| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoli Wang, Kehui Xu, Ying Xiong, Qiao Li, Xia Zha. Effects of GW1929 on uterus, ovary and bone metabolism function in perimenopause rats. American journal of translational research. vol 12. issue 5. 2020-09-28. PMID:32509184. |
following treatment with gw1929, cell apoptosis in uterus and ovary tissues were attenuated, accompanied by a downregulation of bax expression and an upregulation of bcl-2 and cleaved caspase-3 expression. |
2020-09-28 |
2023-08-13 |
rat |
| Yeon-Sang Ryu, Sangyun Shin, Hong-Gyu An, Tae-Uk Kwon, Hyoung-Seok Baek, Yeo-Jung Kwon, Young-Jin Chu. Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells. Biomolecules & therapeutics. vol 28. issue 5. 2020-09-28. PMID:32536618. |
moreover, we found that combination therapy significantly increased the expression level of bax, a mitochondrial proapoptotic factor, but decreased that of the x-linked inhibitor of apoptosis protein. |
2020-09-28 |
2023-08-13 |
human |
| Zhengfang Lin, Yinghua Li, Tiantian Xu, Min Guo, Changbing Wang, Mingqi Zhao, Haiyang Chen, Jianling Kuang, Wanling Li, Yingying Zhang, Tao Lin, Yi Chen, Huanhui Chen, Bing Zh. Inhibition of Enterovirus 71 by Selenium Nanoparticles Loaded with siRNA through Bax Signaling Pathways. ACS omega. vol 5. issue 21. 2020-09-28. PMID:32548434. |
activation of bax apoptosis signaling was restrained either. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hao Wang, Lidong Zhao, Jing Wu, Jiang Hong, Songpo Wan. Propofol induces ROS-mediated intrinsic apoptosis and migration in triple-negative breast cancer cells. Oncology letters. vol 20. issue 1. 2020-09-28. PMID:32566008. |
the relative expression of proteins in the intrinsic apoptosis pathway, such as bak, bax, bcl-2, cytochrome |
2020-09-28 |
2023-08-13 |
Not clear |
| Zuhier A Awan, Usama A Fahmy, Shaimaa M Badr-Eldin, Tarek S Ibrahim, Hani Z Asfour, Mohammed W Al-Rabia, Anas Alfarsi, Nabil A Alhakamy, Wesam H Abdulaal, Hadeel Al Sadoun, Nawal Helmi, Ahmad O Noor, Filippo Caraci, Diena M Almasri, Giuseppe Carus. The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells. Pharmaceutics. vol 12. issue 7. 2020-09-28. PMID:32604984. |
the staining of cells with annex v revealed an increase in early and late apoptosis, in line with the increased cellular content of caspase-3 and bax. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rong Li, Xiaoming Zou, Tong Zhu, Haiyan Xu, Xiaolin Li, Lei Zh. Destruction of Neutrophil Extracellular Traps Promotes the Apoptosis and Inhibits the Invasion of Gastric Cancer Cells by Regulating the Expression of Bcl-2, Bax and NF-κB. OncoTargets and therapy. vol 13. 2020-09-28. PMID:32606746. |
destruction of neutrophil extracellular traps promotes the apoptosis and inhibits the invasion of gastric cancer cells by regulating the expression of bcl-2, bax and nf-κb. |
2020-09-28 |
2023-08-13 |
Not clear |
| Gang Chen, Jiandong Li, Zhenyu Wang, Wenge Li. Ezetimibe protects against spinal cord injury by regulating autophagy and apoptosis through inactivation of PI3K/AKT/mTOR signaling. American journal of translational research. vol 12. issue 6. 2020-09-28. PMID:32655800. |
concurrently, significantly reduced apoptosis was observed following eze intervention, accompanied by increased expression of anti-apoptotic protein bcl-2 and decreased expression of pro-apoptotic proteins bax, cleaved caspase-3 and cleaved caspase-9. |
2020-09-28 |
2023-08-13 |
rat |
| Banglv Ju, Zhilan Liu, Chao Nai, Xinyong Zh. Long non-coding RNA CASC2 induces apoptosis and autophagy in human colon cancer cells via modulation of TRIM16 expression. American journal of translational research. vol 12. issue 6. 2020-09-28. PMID:32655801. |
the inhibition of ht-29 growth was due to the induction of apoptosis which was accompanied by upsurge of bax, depletion of bcl-2 and activation of caspase-3 cleavage. |
2020-09-28 |
2023-08-13 |
human |
| Takahide Kariya, Yasushi Hasegaw. Scallop mantle toxin induces apoptosis in liver tissues of mice. Food science & nutrition. vol 8. issue 7. 2020-09-28. PMID:32724595. |
in addition, mantle toxin increased the mrna expression of endoplasmic reticulum (er) stress- and inflammation-induced genes and the protein expression of caspase-3 and bax (which induce apoptosis), suggesting that the mantle tissue diet causes apoptosis through oxidative stress, er stress, and inflammation in the liver tissue. |
2020-09-28 |
2023-08-13 |
mouse |
| Sang-Seo Park, Hye-Sang Park, Tae-Woon Kim, Sam-Jun Le. Effects of swimming exercise on social isolation-induced memory impairment and apoptosis in old rats. Journal of exercise rehabilitation. vol 16. issue 3. 2020-09-28. PMID:32724780. |
social isolation in rats of old age increased tunel-positive cells, bax and cytochrome c expression, and decreased bcl-2 expression, which promoted apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Sang-Seo Park, Hye-Sang Park, Tae-Woon Kim, Sam-Jun Le. Effects of swimming exercise on social isolation-induced memory impairment and apoptosis in old rats. Journal of exercise rehabilitation. vol 16. issue 3. 2020-09-28. PMID:32724780. |
