| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David L Ebenezer, Panfeng Fu, Ramaswamy Ramchandran, Alison W Ha, Vijay Putherickal, Tara Sudhadevi, Anantha Harijith, Fabian Schumacher, Burkhard Kleuser, Viswanathan Nataraja. S1P and plasmalogen derived fatty aldehydes in cellular signaling and functions. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1865. issue 7. 2020-10-22. PMID:32171908. |
the 2-halofatty aldehydes and ∆2-hde activated jnk signaling, bax, cytoskeletal reorganization and apoptosis in mammalian cells. |
2020-10-22 |
2023-08-13 |
Not clear |
| Luyan Tang, Jian Li, Wenwen Fu, Wenyu Wu, Jinhua X. Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo. Aging. vol 11. issue 24. 2020-10-21. PMID:31866583. |
increased ros generation; induction of mitochondrial-mediated apoptosis via upregulation of bax and active caspases 3 and 9 and downregulation of bcl-2; and cell cycle arrest via downregulation of c-myc and cyclin d1 and upregulation of p21 were all enhanced after fads1 silencing in pig1 melanocytes. |
2020-10-21 |
2023-08-13 |
human |
| Anouar Feriani, Emna Khdhiri, Meriam Tir, Afoua Elmufti, Nizar Tlili, Raouf Hajji, Houcine Ammar, Noureddine Allouche, Souhir Abid, Lakhdar Ghazouani, Kais Mnafgu. (E)-N'-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis. Oxidative medicine and cellular longevity. vol 2020. 2020-10-21. PMID:32215169. |
7-hyd.hc inhibited the cardiac apoptosis by upregulating the expression of bcl-2 and downregulating the expression of bax and caspase-3 genes. |
2020-10-21 |
2023-08-13 |
rat |
| R F Li, S P Liu, Z H Yuan, J E Yi, Y N Tian, J Wu, L X We. Effects of induced stress from the live LaSota Newcastle disease vaccination on the growth performance and immune function in broiler chickens. Poultry science. vol 99. issue 4. 2020-10-20. PMID:32241469. |
this study demonstrated that vaccination-induced stress increased serum adrenocorticotropic hormone and cortisol, affected growth performance (average daily gain, average daily feed intake, and feed conversion ratio), and triggered apoptosis in spleen lymphocytes by downregulating the ratio of bcl-2 to bax and upregulating the gene expressions of caspase-3 and -9, which was concordant with the activation of the enzymatic activities of caspase-3 and -9. |
2020-10-20 |
2023-08-13 |
Not clear |
| Feng Liang, Xin Fu, Yunpengfei Li, Fanglei Ha. Desoxyrhapontigenin attenuates neuronal apoptosis in an isoflurane-induced neuronal injury model by modulating the TLR-4/cyclin B1/Sirt-1 pathway. AMB Express. vol 10. issue 1. 2020-10-20. PMID:32997222. |
neuronal apoptosis was assessed in the hippocampus using the tunel assay, and protein expression of caspase-3, bax, and bcl-2 was measured by western blotting. |
2020-10-20 |
2023-08-13 |
rat |
| Núria Arcarons, Meritxell Vendrell-Flotats, Marc Yeste, Elena Mercade, Manel López-Béjar, Teresa Moga. Cryoprotectant role of exopolysaccharide of Pseudomonas sp. ID1 in the vitrification of IVM cow oocytes. Reproduction, fertility, and development. vol 31. issue 9. 2020-10-19. PMID:31092307. |
however, supplementation with 10 and 100µgml-1 eps id1 led to increased expression of genes involved in epigenetic modifications (dna methyltransferase 3 alpha (dnmt3a) and k (lysine) acetyltransferase 2a (kat2a)) and apoptosis (bcl2 associated x apoptosis regulator (bax) and bcl2-like 1 (bcl2l1)). |
2020-10-19 |
2023-08-13 |
cattle |
| Cailing Gan, Yali Li, Yan Yu, Xi Yu, Hongyao Liu, Qianyu Zhang, Wenya Yin, Luoting Yu, Tinghong Y. Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo. Bioorganic & medicinal chemistry. vol 27. issue 21. 2020-10-19. PMID:31540827. |
