| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dainan Yu, Qingyun Liu, Bo Qiao, Wenyu Jiang, Lixia Zhang, Xin Shen, Liping Xie, Hui Liu, Dalei Zhang, Bei Yang, Haibin Kuan. Exposure to acrylamide inhibits uterine decidualization via suppression of cyclin D3/p21 and apoptosis in mice. Journal of hazardous materials. vol 388. 2020-12-31. PMID:31818667. |
furthermore, acr significantly reduced numbers of polyploidy and pcna-positive decidual cells and expression of cyclin d3 and p21 proteins, and induced apoptosis of decidua, as presented by up-regulation of bax and cleaved-caspase-3, and decreased bcl-2 protein during normal pregnant and pseudopregnant process. |
2020-12-31 |
2023-08-13 |
mouse |
| Lihong Wei, Yun Fan, Lingling Wei, Xiaoxia He, Jiaqing Yang, Xianzhao Zhen. Ablation of TMEM126B protects against oxygen-glucose deprivation/reoxygenation-induced injuries of PC12 cells via maintaining mitochondrial anti-apoptotic functions. Archives of biochemistry and biophysics. vol 696. 2020-12-31. PMID:33075301. |
tmem126b knockdown also attenuated cell apoptosis rate, accompanied with increased expressions of bcl-2, xiap and cleaved parp-1, and decreased expressions of bax, cleaved caspase 3 and cleaved caspase 9. |
2020-12-31 |
2023-08-13 |
Not clear |
| Lei Jiang, Yi-Ming Zhao, Ming-Zhen Yan. Inhibition of autophagy enhances apoptosis induced by bortezomib in AML cells. Oncology letters. vol 21. issue 2. 2020-12-31. PMID:33376542. |
bortezomib treatment induced cell apoptosis in nb4 cells, as assessed by annexin v/propidium iodide analysis, and the detection of cleaved caspase-3, cleaved poly(adp-ribose) polymerase, bax and bcl-2 expression. |
2020-12-31 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Richard Alexa, Abdel Halim Harrat. Puncturevine (Tribulus terrestris L.) affects the proliferation, apoptosis, and ghrelin response of ovarian cells. Reproductive biology. vol 20. issue 1. 2020-12-30. PMID:31924507. |
the expression levels of the proliferation marker pcna and the apoptosis marker bax were analyzed via quantitative immunocytochemical methods. |
2020-12-30 |
2023-08-13 |
Not clear |
| Ming Lu, Enliang Zho. Long noncoding RNA LINC00662-miR-15b-5p mediated GPR120 dysregulation contributes to osteoarthritis. Pathology international. vol 70. issue 3. 2020-12-30. PMID:32037689. |
the decreased gpr120 then contributes to increased expression of inflammatory factors including tumor necrosis factor α (tnf-α), interleukin (il)-6 and il-8, cell apoptosis, and decreased apoptosis-related protein levels including cleaved caspase-3, cleaved caspase-9, and bax in cultured rat chondrocytes. |
2020-12-30 |
2023-08-13 |
rat |
| Shengnan Liu, Li Li, Meihui Li, Junjie Zhan. Effect of miR-26b-5p on cis-diamine dichloroplatinum-induced ovarian granulosa cell injury by targeting MAP3K9. In vitro cellular & developmental biology. Animal. vol 56. issue 3. 2020-12-30. PMID:32185607. |
cell counting kit 8 (cck-8) was used to detect cell viability, flow cytometry was used to detect cell apoptosis, quantitative reverse transcription polymerase chain reaction (qrt-pcr) and western blot (wb) were used to analyze the expression of mir-26b-5p, map3k9, cleaved caspase-3, bax, and bcl-2; dual-luciferase reporter assay results further verify the targeting relation between mir-26b-5p and map3k9. |
2020-12-30 |
2023-08-13 |
rat |
| Jinxi Huang, Zhenhui Q. MiR-21 mediates the protection of kaempferol against hypoxia/reoxygenation-induced cardiomyocyte injury via promoting Notch1/PTEN/AKT signaling pathway. PloS one. vol 15. issue 11. 2020-12-23. PMID:33151961. |
