| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung Hoo Hwang, Soo Jung Park, Won Gyu Ko, Seong-Mun Kang, Da Bin Lee, Junho Bang, Byung-Joo Park, Chung-Beum Wee, Dae Joon Kim, Ik-Soon Jang, Jae-Hong K. Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway. American journal of cancer research. vol 7. issue 3. 2020-09-30. PMID:28401001. |
overall, the results obtained indicate that cordycepin inhibits the erk/slug signaling pathway through the activation of gsk3β which, in turn, upregulates bax, leading to apoptosis of the lung cancer cells. |
2020-09-30 |
2023-08-13 |
human |
| Seong-Hyun Park, Yoon Pyo Choi, Jinhong Park, Andrew Share, Oscar Francesconi, Cristina Nativi, Wan Namkung, Jonathan L Sessler, Stefano Roelens, Injae Shi. Synthetic aminopyrrolic receptors have apoptosis inducing activity. Chemical science. vol 6. issue 12. 2020-09-30. PMID:28757987. |
signaling pathway studies indicate that the synthetic receptors of the present study promote jnk activation, induce bax translocation to the mitochondria, and cause cytochrome c release from the mitochondria into the cytosol, thus promoting caspase-dependent apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bin Wu, Chunli Yu, Bin Zhou, Tingting Huang, Lei Gao, Tao Liu, Xingsheng Yan. Overexpression of TROP2 promotes proliferation and invasion of ovarian cancer cells. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962108. |
trop2 may disrupt the balance in the bax family to participate in apoptosis regulation in a2780 cells. |
2020-09-30 |
2023-08-13 |
human |
| S Thangapandiyan, S Miltonprab. Epigallocatechin gallate supplementation protects against renal injury induced by fluoride intoxication in rats: Role of Nrf2/HO-1 signaling. Toxicology reports. vol 1. 2020-09-30. PMID:28962222. |
egcg also effectively attenuated fluoride-induced renal apoptosis by the up-regulation of anti-apoptotic proteins such as bcl-2 and down-regulation of bax, caspase-3, caspase-9 and cytochrome c. histology and immunohistochemical observations of kim-1 provided further evidence that egcg effectively protects the kidney from fluoride-mediated oxidative damage. |
2020-09-30 |
2023-08-13 |
rat |
| Radhika Kapoor, Poonam Kakka. Naringenin accords hepatoprotection from streptozotocin induced diabetes in vivo by modulating mitochondrial dysfunction and apoptotic signaling cascade. Toxicology reports. vol 1. 2020-09-30. PMID:28962270. |
antioxidant status, liver & kidney biomarker enzymes, reactive oxygen species (ros) generation, mitochondrial membrane potential, expression of apoptotic proteins like bax (bcl-2 associated x), bcl-2 (b-cell lymhoma-2), caspase-3, caspase-9, aif (apoptosis inducing factor) and endo-g (endonuclease-g) were studied in streptozotocin induced diabetic rats. |
2020-09-30 |
2023-08-13 |
rat |
| Radhika Kapoor, Poonam Kakka. Naringenin accords hepatoprotection from streptozotocin induced diabetes in vivo by modulating mitochondrial dysfunction and apoptotic signaling cascade. Toxicology reports. vol 1. 2020-09-30. PMID:28962270. |
hyperglycemia also affected apoptosis and its related genes at both transcriptional and translational level (caspase-3 & 9, bax and bcl-2) in the liver of diabetic rats. |
2020-09-30 |
2023-08-13 |
rat |
| Anshu Jain, Shruti Agrawal, Swaran J S Flor. Arsenic and nicotine co-exposure lead to some synergistic effects on oxidative stress and apoptotic markers in young rat blood, liver, kidneys and brain. Toxicology reports. vol 2. 2020-09-30. PMID:28962476. |
gene expression studies showed marked reduction in catalase, cu-zn sod, gst, there was a significant up regulation in bax, caspase 3 in various tissues along with urinary 8-ohdg levels, indicative of dna damage and apoptosis. |
2020-09-30 |
2023-08-13 |
rat |
| Dengqiang Lin, Xiaoxia Li, Lieyu Xu, Jianpo Lian, Yunze Xu, Li Meng, Xin Xie, Xiaojing Wang, Hongchao He, Danfeng Xu, Chenghe Wang, Yu Zh. Apogossypolone (ApoG2) induces ROS-dependent apoptosis and reduces invasiveness of PC12 cells American journal of translational research. vol 9. issue 9. 2020-09-30. PMID:28979675. |
in addition, apog2 could induce apoptosis through up-regulation of bax and down-regulation of bcl-2, increasing reactive oxygen species (ros) levels, inducing cytochrome c release and cleaving caspase proteins. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuhui Dang, Qianlong Zhao, Boyan Luo, Li Pan, Qian Wei, Ruiping Zhang, Qiaorong Fan, Junyi Chen, Ruixia Chang, Jie Zhang, Zhilan L. Effects of acrylonitrile-induced oxidative stress on testicular apoptosis through activation of NF-κB signaling pathway in male sprague dawley rats. American journal of translational research. vol 9. issue 9. 2020-09-30. PMID:28979696. |
taken together, the data suggested that acn-induced oxidative stress activated the nf-κb signaling pathway, which modulated the expression of bax and contributed to testicular apoptosis. |
2020-09-30 |
2023-08-13 |
rat |
| Tatsunori Oguchi, Ran Ono, Mayumi Tsuji, Hidenobu Shozawa, Masayuki Somei, Manami Inagaki, Yukiko Mori, Taro Yasumoto, Kenjiro Ono, Yuji Kiuch. Cilostazol Suppresses Aβ-induced Neurotoxicity in SH-SY5Y Cells through Inhibition of Oxidative Stress and MAPK Signaling Pathway. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:29089887. |