the occurrence of apoptosis was associated with activation of caspase-3 and bax and decreased expression of bcl-2. |
2020-10-19 |
2023-08-13 |
Not clear |
| Daisuke S Yamamoto, Megumi Sumitani, Katsumi Kasashima, Hideki Sezutsu, Hiroyuki Matsuoka, Hirotomo Kat. A synthetic male-specific sterilization system using the mammalian pro-apoptotic factor in a malaria vector mosquito. Scientific reports. vol 9. issue 1. 2020-10-16. PMID:31160726. |
we recently demonstrated that expression of the mammalian pro-apoptotic factor, b-cell leukaemia/lymphoma 2-associated x protein (bax), can induce apoptosis in specific tissues by using tissue specific promoters in silkworm and mosquito. |
2020-10-16 |
2023-08-13 |
mouse |
| Qi Guo, Jing Zhang, Zhaoshi Zheng, Xinxin Li, Fuli Wang, Songyan Li. Lentivirus-mediated microRNA-26a-modified neural stem cells improve brain injury in rats with cerebral palsy. Journal of cellular physiology. vol 235. issue 2. 2020-10-16. PMID:31264214. |
the neurobehavioral functions, morphology, and ultrastructure of cerebral cortex and hippocampus, apoptosis of brain cells, expression of apoptosis-related protein caspase-3 and bax, together with the expression of the glial fibrillary acidic protein (gfap) in cerebral cortex and hippocampus were determined. |
2020-10-16 |
2023-08-13 |
rat |
| Liangde Jiang, Shuai Ca. Role of microRNA-26a in cartilage injury and chondrocyte proliferation and apoptosis in rheumatoid arthritis rats by regulating expression of CTGF. Journal of cellular physiology. vol 235. issue 2. 2020-10-16. PMID:31267533. |
the degree of secondary joint swelling and arthritis index, expression of mir-26a, pathological changes, proliferation and apoptosis of chondrocytes, and expression of ctgf, interleukin-1β (il-1β), il-6, tumor necrosis factor-α, bax, and bcl-2 were also determined through a series of experiments. |
2020-10-16 |
2023-08-13 |
rat |
| Bianka Bojková, Karol Kajo, Terézia Kisková, Peter Kubatka, Pavol Žúbor, Peter Solár, Martin Péč, Marián Adamko. Metformin and melatonin inhibit DMBA-induced mammary tumorigenesis in rats fed a high-fat diet. Anti-cancer drugs. vol 29. issue 2. 2020-10-15. PMID:29200002. |
tumor growth parameters were analyzed together with histopathological examination and immunohistochemical detection of ki67 (proliferation marker), caspase-3, bax, bcl-2 (apoptosis markers), and cd24 and cd44 (cancer stem cell markers) in mammary tumor samples. |
2020-10-15 |
2023-08-13 |
rat |
| Meng-Meng Li, Xiao-Hui Liu, Yi-Chen Zhao, Xiao-Ye Ma, Yu-Chen Zhou, Yan-Xin Zhao, Xue-Yuan Li. Long noncoding RNA KCNQ1OT1 promotes apoptosis in neuroblastoma cells by regulating miR-296-5p/Bax axis. The FEBS journal. vol 287. issue 3. 2020-10-15. PMID:31433907. |
previously, we found that the target genes of several mirnas, including fadd, fas, casp and bax, are related to neuronal apoptosis and form a regulatory network. |
2020-10-15 |
2023-08-13 |
Not clear |
| Meng-Meng Li, Xiao-Hui Liu, Yi-Chen Zhao, Xiao-Ye Ma, Yu-Chen Zhou, Yan-Xin Zhao, Xue-Yuan Li. Long noncoding RNA KCNQ1OT1 promotes apoptosis in neuroblastoma cells by regulating miR-296-5p/Bax axis. The FEBS journal. vol 287. issue 3. 2020-10-15. PMID:31433907. |
in summary, kcnq1ot1 is a potent promoting factor of cell apoptosis, which acts by sponging mir-296-5p and upregulating bax. |
2020-10-15 |
2023-08-13 |
Not clear |
| Muhammad Shahid Riaz Rajoka, Haobin Zhao, Hafiza Mahreen Mehwish, Na Li, Yao Lu, Ziyang Lian, Dongyan Shao, Mingliang Jin, Qi Li, Liqing Zhao, Junling Sh. Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk. Food research international (Ottawa, Ont.). vol 123. 2020-10-14. PMID:31284979. |
