| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miae Won, Yongyang Luo, Dong-Ho Lee, Eunkyoung Shin, Dae-Shik Suh, Tae-Hyoung Kim, Hanyong Jin, Jeehyeon Ba. BAX is an essential key mediator of AP5M1-induced apoptosis in cervical carcinoma cells. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-22. PMID:31427081. |
bax is an essential key mediator of ap5m1-induced apoptosis in cervical carcinoma cells. |
2020-06-22 |
2023-08-13 |
human |
| Kou-Kou Tang, Xin-Yu Liu, Zhen-Yong Wang, Kui-Chao Qu, Rui-Feng Fa. Trehalose alleviates cadmium-induced brain damage by ameliorating oxidative stress, autophagy inhibition, and apoptosis. Metallomics : integrated biometal science. vol 11. issue 12. 2020-06-22. PMID:31650140. |
finally, the apoptosis rate and the levels of apoptosis marker proteins including b cell leukemia/lymphoma 2 (bcl2) and bcl2-associated x protein (bax) were also measured and the results showed that cd-induced apoptosis was markedly inhibited by tre treatment. |
2020-06-22 |
2023-08-13 |
rat |
| Dandan Yan, Xiaoqi Pan, Jianling Yao, Dun Wang, Xu Wu, Xiaoyi Chen, Nian Shi, Hong Ya. MAPKs and NF-κB-mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5Y. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-19. PMID:30368882. |
inhibition of nf-κb by bay 11-7082 markedly upregulated bax level and decreased bcl-2 expression, and eventually increasing the proportions of neuronal apoptosis compared with that in acr alone. |
2020-06-19 |
2023-08-13 |
human |
| Su-Ya Wang, Jiang-Wei Sang, Wei Ding, Ting-Wu Qin, Lin Bai, Jie Zhang, Jing-Cong Lu. The cytoptrotection of small intestinal submucosa-derived gel in HL-1 cells during hypoxia/reoxygenation-induced injury. Journal of tissue engineering and regenerative medicine. vol 13. issue 8. 2020-06-19. PMID:31062928. |
hl-1 cardiomyocytes seeded on sis matrix-coated plates, sis gel, and uncoated plates were subjected to h/r, cell viability, apoptosis, expression of caspase-3, bcl-2, and bax were investigated. |
2020-06-19 |
2023-08-13 |
Not clear |
| Su-Ya Wang, Jiang-Wei Sang, Wei Ding, Ting-Wu Qin, Lin Bai, Jie Zhang, Jing-Cong Lu. The cytoptrotection of small intestinal submucosa-derived gel in HL-1 cells during hypoxia/reoxygenation-induced injury. Journal of tissue engineering and regenerative medicine. vol 13. issue 8. 2020-06-19. PMID:31062928. |
furthermore, sis gel protected cardiomyocytes from apoptosis by activating protein kinase b (akt) and extracellular-signal-regulated kinase (erk) pathways, and markedly up-regulated antiapoptotic bcl-2 expression but inhibited that of proapoptotic bax and c-caspase 3. |
2020-06-19 |
2023-08-13 |
Not clear |
| Bahram Farhadi Moghadam, Masoud Fereidon. Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat. PloS one. vol 15. issue 3. 2020-06-16. PMID:32150581. |
in addition to quantify the apoptosis processes, tunel staining, as well as expression level of bax and bcl2, were assessed. |
2020-06-16 |
2023-08-13 |
rat |
| Rong Li, Junhui Du, Yang Yao, Guomin Yao, Xiaodi Wan. Adiponectin inhibits high glucose-induced angiogenesis via inhibiting autophagy in RF/6A cells. Journal of cellular physiology. vol 234. issue 11. 2020-06-15. PMID:30982980. |
in the high-glucose group, the protein expression of bax and apoptosis rate of cells increased and the expression of bcl-2 decreased, whereas treatment with adiponectin or 3-ma reversed these results. |
2020-06-15 |
2023-08-13 |
Not clear |
