| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheyi Zhou, Changjun Lu, Shuhui Meng, Linglu Dun, Nannan Yin, Hongwei An, Hong Xu, Guocheng Liu, Yefeng Ca. Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-κB signaling pathway. Journal of cellular physiology. vol 234. issue 12. 2020-06-08. PMID:31222746. |
moreover, ectopic expression of tumor necrosis factor-α significantly elevated the expression of ptgs2, nf-κb, tsp-1, and bax, as well as cell apoptosis and cell cycle arrest, but decreased the expression of vegf, skp2, and bcl-2, as well as proliferation, migration and angiogenesis of epcs, and the ptgs2-sirna group showed an opposite trend. |
2020-06-08 |
2023-08-13 |
mouse |
| Zimei Wu, Wenjing Zai, Wei Chen, Yuxuan Han, Xin Jin, Hongrui Li. Curdione Ameliorated Doxorubicin-Induced Cardiotoxicity Through Suppressing Oxidative Stress and Activating Nrf2/HO-1 Pathway. Journal of cardiovascular pharmacology. vol 74. issue 2. 2020-06-08. PMID:31356549. |
furthermore, curdione inhibited dox-induced cell apoptosis and modulated the expression of bcl-2 and bax proteins, as well as abrogated dox-induced reactive oxygen species accumulation and prevented mitochondria dysfunction. |
2020-06-08 |
2023-08-13 |
Not clear |
| Chun-Xiao Zhan. The protective role of DMBT1 in cervical squamous cell carcinoma. The Kaohsiung journal of medical sciences. vol 35. issue 12. 2020-06-08. PMID:31400059. |
according to the in vitro experiments, siha and caski cells with overexpressed dmbt1 showed the inhibition of proliferative ability and the enhancement of apoptosis with the upregulated pro-apoptosis proteins (bax and cleaved caspase-3) and down-regulated anti-apoptosis protein bcl-2. |
2020-06-08 |
2023-08-13 |
human |
| Raven E Ulieme, Surjania Awer, John C Stagg, Wilson Yau, Worlanyo E Gat. The hepatic effects in dams that ingested 2-aminoanthracene during gestation and lactation. Toxicology and industrial health. vol 35. issue 9. 2020-06-08. PMID:31558114. |
overexpression of genes ddit4, cdkn1c, ccng1, bax, cd93, and cd68 point to hepatic inflammation and apoptosis. |
2020-06-08 |
2023-08-13 |
rat |
| Zhengyi Ruan, Dong Zha. Long intergenic noncoding RNA LINC00284 knockdown reduces angiogenesis in ovarian cancer cells FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 11. 2020-06-08. PMID:31574234. |
afterwards, the expression of matrix metalloproteinase (mmp)-2, mmp-9, b-cell lymphoma 2 (bcl-2), bcl-2-associated protein x (bax), vegf, and cd31 was determined to assess the effect of linc00284 on oc cell proliferation, invasion, migration angiogenesis, and apoptosis. |
2020-06-08 |
2023-08-13 |
mouse |
| Zhengyi Ruan, Dong Zha. Long intergenic noncoding RNA LINC00284 knockdown reduces angiogenesis in ovarian cancer cells FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 11. 2020-06-08. PMID:31574234. |
si-linc00284 or si-nf-κb1 led to the reduction in cell proliferation, migration, invasion, tube formation, angiogenesis, and tumorigenic ability and promoted apoptosis in oc by down-regulating mmp-2, mmp-9, bcl-2, vegf, and cd31 and up-regulating bax. |
2020-06-08 |
2023-08-13 |
mouse |
| Jie-Jie Hu, Li-Jun Qin, Zhi-Yan Liu, Pei Liu, Hai-Ping Wei, Hao-Yue Wang, Chong-Chong Zhao, Zhao-Ming G. miR-15a regulates oxygen glucose deprivation/reperfusion (OGD/R)-induced neuronal injury by targeting BDNF. The Kaohsiung journal of medical sciences. vol 36. issue 1. 2020-06-08. PMID:31631531. |
the findings showed that mir-15a may mediate the apoptosis of neurons submitted to ogd/r, and lower expression of bcl-2 and higher expression of bax and cleaved caspase-3 were observed. |
2020-06-08 |
2023-08-13 |
rat |
| Dehua Jiang, Minghui Li, Ying Yu, Hui Shi, Ruizhen Che. microRNA-34a aggravates coxsackievirus B3-induced apoptosis of cardiomyocytes through the SIRT1-p53 pathway. Journal of medical virology. vol 91. issue 9. 2020-06-03. PMID:30968966. |
moreover, mir-34a expression and cvb3-induced apoptosis of cardiomyocytes were attenuated by pretreatment with srt1720, tsa, or pifithrin-α, accompanied with bax downregulation and bcl-2 upregulation. |
2020-06-03 |
2023-08-13 |
Not clear |
| Nataliya Finiuk, Olha Klyuchivska, Iryna Ivasechko, Volodymyr Hreniukh, Yuriy Ostapiuk, Yaryna Shalai, Rostyslav Panchuk, Vasyl Matiychuk, Mykola Obushak, Rostyslav Stoika, Andriy Babsk. Proapoptotic effects of novel thiazole derivative on human glioma cells. Anti-cancer drugs. vol 30. issue 1. 2020-06-02. PMID:30130258. |
compound 5 induced apoptosis in u251 cells by parp1 and caspase 3 cleavage mechanisms, also inducing an increase in the level of bax and bim proapoptotic proteins and a decrease in the level of phosho-erk1/2 kinase. |
2020-06-02 |
2023-08-13 |
human |
| M A Al Kahtan. Effect of both selenium and biosynthesized nanoselenium particles on cadmium-induced neurotoxicity in albino rats. Human & experimental toxicology. vol 39. issue 2. 2020-06-02. PMID:31619074. |