swimming exercise suppressed tunel-positive cells, bax and cytochrome c expression, and increased bcl-2 expression, which inhibited apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Ying-Jung Hsu, Chao-Wen Lin, Sheng-Li Cho, Wei-Shiung Yang, Chung-May Yang, Chang-Hao Yan. Protective Effect of Fenofibrate on Oxidative Stress-Induced Apoptosis in Retinal-Choroidal Vascular Endothelial Cells: Implication for Diabetic Retinopathy Treatment. Antioxidants (Basel, Switzerland). vol 9. issue 8. 2020-09-28. PMID:32764528. |
pretreatment with fenofibrate suppressed reactive oxygen species (ros) production, decreased cellular apoptosis, diminished the changes in the mitochondrial membrane potential, increased the mrna levels of peroxiredoxin (prx), thioredoxins (trxs), b-cell lymphoma 2 (bcl-2), and bcl-xl, and reduced the level of b-cell lymphoma 2-associated x protein (bax) in pq-stimulated rf/6a cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jing Zhang, Jiye Fa. Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway. Experimental and therapeutic medicine. vol 20. issue 2. 2020-09-28. PMID:32765662. |
by contrast, u251 and u81 cell apoptosis, as well as the protein expression levels of bax and active caspase-3 were increased after prazosin treatment (p<0.05). |
2020-09-28 |
2023-08-13 |
human |
| Bo Deng, Ying Hu, Xia Sheng, Huijun Zeng, Yanan Hu. miR-223-3p reduces high glucose and high fat-induced endothelial cell injury in diabetic mice by regulating NLRP3 expression. Experimental and therapeutic medicine. vol 20. issue 2. 2020-09-28. PMID:32765674. |
after modeling, mir-223-3p overexpression downregulated the expression levels of nlrp3 mrna, bax and nlrp3 protein, as well as inhibited endothelial cell apoptosis (p<0.05), while the inhibition of mir-223-3p expression upregulated the expression levels and promoted apoptosis. |
2020-09-28 |
2023-08-13 |
mouse |
| Tingrui Ge, Ping Xiang, Haibing Mao, Shumin Tang, Jinyi Zhou, Yonggang Zhan. Inhibition of miR-96 enhances the sensitivity of colorectal cancer cells to oxaliplatin by targeting TPM1. Experimental and therapeutic medicine. vol 20. issue 3. 2020-09-28. PMID:32765688. |
furthermore, knockdown of mir-96 combined with oxaliplatin reduced the viability and induced apoptosis of crc cells, which was further verified by decreased expression of bcl-2 and the increased expression of tpm1 and bax. |
2020-09-28 |
2023-08-13 |
human |
| Lishan Cui, Lanxi Xu, Guanling Wang, Jing Wen, Lili Luo, Haitao Zhao, Shuide Chen, Mingcheng Zheng, Cuiling Sun, Xin Jin, Lichao Yan. STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells. Oncology letters. vol 20. issue 4. 2020-09-28. PMID:32774480. |
the findings of the present study revealed that stat3 induced pttg11 expression, which subsequently induced downstream c-myc and bcl-2 expression while inhibiting bax expression, thereby promoting cell viability and inhibiting apoptosis. |
2020-09-28 |
2023-08-13 |
human |
| Xinping Gao, Qing Li, Guobin Chen, Haipeng He, Ying M. MAGEA3 promotes proliferation and suppresses apoptosis in cervical cancer cells by inhibiting the KAP1/p53 signaling pathway. American journal of translational research. vol 12. issue 7. 2020-09-28. PMID:32774721. |
further mechanistic study revealed that magea3 interacts with kap1, thereby suppressing p53 transcriptional activity, thus suppressing p53-mediated regulation of the expression of genes involved in the cell cycle (p21, cyclin d1) and apoptosis (bax, bcl-2, and puma). |
2020-09-28 |
2023-08-13 |
Not clear |
| Ike Sulistiyowati, Junaedy Yunus, Dwi Cahyani Ratna Sari, Nur Arfia. Upregulation of p16, Bax and Bcl-2 mRNA Expression Associated with Epithelial Apoptosis and Myofibroblast Proliferation in Kidney Fibrosis Model in Mice. The Malaysian journal of medical sciences : MJMS. vol 27. issue 2. 2020-09-28. PMID:32788839. |
upregulation of p16, bax and bcl-2 mrna expression associated with epithelial apoptosis and myofibroblast proliferation in kidney fibrosis model in mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Honghua Wang, Guobao Yang, Yang Yu, Peibing G. MicroRNA-490-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells via targeting TMOD3. Oncology letters. vol 20. issue 4. 2020-09-28. PMID:32831914. |
mir-490-3p mimics significantly induced liver cancer cell apoptosis via upregulating bax and cleaved caspase-3 and downregulating anti-apoptotic protein bcl-2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hyun Hwangbo, So Young Kim, Hyesook Lee, Shin-Hyung Park, Su Hyun Hong, Cheol Park, Gi-Young Kim, Sun-Hee Leem, Jin Won Hyun, Jaehun Cheong, Yung Hyun Cho. Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway. Biomolecules & therapeutics. vol 28. issue 5. 2020-09-28. PMID:32856616. |
the induction of apoptosis by the combined treatment caused the loss of mitochondrial membrane potential (ΔΨm) and upregulation of bax. |
2020-09-28 |
2023-08-13 |
human |