| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daolei Cui, Jue Bi, Zhen-Ning Zhang, Meng-Ying Li, Yi-Shu Qin, Ping Xiang, Lena Q M. Organophosphorus flame retardant TDCPP-induced cytotoxicity and associated mechanisms in normal human skin keratinocytes. The Science of the total environment. vol 726. 2020-07-10. PMID:32304943. |
the effects of tdcpp on cell morphology, viability, apoptosis, and cycle, and the mrna levels of apoptosis (bcl-2, bax and caspase-3) and cell cycle (cyclin d1, cdk2, cdk4 and cdk6) regulatory genes were investigated. |
2020-07-10 |
2023-08-13 |
human |
| Camila Ferreira Sales, Rafael Magno Costa Melo, Ana Paula Barbosa Pinheiro, Ronald Kennedy Luz, Nilo Bazzoli, Elizete Rizz. Autophagy and Cathepsin D mediated apoptosis contributing to ovarian follicular atresia in the Nile tilapia. Molecular reproduction and development. vol 86. issue 11. 2020-07-07. PMID:31355486. |
in the late af, follicular cells had a markedly electron-lucid cytoplasm and immunoreactivity for bax and tunel assay indicated an elevated apoptosis rate. |
2020-07-07 |
2023-08-13 |
Not clear |
| Dongxu Zhang, Houxian Liu, Binbin Yang, Jiasheng Hu, Yue Chen. L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways. Bioscience reports. vol 39. issue 5. 2020-07-06. PMID:30975734. |
furthermore, results of western blotting showed that the involvement of mitochondrial apoptotic pathway in the l-securinine-induced apoptosis of du145 cell, as evidenced by an increase in the protein expression of bax, cleaved caspase-9, cleaved caspase-3, cytosolic cytochrome c, and cleaved parp, together with a unchanged cleaved caspase-8 and decreased bcl-2 protein expression. |
2020-07-06 |
2023-08-13 |
human |
| Jing Wang, Huanying Deng, Jixiang Zhang, Dandan Wu, Jiao Li, Jingjing Ma, Weiguo Don. α-Hederin induces the apoptosis of gastric cancer cells accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway. Phytotherapy research : PTR. vol 34. issue 3. 2020-07-03. PMID:31777126. |
moreover, the detection of mitochondrial and cytosol proteins with apoptosis-inducing factor, apoptosis protease activating factor-1, and cytochrome c showed an increase in the cytosol, followed by a decrease of bcl-2 levels and increases of caspase-3, caspase-8, caspase-9, and bax, which revealed that α-hederin induced apoptosis via triggering activation of the mitochondrial pathway. |
2020-07-03 |
2023-08-13 |
human |
| Jinghui Zhai, Lina Tao, Sixi Zhang, Huan Gao, Yueming Zhang, Jingmeng Sun, Yanqing Song, Xiaoyu Q. Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway. Phytotherapy research : PTR. vol 34. issue 3. 2020-07-03. PMID:31858651. |
ca increased h9c2 cell viability and reduced apoptosis induced by dox via bcl-2, bax, and the pi3k-akt signaling pathway. |
2020-07-03 |
2023-08-13 |
mouse |
| Kun Chen, Liang Zhan. Effect of drug-loaded microbubbles combined with ultrasound on the apoptosis of cancer cells and the expression of Bax and Bcl-2 in a rabbit VX2 liver tumor model. Bioscience reports. vol 39. issue 5. 2020-07-01. PMID:30578377. |
effect of drug-loaded microbubbles combined with ultrasound on the apoptosis of cancer cells and the expression of bax and bcl-2 in a rabbit vx2 liver tumor model. |
2020-07-01 |
2023-08-13 |
rabbit |
| Kun Chen, Liang Zhan. Effect of drug-loaded microbubbles combined with ultrasound on the apoptosis of cancer cells and the expression of Bax and Bcl-2 in a rabbit VX2 liver tumor model. Bioscience reports. vol 39. issue 5. 2020-07-01. PMID:30578377. |
the aim of the present study was to investigate whether the use of drug-loaded microbubbles combined with ultrasound promotes the apoptosis of cancer cells by regulating b-cell lymphoma-2 (bcl-2) and bcl-2-associated x protein (bax) expression. |