rt-qpcr and western blot analysis showed the induction of apoptosis was achieved via the up-regulation of bad, bax, caspase3, caspase8, caspase9, and down-regulation of bcl-2 genes in hela cells. |
2020-10-14 |
2023-08-13 |
human |
| Tomomi Kuwana, Louise E King, Katia Cosentino, Julian Suess, Ana J Garcia-Saez, Andrew P Gilmore, Donald D Newmeye. Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization. The Journal of biological chemistry. vol 295. issue 6. 2020-10-14. PMID:31901077. |
mitochondrial residence of the apoptosis inducer bax is more important than bax oligomerization in promoting membrane permeabilization. |
2020-10-14 |
2023-08-13 |
mouse |
| Tomomi Kuwana, Louise E King, Katia Cosentino, Julian Suess, Ana J Garcia-Saez, Andrew P Gilmore, Donald D Newmeye. Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization. The Journal of biological chemistry. vol 295. issue 6. 2020-10-14. PMID:31901077. |
the bcl-2-associated x apoptosis regulator (bax) protein critically contributes to this process by forming pores in the mitochondrial outer membrane. |
2020-10-14 |
2023-08-13 |
mouse |
| Tomomi Kuwana, Louise E King, Katia Cosentino, Julian Suess, Ana J Garcia-Saez, Andrew P Gilmore, Donald D Newmeye. Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization. The Journal of biological chemistry. vol 295. issue 6. 2020-10-14. PMID:31901077. |
yet, when transduced into cells, baxt182i resided predominantly on mitochondria, because of its slow retrotranslocation and mediated apoptosis as efficiently as wt bax. |
2020-10-14 |
2023-08-13 |
mouse |
| Yosra Ben Othmène, Hiba Hamdi, Intidhar Ben Salem, Emna Annabi, Ines Amara, Fadwa Neffati, Mohamed Fadhel Najjar, Salwa Abid-Essef. Oxidative stress, DNA damage and apoptosis induced by tebuconazole in the kidney of male Wistar rat. Chemico-biological interactions. vol 330. 2020-10-14. PMID:32735800. |
moreover, teb down-regulated the expression of bcl2 and up-regulated the expression of bax and caspase 3, which triggered apoptosis via the bax/bcl2 and caspase pathway. |
2020-10-14 |
2023-08-13 |
rat |
| Hongbin Chen, Wei Lin, Peiqiang Lin, Mouwei Zheng, Yongxing Lai, Manli Chen, Yixian Zhang, Jianhao Chen, Xiaohui Lin, Longzai Lin, Quan Lan, Qilin Yuan, Ronghua Chen, Xinhong Jiang, Yingchun Xiao, Nan Li. IL-10 produces a dual effect on OGD-induced neuronal apoptosis of cultured cortical neurons via the NF-κB pathway. Aging. vol 11. issue 23. 2020-10-09. PMID:31801113. |
the current study found that il-10 had distinct effects on the neuronal apoptosis at different ogd stages: at an early stage after ogd, il-10 promoted the ogd-induced neuronal apoptosis in the cultured primary cortical neurons by activating p65 subunit, which up-regulated bax expression and down-regulated bcl-xl expression; at a late ogd stage, however, it attenuated the ogd-induced neuronal apoptosis by activating c-rel, which up-regulated bcl-xl expression and down-regulated bax expression. |
2020-10-09 |
2023-08-13 |
Not clear |
| Xiaohe Fang, Yong Dong, Ruilin Yang, Lunshou We. LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML. Archives of biochemistry and biophysics. vol 689. 2020-10-09. PMID:32359894. |
ectopic expression and depletion experiments were conducted to assess the effects of linc00619, mir-224-5p and opcml on cell proliferation, invasion, migration and apoptosis as well as their effects on the expression of apoptosis- and metastasis-related genes (bcl-2, bax, mmp-2 and mmp-9). |
2020-10-09 |
2023-08-13 |
mouse |