| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qun-Bang Chen, Zhao-Hui Li, Yao Fu, Ning-Ning Lv, Nan Tian, Liang Han, Yu Tia. Downregulated long non-coding RNA LINC00899 inhibits invasion and migration of spinal ependymoma cells via RBL2-dependent FoxO pathway. Cell cycle (Georgetown, Tex.). vol 18. issue 19. 2020-09-09. PMID:31432742. |
moreover, we found that sirna-linc00899 could elevate rbl2, p21, p27 and bax levels, decrease foxo, bcl-2, vimentin, annexin levels, reduced cell proliferation, migration and invasion and enhanced apoptosis. |
2020-09-09 |
2023-08-13 |
Not clear |
| Anqi Zeng, Hua Hua, Li Liu, Junning Zha. Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo. Bioorganic & medicinal chemistry. vol 27. issue 12. 2020-09-08. PMID:30910472. |
moreover, ba could induce cell apoptosis by upregulating expression of bax and cleaved caspase-3 and downregulating protein of bcl-2. |
2020-09-08 |
2023-08-13 |
mouse |
| Laifang Wang, Na Wang, Qing Zhao, Bingyi Zhang, Yanjie Din. Pectolinarin inhibits proliferation, induces apoptosis, and suppresses inflammation in rheumatoid arthritis fibroblast-like synoviocytes by inactivating the phosphatidylinositol 3 kinase/protein kinase B pathway. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-08. PMID:31020684. |
apoptosis was determined by flow cytometry analysis and western blot analysis of bax and bcl-2 levels. |
2020-09-08 |
2023-08-13 |
Not clear |
| Huma Naz, Mohd Tarique, Shahzaib Ahamad, Mohamed F Alajmi, Afzal Hussain, Md Tabish Rehman, Suaib Luqman, Md Imtaiyaz Hassa. Hesperidin-CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-08. PMID:31021496. |
hesperidin has significantly reduced the proliferation of hepg2 and sh-sy5y cells and induces apoptosis by activating the caspase-3-dependent intrinsic pathway through the upregulation of proapoptotic bax protein. |
2020-09-08 |
2023-08-13 |
human |
| Tianhui Wu, Fei Yin, Huimin Kong, Jing Pen. Germacrone attenuates cerebral ischemia/reperfusion injury in rats via antioxidative and antiapoptotic mechanisms. Journal of cellular biochemistry. vol 120. issue 11. 2020-09-08. PMID:31318092. |
real-time pcr and western blotting were utilized to quantify the expression of apoptosis markers, such as caspase-3, bax, and bcl-2. |
2020-09-08 |
2023-08-13 |
rat |
| Haroon Badshah, Muhammad Ikram, Waqar Ali, Sareer Ahmad, Jong Ryeal Hahm, Myeong Ok Ki. Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. Biomolecules. vol 9. issue 11. 2020-09-08. PMID:31717470. |
moreover, we found enhanced expression of bcl2-associated x, apoptosis regulator (bax), and cleaved caspase-3, and reduced expression of b-cell lymphoma 2 (bcl-2) in the lps-treated group, which were markedly reversed in the lps + caffeine co-treated group. |
2020-09-08 |
2023-08-13 |
mouse |
| Qiuyan Huang, Bo Liu, Rufang Jiang, Shengbin Liao, Zhiyao Wei, Yin Bi, Xueyuan Liu, Rong Deng, Yufu Jin, Ying Tan, Yihua Yang, Aiping Qi. G-CSF-mobilized peripheral blood mononuclear cells combined with platelet-rich plasma accelerate restoration of ovarian function in cyclophosphamide-induced POI rats†. Biology of reproduction. vol 101. issue 1. 2020-09-07. PMID:31034039. |
additionally, pbmcs in combination with prp mitigated granulosa cell apoptosis by downregulating bax and upregulating bcl-2. |
2020-09-07 |
2023-08-13 |
rat |
| Di Jing, Weibing Zhou, Lin Shen, Qian Zhang, Wang-Ti Xie, Erdong Shen, Zhi Li, Liang-Fang Shen, Lun-Quan Su. RIG-I promotes IFN/JAK2 expression and the endoplasmic reticulum stress response to inhibit chemoradiation resistance in nasopharyngeal carcinoma. Cancer medicine. vol 8. issue 14. 2020-09-07. PMID:31464090. |
rig-i overexpression promoted radiotherapy and chemotherapy sensitivity in npc cells, leading to cellular apoptosis and increased expression of the proapoptotic factors bax and caspase-3. |
2020-09-07 |
2023-08-13 |
Not clear |
| Zhiliang Huang, Yu Gao, Dianchen Ho. Interleukin-22 enhances chemoresistance of lung adenocarcinoma cells to paclitaxel. Human cell. vol 33. issue 3. 2020-09-07. PMID:32452013. |
furthermore, il-22 sirna inhibited the proliferation and promoted the apoptosis of a549/ptx and h358/ptx cells, and il-22 sirna also suppressed the expression levels of akt and bcl-2 and increased the expression levels of bax and cleaved caspase 3. |
2020-09-07 |
2023-08-13 |
Not clear |
| Zhouke Tan, Fan Guo, Zhuo Huang, Zijing Xia, Jing Liu, Sibei Tao, Lingzhi Li, Yuying Feng, Xiaoyan Du, Liang Ma, Ping F. Pharmacological and genetic inhibition of fatty acid-binding protein 4 alleviated cisplatin-induced acute kidney injury. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-09-04. PMID:31286669. |
mechanistically, cisplatin injection induced the increased apoptosis and regulated the corresponding protein expression of bcl-2, bcl-xl, bax, cleaved caspase 3 and caspase 12 in the injured kidney tissues. |
2020-09-04 |
2023-08-13 |
mouse |