2020-07-01 |
2023-08-13 |
rabbit |
| Peng Zhang, Wen-Wei Yu, Jing Peng, Liang-Fei Xu, Chang-Cheng Zhao, Wen-Jiao Chang, Xiao-Ling M. LukS-PV induces apoptosis in acute myeloid leukemia cells mediated by C5a receptor. Cancer medicine. vol 8. issue 5. 2020-06-30. PMID:30955242. |
as the c5ar antagonist concentration increased, the rate of apoptosis induced by luks-pv decreased, the mmp increased, and expression of pro-apoptotic bax and bak genes and proteins was downregulated while that of anti-apoptotic bcl-2 and bcl-x genes and proteins was upregulated. |
2020-06-30 |
2023-08-13 |
human |
| Pawan Kumar Raghav, Rajesh Kumar, Vinod Kumar, Gajendra P S Raghav. Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells. Molecular genetics & genomic medicine. vol 7. issue 11. 2020-06-30. PMID:31490001. |
docking-based approach for identification of mutations that disrupt binding between bcl-2 and bax proteins: inducing apoptosis in cancer cells. |
2020-06-30 |
2023-08-13 |
Not clear |
| Meini Kang, Shuai Shao, Yue Zhang, Xue Liang, Kai Zhang, Guangping L. Beneficial Effects of Ticagrelor on Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Apoptosis in Human Umbilical Vein Endothelial Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-06-26. PMID:31863577. |
apoptosis rates of huvecs was evaluated by flow cytometry, and the expression levels of akt, p-akt, bcl-2, bax, caspase-3, endothelial nitric oxide synthase (enos), and nitric oxide (no) concentration were assessed. |
2020-06-26 |
2023-08-13 |
human |
| Meini Kang, Shuai Shao, Yue Zhang, Xue Liang, Kai Zhang, Guangping L. Beneficial Effects of Ticagrelor on Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Apoptosis in Human Umbilical Vein Endothelial Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-06-26. PMID:31863577. |
results after treatment with 50 ug/ml ox-ldl or 100 ug/ml ox-ldl, we found that the late apoptosis and necrosis rate and the expression levels of bax and caspase-3 were significantly increased in huvecs, whereas the expression levels of akt, p-akt, bcl-2, enos, and no were significantly decreased. |
2020-06-26 |
2023-08-13 |
human |
| Zhi-Chuan Zhu, Ji-Wei Liu, Can Yang, Miao Zhao, Zhi-Qi Xion. XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis. Cell death & disease. vol 10. issue 6. 2020-06-25. PMID:31113936. |
kpt-330/a-1331852 combination disrupted bindings of mcl-1 and bcl-xl to bax, bak, and/or bim, elicited mitochondrial outer membrane permeabilization, and triggered apoptosis. |
2020-06-25 |
2023-08-13 |
Not clear |
| Jun Li, Sha-Sha Zuo, Xiao-Xuan Qiu, Xi Xu, Ying-Ying Luo, Hong-Wei Gao, Yu-Lin Feng, Li-Jun DU, Qin Gon. [Expression characteristics of inflammatory and apoptosis factors and regulatory effect of anemoside B4 in mice with acute kidney injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 1. 2020-06-25. PMID:32237425. |
after the serum was separated, serum urea nitrogen(bun), creatinine(cre), total protein(tp), and albumin(alb) were tested by using an automatic biochemical analyzer; the changes of kidney pathological morphology were observed by pas staining; the protein expression levels of inflammatory factors including nucleotide binding oligomerization domain-like receptor(nlrp3), cysteinyl aspartate specific proteinase 1(caspase-1), interleukin-18(il-18), interleukin-1β(il-1β), tumor necrosis factor(tnf-α), and interleukin-6(il-6) and apoptosis factors including p53, caspase-3, cleaved-caspase-3, bcl-2 associated x protein(bax), and b-cell lymphoma-2(bcl-2) were analyzed by western blot. |
2020-06-25 |
2023-08-13 |
mouse |