| Guang-Cai Li, Xu-Ling Qin, Huai-Hua Song, Ying-Ni Li, Yu-Yan Qiu, Shi-Chang Cui, Yong-Sheng Wang, Hui Wang, Jun-Ling Gon. Upregulated microRNA-15b alleviates ovarian cancer through inhitbition of the PI3K/Akt pathway by targeting LPAR3. Journal of cellular physiology. vol 234. issue 12. 2020-06-15. PMID:31140597. |
restored mir-15b promoted bax expression, apoptosis, and senescence, inhibited expression of lpar3 and bcl-2, the extent of pi3k and akt phosphorylation, as well as ovarian cancer cell proliferation, migration, and invasion. |
2020-06-15 |
2023-08-13 |
mouse |
| Yong Hoi Lee, Siew Wai Pang, Esther Revai Lechtich, Khalid Shah, Samson Eugin Simon, Suriyan Ponnusamy, Ramesh Narayanan, Chit Laa Poh, Kuan Onn Ta. Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1. Journal of cancer research and clinical oncology. vol 146. issue 7. 2020-06-15. PMID:32377840. |
although important for apoptosis, the signaling pathway involving moap-1(modulator of apoptosis 1), rassf1a (ras association domain family 1a), and bax (bcl-2 associated x protein) is likely to be dysfunctional in many types of human cancers due to mechanisms associated with gene mutation and dna hyper-methylation. |
2020-06-15 |
2023-08-13 |
human |
| Brunno Felipe Ramos Caetano, Mariana Baptista Tablas, Guilherme Ribeiro Romualdo, Maria Aparecida Marchesan Rodrigues, Luís Fernando Barbisa. Early molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development. Toxicology letters. vol 329. 2020-06-15. PMID:32387197. |
apoptosis effectors were upregulated in the liver (bax, casp3 and fas), and developmental genes were downregulated in both colon and liver (foxa1, foxa2, smad2 and smad4). |
2020-06-15 |
2023-08-13 |
rat |
| Suwen Liu, Qianqian Sui, Jian Zou, Yanxue Zhao, Xuedong Chan. Protective effects of hawthorn (Crataegus pinnatifida) polyphenol extract against UVB-induced skin damage by modulating the p53 mitochondrial pathway in vitro and in vivo. Journal of food biochemistry. vol 43. issue 2. 2020-06-12. PMID:31353662. |
consequently, hpe upregulates the expression of antiapoptotic bcl-2 and downregulates that of proapoptotic bax, thereby reducing the activation of caspase-3/9 and inhibiting apoptosis. |
2020-06-12 |
2023-08-13 |
mouse |
| Wenqian Yang, Qulian Guo, Jingyi Li, Ximei Wang, Bingbing Pan, Yunjiao Wang, Lei Wu, Jianqin Yan, Zhigang Chen. microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31131895. |
the treatment of mir-124 agomir improved rats' spatial learning and memory ability and notably increased hippocampal neuron viability and resistance to apoptosis, corresponding to an increased brain-derived neurotrophic factor (bdnf) expression, inhibited expression of proapoptotic factors (cleaved-caspase-3 and bax), and enhanced the expression of antiapoptotic factor (bcl-2). |
2020-06-11 |
2023-08-13 |
rat |
| Ye Yuan, Yong-Yi Wang, Xin Liu, Bin Luo, Lei Zhang, Fei Zheng, Xing-Yuan Li, Ling-Yun Guo, Lu Wang, Miao Jiang, Ya-Mu Pan, Yu-Wen Yan, Jian-Ye Yang, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tan. KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31148189. |
kpc1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though bax degradation. |
2020-06-11 |
2023-08-13 |
rat |
| Ye Yuan, Yong-Yi Wang, Xin Liu, Bin Luo, Lei Zhang, Fei Zheng, Xing-Yuan Li, Ling-Yun Guo, Lu Wang, Miao Jiang, Ya-Mu Pan, Yu-Wen Yan, Jian-Ye Yang, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tan. KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31148189. |
