| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leilei Zhang, Danyelle M Townsend, Morgan Morris, Eduardo N Maldonado, Yu-Lin Jiang, Ann-Marie Broome, Jennifer R Bethard, Lauren E Ball, Kenneth D Te. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. The Journal of pharmacology and experimental therapeutics. vol 374. issue 2. 2020-11-12. PMID:32546528. |
we conclude that vdac1 and 2, as mediators of the response to oxidative stress, have roles in modulating ros generation, bax translocation, and cytochrome c release during mitochondrial-mediated apoptosis caused by me-344. |
2020-11-12 |
2023-08-13 |
Not clear |
| Azmat Ali Khan, Amer M Alanazi, Mumtaz Jabeen, Arun Chauhan, Mohammad Azam Ansar. Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice. Scientific reports. vol 9. issue 1. 2020-11-11. PMID:31676815. |
increased dna fragmentation and potential modulation of caspase-3, bax and bcl-2 factors specified the induction of apoptosis that helped in significant inhibition of hcc progression. |
2020-11-11 |
2023-08-13 |
mouse |
| Minna Yao, Ruili Li, Zhifu Yang, Yi Ding, Wei Zhang, Weiwei Li, Meiyou Liu, Chao Zhao, Yanhua Wang, Haifeng Tang, Jingwen Wang, Aidong We. PP9, a steroidal saponin, induces G2/M arrest and apoptosis in human colorectal cancer cells by inhibiting the PI3K/Akt/GSK3β pathway. Chemico-biological interactions. vol 331. 2020-11-10. PMID:32877639. |
meanwhile, pp9 upregulated cleaved caspase 3, cleaved caspase 9 and cleaved parp and bax, while downregulating bcl-2 to stimulate cell apoptosis. |
2020-11-10 |
2023-08-13 |
mouse |
| Shuang Wang, Shan Tang, Xuan Chen, Xin Li, Shuang Jiang, Hui-Ping Li, Pin-Hui Jia, Ming-Jie Song, Peng Di, Wei L. Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-κB and MAPK mediated apoptosis signaling pathways in mice. Chemico-biological interactions. vol 331. 2020-11-10. PMID:32991863. |
furthermore, pb4 regulated mapk signaling pathway and its downstream apoptotic factors to inhibit the occurrence of apoptosis, such as bax, bcl-2, caspase 3 and caspase 9. |
2020-11-10 |
2023-08-13 |
mouse |
| Liao Zi, Zhang Jia-Qiong, F U Xian-Yun, Wang Wei, Zhuang Ming-Ya. [Study on mechanism of Rhei Radix et Rhizoma-Persicae Semen in treatment of adenomyosis based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 17. 2020-11-10. PMID:33164395. |
animal experiments proved that the effective components of rhei radix et rhizoma and persicae semen can interfere with the p53 signaling pathway and the apoptotic signaling pathway at the junction of endometrial muscle layer, increase the expression of p53 and bax in muscle layer cells, and promote the apoptosis of cells with abnormal proliferation ability. |
2020-11-10 |
2023-08-13 |
mouse |
| Yongjie Xiong, Qirun Yin, Erhui Jin, Huatao Chen, Shaojun H. Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells. Molecules (Basel, Switzerland). vol 25. issue 3. 2020-11-09. PMID:32012916. |
the heat treatment for 6-48 h induced apoptosis, potentiated caspase 3 activity, increased the expression levels of apoptosis-related gene bax and er stress markers, glucose-regulated protein 78 (grp78), and ccaat/enhancer binding protein homologous protein (chop) in mouse granulosa cells. |
2020-11-09 |
2023-08-13 |
mouse |
| Yongjie Xiong, Qirun Yin, Erhui Jin, Huatao Chen, Shaojun H. Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells. Molecules (Basel, Switzerland). vol 25. issue 3. 2020-11-09. PMID:32012916. |
