| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Zhang, Honghua Wan. Morroniside protects against chronic atrophic gastritis in rat via inhibiting inflammation and apoptosis. American journal of translational research. vol 11. issue 9. 2020-09-30. PMID:31632569. |
moreover, mr inhibited apoptosis of gastric mucosal cell as presented by tunel, coupled with an upregulation in bcl-2 expression and a downregulation in bax, cleaved caspase-3 and cleaved caspase-9 expression. |
2020-09-30 |
2023-08-13 |
rat |
| Anzana Parvin, Shuang-Li Hao, Fu-Qing Tan, Wan-Xi Yan. Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell. Gene. vol 760. 2020-09-30. PMID:32717307. |
moreover, depletion of kifc1 reduced cells entering the cell cycle and caused pca cells death through apoptosis by increasing the expression of bax and cytochrome c. thereby, kifc1 silencing and inhibition decreased the pca cells survival by inducing multipolar mitosis as well as apoptosis, suggesting inhibition of kifc1 using az82 might be a strategy to treat pca by controlling the cancer cell proliferation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiu-Li Zhu, Lian Jiang, Fan Qu, Zhi-Yu Wang, Lian-Mei Zha. Inhibitory effect of Embelin on human acute T cell lymphoma Jurkat cells through activation of the apoptotic pathway. Oncology letters. vol 10. issue 2. 2020-09-29. PMID:26622596. |
expression of x-linked inhibitor of apoptosis protein (xiap); poly adp ribose polymerase; caspase-3; caspase-8; caspase-9; the proapoptotic protein, bax; and the antiapoptotic proteins, bcl-xl and bcl-2, were assessed. |
2020-09-29 |
2023-08-13 |
human |
| Yanqiu Lu, Jiyu Lou, Xiaojun Liu, Shengfeng Wan. Oxysophocarpine reduces oxygen-glucose deprivation-induced microglial activation and injury. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559977. |
in addition, osc suppressed ogd/r-elicited bv-2 cell apoptosis, as indicated as follows: the restored mitochondrial membrane potential and the reduced caspase-3 activity; the decrease of bax and cleaved caspase-3 and the increase of bcl-2; the enhanced phosphorylation of akt and mtor. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yanyun Jiang, Yanzhi Sang, Qinghua Qi. microRNA-383 mediates high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells by repressing peroxiredoxin 3. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559987. |
overexpression of mir-383 inhibited cell viability and promoted apoptosis and ros formation in arpe-19 cells, which was coupled with deregulation of bcl-2 and bax. |
2020-09-29 |
2023-08-13 |
human |
| Song Wang, Shuhong Liang, Xiaoyu Zhao, Yujie He, Yuedong Q. Propofol inhibits cell proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes via the nuclear factor-κB pathway. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559993. |
propofol exposure for 48 h led to reduction of proliferation and induction of apoptosis in ra-flss, which was coupled with increased bax and decreased bcl-2 and survivin levels. |
2020-09-29 |
2023-08-13 |
Not clear |
| Chih-Chao Yang, Hon-Kan Yip, Kuan-Hung Chen, Cheuk-Kwan Sun, Yen-Ta Chen, Han-Tan Chai, Pei-Hsun Sung, Hsin-Ju Chiang, Sheung-Fat Ko, Sheng-Ying Chung, Chih-Hung Chen, Kun-Chen Lin, Pao-Yuan Lin, Jiunn-Jye She. Impact of impaired cardiac function on the progression of chronic kidney disease---role of pharmacomodulation of valsartan. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28560004. |
protein expressions of inflammation (il-1β/mmp-9), oxidative stress (nox-1/nox-2/oxidized protein, angiotensin-ii receptor), apoptosis (bax, cleaved caspase-3/parp), fibrosis (smad3/tgf-β), and kidney injured (kim-1/fsp-1) markers showed an identical pattern, whereas anti-fibrosis (smad5/bmp-2) indices exhibited an opposite pattern compared to that of creatinine level among all groups (all p < 0.01). |
2020-09-29 |
2023-08-13 |
rat |
| Zhibing Wu, Ting Wang, Yanmei Zhang, Zhishuang Zheng, Shuhuan Yu, Saisai Jing, Sumei Chen, Hao Jiang, Shenglin M. Anticancer effects of β-elemene with hyperthermia in lung cancer cells. Experimental and therapeutic medicine. vol 13. issue 6. 2020-09-29. PMID:28588670. |
this occurs through reducing s phase and inducing apoptosis, via an increase in p21 and bax expression and a decrease in caspase-9, bcl-2 and survivin expression. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shun Li, Yi Zhang, Qingyong Liu, Qingli Zhao, Liuyu Xu, Shengliang Huang, Shiming Huang, Xuebin We. Oxymatrine inhibits proliferation of human bladder cancer T24 cells by inducing apoptosis and cell cycle arrest. Oncology letters. vol 13. issue 6. 2020-09-29. PMID:28588714. |
oxymatrine also induced apoptosis and cell cycle arrest in the cells, in association with the upregulation of caspase-3 and bax, and the downregulation of survivin, bcl-2 and p53 expression. |
2020-09-29 |
2023-08-13 |
human |
| Priyanka Aryappalli, Sarah S Al-Qubaisi, Samir Attoub, Junu A George, Kholoud Arafat, Khalil B Ramadi, Yassir A Mohamed, Mezoon M Al-Dhaheri, Ashraf Al-Sbiei, Maria J Fernandez-Cabezudo, Basel K Al-Ramad. The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells. Frontiers in oncology. vol 7. 2020-09-29. PMID:28856117. |
