| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roya Hosseini, Mohammad Reza Bigdeli, Sepideh Khaksar, Abbas Aliaghae. The Effect of Allograft Transplantation of Sertoli Cell on Expression of NF-кB, Bax Proteins, and Ischemic Tolerance in Rats with Focal Cerebral Ischemia. Iranian journal of pharmaceutical research : IJPR. vol 19. issue 2. 2020-11-24. PMID:33224215. |
probably, a reduction in inflammation (nf-кb factor) and apoptosis (bax) following injection of sertoli cells result in amelioration of ischemic damages induced by mcao surgery. |
2020-11-24 |
2023-08-13 |
rat |
| Wanatchaporn Arunmanee, Gea Abigail U Ecoy, Hnin Ei Ei Khine, Methawee Duangkaew, Eakachai Prompetchara, Pithi Chanvorachote, Chatchai Chaotha. Colicin N Mediates Apoptosis and Suppresses Integrin-Modulated Survival in Human Lung Cancer Cells. Molecules (Basel, Switzerland). vol 25. issue 4. 2020-11-23. PMID:32069989. |
the activation of extrinsic apoptosis evidenced with the reduction of c-flip and caspase-8, as well as the modulation of intrinsic apoptosis signaling proteins including bax and mcl-1 were observed via western blot analysis in lung cancer cells cultured with colicin n (10-15 µm) for 12 h. moreover, 5-15 µm of colicin n down-regulated the expression of activated akt (p-akt) and its upstream survival molecules, integrin β1 and αv in human lung cancer cells. |
2020-11-23 |
2023-08-13 |
human |
| Samuel Kumi Okyere, Quan Mo, Gao Pei, Zhihua Ren, Junliang Deng, Yanchun H. Euptox A Induces G0 /GI arrest and apoptosis of hepatocyte via ROS, mitochondrial dysfunction and caspases-dependent pathways in vivo. The Journal of toxicological sciences. vol 45. issue 11. 2020-11-23. PMID:33132240. |
the results showed that euptox a similarly induced hepatocyte g0 /gi arrest and apoptosis mainly by ros accumulation and mitochondria-mediated and caspase-dependent pathways, elucidated by the loss of mitochondrial membrane potential, release of cytochrome c and aif, activation of caspase-3/-9, bax, as well as suppression of bcl-2. |
2020-11-23 |
2023-08-13 |
mouse |
| Win-Long Lu, Chang-Tze Ricky Yu, Hsiu-Man Lien, Gwo-Tarng Sheu, Shur-Hueih Chern. Cytotoxicity of naringenin induces Bax-mediated mitochondrial apoptosis in human lung adenocarcinoma A549 cells. Environmental toxicology. vol 35. issue 12. 2020-11-20. PMID:32667124. |
knockdown of the bax expression by the shrna method dramatically protected a549 cells against ngen-induced apoptosis. |
2020-11-20 |
2023-08-13 |
human |
| Kiruthika Sundarraj, Azhwar Raghunath, Lakshmikanthan Panneerselvam, Ekambaram Peruma. Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells. BioFactors (Oxford, England). vol 46. issue 1. 2020-11-19. PMID:31634424. |
fisetin reduced the expression of bcl2, and elevated levels of bax, caspase-3, and parp and thus induced apoptosis in hepg2 cells. |
2020-11-19 |
2023-08-13 |
human |
| Jan Borys, Mateusz Maciejczyk, Bożena Antonowicz, Jarosław Sidun, Magdalena Świderska, Anna Zalewsk. Free Radical Production, Inflammation and Apoptosis in Patients Treated With Titanium Mandibular Fixations-An Observational Study. Frontiers in immunology. vol 10. 2020-11-18. PMID:31781128. |
the markers of inflammation [interleukin 1 (il-1), interleukin 6 (il-6), tumor necrosis factor α (tnf-α), transforming growth factor β (tgf-β) and β-glucuronidase (glu)] as well as apoptosis [bax, bax/bcl-2 ratio, caspase-3 (cas-3) and nitric oxide (no)] were significantly elevated in periosteum covering titanium fixations compared to the control group. |
2020-11-18 |
2023-08-13 |
human |
| Zhenjie Zhu, Min Ge, Chunlei Li, Liqiang Yu, Yudan Gu, Yuming Hu, Zhilong Ca. Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 78. 2020-11-17. PMID:32360159. |
