| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin He, Wen Wei, Ji Liu, Yundan Xu, Gang Zha. Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells. Oncology letters. vol 14. issue 3. 2020-10-01. PMID:28927092. |
the expression of the apoptosis regulator b-cell lymphoma-2 (bcl-2) and bcl-2-associated x protein (bax) were detected by western blotting analysis. |
2020-10-01 |
2023-08-13 |
human |
| Bin He, Wen Wei, Ji Liu, Yundan Xu, Gang Zha. Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells. Oncology letters. vol 14. issue 3. 2020-10-01. PMID:28927092. |
the rate of apoptosis, caspase-3/caspase-8 activity and the expression of bax were significantly increased, whereas bcl-2 expression was significantly reduced following treatment with curcumin and/or fp, compared with the untreated control group. |
2020-10-01 |
2023-08-13 |
human |
| Bin He, Wen Wei, Ji Liu, Yundan Xu, Gang Zha. Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells. Oncology letters. vol 14. issue 3. 2020-10-01. PMID:28927092. |
therefore, curcumin may enhance the anticancer effects of fp chemotherapy in mgc-803 cells through the promotion of apoptosis via the caspase-3/caspase-8, bcl-2 and bax signaling pathways. |
2020-10-01 |
2023-08-13 |
human |
| Jia-Jia Li, Jing-Jing Zhang, Xiu Wang, Zi-Min Su. Effects of 17-DMAG on diffuse large B-cell lymphoma cell apoptosis. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042970. |
the underlying mechanism may be that 17-dmag induces oxidative stress, which inhibits the expression of hspa5 and bcl-2 and promotes the expression of bax, leading to the apoptosis of su-dhl-4 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tao Jiang, Xiu-Qin Wang, Chuan Ding, Xue-Lian D. Genistein attenuates isoflurane-induced neurotoxicity and improves impaired spatial learning and memory by regulating cAMP/CREB and BDNF-TrkB-PI3K/Akt signaling. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 21. issue 6. 2020-10-01. PMID:29200900. |
genistein significantly reduced apoptosis in the hippocampus, reduced the expression of proapoptotic factors (bad, bax, and cleaved caspase-3), and increased the expression of bcl-2 and bcl-xl. |
2020-10-01 |
2023-08-13 |
rat |
| Xuan Li, Kai Wei, Rong Hu, Bo Zhang, Li Li, Li Wan, Chuanhan Zhang, Wenlong Ya. Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:29218001. |
in this study, postnatal day-7 (p7) rat pups and primary hippocampal neurons were exposed to 2% isoflurane for 6 h. terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining was used to detect neuronal apoptosis, and the expression of proteins involved in apoptosis (cleaved caspase-3, bax and bcl-2) was assessed by western blot. |
2020-10-01 |
2023-08-13 |
rat |
| Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Songliu Yang, Kaijiang Yu, Mingyan Zha. Dexmedetomidine alleviates LPS-induced septic cardiomyopathy via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 11. 2020-10-01. PMID:29218102. |
the pathological examinations were performed on he- stained myocardium tissues, apoptosis was determined using tunel assay, mrna expression of nf-κb p65, caspase-3, caspase-8, bcl-2, bax, p53 and α7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Bowen Li, Lu Wang, Zheng Li, Weizhi Wang, Xiaofei Zhi, Xiaoxu Huang, Qiang Zhang, Zheng Chen, Xuan Zhang, Zhongyuan He, Jianghao Xu, Lu Zhang, Hao Xu, Diancai Zhang, Zekuan X. miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10. Molecular therapy. Nucleic acids. vol 9. 2020-10-01. PMID:29246308. |
notably, arhgap10 promoted mitochondria-dependent apoptosis by enhancing p53 expression, which was followed by bax trans-activation and caspase cleavage. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhaojin Du, Zhilei Qiu, Zhankun Wang, Xinsheng Wan. The inhibitory effects of soybean isoflavones on testicular cell apoptosis in mice with type 2 diabetes. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29250153. |
si exhibited an inhibitory effect on testicular tissue cell apoptosis in mice with type 2 diabetes, with this effect possibly mediated by a decreased expression of caspase-3 and bax and increased bcl-2 protein expression. |
2020-10-01 |
2023-08-13 |
mouse |
| Xueqin Pang, Rui Li, Dongtao Shi, Xudong Pan, Chen Ma, Guangbo Zhang, Chuanyong Mu, Weichang Che. Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells. Oncology letters. vol 14. issue 6. 2020-10-01. PMID:29250187. |
furthermore, the silencing of rtkn2 in the cells induced apoptosis by reducing the expression level of bax and increasing the expression level of bcl2. |
2020-10-01 |
2023-08-13 |
human |