| Alexander Abazid, Benedikt Martin, Anja Choinowski, Rhiannon V McNeill, Lars-Ove Brandenburg, Patrick Ziegler, Uwe Zimmermann, Martin Burchardt, Holger Erb, Matthias B Stop. The androgen receptor antagonist enzalutamide induces apoptosis, dysregulates the heat shock protein system, and diminishes the androgen receptor and estrogen receptor β1 expression in prostate cancer cells. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-02. PMID:31297844. |
in the presence of enzalutamide, apoptosis occurred which was shown by increased bax expression, decreased bcl-2 expression, nuclear pyknosis, and genomic dna fragmentation. |
2020-09-02 |
2023-08-13 |
Not clear |
| Khin Wah Wah Han, Wah Wah Po, Uy Dong Sohn, Hyun-Jung Ki. Benzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells. Biomolecules. vol 9. issue 12. 2020-09-02. PMID:31817791. |
western blotting indicated that bitc regulated the expressions of the mitochondria-mediated apoptosis signaling molecules, b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein (bax), and cytochrome c (cyt c). |
2020-09-02 |
2023-08-13 |
Not clear |
| Markus Kleih, Kathrin Böpple, Meng Dong, Andrea Gaißler, Simon Heine, Monilola A Olayioye, Walter E Aulitzky, Frank Essman. Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell death & disease. vol 10. issue 11. 2020-09-01. PMID:31699970. |
mitochondria are in two ways pivotal for cisplatin sensitivity because not only knock-down of bax and bak but also the ros scavenger glutathione diminish cisplatin induced apoptosis. |
2020-09-01 |
2023-08-13 |
Not clear |
| Tao Zhong, Jianmei Zhang, Xiaoying Han, Xiaoxiao Gongye, Tianqi Lyu, Menghan Jiang, Kaiwei Yu, Xiaoqian Meng, Dong Cheng, Hui Lyu, Tianliang Zhang, Lei Zhang, Shuzhen Li. 3,3',4,4',5-Pentachlorobiphenyl influences mitochondrial apoptosis pathway in granulosa cells. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-31. PMID:31038814. |
the expression of bax, bcl-2, and bim related to the mitochondrial apoptosis pathway were also influenced to different degrees. |
2020-08-31 |
2023-08-13 |
mouse |
| Xiao-Jing Li, Zhi-Feng Li, Yan-Yan Xu, Zhao Han, Zhi-Jun Li. microRNA-374 inhibits proliferation and promotes apoptosis of mouse melanoma cells by inactivating the Wnt signalling pathway through its effect on tyrosinase. Journal of cellular and molecular medicine. vol 23. issue 8. 2020-08-31. PMID:31207106. |
it was observed that up-regulated mir-374 or down-regulated tyr increased expression of bax and decreased expressions of tyr, β-catenin, lrp6, bcl-2, cyclind1 and lgr5, along with diminished cell proliferation, migration, invasion and enhanced apoptosis. |
2020-08-31 |
2023-08-13 |
mouse |
| Alexander V Sirotkin, Monika Radosová, Adam Tarko, Iris Martín-García, Francisco Alons. Effect of morphology and support of copper nanoparticles on basic ovarian granulosa cell functions. Nanotoxicology. vol 14. issue 5. 2020-08-31. PMID:32189538. |
cell viability, proliferation (accumulation of proliferating cell nuclear antigen, pcna), apoptosis (accumulation of bcl-2-associated x protein, bax) and release of steroid hormones progesterone, testosterone, and 17 |
2020-08-31 |
2023-08-13 |
Not clear |
| Jiaxun Tian, Jiamei Mo, Lan Xu, Rui Zhang, Yun Qiao, Bin Liu, Lei Jiang, Siyang Ma, Gang Sh. Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells. Chemico-biological interactions. vol 327. 2020-08-31. PMID:32590070. |
apoptosis was assessed by flow cytometry analysis, caspase-3/7 activity assay, and western blot analysis of bax, bcl-2 and cytochrome c (cyt c) expression. |
2020-08-31 |
2023-08-13 |
Not clear |
| Juguang Sun, Fenglei Yu. Suppression of REDD1 attenuates oxygen glucose deprivation/reoxygenation-evoked ischemic injury in neuron by suppressing mTOR-mediated excessive autophagy. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-27. PMID:31021470. |
simultaneously, suppression of redd1 also antagonized ogd/r-evoked cell apoptosis, bax expression, and caspase-3 activity. |
2020-08-27 |
2023-08-13 |
Not clear |
| Qing Mao, Xiulin Liang, Yufu Wu, Yongxiang L. Nobiletin protects against myocardial injury and myocardial apoptosis following coronary microembolization via activating PI3K/Akt pathway in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 9. 2020-08-27. PMID:31073648. |
in addition, nobiletin inhibited myocardial apoptosis, which may be connected to downregulated apoptotic index, upregulated bcl-2, and cleaved caspase-3 and bax, while it increased protein levels in phosphorylated akt. |
2020-08-27 |
2023-08-13 |
rat |
| Pedro A Dionísio, Sara R Oliveira, Maria M Gaspar, Maria J Gama, Margarida Castro-Caldas, Joana D Amaral, Cecilia M P Rodrigue. Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease. Cell death & disease. vol 10. issue 11. 2020-08-26. PMID:31690718. |
moreover, mptp led to dna fragmentation, caspase-3 activation, lipid peroxidation and bax expression in wt mice, in the absence of caspase-8 cleavage, suggesting intrinsic apoptosis. |
2020-08-26 |
2023-08-13 |
mouse |