| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tyler M MacDonald, Lynn N Thomas, Emily Daze, Paola Marignani, Penelope J Barnes, Catherine Kl To. Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells. American journal of cancer research. vol 9. issue 7. 2020-10-01. PMID:31392083. |
edd sirna-induced apoptosis in mcf-7 cells correlated with significantly increased levels of pro-apoptotic bim and bak mrnas and proteins (p < 0.05, n = 3-6), and increased levels of pro-apoptotic bax and moap-1 proteins (p < 0.001, n = 3-6), leading to increased cleavage of caspase-7 and caspase substrate poly-adp-ribose polymerase-1 (parp-1), as compared to control cells. |
2020-10-01 |
2023-08-13 |
human |
| Yingying Zhang, Jinfeng Liu, Yan Lv, Chao Zhang, Shuai Gu. LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies. American journal of translational research. vol 11. issue 7. 2020-10-01. PMID:31396320. |
furthermore, overexpression of meg3 (a) decreased proliferation, migration, and invasion of hepg2 cells; (b) enhanced apoptosis and the proportion of hepg2 cells in g1 of the cell cycle; (c) increased the expression of phosphatase and tensin homolog (pten), bcl2-associated x (bax), and p53 proteins; and (d) decreased the expression of mirna-10a-5p, akt, p-akt, bcl-2, and the matrix metalloproteinases (mmps)-2 and -9. |
2020-10-01 |
2023-08-13 |
Not clear |
| Liang Zhang, Jian Zhang, Qiguang Tong, Guannan Wang, Hongling Dong, Zhonglu Wang, Qi Sun, Hangyu W. Reduction of miR-29a-3p induced cardiac ischemia reperfusion injury in mice via targeting Bax. Experimental and therapeutic medicine. vol 18. issue 3. 2020-10-01. PMID:31410131. |
hence, the authors of the current study propose that reduced mir-29a-3p levels in primary cardiomyocytes contribute to cir injury-related apoptosis mainly by targeting bax. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiuchun Wang, Xuemei Wan. Long non-coding RNA colon cancer-associated transcript 2 may promote esophageal cancer growth and metastasis by regulating the Wnt signaling pathway. Oncology letters. vol 18. issue 2. 2020-10-01. PMID:31423241. |
the treatments also promoted apoptosis, upregulated the expression of bax and apc proteins, and downregulated β-catenin, pcna, cyclin d1 and c-myc proteins. |
2020-10-01 |
2023-08-13 |
human |
| Tie-Ning Zhang, Julie E Goodwin, Bing Liu, Da Li, Ri Wen, Ni Yang, Jing Xia, Han Zhou, Tao Zhang, Wen-Liang Song, Chun-Feng Li. Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression. Molecular therapy. Nucleic acids. vol 17. 2020-10-01. PMID:31472370. |
by silencing this lncrna, we demonstrated knockdown of pvt1 expression could induce cell apoptosis in lipopolysaccharide-induced heart cells, through increasing the expression of c-myc, bid, bax, and caspase-3 and decreasing the expression of myd88 and bcl-2, thereby proving its functional role in myocardial depression. |
2020-10-01 |
2023-08-13 |
rat |
| Feng Li, Jing-Tao Wu, Peng-Fei Wang, Li-Zhen Q. NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway. Experimental and therapeutic medicine. vol 18. issue 4. 2020-10-01. PMID:31555387. |
in addition, downregulation of nkap increased the levels of bax and cleaved caspase 3, but decreased bcl2 levels, which suggested that the mitochondrial apoptosis pathway was activated. |
2020-10-01 |
2023-08-13 |
human |
| Guoxin Tong, Yongmei Wang, Chenke Xu, Yizhou Xu, Xianhua Ye, Liang Zhou, Gangjie Zhu, Zhanlin Zhou, Jinyu Huan. Long non-coding RNA FOXD3-AS1 aggravates ischemia/reperfusion injury of cardiomyocytes through promoting autophagy. American journal of translational research. vol 11. issue 9. 2020-10-01. PMID:31632535. |
in addition, foxd3-as1 overexpression increased the levels of ck, ck-mb, ctni, tnf-α, il-1β, il-6, ros and no, whereas the increase of above factors were reversed following treatment with 3 m. moreover, foxd3-as1 overexpression enhanced the rate of apoptosis cells coupled with a decrease of bcl-2 expression and an increase of bax and cleaved caspase 3 expression, which were reversed by 3 m. furthermore, foxd3-as1 overexpression promoted the activation of nf-κb/inos/cox2 signaling, which was blocked following treatment with 3 m. these findings demonstrate that overexpression of lncrna foxd3-as1 aggravates myocardial i/r injury through promoting autophagy, which was regulated by activating nf-κb/inos/cox2 signaling. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jianxin Jiang, Xiaolin Wang, Guangzhong Gao, Xiaoxin Liu, Hao Chang, Ran Xiong, Jun Lu, Zhiyang Su. Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: American journal of translational research. vol 11. issue 10. 2020-10-01. PMID:31737190. |
lncrna hoxa11-as silencing could inhibit cell migration, invasion, proliferation, and promote apoptosis, while up-regulate the expression of caspase-3/8/9 and bax, inhibit the expression of bcl-2 and gab2 in u251 cells. |
2020-10-01 |
2023-08-13 |
human |
| Xing Li, Jiheng Zhan, Yu Hou, Shudong Chen, Yonghui Hou, Zhifeng Xiao, Dan Luo, Dingkun Li. Coenzyme Q10 suppresses oxidative stress and apoptosis via activating the Nrf-2/NQO-1 and NF-κB signaling pathway after spinal cord injury in rats. American journal of translational research. vol 11. issue 10. 2020-10-01. PMID:31737205. |