results revealed that kaempferol obviously attenuates h/r-induced the damages of h9c2 cells as evidence by the up-regulation of cell viability, the down-regulation of lactate dehydrogenase (ldh) activity, the reduction of apoptosis rate and pro-apoptotic protein (bax) expression, and the increases of anti-apoptotic protein (bcl-2) expression. |
2020-12-23 |
2023-08-13 |
Not clear |
| K E Ying-Mei, Jiang Min, Zhou Shu-Bo, Y U Hong, Wang Juan, G E Fen. [Component analysis of Ophiocordyceps lanpingensis polysaccharides and study on alleviation of hepatic fibrosis in mice by polysaccharides]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 21. 2020-12-23. PMID:33350243. |
further study indicated that olp could restrain the apoptosis of hepatic cells due to the decrease of the apoptosis index and down-regulations of protein expression levels of bcl-2 associated x protein(bax), cysteinyl aspartate specific proteinase-3(caspase-3) and cysteinyl aspartate specific proteinase-9(caspase-9), and the promotion of protein expression level of b-cell lymphoma-2(bcl-2) in livers. |
2020-12-23 |
2023-08-13 |
mouse |
| Krzysztof Jan Witek, Adam J Ziecik, Izabela Małysz-Cymborska, Aneta Andronowsk. The presence of CC chemokines and their aberrant role in the porcine corpus luteum. Reproduction in domestic animals = Zuchthygiene. vol 55. issue 5. 2020-12-21. PMID:32119150. |
ccl2 treatment alone upregulated the expression of genes bax, bcl2 and star in cl cells in vitro, but additional experiments showed that the chemokines ccl2, ccl4 and ccl5 alone do not cause apoptosis in a mixed population of cl cells. |
2020-12-21 |
2023-08-13 |
Not clear |
| Nishat Fatima, Syed Habeeb Ahmed, S S Chauhan, Owais Mohammad, Syed Mohd Fazlur Rehma. Structural equation modelling analysis determining causal role among methyltransferases, methylation, and apoptosis during human pregnancy and abortion. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32709893. |
a significant and negative correlation (with p-value < 0.001) between the degree of p53 methylation during the first trimester and that of the expression level of tunel assay (apoptosis), p53, bax, and caspase-6 are also observed in the present study. |
2020-12-21 |
2023-08-13 |
human |
| Nishat Fatima, Syed Habeeb Ahmed, S S Chauhan, Owais Mohammad, Syed Mohd Fazlur Rehma. Structural equation modelling analysis determining causal role among methyltransferases, methylation, and apoptosis during human pregnancy and abortion. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32709893. |
the analysis performed using structural equation modelling (sem) further throws light on the causal relationship between sustenance of pregnancy or ursa during the first trimester of a human pregnancy and degree of methylation of p53 which is closely correlated with the interaction between g9amt, dnmt1, bcl-2, bax, p53, caspase-6, and apoptosis. |
2020-12-21 |
2023-08-13 |
human |
| Saurabh Sharma, Sudeep Sudesh Pukale, Deepak K Sahel, Devesh S Agarwal, Manu Dalela, Sujata Mohanty, Rajeev Sakhuja, Anupama Mittal, Deepak Chitkar. Folate-Targeted Cholesterol-Grafted Lipo-Polymeric Nanoparticles for Chemotherapeutic Agent Delivery. AAPS PharmSciTech. vol 21. issue 7. 2020-12-21. PMID:33037506. |
the developed f-dtx-lpns showed improved cytotoxicity, apoptosis, and significant fold-change in expression levels of bcl-2, bax and ki-67 as compared to non-targeted dtx-lpns and free dtx. |
2020-12-21 |
2023-08-13 |
rat |
| Xiangyu Cao, Mingyang Fu, Ruochen Bi, Xiaomei Zheng, Baorong Fu, Siqi Tian, Chengying Liu, Qijiu Li, Jianli Li. Cadmium induced BEAS-2B cells apoptosis and mitochondria damage via MAPK signaling pathway. Chemosphere. vol 263. 2020-12-21. PMID:33297271. |