bax triggers cell apoptosis by permeabilizing the outer mitochondrial membrane, leading to membrane potential loss and cytochrome c release. |
2020-06-11 |
2023-08-13 |
rat |
| Ye Yuan, Yong-Yi Wang, Xin Liu, Bin Luo, Lei Zhang, Fei Zheng, Xing-Yuan Li, Ling-Yun Guo, Lu Wang, Miao Jiang, Ya-Mu Pan, Yu-Wen Yan, Jian-Ye Yang, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tan. KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31148189. |
bax can be a novel target for the antiapoptotic effects of kpc1 on i/r-induced cardiomyocyte apoptosis and render mechanistic penetration into at least a subset of the mitochondrial effects of kpc1. |
2020-06-11 |
2023-08-13 |
rat |
| Pan Chen, Ying Miao, PuJun Yan, Xiao Jie Wang, ChunXia Jiang, Yi Le. MiR-455-5p ameliorates HG-induced apoptosis, oxidative stress and inflammatory via targeting SOCS3 in retinal pigment epithelial cells. Journal of cellular physiology. vol 234. issue 12. 2020-06-10. PMID:31041827. |
in addition, forced expression of mir-455-5p markedly enhanced cell viability and restrained hg-induced apoptosis accompanied by decreased bcl2-associated x protein (bax)/b-cell leukemia/lymphoma 2 (bcl-2) ratio and expression of apoptotic marker cleaved caspase-3 during hg challenged. |
2020-06-10 |
2023-08-13 |
Not clear |
| Xiaoxi Pei, Yucheng Li, Liangfu Zhu, Zhilong Zho. Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke. Experimental cell research. vol 382. issue 2. 2020-06-10. PMID:31229506. |
as-exo were injected intravenously through the tail vein into ischemic mice at a concentration of 80 μg per 2 ml after 60 min of the ligation operation the results showed that as-exo enhanced neurons viability; inhibited ogd-induced apoptosis, inhibited ogd-induced expressions of caspase-3 and bax and levels of tnf-α, il-6 and il-1β in ht-22 cells. |
2020-06-10 |
2023-08-13 |
mouse |
| Xin Zhu, Xiaolan L. MiR-423-5p inhibition alleviates cardiomyocyte apoptosis and mitochondrial dysfunction caused by hypoxia/reoxygenation through activation of the wnt/β-catenin signaling pathway via targeting MYBL2. Journal of cellular physiology. vol 234. issue 12. 2020-06-09. PMID:31074036. |
cell apoptosis rate, caspase 3/7 activities, bax and cleaved-caspase 3 (c-caspase 3) protein levels were assayed by flow cytometry, caspase-glo 3/7 assay kit, western blot analysis, respectively. |
2020-06-09 |
2023-08-13 |
Not clear |
| Xin Zhu, Xiaolan L. MiR-423-5p inhibition alleviates cardiomyocyte apoptosis and mitochondrial dysfunction caused by hypoxia/reoxygenation through activation of the wnt/β-catenin signaling pathway via targeting MYBL2. Journal of cellular physiology. vol 234. issue 12. 2020-06-09. PMID:31074036. |
overexpression of mir-423-5p promoted cardiomyocyte apoptosis, enhanced the activities of caspase 3/7, upregulated the expression of bax and c-caspase 3. mir-423-5p upregulation caused the loss of mitochondrial membrane potential and the reduction of atp content, the augment of ros production and drp1 expression. |
2020-06-09 |
2023-08-13 |
Not clear |
| Citong Zhang, Wei Wei, Minghan Chi, Yao Wan, Xue Li, Manlin Qi, Yanmin Zho. FOXO1 Mediates Advanced Glycation End Products Induced Mouse Osteocyte-Like MLO-Y4 Cell Apoptosis and Dysfunctions. Journal of diabetes research. vol 2019. 2020-06-09. PMID:31886284. |
qpcr and western blot results have shown that age upregulates proapoptotic gene p53 and its downstream target gene bax, which leads to enhanced activation of caspase-3, thus inducing apoptosis in mlo-y4 cells. |
2020-06-09 |
2023-08-13 |
mouse |