therefore, we designed experiments to measure the changes in antioxidant capacity (glutathione (gsh), superoxide dismutase (sod) and the end product of lipid peroxidation (mda)) and apoptosis products (bax, bcl-2 and caspase-3) to evaluate the protective effects of coq10 on sci and investigated whether coq10 exerts its functions through the nrf-2/nqo-1 and nf-κb signaling pathway. |
2020-10-01 |
2023-08-13 |
rat |
| Xing Li, Jiheng Zhan, Yu Hou, Shudong Chen, Yonghui Hou, Zhifeng Xiao, Dan Luo, Dingkun Li. Coenzyme Q10 suppresses oxidative stress and apoptosis via activating the Nrf-2/NQO-1 and NF-κB signaling pathway after spinal cord injury in rats. American journal of translational research. vol 11. issue 10. 2020-10-01. PMID:31737205. |
our results showed that coq10 treatment could significantly decrease the levels of oxidative products (mda) and increase the activities of antioxidant enzymes (sod and gsh) against oxidative stress, as well as decrease the levels of pro-apoptotic proteins (bax and caspase-3) and increase the levels of anti-apoptotic proteins (bcl-2) against apoptosis after sci. |
2020-10-01 |
2023-08-13 |
rat |
| Huan Li, Lu Cao, Pei-Qiang Yi, Cheng Xu, Jun Su, Pei-Zhan Chen, Min Li, Jia-Yi Che. Pituitary adenylate cyclase-activating polypeptide ameliorates radiation-induced cardiac injury. American journal of translational research. vol 11. issue 10. 2020-10-01. PMID:31737210. |
moreover, pacap38 suppressed myocardial apoptosis and g2/m arrest through blunting the radiation-induced down-regulation of bcl-2, cyclinb1 and cdc2, and inhibiting the up-regulation of bax. |
2020-10-01 |
2023-08-13 |
mouse |
| Yong Liang, Chunsheng Li, Bo Liu, Qiang Zhang, Xiaoli Yuan, Yun Zhang, Jiyang Ling, Lianxing Zha. Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs. Experimental and therapeutic medicine. vol 18. issue 6. 2020-10-01. PMID:31777541. |
additionally, pathological staining demonstrated that the intestinal mucosa tissue in the cpr+ecmo group exhibited less apoptosis, necrosis and inflammatory cell infiltration, which was further supported by a decrease in bax expression and an increase in bcl-2 expression. |
2020-10-01 |
2023-08-13 |
human |
| Lan Wen, Lei Liu, Linyan Tong, Jinfang Li, Keming Zhang, Qinbin Zhang, Changqing L. NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis. Genes & diseases. vol 6. issue 4. 2020-10-01. PMID:31832525. |
furthermore, adenovirus-mediated ndrg4 inhibited cell apoptosis in the brains of ir rats and regulated the expression of bcl-2, bax, caspase-3, and c-fos. |
2020-10-01 |
2023-08-13 |
rat |
| Yinong Yang, Qing Li, Feng Tan, Jun Zhang, Wu Zh. Mechanism of IL-8-induced acute lung injury through pulmonary surfactant proteins A and B. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853301. |
silencing il-8 led to increased expression levels of sp-a, sp-b and bcl2, decreased expression levels of caspase-9, caspase-3, bax, tnf-α, il-17 and il-1β, reduced cell apoptosis rate, and enhanced cell viability. |
2020-10-01 |
2023-08-13 |
human |
| Xiaowei Shen, Jiaqi Lei, Lei D. miR-31-5p may enhance the efficacy of chemotherapy with Taxol and cisplatin in TNBC. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853314. |
furthermore, the overexpression of mir-31-5p increased the sensitivity of cells to chemotherapy, which exhibited an increase in apoptosis and in the expression level of bax, and a decrease in the expression level of bcl-2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
mir-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes bcl-2 and bax in depression model rats through notch pathway. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
effects of micro ribonucleic acid (mir)-9 on neuronal apoptosis and expression levels of apoptosis genes b-cell lymphoma-2 (bcl-2) and bcl-2 associated x protein (bax) in depression model rats, as well as its regulatory mechanism, were investigated. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
compared with the control group, the rats in the model group presented significantly decreased learning and memory abilities, poor neuronal morphology of the brain, significantly higher neuronal apoptosis rate in the brain, decreased level of serum bcl-2, increased level of serum bax, and significantly decreased protein levels of notch1 and hes1 in brain tissues. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
compared with the model group, the rats in mir-9 inhibitor group showed obviously improved learning and memory abilities, improved neuronal morphology of the brain, an obviously lower neuronal apoptosis rate in the brain, increased level of serum bcl-2, decreased level of serum bax, and obviously increased protein levels of notch1 and hes1 in brain tissues. |
2020-10-01 |
2023-08-13 |
rat |
| Wei Wang, Yan Dong, Xiaoyan Li, Yingying Pan, Jiexin Du, Daotong Li. MicroRNA-431 serves as a tumor inhibitor in breast cancer through targeting FGF9. Oncology letters. vol 19. issue 1. 2020-10-01. PMID:31897213. |
mir-431 induced apoptosis through enhancing bax expression. |
2020-10-01 |
2023-08-13 |
human |