| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yinping Tong, Gongye Zhang, Yang Li, Jiajia Xu, Jiahui Yuan, Bing Zhang, Tianhui Hu, Gang Son. Corilagin inhibits breast cancer growth via reactive oxygen species-dependent apoptosis and autophagy. Journal of cellular and molecular medicine. 2021-01-09. PMID:29923307. |
the expression of procaspase-8, procaspase-3, parp, bcl-2 and procaspase-9 was down-regulated while caspase-8, cleaved parp, caspase-9 and bax were up-regulated after corilagin treatment, indicating apoptosis mediated by extrinsic and mitochondrial pathways occurred in mcf-7 cell. |
2021-01-09 |
2023-08-13 |
mouse |
| Chen Luo, Qilin Huang, Xiaohui Yuan, Yi Yang, Bing Wang, Zhu Huang, Lijun Tang, Hongyu Su. Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway. Apoptosis : an international journal on programmed cell death. vol 25. issue 3-4. 2021-01-08. PMID:32100210. |
notably, apd treatment enhanced cell apoptosis and reduced necrosis in pancreatic tissues, as evidenced by tunnel staining, the increased pro-apoptosis proteins (cleaved-caspase-3 and bax) and decreased anti-apoptosis protein (bcl-2). |
2021-01-08 |
2023-08-13 |
rat |
| Alexander V Sirotkin, Martina Macejková, Adam Tarko, Zuzana Fabova, Abdulkarem Alrezaki, Saleh Alwasel, Abdel Halim Harrat. Effects of benzene on gilts ovarian cell functions alone and in combination with buckwheat, rooibos, and vitex. Environmental science and pollution research international. vol 28. issue 3. 2021-01-08. PMID:32915450. |
cell viability, proliferation (accumulation of proliferating cell nuclear antigen, pcna), apoptosis (accumulation of bcl-2-associated x protein , bax), and the release of progesterone (p) and estradiol (e) were analyzed by the trypan blue test, quantitative immunocytochemistry, and enzyme-linked immunosorbent assay, respectively. |
2021-01-08 |
2023-08-13 |
Not clear |
| Haiwen Li, Zhiming Yang, Fuping Gao, Ruiqin Zhang, Chanjuan Cha. [Silencing miRNA210 Alleviates Myocardial Cell Damage in Myocarditis by Hypoxia Inducible Factor-vascular Endothelial Growth Factor Pathway]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 42. issue 5. 2021-01-08. PMID:33131511. |
objective to investigate the effect of mirna210 on primary myocardial cells in lipopolysaccharide(lps)-induced myocarditis.methods cck8 method was used to detect the effect of mirna210 on the viability of primary myocardial cells in normal or lps-induced myocarditis rats.elisa was performed to detect the secretion of tumor necrosis factor(tnf)-α and interleukin(il)-1β after mirna210 treatment.flow cytometry was used to detect the apoptosis of primary myocardial cells before and after the intervention.western blotting was used to detect the expression of tnf-α and il-1β.the expression of apoptosis-related proteins bcl-2,bax,caspase-3,and hypoxia inducible factor 1 (hif1)-vascular endothelial growth factor(vegf)were detected by western blotting.results cck8 detection results showed that,compared with the control group,the effect of mirna210 mimic( |
2021-01-08 |
2023-08-13 |
Not clear |
| Tongyu Rui, Zufeng Wang, Qianqian Li, Haochen Wang, Tao Wang, Mingyang Zhang, Luyang Tao, Chengliang Lu. A TrkB receptor agonist N-acetyl serotonin provides cerebral protection after traumatic brain injury by mitigating apoptotic activation and autophagic dysfunction. Neurochemistry international. vol 132. 2021-01-07. PMID:31760035. |
nas treatment decreased tbi-induced cell death and apoptosis activation (detected by propidium iodide labeling, tunel staining, blots for bcl-2, bax and caspase-3). |
2021-01-07 |
2023-08-13 |
mouse |
| Emílio Pereira de Brito Neto, Evelyze Pinheiro Dos Reis, Jurandy Mauro Penitente-Filho, José Carlos Montes, Karine Assis Costa, Susana Amaral Teixeira, Walmir Silva, Rogério Pinho, José Domingos Guimarães, Eduardo Paulino da Costa, Marcos Soares Lopes, Simone Eliza Facioni Guimarãe. Expression of apoptosis and myogenesis related genes during prenatal life in two divergent breeds of pigs. Theriogenology. vol 145. 2021-01-07. PMID:32004820. |
expression of apoptosis and myogenesis related genes (bax, bcl2, fgf4, ihh, hhip, shh, sox2, wnt1 and wnt4) were evaluated by quantitative real time pcr. |
2021-01-07 |
2023-08-13 |
Not clear |
| Yongxiang Xie, Fang Lan, Jie Zhao, Wei Sh. Hirudin improves renal interstitial fibrosis by reducing renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice. International immunopharmacology. vol 81. 2021-01-07. PMID:32066115. |