in addition, pretreatment with csz suppressed aβ-induced apoptosis and increased cell viability via suppression of bax (a proapoptotic protein), upregulation of bcl-2 (an antiapoptotic protein) and cu/zn-sod (a superoxide scavenging enzyme), and phosphorylation of creb. |
2020-09-30 |
2023-08-13 |
human |
| Xian-Rang Li, Jian Li, Qiang Ren, Shui Su. The molecular mechanism of treating osteoarthritis with dipsacus saponins by inhibiting chondrocyte apoptosis. Experimental and therapeutic medicine. vol 14. issue 5. 2020-09-30. PMID:29104661. |
thus, dipsacus saponins inhibited the apoptosis of chondrocytes by up-regulating bcl-2 and down-regulating caspase-9, caspase-3 and bax expression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kongliang Ke, Tingting Lo. MicroRNA-10a suppresses breast cancer progression via PI3K/Akt/mTOR pathway. Oncology letters. vol 14. issue 5. 2020-09-30. PMID:29113237. |
the expression of phosphorylated (p-)protein kinase b (akt), p-mammalian target of rapamycin (p-mtor), p-ribosomal protein s6 kinase β-1 (p-p70s6k), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (pik3ca), cytochrome c (cyt c), b-cell lymphoma 2 (bcl-2), bcl-2 associated x, apoptosis regulator (bax), and cleaved caspase-3 were analyzed by western blotting. |
2020-09-30 |
2023-08-13 |
human |
| Liugen Gan, Liang Zhong, Zhiling Shan, Chunlan Xiao, Ting Xu, Hao Song, Liu Li, Rong Yang, Beizhong Li. Epigallocatechin-3-gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP-1-p38α MAPK-Bax cascade. Oncology letters. vol 14. issue 5. 2020-09-30. PMID:29113283. |
in addition, egcg treatment induced apoptosis and increased the levels of (bcl-2-like protein 4) bax protein expression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Liugen Gan, Liang Zhong, Zhiling Shan, Chunlan Xiao, Ting Xu, Hao Song, Liu Li, Rong Yang, Beizhong Li. Epigallocatechin-3-gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP-1-p38α MAPK-Bax cascade. Oncology letters. vol 14. issue 5. 2020-09-30. PMID:29113283. |
pretreatment with pd169316 (a p38 mapk inhibitor) partially blocked egcg-induced apoptosis and inhibited egcg-mediated bax expression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Liugen Gan, Liang Zhong, Zhiling Shan, Chunlan Xiao, Ting Xu, Hao Song, Liu Li, Rong Yang, Beizhong Li. Epigallocatechin-3-gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP-1-p38α MAPK-Bax cascade. Oncology letters. vol 14. issue 5. 2020-09-30. PMID:29113283. |
similarly, pretreatment with nsc87877, an inhibitor of shp-1, partially blocked egcg-induced apoptosis and inhibited egcg-mediated increases in p-p38α mapk and bax expression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shaohua Dai, Qirong Xu, Sheng Liu, Bentong Yu, Jichun Liu, Jian Tan. Role of autophagy and its signaling pathways in ischemia/reperfusion injury. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118909. |
the expression of cd31, lc3-ii, bcl-2, bax, lc3-ii, beclin 1, akt, p-akt, ampk and p-ampk, apoptosis, cell viability and migration ability were determined. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shaohua Dai, Qirong Xu, Sheng Liu, Bentong Yu, Jichun Liu, Jian Tan. Role of autophagy and its signaling pathways in ischemia/reperfusion injury. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118909. |
apoptosis mediated by hypoxia and reperfusion-induced autophagy was reduced by 3-ma and beclin-1 knockdown, which increased and reduced the expression of bcl-2 and bax, respectively, leading to significant decreased bax/bcl-2 ratio. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yang Gao, Kai Kang, Haitao Liu, Weilan Kong, Qiuyuan Han, Xing Zhang, Rui Huang, Jingdong Qu, Hongliang Wang, Sicong Wang, Ruijin Liu, Yansong Liu, Kaijiang Y. GTS-21 attenuates LPS-induced renal injury via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118926. |
the pathological examinations were performed on he stained renal tissues, apoptosis was determined using tunel assay, mrna expression of nf-kb p65, caspase-3, caspase-8, bcl-2, bax, p53 and a7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blots. |
2020-09-30 |
2023-08-13 |
mouse |
| Rebecca A Kirkland, James L Frankli. Bax and caspases regulate increased production of mitochondria-derived reactive species in neuronal apoptosis: LACK of A role for depletion of cytochrome c from the mitochondrial electron transport chain. Biochemistry and biophysics reports. vol 4. 2020-09-30. PMID:29124200. |
bax and caspases regulate increased production of mitochondria-derived reactive species in neuronal apoptosis: lack of a role for depletion of cytochrome c from the mitochondrial electron transport chain. |
2020-09-30 |
2023-08-13 |
mouse |
| Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwan. Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells. Biomolecules & therapeutics. vol 26. issue 5. 2020-09-30. PMID:29310425. |
based on these results, the effects of tcs, bpa, kaem, and dim on protein expression of apoptosis and ros production-related markers such as bax and bcl-xl, as well as endoplasmic reticulum (er) stress-related markers such as eif2α and chop were investigated by western blot assay. |
2020-09-30 |
2023-08-13 |
Not clear |