask-1 cdna and cultured with leptin or fsh. |
2020-08-10 |
2023-08-13 |
Not clear |
| Chao Han, Yuanyuan Wei, Yumeng Geng, Yuqing Cui, Shuying Li, Yongzhan Bao, Wanyu Sh. Bisphenol A in utero exposure induces ovary dysfunction in mice offspring and the ameliorating effects of Cuscuta chinensis flavonoids. Environmental science and pollution research international. vol 27. issue 25. 2020-08-07. PMID:32488702. |
the expression of caspase-7, caspase-9, bcl-2, and bax in ovaries and testes of offspring mice were detected by western blot, and apoptosis in ovaries and testes was detected by tunel. |
2020-08-07 |
2023-08-13 |
mouse |
| Wen-Li Zhou, Jian-Tao Zhang, Wei Xu, Jing-Hui Su. Protective effects of polygalasaponin F on oxidative stress and apoptosis-induced ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damage. Neuroreport. vol 30. issue 17. 2020-08-06. PMID:31609825. |
the mechanisms of its protective effect involved in (1) reducing oxidant stress injury, (2) reducing the apoptosis rate of myocardial cells through increasing the bcl-2 protein level and decreasing the cyt-c and bax values, and (3) alleviating liver and kidney damage caused by cerebral hypoxia and ischemia via reducing the damage markers. |
2020-08-06 |
2023-08-13 |
rat |
| J I Bertucci, S Malala Irugal Bandaralage, M Hecke. Assessing the cytotoxic effect of hexabromocyclododecane (HBCD) on liver tissue cultures from fathead minnow (Pimephales promelas). Aquatic toxicology (Amsterdam, Netherlands). vol 225. 2020-08-06. PMID:32531534. |
changes in the expression of genes related to apoptosis (apoen, apoin, caspase2, caspase9 and bax) were also time- and concentration-dependent. |
2020-08-06 |
2023-08-13 |
Not clear |