meanwhile, the expression of b-cell lymphoma-2 (bcl-2) was downregulated, while the expression of bcl-2-associated x protein (bax) and the cleaved caspase-3 was upregulated, which indicated mitochondria-mediated intrinsic apoptosis pathway was activated. |
2020-12-21 |
2023-08-13 |
human |
| Yi He, Yong Chen, Daniel L Morris, Duck-Yeon Lee, Nico Tjandr. Bax expression is optimal at low oxygen tension and constant agitation. Protein expression and purification. vol 165. 2020-12-18. PMID:31542563. |
the structure of inactive bax has been solved, but despite intensive investigation, the mechanism by which it regulates apoptosis is not established. |
2020-12-18 |
2023-08-13 |
Not clear |
| Yasmin Hamdy Haddad, Riham S Said, Rehab Kamel, Engy M El Morsy, Ebtehal El-Demerdas. Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: co-operative role of ER-β, TGF-β, and FOXL-2. Scientific reports. vol 10. issue 1. 2020-12-18. PMID:32782329. |
mechanistically, gen inhibited the intrinsic pathway of apoptosis by repressing bax expression and augmenting bcl-2 expression resulted in reduced bax/bcl-2 ratio with subsequent reduction in cytochrome c and caspase 3 expression. |
2020-12-18 |
2023-08-13 |
rat |
| Qing Tao, Xianhe Wang, Lei Liu, Yongsheng Ji, Qingli Luo, Jian Du, Li Yu, Jilong Shen, Deyong Ch. Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis. Acta tropica. vol 210. 2020-12-17. PMID:32492398. |
furthermore, tgctwh6 infection also caused the increased expression of bax and caspase3, the decreased expression of bcl-xl in ht22 cells, which had both early and late apoptosis. |
2020-12-17 |
2023-08-13 |
mouse |
| Ryoko Ichikawa, Rie Kawasaki, Aya Iwata, Sayaka Otani, Eiji Nishio, Hiroyuki Nomura, Takuma Fuji. MicroRNA‑126‑3p suppresses HeLa cell proliferation, migration and invasion, and increases apoptosis via the PI3K/PDK1/AKT pathway. Oncology reports. vol 43. issue 4. 2020-12-16. PMID:32323808. |
in contrast, apoptotic‑related proteins including the bcl‑2‑associated agonist of cell death (bad), b‑cell lymphoma‑extra‑large (bcl‑xl) and bcl‑2‑associated x (bax), were all upregulated by mir‑126‑3p, resulting in increased caspase 3/7 activity and apoptosis. |
2020-12-16 |
2023-08-13 |
Not clear |
| Yakun Wang, Yinghui Qi, Tingting Ji, Bo Tang, Xiaoying Li, Pengxi Zheng, Shoujun Ba. Circ_LARP4 regulates high glucose-induced cell proliferation, apoptosis, and fibrosis in mouse mesangial cells. Gene. vol 765. 2020-12-16. PMID:32891769. |
as measured by western blot, circ_larp4 overexpression enhanced bax expression but reduced bcl-2 expression, also suggesting an enhancement of cell apoptosis. |
2020-12-16 |
2023-08-13 |
mouse |
| Huiying Huang, Michael Zepp, Rania B Georges, Mostafa Jarahian, Maryam Kazemi, Ergül Eyol, Martin R Berge. The CCR5 antagonist maraviroc causes remission of pancreatic cancer liver metastasis in nude rats based on cell cycle inhibition and apoptosis induction. Cancer letters. vol 474. 2020-12-15. PMID:31954769. |
the treatment significantly inhibited their proliferation and induced apoptosis of exposed cells as evidenced by caspases activation and increased bax levels. |
2020-12-15 |
2023-08-13 |
human |
| Yuji Nozaki, Jinhai Ri, Kenji Sakai, Kaoru Niki, Masanori Funauchi, Itaru Matsumur. Protective Effects of Recombinant Human Soluble Thrombomodulin on Lipopolysaccharide-Induced Acute Kidney Injury. International journal of molecular sciences. vol 21. issue 7. 2020-12-15. PMID:32260474. |
in this study using a mouse model of lps-induced aki, we found that rtm attenuated renal damage by reducing both cytokine and cell activation and apoptosis signals with the accumulation of cd4+ t-cells, cd11c+ cells, and f4/80+ cells via phospho c-jun activations and bax expression. |
2020-12-15 |
2023-08-13 |
mouse |