| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Jianyuan Pan, Mengsi Yang, Xiaoqin Jin, Jun Feng, Ailing Wang, Zhenfei Che. Upregulating MicroRNA-203 Alleviates Myocardial Remodeling and Cell Apoptosis Through Downregulating Protein Tyrosine Phosphatase 1B in Rats With Myocardial Infarction. Journal of cardiovascular pharmacology. vol 74. issue 5. 2020-07-20. PMID:31725080. |
however, overexpressing mir-203 greatly improved the cardiac function, reduced infarct size in rats after mi and weakened infarction-induced apoptosis by increasing bcl-2 and reducing decreasing bax, cleaved caspase-3, and cleaved caspase-9. |
2020-07-20 |
2023-08-13 |
rat |
| Zohreh Abdolvahabi, Mitra Nourbakhsh, Saman Hosseinkhani, Zahra Hesari, Mohsen Alipour, Meisam Jafarzadeh, Seyedeh Sara Ghorbanhosseini, Parvaneh Seiri, Zeynab Yousefi, Sahar Yarahmadi, Pegah Golpou. MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30520099. |
in addition, there was an increase in p53 and its acetylated form that ultimately led to upregulation of bax and p21 expression, suppression of cell survival, and considerable induction of apoptosis in breast cancer cells. |
2020-07-17 |
2023-08-13 |
human |
| Ding Liu, Shu Li, Lina Gong, Yan Yang, Yaru Han, Miao Xie, Chen Zhan. Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30548678. |
overexpression of mirna-141 induced nerve cell apoptosis, suppressed proliferation, promoted caspase-3/9, bax and p53 protein expression, and reduced silent information regulator 1 (sirt1) protein expression in vitro model. |
2020-07-17 |
2023-08-13 |
mouse |
| Ding Liu, Shu Li, Lina Gong, Yan Yang, Yaru Han, Miao Xie, Chen Zhan. Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30548678. |
in addition, the downexpression mirna-141 using si-mirna-141 reduced nerve cell apoptosis and increased proliferation, suppressed caspase-3/9, bax and p53 protein expression, induced sirt1 protein expression. |
2020-07-17 |
2023-08-13 |
mouse |
| Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Vikas Kumar Ro. Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model. Molecular reproduction and development. vol 86. issue 12. 2020-07-15. PMID:31566824. |
the treatment of vitamin d3 at lower doses to aged rats showed increased expression of bax and active caspase-3 in the sperm, this finding suggests that increased apoptosis may be responsible for removal of poor quality sperm during aging. |
2020-07-15 |
2023-08-13 |
rat |
| Zheng-Lin Wang, Cong Wang, Wei Liu, Zhi-Long A. Upregulation of microRNA-143-3p induces apoptosis and suppresses proliferation, invasion, and migration of papillary thyroid carcinoma cells by targeting MSI2. Experimental and molecular pathology. vol 112. 2020-07-15. PMID:31738908. |
this was accompanied by inhibited cell proliferation, cell invasion, and migration, as well as a significant increase in bax expression, cell cycle arrest, and cell apoptosis. |
2020-07-15 |
2023-08-13 |
mouse |
| Qi An, Kaishu Zhang, Longlong Fu, Ying Guo, Changyong Zhang, Zhengyan Ge, Jing Ma, Yiqun Gu, Liandong Zu. The impact of exogenous testosterone supplementation on spermatogenesis in a rat model of oligoasthenospermia. International journal of clinical and experimental pathology. vol 13. issue 6. 2020-07-15. PMID:32661465. |
the improvement of sperm and testicular function acted mainly by curbing mitochondrial apoptosis in the testis by modulation of bcl-2, bax, caspase-3, and caspase-9 expression. |
2020-07-15 |
2023-08-13 |
rat |
| Kai Liu, Xinru Mao, Hu Li, Dandan Liu, Guannan Le, Fang Gan, Cuiling Pan, Kehe Huang, Xingxiang Che. Regulation of taurine in OTA-induced apoptosis and autophagy. Toxicon : official journal of the International Society on Toxinology. vol 181. 2020-07-14. PMID:32371067. |
