| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-Gao Hu, Chao-Wen Zheng, Hui-Zhao Su, Yong-Lian Zeng, Cheng-Jie Lin, Zhen-Ya Guo, Fu-Di Zhong, Guan-Dou Yuan, Song-Qing H. MicroRNA-329-mediated PTTG1 downregulation inactivates the MAPK signaling pathway to suppress cell proliferation and tumor growth in cholangiocarcinoma. Journal of cellular biochemistry. vol 120. issue 6. 2020-08-05. PMID:30582202. |
upregulation of mir-329 and silencing of pttg1 inhibited the cca cell proliferation, induced cell-cycle arrest, and subsequently promoted apoptosis with elevations in bax, cleaved caspase-3, and total caspase-3, but showed declines in pcna, cyclin d1, and bcl-2. |
2020-08-05 |
2023-08-13 |
Not clear |
| Sina Heimer, Gertrud Knoll, Klaus Schulze-Osthoff, Martin Ehrenschwende. Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis. Cell death & disease. vol 10. issue 8. 2020-08-03. PMID:31324752. |
raptinal bypasses bax, bak, and bok for mitochondrial outer membrane permeabilization and intrinsic apoptosis. |
2020-08-03 |
2023-08-13 |
Not clear |
| Sina Heimer, Gertrud Knoll, Klaus Schulze-Osthoff, Martin Ehrenschwende. Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis. Cell death & disease. vol 10. issue 8. 2020-08-03. PMID:31324752. |
the activation threshold of bax and bak also correlates inversely with the required strength of an apoptotic stimulus to induce momp and thereby effectively determines a cell's readiness to undergo apoptosis. |
2020-08-03 |
2023-08-13 |
Not clear |
| Cunzhi Lin, Yuanyuan Zhang, Jun Wang, Aihua Sui, Lulu Xiu, Xinhong Zh. The study of effect and mechanism of 630-nm laser on human lung adenocarcinoma cell xenograft model in nude mice mediated by hematoporphyrin derivatives. Lasers in medical science. vol 35. issue 5. 2020-08-03. PMID:31642999. |
the 630-nm laser mediated by hematoporphyrin derivatives can significantly inhibit the growth of human lung adenocarcinoma xenograft tumor in nude mice, the mechanism of which is related to the inhibition of tumor angiogenesis by down-regulating vegf and hif-1α gene expression, and the promotion of tumor apoptosis by up-regulating bax, caspase-3, and down-regulating bcl-2 gene expression. |
2020-08-03 |
2023-08-13 |
mouse |
| Qian Li, Dongdong Tong, Chen Guo, Fei Wu, Fang Li, Xiaofei Wang, Qiuyu Jiang, Yameng Wei, Liying Liu, Lei Ni, Bo Guo, Chen Huan. MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R. American journal of physiology. Cell physiology. vol 318. issue 3. 2020-07-30. PMID:31940247. |
moreover, silencing hur with rna interference inhibited cell viability and induced cell apoptosis through the apoptosis-related regulators (bcl-2 and bax) in gc cells. |
2020-07-30 |
2023-08-13 |
Not clear |
| Katayoon Hafezi, Ali Asghar Hemmati, Hassan Abbaszadeh, Armita Valizadeh, Manoochehr Makvand. Anticancer activity and molecular mechanisms of α-conidendrin, a polyphenolic compound present in Taxus yunnanensis, on human breast cancer cell lines. Phytotherapy research : PTR. vol 34. issue 6. 2020-07-30. PMID:31971313. |
α-conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and bax, downregulation of bcl-2, depolarization of mitochondrial membrane potential (mmp), release of cytochrome c from mitochondria, and activation of caspases-3 and -9. |
2020-07-30 |
2023-08-13 |
human |
| Lihong Zhu, Shumei Yang, Jianfeng Wan. miR-217 inhibits the migration and invasion of HeLa cells through modulating MAPK1. International journal of molecular medicine. vol 44. issue 5. 2020-07-27. PMID:31485607. |
it was also found that apoptosis was increased and cell cycle was inhibited by the mir‑217mimic, which was supported by changes in bcl‑2, bax and cleaved caspase‑3. |
2020-07-27 |
2023-08-13 |
Not clear |
| Qi Wei, Huan-Yu Zhou, Xiao-Dong Shi, Hong-Yan Cao, Ling Qi. Long Noncoding RNA NEAT1 Promotes Myocardiocyte Apoptosis and Suppresses Proliferation Through Regulation of miR-129-5p. Journal of cardiovascular pharmacology. vol 74. issue 6. 2020-07-27. PMID:31815867. |