| Chan-Na Zhao, Peng Wang, Yan-Mei Mao, Yi-Lin Dan, Qian Wu, Xiao-Mei Li, De-Guang Wang, Callan Davis, Wenbiao Hu, Hai-Feng Pa. Potential role of melatonin in autoimmune diseases. Cytokine & growth factor reviews. vol 48. 2020-06-24. PMID:31345729. |
moreover, mlt inhibits nf-κb signaling pathway to reduce tnf-α and il-1β expression, promotes nrf2 gene and protein expression to reduce oxidative and inflammatory states and regulates bax and bcl-2 to reduce apoptosis; all of which alleviate the development of autoimmune diseases. |
2020-06-24 |
2023-08-13 |
Not clear |
| Kian Aghaabbasi, Nahid Askari, Hassan Hassani Kumleh, Masoud Torkzadeh-Mahani, Abdullah Ramzani-Ghar. The Blepharis persica seed hydroalcoholic extract synergistically enhances the apoptotic effect of doxorubicin in human colon cancer and gastric cancer cells. Molecular biology reports. vol 47. issue 2. 2020-06-23. PMID:31848915. |
these results showed b. persica extract induced apoptosis in ags and ht29 cells and its extract caused dose-dependent increase in up-regulation of bax level (p < 0.05) and down-regulation of bcl |
2020-06-23 |
2023-08-13 |
human |
| Yang Liu, Jiakai Han, Zhenyu Zhou, Dandan L. Tangeretin inhibits streptozotocin-induced cell apoptosis via regulating NF-κB pathway in INS-1 cells. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30216514. |
tangeretin reduced the increase of apoptosis ratio and revered the altered expressions of bax and bcl-2 caused by stz induction. |
2020-06-22 |
2023-08-13 |
Not clear |
| Sithuraj Saranya, Rathinasamy Baskaran, Paramasivan Poornima, Viswanadha Vijaya Padm. Berbamine ameliorates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and apoptosis in rats. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30485494. |
furthermore, pretreatment with bbm protected the heart tissue from iso-induced apoptosis as evident from decreased terminal dutp nickend-labeling positive cells and decreased expression of bax, cytochrome c, cleaved caspase-9, and caspase-3, and poly (adp-ribose) polymerase and increased expression of bcl-2 in iso-induced rats. |
2020-06-22 |
2023-08-13 |
rat |
| Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew I Webb, Dana Westphal, Grant Dewson, Jerry M Adam. BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association. Cell reports. vol 27. issue 2. 2020-06-22. PMID:30970242. |
to elicit apoptosis, bax metamorphoses from an inert cytosolic monomer into homo-oligomers that permeabilize the mitochondrial outer membrane (mom). |
2020-06-22 |
2023-08-13 |
Not clear |
| Riyong Li, Xiaokun Wang, Xuan Zhang, Jiahong Yu, Jinqiu Feng, Ping Lv, Yaxin Lou, Yingyu Che. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway. Biochemical and biophysical research communications. vol 513. issue 3. 2020-06-22. PMID:30982575. |
in this study, we report that adenovirus-mediated ectopic overexpression of emc6 (ad5-emc6) in bgc823 and sgc7901 gastric cancer cells decreases the activity of erk1/2, down-regulates the levels of bcl-2 protein and phosphorylated bcl-2, increases the expression of tbid and bax, and decreases mitochondrial membrane potential and subsequently leading to cell apoptosis. |
2020-06-22 |
2023-08-13 |
mouse |
| Hany H Arab, Samir A Salama, Ahmed H Eid, Ahmed M Kabel, Nancy N Shahi. Targeting MAPKs, NF-κB, and PI3K/AKT pathways by methyl palmitate ameliorates ethanol-induced gastric mucosal injury in rats. Journal of cellular physiology. vol 234. issue 12. 2020-06-22. PMID:31115047. |
in the context of apoptosis, mp inhibited the cleavage of caspase-3 and poly(adp-ribose)polymerase (parp) and bax protein expression with upregulating b cell lymphoma-2 expression (bcl-2), thus, promoting gastric cellular survival. |
2020-06-22 |
2023-08-13 |
rat |