in the present study, we demonstrated that ota treatment at 4.0-8.0 μm increased apoptosis in pk-15 cells as shown by increased the ratio of apoptosis and protein expression of bax and cleaved-caspase-3, decreased protein expression of bcl-2. |
2020-07-14 |
2023-08-13 |
Not clear |
| Kai Liu, Xinru Mao, Hu Li, Dandan Liu, Guannan Le, Fang Gan, Cuiling Pan, Kehe Huang, Xingxiang Che. Regulation of taurine in OTA-induced apoptosis and autophagy. Toxicon : official journal of the International Society on Toxinology. vol 181. 2020-07-14. PMID:32371067. |
taurine supplementation decreased ota-induced cytotoxicity and attenuated apoptosis as shown by the decreased annexin v/pi staining and the decreased expression of apoptosis-related proteins including bax and caspase-3. |
2020-07-14 |
2023-08-13 |
Not clear |
| Yongxia Zhu, Weiqiong Zuo, Lijuan Chen, Shasha Bian, Jiayu Jing, Cailin Gan, Xiuli Wu, Hongyao Liu, Xingping Su, Wanglai Hu, Yuqi Guo, Yue Wang, Tinghong Y. Repurposing of the anti-helminthic drug niclosamide to treat melanoma and pulmonary metastasis via the STAT3 signaling pathway. Biochemical pharmacology. vol 169. 2020-07-13. PMID:31465777. |
further, western blot analysis indicated that cell apoptosis was correlated with activation of bax and cleaved caspase-3 and decreased expression of bcl-2. |
2020-07-13 |
2023-08-13 |
Not clear |
| Daniel L Morris, David W Kastner, Sabrina Johnson, Marie-Paule Strub, Yi He, Christopher K E Bleck, Duck-Yeon Lee, Nico Tjandr. Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization. The Journal of biological chemistry. vol 294. issue 50. 2020-07-13. PMID:31690630. |
humanin induces conformational changes in the apoptosis regulator bax and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization. |
2020-07-13 |
2023-08-13 |
Not clear |
| Daniel L Morris, David W Kastner, Sabrina Johnson, Marie-Paule Strub, Yi He, Christopher K E Bleck, Duck-Yeon Lee, Nico Tjandr. Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization. The Journal of biological chemistry. vol 294. issue 50. 2020-07-13. PMID:31690630. |
bcl-2-associated x apoptosis regulator (bax) plays a pivotal role in the initiation of mitochondria-mediated apoptosis as one of the factors causing mitochondrial outer-membrane permeabilization (momp). |
2020-07-13 |
2023-08-13 |
Not clear |
| Daniel L Morris, David W Kastner, Sabrina Johnson, Marie-Paule Strub, Yi He, Christopher K E Bleck, Duck-Yeon Lee, Nico Tjandr. Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization. The Journal of biological chemistry. vol 294. issue 50. 2020-07-13. PMID:31690630. |
among them, humanin (hn) has been shown to suppress apoptosis by inhibiting bax translocation to the mitochondrial outer membrane, but the molecular mechanism of this interaction is unknown. |
2020-07-13 |
2023-08-13 |
Not clear |
| Zhang Yan, Luo Ruoyu, Li Xing, Liang Hua, Zhang Jun, Peng Yaqin, Wang Lu, Tan Aili, Zhao Yuzi, Mao Lin, Tan Huipin. Long non-coding RNA GAS5 regulates the growth and metastasis of human cervical cancer cells via induction of apoptosis and cell cycle arrest. Archives of biochemistry and biophysics. vol 684. 2020-07-13. PMID:32105659. |
the decrease in the proliferation rate was attributed to the induction of apoptosis of c33a and hela cells which was accompanied with upregulation of bax and suppression of bcl-2. |
2020-07-13 |
2023-08-13 |
human |
| Zhong Li, Yuan Li, Yunhao Jia, Bo Ding, Jinsong Y. Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway. Archives of biochemistry and biophysics. vol 685. 2020-07-13. PMID:32240637. |
apoptosis was estimated by flow cytometry analysis and western blot analysis of b cell lymphoma 2 (bcl-2), myeloid cell leukemia 1 (mcl-1), bcl-2 associated x (bax), and bcl-2 homologous antagonist/killer (bak) expression. |