compared with normal group, escape latency and inclined plane test time were prolonged, the number of passing through the platform and tail suspension time were reduced (all p < 0.05); bax and caspase-3 mrna and protein expression levels and p-p38 mapk protein level were increased, bcl-2 mrna level was decreased, and neuronal apoptosis proportion was increased in model group (all p < 0.05). |
2020-11-17 |
2023-08-13 |
rat |
| Fang Lei, Wen Wang, Yating Fu, Ji Wang, Yu Zhen. Mitochondrial KATP channels contribute to the protective effects of hydrogen sulfide against impairment of central chemoreception of rat offspring exposed to maternal cigarette smoke. PloS one. vol 15. issue 10. 2020-11-17. PMID:33064729. |
in addition, nahs declined pro-apoptotic proteins related to mitochondrial pathway apoptosis in cs rat offspring pfrg, such as bax, cytochrome c, caspase9 and caspase3. |
2020-11-17 |
2023-08-13 |
rat |
| Maryam Aghaei, Hossein KhanAhmad, Shahrzad Aghaei, Mohammad Ali Nilforoushzadeh, Mohammad-Ali Mohaghegh, Seyed Hossein Hejaz. The role of Bax in the apoptosis of Leishmania-infected macrophages. Microbial pathogenesis. vol 139. 2020-11-16. PMID:31778755. |
the role of bax in the apoptosis of leishmania-infected macrophages. |
2020-11-16 |
2023-08-13 |
Not clear |
| Maryam Aghaei, Hossein KhanAhmad, Shahrzad Aghaei, Mohammad Ali Nilforoushzadeh, Mohammad-Ali Mohaghegh, Seyed Hossein Hejaz. The role of Bax in the apoptosis of Leishmania-infected macrophages. Microbial pathogenesis. vol 139. 2020-11-16. PMID:31778755. |
in this review, we summarized the appropriate manuscripts regarding the bax includes, its different types and the effect of bax on the apoptosis of leishmania and parasite-infected macrophages. |
2020-11-16 |
2023-08-13 |
Not clear |
| Lingqi Yu, Jie Zheng, Junying Li, Yuzhen Wang, Xiaoyan Lu, Xiaohui Fa. Integrating serum exosomal microRNA and liver microRNA profiles disclose the function role of autophagy and mechanisms of Fructus Meliae Toosendan-induced hepatotoxicity in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 123. 2020-11-16. PMID:31855734. |
moreover, in vivo validation studies suggested that the protein expression levels of pten, p-akt, p53, and bax were indeed regulated in the mouse liver after high-dose fmt administration, indicating hepatocyte apoptosis may be mediated by these three pathways mentioned above. |
2020-11-16 |
2023-08-13 |
mouse |
| Sang-Seok Oh, Ki Won Lee, Hamadi Madhi, Jin-Woo Jeong, Soojong Park, Minju Kim, Yerin Lee, Hyun-Tak Han, Cheol Hwangbo, Jiyun Yoo, Kwang Dong Ki. Cordycepin Resensitizes T24R2 Cisplatin-Resistant Human Bladder Cancer Cells to Cisplatin by Inactivating Ets-1 Dependent MDR1 Transcription. International journal of molecular sciences. vol 21. issue 5. 2020-11-16. PMID:32131547. |
treatment with cordycepin or cisplatin (2 μg/ml) alone failed to induce cell death in t24r2 cells, but combination treatment with these drugs significantly induced apoptosis through mitochondrial pathways, including depolarization of mitochondrial membranes, decrease in anti-apoptotic proteins bcl-2, bcl-xl, and mcl-1, and increase in pro-apoptotic proteins bak and bax. |
2020-11-16 |
2023-08-13 |
human |
| Muhammad Shahid, Eduardo R Cobo, Liben Chen, Paloma A Cavalcante, Herman W Barkema, Jian Gao, Siyu Xu, Yang Liu, Cameron G Knight, John P Kastelic, Bo Ha. Prototheca zopfii genotype II induces mitochondrial apoptosis in models of bovine mastitis. Scientific reports. vol 10. issue 1. 2020-11-13. PMID:31959834. |
this p. zopfii gt-ii driven apoptosis corresponded to mitochondrial pathways; mitochondrial transmembrane resistance (ΔΨm) was altered and modulation of mitochondrion-mediated apoptosis regulating genes changed (increased transcriptional bax, cytochrome-c and apaf-1 and downregulated bcl-2), whereas caspase-9 and -3 expression increased. |