selenium treatment significantly attenuated the chs- or thapsigargin (tg, an er stress activator)-induced apoptosis, potentiation of caspase 3 activity, and the increased protein expression levels of bax, grp78, and chop. |
2020-11-09 |
2023-08-13 |
mouse |
| Lang Zhao, Kang Fu, Xiaoxing Li, Rui Zhang, Wenjun Wang, Feng Xu, Xiaoping Ji, Yuguo Chen, Chuanbao L. Aldehyde dehydrogenase 2 protects cardiomyocytes against lipotoxicity via the AKT/glycogen synthase kinase 3 beta pathways. Biochemical and biophysical research communications. vol 525. issue 2. 2020-11-09. PMID:32089266. |
in addition, aldehyde dehydrogenase 2 overexpression inhibited the expression of bcl2 associated x, apoptosis regulator (bax) and caspase 3, while it enhanced protein kinase b (akt) and glycogen synthase kinase 3 beta (gsk-3β) phosphorylation. |
2020-11-09 |
2023-08-13 |
Not clear |
| Ming Guo, Miao Lv, Yina Shao, Weiwei Zhang, Xuelin Zhao, Chenghua L. Bax functions as coelomocyte apoptosis regulator in the sea cucumber Apostichopus japonicus. Developmental and comparative immunology. vol 102. 2020-11-06. PMID:31494220. |
bax functions as coelomocyte apoptosis regulator in the sea cucumber apostichopus japonicus. |
2020-11-06 |
2023-08-13 |
Not clear |
| Ming Guo, Miao Lv, Yina Shao, Weiwei Zhang, Xuelin Zhao, Chenghua L. Bax functions as coelomocyte apoptosis regulator in the sea cucumber Apostichopus japonicus. Developmental and comparative immunology. vol 102. 2020-11-06. PMID:31494220. |
however, the functional role of bax in apoptosis in invertebrates is limited. |
2020-11-06 |
2023-08-13 |
Not clear |
| Debapriya De, Priyanka Chowdhury, Sujogya K Panda, Utpal Ghos. Ethanolic extract of leaf of Dillenia pentagyna reduces in-vitro cell migration and induces intrinsic pathway of apoptosis via downregulation of NF-κβ in human NSCLC A549 cells. Journal of cellular biochemistry. vol 120. issue 12. 2020-11-05. PMID:31318086. |
the intrinsic pathway of apoptosis was triggered by eeldp via the nf-κβ pathway through the increase of the bax to bcl |
2020-11-05 |
2023-08-13 |
human |
| L M Zhang, Q Y Zhu, L Chen, X Q Tang, Y F Zou, P Lv, M W Liu, Y F D. miR-382-3p Overexpression attenuates N-methyl-D-aspartate-induced HT22 cell apoptosis via the regulation of the RhoC/ROCK1 signaling pathway. Journal of biological regulators and homeostatic agents. vol 34. issue 4. 2020-11-05. PMID:32907306. |
the results found that nmda can increase the oxidative stress of ht22 cells in a dose-dependent manner, downregulate the expression of mir-382-3p, upregulate the expression of mrna and protein abundance of rock1 and rhoc, increase the expression levels of proapoptotic proteins bax, caspase-3, and caspase-9, increase the apoptosis of ht22 cells, and reduce the activity and survival rate of ht22 cells. |
2020-11-05 |
2023-08-13 |
Not clear |
| L M Zhang, Q Y Zhu, L Chen, X Q Tang, Y F Zou, P Lv, M W Liu, Y F D. miR-382-3p Overexpression attenuates N-methyl-D-aspartate-induced HT22 cell apoptosis via the regulation of the RhoC/ROCK1 signaling pathway. Journal of biological regulators and homeostatic agents. vol 34. issue 4. 2020-11-05. PMID:32907306. |
compared with the nmda-induced group, the mir-382-3p mimic-transfected ht22 cells increased the expression of mir- 382-3p, reduced the expression of the mrna and protein abundance of rock1 and rhoc, inhibited the expression of proapoptotic proteins bax, caspase-3, and caspase-9, reduced the apoptosis of ht22 cells, and increased the activity and survival rate of ht22 cells. |
2020-11-05 |
2023-08-13 |
Not clear |