| Lei Hu, Na Cai, Hui Ji. Pterostilbene attenuates myocardial ischemia-reperfusion injury via the phosphatidylinositol 3'-kinase-protein kinase B signaling pathway. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285084. |
the results demonstrated that treatment with ptb significantly reduced cardiomyocyte apoptosis, significantly increased bcl-2 and p-akt levels and decreased bax expression in the hearts of rats subjected to i/r injury. |
2020-10-01 |
2023-08-13 |
rat |
| Yi-Peng Gu, Xiao-Mei Yang, Zhen-Hua Duan, Ping Luo, Jiang-Hua Shang, Wei Xiao, Ye-Xing Tao, Da-Yan Zhang, Yun-Bo Zhang, Hua-Zhong Li. Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285137. |
furthermore, the altered expression levels, including the upregulation of bax and caspase 3, downregulation of bcl-2 and the increased bax/bcl-2 ratio, indicated that apoptosis occurred in cp exposed testes of mice; however, the alterations were reversed in mice treated with sip. |
2020-10-01 |
2023-08-13 |
mouse |
| Lina Sun, Lei Zhao, Dan Li, Shuai Xu, Xuexin Hou, Zhenjun L. Low risk HPV-6E6 induces apoptosis in bone marrow-derived dendritic cells. Oncology letters. vol 15. issue 1. 2020-10-01. PMID:29422974. |
furthermore, the expression of apoptosis-associated proteins, including p53, bcl2 associated x apoptosis regulator (bax), bcl2 homologous antagonist/killer (bak) and cytochrome |
2020-10-01 |
2023-08-13 |
mouse |
| Peng Qian, Li-Jie Yan, Yong-Qiang Li, Hai-Tao Yang, Hong-Yan Duan, Jin-Tao Wu, Xian-Wei Fan, Shan-Ling Wan. Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis. Experimental and therapeutic medicine. vol 15. issue 2. 2020-10-01. PMID:29434790. |
furthermore, the results revealed that the translocation of apoptosis regulator bax (bax) from the cytoplasm to the mitochondrial membrane serves an essential role in cisplatin-induced apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Agnieszka Gornowicz, Anna Bielawska, Wojciech Szymanowski, Halina Gabryel-Porowska, Robert Czarnomysy, Krzysztof Bielawsk. Mechanism of anticancer action of novel berenil complex of platinum(II) combined with anti-MUC1 in MCF-7 breast cancer cells. Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434943. |
the effect of combined treatment on the concentration of selected markers of apoptosis including proapoptotic b-cell lymphoma 2 associated x protein (bax), caspase-8, cytochrome |
2020-10-01 |
2023-08-13 |
Not clear |
| Yuanyi Zhang, Yan Qi, Yang Zhao, Hongyan Sun, Jingyan Ge, Zhonghui Li. Activin A induces apoptosis of mouse myeloma cells via the mitochondrial pathway. Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434978. |
in addition, activin a-induced promotion of ns-1 cell apoptosis was accompanied by upregulated expression of bcl2 associated x, apoptosis regulator (bax), but downregulated expression of b cell lymphoma-2 (bcl-2), resulting in an increase of the bax/bcl-2 ratio. |
2020-10-01 |
2023-08-13 |
mouse |
| Yuanyuan Zhang, Jianchun Lian, Xiaowei Wan. Actein inhibits cell proliferation and migration and promotes cell apoptosis in human non-small cell lung cancer cells. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435050. |
the protein expression levels of cytoplasmic bcl2 apoptosis regulator (bcl-2) and bcl2 associated x (bax) were markedly decreased, while the protein expression levels of mitochondrial bax, caspase-3, -9 and cytochrome |
2020-10-01 |
2023-08-13 |
human |
| Rajeev Gupta, Subhendu Ghos. JNK3 phosphorylates Bax protein and induces ability to form pore on bilayer lipid membrane. Biochimie open. vol 4. 2020-10-01. PMID:29450140. |
in cells undergoing apoptosis the pore formed by the phosphorylated bax could be important in cytochrome |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhipai Lyu, Jing Cao, Ju Wang, Hongmei Lia. Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1α, VEGF and p38 MAPK signaling pathway Experimental and therapeutic medicine. vol 15. issue 3. 2020-10-01. PMID:29456715. |
the results demonstrated that vitexin pretreatment significantly reduced neuronal apoptosis, and inhibited caspase-3 activity, apoptosis regulator bax protein expression and malondialdehyde levels in sevoflurane-induced newborn rats. |
2020-10-01 |
2023-08-13 |
rat |
| Sei Kuriyama, Tadahiro Tsuji, Tetsushi Sakuma, Takashi Yamamoto, Masamistu Tanak. PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. Cell death discovery. vol 4. 2020-10-01. PMID:29531808. |
multiple death signals influence mitochondria during apoptosis, and though many studies have attempted to elucidate these complicated pathways, bax oligomerization, an important step in the process, remains controversial. |
2020-10-01 |
2023-08-13 |
human |