collagen deposition and apoptosis were evaluated by western blot detection of collagen and apoptotic proteins, including capase3, bax, and bcl2. |
2020-07-27 |
2023-08-13 |
Not clear |
| Alexander Sirotkin, Zuzana Záhoranska, Adam Tarko, Florina Popovska-Percinic, Saleh Alwasel, Abdel Halim Harrat. Plant isoflavones can prevent adverse effects of benzene on porcine ovarian activity: an in vitro study. Environmental science and pollution research international. vol 27. issue 23. 2020-07-27. PMID:32445151. |
we evaluated the influence of the oil-related environmental contaminant benzene (0, 10, 100, or 1000 ng/ml) alone and in combination with apigenin, daidzein, or rutin (10 μg/ml each) on viability; proliferation (accumulation of proliferating cell nuclear antigen); apoptosis (accumulation of bax); and release of progesterone (p), testosterone (t), and estradiol (e) in cultured porcine ovarian granulosa cells. |
2020-07-27 |
2023-08-13 |
Not clear |
| Liying Cao, Dongyun Zhi, Jing Han, Sushil Kumar Sah, Yunhui Xi. Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway. Journal of food biochemistry. vol 43. issue 7. 2020-07-23. PMID:31353717. |
furthermore, gm agitated apoptosis was affectedly diminished by the combinational treatment of metformin and curcumin via down-regulating activity of cleaved caspase-3 and pro-apoptotic factor bax, whereas increasing anti-apoptotic factor bcl-2 signaling pathways. |
2020-07-23 |
2023-08-13 |
Not clear |
| Rui Zheng, Minyao Wu, Hongyuan Wang, Jufang Pen. Response Patterns of Biomarkers as Tools to Identify Toxic Effects of Cadmium and Lead on Bufo gargarizans Embryo. Bulletin of environmental contamination and toxicology. vol 105. issue 1. 2020-07-23. PMID:32474622. |
the genes related to oxidative stress (hsp, gpx and sod) are the first response in the development of embryo, followed by the apoptosis (bax, bclaf1 and trail) and inflammation and immune response (socs3, il-27 and il-17d), respectively. |
2020-07-23 |
2023-08-13 |
Not clear |
| Zhigang Huang, Na Li, Yi Shan, Chun Lian. Hsa-miRNA-29a protects against high glucose-induced damage in human umbilical vein endothelial cells. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-22. PMID:30520097. |
study of the underlying mechanism showed that hsa-mirna-29a/bax plays an essential role in the decreased proliferation and increased apoptosis of huvecs induced by hg, and overexpression of hsa-mirna-29a effectively inhibits hg-induced apoptosis and restores the proliferation and tube formation of huvecs exposed to hg by inhibiting its target gene bax. |
2020-07-22 |
2023-08-13 |
human |
| Shu-Hong Zhang, Donghai Liu, Qingyun Hu, Jinling Zhu, Shuqiu Wang, Shaobo Zho. Ferulic acid ameliorates pentylenetetrazol-induced seizures by reducing neuron cell death. Epilepsy research. vol 156. 2020-07-22. PMID:31404716. |
western blotting was used to further analyse the expression of apaf-1, caspase-9, caspase-3, bcl-2, bid, bax, cleaved caspase-3 and cytochrome c. the results showed that compared to the those of the ptz group, fa pre-treatment significantly (p < 0.01) reduced the racine scores starting at day 4, prolonged the latency of the onset of seizure at day 28, reduced the escape latency period starting at day 2, increased the frequency of crossing the platform location, increased the sod activity, reduced the mda content and apoptosis percentage, and upregulated the bcl-2 levels whilst downregulating the bax, cytochrome c, apaf-1, caspase-9, caspase-3, cleaved caspase-3 and bid expression levels. |
2020-07-22 |
2023-08-13 |
rat |
| Yi-Feng Zheng, Jie Luo, Guo-Lian Gan, Wei L. Overexpression of microRNA-98 inhibits cell proliferation and promotes cell apoptosis via claudin-1 in human colorectal carcinoma. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-21. PMID:30506722. |