| Markus Teucher, Hui Zhang, Verian Bader, Konstanze F Winklhofer, Ana J García-Sáez, Andrzej Rajca, Stephanie Bleicken, Enrica Bordigno. A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels. Scientific reports. vol 9. issue 1. 2020-11-04. PMID:31506457. |
bax is a bcl-2 protein crucial for apoptosis initiation and execution, whose active conformation is only partially understood. |
2020-11-04 |
2023-08-13 |
human |
| Fojan Agahi, Neda Álvarez-Ortega, Guillermina Font, Ana Juan-García, Cristina Jua. Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin. Toxicology letters. vol 334. 2020-11-04. PMID:32956828. |
it was further examined the expression of genes involved in cell apoptosis (casp3, bax, bcl2) and receptors of (endogenous or exogenous) estrogens (erβ and gper1), by rt-pcr in those same conditions. |
2020-11-04 |
2023-08-13 |
human |
| Fojan Agahi, Neda Álvarez-Ortega, Guillermina Font, Ana Juan-García, Cristina Jua. Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin. Toxicology letters. vol 334. 2020-11-04. PMID:32956828. |
also, the results revealed a significant increase in gsh/gssg ratio at all concentrations after 24 h. expression levels of casp3 and bax were up regulated by α-zel while casp3 and bcl2 were down regulated by β-zel, revealing how zea´s metabolites can induce the expression of cell apoptosis genes. |
2020-11-04 |
2023-08-13 |
human |
| Zita Bognar, Anna Maria Cseh, Katalin Fekete, Csenge Antus, Rita Bognar, Antal Tapodi, Fadi H J Ramadan, Balazs Sumegi, Ferenc Gallya. Amiodarone's major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model. PloS one. vol 15. issue 9. 2020-11-04. PMID:32977329. |
it arrested the cells in g0/g1 phase of their cycle likely via p21 in a p53-dependent fashion, and induced caspase mediated apoptosis likely via inversely regulating bcl-2 and bax levels, and reducing akt and erk1/2 activation. |
2020-11-04 |
2023-08-13 |
Not clear |
| Lijie Dong, Lulu Xie, Minjing Li, Hanhan Dai, Xia Wang, Peiyuan Wang, Qiang Zhang, Wei Liu, Xuemei Hu, Mingdong Zha. Downregulation of B7-H4 suppresses tumor progression of hepatocellular carcinoma. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31619714. |
knockdown b7-h4 expression induced hcc cells apoptosis by flow cytometry and colony formation assays and increased several apoptosis-related proteins, including survivin, cleaved caspase-3, cleaved caspase-7, and bax, while the pro-growth protein survivin was reduced. |
2020-11-02 |
2023-08-13 |
mouse |
| Garret Rochford, Zara Molphy, Kevin Kavanagh, Malachy McCann, Michael Devereux, Andrew Kellett, Orla How. Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis. Metallomics : integrated biometal science. vol 12. issue 1. 2020-11-02. PMID:31720645. |
these results indicate that while dna damage-induced apoptosis by bax, xiap and caspase-9 and -3 expression is moderate for the cu(ii) complexes when compared to cisplatin, protein targets independent of dna exert a multimodal mechanistic effect. |
2020-11-02 |
2023-08-13 |
Not clear |
| Xiu-Ying Qin, Ya-Nan Wang, Han-Fu Liu, Zhao-Hui Luo, Pei-Lu Zhang, Huang Li-Fang, Mei-Rong Li. Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis. Metallomics : integrated biometal science. vol 12. issue 1. 2020-11-02. PMID:31750487. |
anti-cancer activities of metal-based complexes by regulating the vegf/vegfr2 signaling pathway and apoptosis-related factors bcl-2, bax, and caspase-9 to inhibit angiogenesis and induce apoptosis. |
2020-11-02 |
2023-08-13 |
Not clear |