mh induced apoptosis of mda-mb-231 cells through activation of caspases 8, 9, 6, and 3/7 and this correlated with a loss of bcl-2 and increased bax protein expression in mh-treated cells. |
2020-09-29 |
2023-08-13 |
human |
| Mao Li, Ruo Fei Liang, Xiang Wang, Qing Mao, Yan Hui Li. BKM120 sensitizes C6 glioma cells to temozolomide via suppression of the PI3K/Akt/NF-κB/MGMT signaling pathway. Oncology letters. vol 14. issue 6. 2020-09-29. PMID:29151909. |
the level of apoptosis was evaluated by hoechst 33342 and tunel staining, and the levels of cleaved caspase-3 and bcl-2-like protein 4 (bax) expression was measured. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mao Li, Ruo Fei Liang, Xiang Wang, Qing Mao, Yan Hui Li. BKM120 sensitizes C6 glioma cells to temozolomide via suppression of the PI3K/Akt/NF-κB/MGMT signaling pathway. Oncology letters. vol 14. issue 6. 2020-09-29. PMID:29151909. |
results from the tunel assay, hoechst 33342 staining and evaluation of the levels of cleaved caspase-3 and bax expression also confirmed the finding that the combination treatment induced a higher level of apoptosis compared with the tmz monotherapy. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lanlan Wan, Daqi Zhang, Jinnan Zhang, Liqun Re. TT-1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl-2 and Bax. Oncology letters. vol 15. issue 1. 2020-09-29. PMID:29387245. |
tt-1, an analog of melittin, triggers apoptosis in human thyroid cancer tt cells via regulating caspase, bcl-2 and bax. |
2020-09-29 |
2023-08-13 |
human |
| Özgür Işık, Turgut Karlıdağ, Bengü Çobanoğlu Şimşek, Erol Keleş, İrfan Kaygusuz, Şinasi Yalçın, İsrafil Orhan, Emrah Sapma. Evaluation of bcl-2, bax and c-erbB-2 Levels in Chronic Otitis Patients with or without Cholesteatoma. Turkish archives of otorhinolaryngology. vol 53. issue 2. 2020-09-29. PMID:29391981. |
the aim of this study was to evaluate bcl-2, bax, and c-erbb-2 expressions in primary and secondary acquired cholesteatoma and to indicate the role of apoptosis and accompanying increased cellular proliferation in the pathogenesis of cholesteatoma. |
2020-09-29 |
2023-08-13 |
Not clear |
| Xin He, Jiankui Sun, Xiaoyu Huan. Expression of caspase-3, Bax and Bcl-2 in hippocampus of rats with diabetes and subarachnoid hemorrhage. Experimental and therapeutic medicine. vol 15. issue 1. 2020-09-29. PMID:29399092. |
in conclusion, hippocampal neuron apoptosis was induced by diabetes + sah and expression levels of caspase-3, bax and bcl-2 were also increased. |
2020-09-29 |
2023-08-13 |
rat |
| Daoud Ali, Abhilasha Tripathi, Hussain Al Ali, Yadvendra Shahi, Kamlesh K Mishra, Saud Alarifi, Abdullah A Alkahtane, Salem Manoharda. ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells. OncoTargets and therapy. vol 11. 2020-09-29. PMID:29416349. |
zineb increased levels of bax and caspase 3 and inhibited the level of bcl2, which subsequently induced apoptosis via the bax/bcl2 and caspase pathway. |
2020-09-29 |
2023-08-13 |
human |
| Yuying Feng, Rongshuang Huang, Fan Guo, Yan Liang, Jin Xiang, Song Lei, Min Shi, Lingzhi Li, Jing Liu, Yanhuan Feng, Liang Ma, Ping F. Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis. Frontiers in pharmacology. vol 9. 2020-09-29. PMID:29632491. |
hdac6 inhibition also resulted in reduced tdt-mediated dutp nick-end labeling (tunel)-positive tubular cells, suppressed bax, bak, cleaved caspase-3 levels, and preserved bcl-2 expression, indicating that 23bb exerted potent renoprotective effects by the regulation of tubular cell apoptosis. |
2020-09-29 |
2023-08-13 |
mouse |
| Hong Gao, Hai Dong, Guijun Li, Hui Ji. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncology letters. vol 15. issue 6. 2020-09-29. PMID:29928333. |
expression levels of apoptosis-related proteins, including bcl2 apoptosis regulator (bcl-2), bcl2 associated x (bax) and caspase-3, and of proliferation-related proteins, including proliferating cell nuclear antigen (pcna) and tumor protein p53 (p53), were detected using western blotting. |
2020-09-29 |
2023-08-13 |
Not clear |
| Sen Lu, Caizhao Lin, Xiaobin Cheng, Hanju Hua, Tao Xiang, Yu Huang, Xi Huan. Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF-κB pathway Oncology letters. vol 15. issue 6. 2020-09-29. PMID:29928339. |
cardamonin significantly suppressed the growth of chemotherapy-resistant colon cancer cells, induced apoptosis and promoted caspase-3/9 activity and bax protein expression in 5-fluorouracil (5-fu)-resistant hct-116 cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Ning Yang, Shuzhan Yao, Dong Li. Tumor necrosis factor-related apoptosis-inducing ligand additive with Iodine-131 of inhibits non-small cell lung cancer cells through promoting apoptosis. Oncology letters. vol 16. issue 1. 2020-09-29. PMID:29928412. |
results demonstrated that trail-i-131 treatment induced apoptosis of nsclc cells, with western blot analysis confirming that trail-i-131 treatment increased proapoptotic bad and bax expression levels, while antiapoptotic bcl-2 and bcl-w protein levels were decreased in nsclc cells. |
2020-09-29 |
2023-08-13 |
human |