the overexpression of mir-98 or silencing of cldn1 was shown to increase the expression of bax and runx3 along with promoted cell apoptosis and arrested cells in g1 phase, while decreasing the expression of cldn1, bcl-2, c-myc, and pcna with suppressed proliferation, migration, and invasion. |
2020-07-21 |
2023-08-13 |
human |
| Kelvin Kai-Wan Hui, Chesarahmia Dojo Soeandy, Stephano Chang, Frederick S Vizeacoumar, Thomas Sun, Alessandro Datti, Jeffrey T Henderso. Cell-based high-throughput screen for small molecule inhibitors of Bax translocation. Journal of cellular and molecular medicine. vol 23. issue 3. 2020-07-21. PMID:30548903. |
consistent with their effects on bax translocation, these compounds exhibited significant rescue against in vitro and in vivo cisplatin-induced apoptosis. |
2020-07-21 |
2023-08-13 |
human |
| Ki Yun Kim, Su-Kyeong Hwang, Shin Young Park, Min Ju Kim, Do Youn Jun, Young Ho Ki. l-Serine protects mouse hippocampal neuronal HT22 cells against oxidative stress-mediated mitochondrial damage and apoptotic cell death. Free radical biology & medicine. vol 141. 2020-07-21. PMID:31326607. |
ros-mediated apoptosis was accompanied by the induction of the endoplasmic reticulum (er) stress-mediated apoptotic pathway, involving chop/gadd153 upregulation, jnk and p38 mapk activation, and caspase-12 and caspase-8 activation, and subsequent induction of the mitochondrial apoptotic pathway through bak and bax activation, mitochondrial membrane potential (Δψm) loss, caspase-9 and caspase-3 activation, parp cleavage, and nucleosomal dna fragmentation. |
2020-07-21 |
2023-08-13 |
mouse |
| Yuan-Fang Fan, Ying Xu, Xiao-Hui Su, Li-Ling Liu, Ya-Ge Tian, Yuan Zhao, Xiang-Ying Kong, Na Li. [Effect of Tripterygium Glycosides Tablets on reproductive toxicity in male rats with Ⅱ type collagen induced arthritis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 4. 2020-07-21. PMID:32237475. |
immunohistochemistry was used to observe the expression of bax and bcl-2 related proteins in the apoptosis pathway of testis and epididymis. |
2020-07-21 |
2023-08-13 |
rat |
| Jian-Sheng Wang, Wei-Wei Xiao, Yong-Sheng Zhong, Xue-Dong Li, Shi-Xin Du, Peng Xie, Gui-Zhou Zheng, Jing-Ming Ha. Galectin-3 deficiency protects lipopolysaccharide-induced chondrocytes injury via regulation of TLR4 and PPAR-γ-mediated NF-κB signaling pathway. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30565728. |
moreover, ablation of gal-3 dramatically augmented cell ability and attenuated cell apoptosis accompanied by an increase in the expression of antiapoptotic protein bcl-2 and a decrease in the expression of proapoptotic protein bax and caspase-3 in atdc5 cells subjected with lps. |
2020-07-20 |
2023-08-13 |
Not clear |
| Dainan Yu, Xingxing Xie, Bo Qiao, Wenjing Ge, Lixin Gong, Dan Luo, Dalei Zhang, Yuezhen Li, Bei Yang, Haibin Kuan. Gestational exposure to acrylamide inhibits mouse placental development in vivo. Journal of hazardous materials. vol 367. 2020-07-20. PMID:30594716. |
furthermore, acrylamide treatment inhibited proliferation and induced apoptosis of placentas, as shown by decreased ki67-positive cells and bcl-2 protein, and increased the expression of bax, cleaved-caspase-3, and cleaved-caspase-8 proteins. |
2020-07-20 |
2023-08-13 |
mouse |
| Qi-Quan Wu, Bin Zheng, Guo-Bin Weng, Hou-Meng Yang, Yu Ren, Xi-Jun Weng, Shu-Wei Zhang, Wei-Zhi Zh. Downregulated NOX4 underlies a novel inhibitory role of microRNA-137 in prostate cancer. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30637800. |
moreover, pc-3 cells were transfected with small interfering rna (sinox4) and mir-137 mimic for exploring the effect of mir-137 on glycolysis, cell proliferation, and apoptosis in prostate cancer by evaluating lactate production, glucose uptake, adenosine triphosphate (atp) production, viability rate, and expression of cleaved caspases 3, 8, and 9, cytochrome c, cleaved poly adp ribose polymerase (parp), bax, and bcl-2. |
2020-07-20 |
2023-08-13 |
Not clear |