consequently, cd increases the formation of amyloid β, a neurotoxic index, and induces apoptosis by changing the quality and the quantity of bcl-2, bax and p53 proteins. |
2020-06-02 |
2023-08-13 |
rat |
| Jun Shao, Xubin Pan, Xiaowen Yin, Guangming Fan, Chengye Tan, Yong Yao, Yu Xin, Chao Su. KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor. Journal of cellular physiology. vol 234. issue 10. 2020-06-01. PMID:30784065. |
using mir-1470 mimic or knockdown of kcnq1ot1 could lead to the similar phenomenon; phospho-akt, bax, b-cell lymphoma 2, and cleaved poly-adp ribose polymerase (parp) were regulated, while vascularization was inhibited and apoptosis was promoted. |
2020-06-01 |
2023-08-13 |
human |
| Meihan Liu, Jingzhe Zhang, Hang Dong, Wenjun Wan. Nimotuzuma restrains proliferation and induces apoptosis in human osteosarcoma cells by regulation of EGFR/PI3K/AKT signal pathway. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31001861. |
in addition, nimotuzuma obviously evoked cell apoptosis, meanwhile elevated bid, bax, and cleaved-caspase-3. |
2020-06-01 |
2023-08-13 |
human |
| Yanqin Fu, Chongxian Wang, Dongming Zhang, Xiaojing Chu, Yuanyuan Zhang, Jun L. miR-15b-5p ameliorated high glucose-induced podocyte injury through repressing apoptosis, oxidative stress, and inflammatory responses by targeting Sema3A. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31025335. |
meanwhile, forced expression of mir-15b-5p apparently restrained hg-triggered apoptosis of podocytes, concomitant with downregulated in the proapoptotic protein markers bax and cleavage caspase-3, and upregulated the antiapoptotic protein bcl-2. |
2020-06-01 |
2023-08-13 |
Not clear |
| Leila Karimi, Tahereh Zeinali, Nayer Hosseinahli, Behzad Mansoori, Ali Mohammadi, Mehdi Yousefi, Milad Asadi, Sanam Sadreddini, Behzad Baradaran, Dariush Shanehband. miRNA-143 replacement therapy harnesses the proliferation and migration of colorectal cancer cells in vitro. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31032951. |
finally, the ratio of bax to bcl-2 expression, as a potential marker of the response to apoptosis stimuli, was compared between the control and test groups. |
2020-06-01 |
2023-08-13 |
Not clear |
| Qin Sun, Qing-Cui Zeng, Yan-Qiu Chen, Min Zhang, Ling-Ling Wei, Ping Che. Long intergenic noncoding RNA p21 suppresses the apoptosis of hippocampus neurons in streptozotocin-diabetic mice by sponging microRNA-221 through upregulation of FOS. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31081202. |
mir-221 silencing or lincrna p21 overexpression in the diabetes mice reduced the cell apoptosis rate, and the expression of bax and cleaved caspase-3, whereas increase the bcl-2 expression. |
2020-06-01 |
2023-08-13 |
mouse |
| Yinlong Zhao, Lingzhi Zhao, Junfeng Li, Lili Zhon. Silencing of long noncoding RNA RP11-476D10.1 enhances apoptosis and autophagy while inhibiting proliferation of papillary thyroid carcinoma cells via microRNA-138-5p-dependent inhibition of LRRK2. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31102261. |
the results showed that silenced lncrna rp11-476d10.1 or overexpressed mir-138-5p enhanced the apoptosis and autophagy of ptc cells while reducing cell proliferation, with increased levels of bax, lc3b, and beclin1 and decreased bcl-2 level were observed. |
2020-06-01 |
2023-08-13 |
mouse |
| Huiyuan Wang, Yuheng He, Donger Cheng, Danhua Pu, Rongrong Tan, Li Gao, Yugui Cui, Jie W. Cypermethrin exposure reduces the ovarian reserve by causing mitochondrial dysfunction in granulosa cells. Toxicology and applied pharmacology. vol 379. 2020-06-01. PMID:31351989. |
interestingly, the apoptosis signals were mainly located in granulosa cells, and the expression levels of caspase 3, bax and bcl-2 were increased in the 25 and 50 mg/kg/d groups. |
2020-06-01 |
2023-08-13 |
mouse |
| Jan Jezek, Kai-Ti Chang, Amogh M Joshi, Randy Stric. Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment. EMBO reports. vol 20. issue 9. 2020-06-01. PMID:31385392. |
mitochondrial translocation of cyclin c stimulates intrinsic apoptosis through bax recruitment. |
2020-06-01 |
2023-08-13 |
Not clear |
| Jan Jezek, Kai-Ti Chang, Amogh M Joshi, Randy Stric. Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment. EMBO reports. vol 20. issue 9. 2020-06-01. PMID:31385392. |
intrinsic apoptosis requires mitochondrial outer membrane disruption triggered by recruitment, activation, and oligomerization of the bcl-2 homology protein bax. |
2020-06-01 |
2023-08-13 |
Not clear |
| Maqusood Ahamed, Mohd Javed Akhtar, Hisham A Alhadla. Influence of silica nanoparticles on cadmium-induced cytotoxicity, oxidative stress, and apoptosis in human liver HepG2 cells. Environmental toxicology. vol 35. issue 5. 2020-06-01. PMID:31904905. |
coexposure of si nps and cd also augmented mitochondria-mediated apoptosis in hepg2 cells indicated by altered regulation of apoptotic genes (p53, bax, bcl-2, caspase-3, and caspase-9) along with reduced mitochondrial membrane potential. |
2020-06-01 |
2023-08-13 |
human |