2020-11-13 |
2023-08-13 |
mouse |
| Wanpeng Wang, Han Zhao, Baihua Che. DJ-1 protects retinal pericytes against high glucose-induced oxidative stress through the Nrf2 signaling pathway. Scientific reports. vol 10. issue 1. 2020-11-13. PMID:32051471. |
our results showed after dj-1 overexpression, apoptosis of rat retinal pericytes (rrps) decreased, the ratio of b-cell lymphoma-2 (bcl-2) to bcl2-associated x protein (bax) increased, the production of ros decreased, and the protein expression and activity of manganese superoxide dismutase (mnsod, also called sod2) and catalase (cat) increased. |
2020-11-13 |
2023-08-13 |
rat |
| Wanpeng Wang, Han Zhao, Baihua Che. DJ-1 protects retinal pericytes against high glucose-induced oxidative stress through the Nrf2 signaling pathway. Scientific reports. vol 10. issue 1. 2020-11-13. PMID:32051471. |
dj-1 overexpression activated nrf2 expression, however, after nrf2 silencing, apoptosis of rrps increased, the ratio of bcl-2 to bax decreased, the production of ros increased, the protein expression of mnsod and cat decreased, and the expression of heme oxygenase-1 (ho-1), nadp(h) quinone oxidoreductase (nqo1), glutamate-cysteine ligase catalytic subunit (gclc) and modifier subunit (gclm) decreased. |
2020-11-13 |
2023-08-13 |
rat |
| Xin Zhou, Ningou Huang, Wenxin Chen, Tang Xiaoling, Behnam Mahdavi, Amir Raoofi, Davood Mahdian, Hadi Atabat. HPLC phenolic profile and induction of apoptosis by Linum usitatissimum extract in LNCaP cells by caspase3 and Bax pathways. AMB Express. vol 10. issue 1. 2020-11-13. PMID:33169228. |
hplc phenolic profile and induction of apoptosis by linum usitatissimum extract in lncap cells by caspase3 and bax pathways. |
2020-11-13 |
2023-08-13 |
Not clear |
| Jun-Ichi Takino, Takuma Sato, Kentaro Nagamine, Takamitsu Hor. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells. Scientific reports. vol 9. issue 1. 2020-11-12. PMID:31723205. |
the inhibition of bax activation-induced apoptosis by rasgrp2 via r-ras-pi3k-akt signaling pathway in the endothelial cells. |
2020-11-12 |
2023-08-13 |
human |
| Jun-Ichi Takino, Takuma Sato, Kentaro Nagamine, Takamitsu Hor. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells. Scientific reports. vol 9. issue 1. 2020-11-12. PMID:31723205. |
taken together, it was suggested that rasgrp2 suppresses the bax activation-induced apoptosis by promoting hk-2 translocation to mitochondria via r-ras-pi3k-akt signaling pathway. |
2020-11-12 |
2023-08-13 |
human |
| Nazila Jalilzadeh, Naser Samadi, Roya Salehi, Gholamreza Dehghan, Mehrdad Iranshahi, Mohammad Reza Dadpour, Hamed Hamishehka. Novel nano-vehicle for delivery and efficiency of anticancer auraptene against colon cancer cells. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32005894. |
real time pcr results indicated that bax /bcl2 expression ratio as an apoptosis predicting criterion, in free aur, aur loaded tb and aur loaded pb have increased 6, 9 and 13 times, respectively (p value < 0.05). |
2020-11-12 |
2023-08-13 |
Not clear |
| Leilei Zhang, Danyelle M Townsend, Morgan Morris, Eduardo N Maldonado, Yu-Lin Jiang, Ann-Marie Broome, Jennifer R Bethard, Lauren E Ball, Kenneth D Te. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. The Journal of pharmacology and experimental therapeutics. vol 374. issue 2. 2020-11-12. PMID:32546528. |
mechanistically, vdac1 and vdac2 knockdown prevented me-344-induced apoptosis by inhibiting bax mitochondrial translocation and cytochrome c release as well as apoptosis in these h460 cells. |
2020-11-12 |
2023-08-13 |
Not clear |