2020-07-13 |
2023-08-13 |
rat |
| Mai M Elkeiy, Abeer A Khamis, Mona M El-Gamal, Maha M Abo Gazia, Zeinb A Zalat, Mohammed A El-Mag. Chitosan nanoparticles from Artemia salina inhibit progression of hepatocellular carcinoma in vitro and in vivo. Environmental science and pollution research international. vol 27. issue 16. 2020-07-10. PMID:30293105. |
administration of cnps decreased hcc progression as evidenced by (1) induced hepg2 cell death as detected by mtt assay; (2) induced necrosis as indicated by acridine orange/propidium iodide (ao/pi) red staining, annexin v/7-aad positive staining (detected by flow cytometry), and upregulated expression of necrosis markers (parp1 and its downstream target, rip1 genes), but no effect on apoptosis as revealed by insignificant changes in caspase 3 activity and mrna levels of bax and aif; (3) increased intracellular ros and decreased mitochondrial membrane potential in hepg2; (4) decreased liver relative weight, serum levels of liver enzymes (alt, ast, and alp), total bilirubin, and cancer markers (afp and ggt), number and area of gst-p positive tumor nodules; and (5) reduced oxidative stress (decrease in mda levels) and increased activities of sod, cat, and gpx enzymes in rat liver. |
2020-07-10 |
2023-08-13 |
rat |
| Jian-Nan Deng, Yan-Qin Li, Yang Liu, Qi Li, Ye Hu, Jian-Qiao Xu, Tian-Yu Sun, Li-Xin Xi. Exosomes derived from plasma of septic patients inhibit apoptosis of T lymphocytes by down-regulating bad via hsa-miR-7-5p. Biochemical and biophysical research communications. vol 513. issue 4. 2020-07-10. PMID:31003766. |
sepsis-exos were demonstrated to downregulate the mrna and protein levels of proapoptotic gene bad, active caspase-3 and bax, while upregulate that of antiapoptotic gene bcl-2 via hsa-mir-7-5p, thus inhibited apoptosis of t lymphocytes induced by lipopolysaccharide (lps) in vitro. |
2020-07-10 |
2023-08-13 |
mouse |
| Cao Yirong, Wang Shengchen, Sun Jiaxin, Wang Shuting, Zhang Ziwe. DEHP induces neutrophil extracellular traps formation and apoptosis in carp isolated from carp blood via promotion of ROS burst and autophagy. Environmental pollution (Barking, Essex : 1987). vol 262. 2020-07-10. PMID:32179220. |
moreover, our results proved that dehp could increase reactive oxygen species (ros) levels, decrease the expression of the anti-autophagy factor (mtor) and the anti-apoptosis gene bcl-2, and increase the expression of pro-autophagy genes (dynein, beclin-1 and lc3b) and the pro-apoptosis factors (bax, fas, fasl, caspase3, caspase8, and caspase9), thus promoting autophagy and apoptosis. |
2020-07-10 |
2023-08-13 |
Not clear |
| Xing Zhang, Wenyi Gu, Zhongliang Ma, Yun Liu, Hongbo Ru, Jizhi Zhou, Yi Zang, ZhiPing Xu, Guangren Qia. Short-term exposure to ZnO/MCB persistent free radical particles causes mouse lung lesions via inflammatory reactions and apoptosis pathways. Environmental pollution (Barking, Essex : 1987). vol 261. 2020-07-10. PMID:32220747. |
epfr particles decreased the mitochondrial membrane potential (mmp) and induced cell apoptosis, including the activation of caspase-3, bax, and bcl-2 apoptotic signalling pathways. |
2020-07-10 |
2023-08-13 |
mouse |
| Omnia E Hussein, Walaa G Hozayen, May N Bin-Jumah, Mousa O Germoush, Sanaa M Abd El-Twab, Ayman M Mahmou. Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling. Environmental science and pollution research international. vol 27. issue 17. 2020-07-10. PMID:32246423. |
consequently, ca inhibited apoptosis by increasing bcl-2 expression and suppressing bax, cytochrome c, and caspase-3 in mtx-administered rats. |
2020-07-10 |
2023-08-13 |
rat |