the apoptosis related proteins (pro-caspase3, pro-caspase9, bcl2 and bax) expression was also down-regulated in renal tissues of uuo rats. |
2021-01-07 |
2023-08-13 |
mouse |
| Yan Chang, Xinying Xue, Chunsun Li, Wei Zhao, Yongfu Ma, Fei Xu, Zhen Wu, Yu Dai, Yunjing Li, Yang Liu, Liang'an Che. MIR205HG facilitates carcinogenesis of lung squamous cell carcinoma in vitro revealed by long noncoding RNA profiling. Acta biochimica et biophysica Sinica. vol 52. issue 4. 2021-01-06. PMID:32188965. |
most importantly, our results showed that mir205hg prohibits lusc apoptosis via regulating bcl-2 and bax. |
2021-01-06 |
2023-08-13 |
human |
| Mengyu Xi, Wan He, Bo Li, Jinfeng Zhou, Zhijian Xu, Huiqun Wu, Yong Zhang, Dongliang Song, Liangning Hu, Ye Lu, Wenxuan Bu, Yuanyuan Kong, Gege Chen, Shuaikang Chang, Jumei Shi, Weiliang Zh. Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells. Acta biochimica et biophysica Sinica. vol 52. issue 4. 2021-01-06. PMID:32259210. |
western blot analysis results showed that the expression of caspase-3, caspase-8, caspase-9 and bax was increased, while bcl-2 and bcl-xl levels were decreased, which suggested that dcz0801 inhibited cell proliferation and promoted intrinsic apoptosis. |
2021-01-06 |
2023-08-13 |
mouse |
| Guangmeng Xu, Yajuan Sun, Huaiqiang He, Qiuli Xue, Yajie Liu, Lihua Don. Effect of TrkB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis. Acta biochimica et biophysica Sinica. vol 52. issue 6. 2021-01-06. PMID:32445466. |
mice in the model and k252a groups showed blocked enterocyte cycle progression, elevated apoptosis ratio, and significantly increased mrna and protein expressions of caspase3, bax, fasl, and fas, but significantly reduced mrna and protein expressions of p-trkb, plc-γ1, ip3, and bcl-2 (p<0.05). |
2021-01-06 |
2023-08-13 |
mouse |
| Seong-Hyun Park, Wooseok Ko, Sang-Hyun Park, Hyun Soo Lee, Injae Shi. Evaluation of the Interaction between Bax and Hsp70 in Cells by Using a FRET System Consisting of a Fluorescent Amino Acid and YFP as a FRET Pair. Chembiochem : a European journal of chemical biology. vol 21. issue 1-2. 2021-01-05. PMID:31206981. |
to gain insight into factors that lead to dissociation of bax from a complex with hsp70 during apoptosis, we recently constructed a fluorescence resonance energy transfer (fret) system composed of the hsp70-yfp (yfp=yellow fluorescent protein) fusion protein and fluorescent amino acid (anap=6-acetyl(naphthalen-2-ylamino)-2-aminopropanoic acid)-containing bax (bax-anap), which was produced by using the genetic code expansion technique. |
2021-01-05 |
2023-08-13 |
Not clear |
| Seong-Hyun Park, Wooseok Ko, Sang-Hyun Park, Hyun Soo Lee, Injae Shi. Evaluation of the Interaction between Bax and Hsp70 in Cells by Using a FRET System Consisting of a Fluorescent Amino Acid and YFP as a FRET Pair. Chembiochem : a European journal of chemical biology. vol 21. issue 1-2. 2021-01-05. PMID:31206981. |
in the current study, the fret system was employed to elucidate how brefeldin a (an endoplasmic reticulum stress inducer), chlorpromazine and apoptozole (lysosomal membrane destabilizers), bafilomycin a1 (an inhibitor of lysosomal acidification) as well as raptinal and az-tpp-o3 (mitochondria-targeted apoptosis inducers) affect the interaction between bax and hsp70. |
2021-01-05 |
2023-08-13 |
Not clear |
| Shenyu Wang, Gongyin Zhao, Shujie Zhao, Yusen Qiao, Huilin Yan. The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32312946. |
the use of an il-33 gene plasmid promoted osteosarcoma cell viability, inhibited cell apoptosis, increased the expression of bcl-2, and reduced the expression of bax. |
2021-01-05 |
2023-08-13 |
human |
| Yicong Chang, Liang Yuan, Jiarui Liu, Ishfaq Muhammad, Chuanbao Cao, Chenxi Shi, Yuanyuan Zhang, Rui Li, Changwen Li, Fangping Li. Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway. Veterinary research. vol 51. issue 1. 2021-01-05. PMID:32448367. |
dhm inhibited apoptosis through the reduction of the expression of bax and caspase-3 and restored the expression of bcl-2. |
2021-01-05 |
2023-08-13 |
chicken |
| Choong Heon Ryu, Sung Hyun Kim, Dae Young Hu. Nicotinamide adenine dinucleotide phosphate oxidase inhibitor induces apoptosis on Epstein-Barr virus positive B lymphoma cells. Anatomy & cell biology. vol 53. issue 4. 2021-01-05. PMID:33361545. |
the nox2 inhibitor also caused up-regulation of bim and noxa, down-regulation of mcl-1, translocation of bax, release of cytochrome c, and caspase cascade activation, resulting in apoptosis. |
2021-01-05 |
2023-08-13 |
Not clear |
| Wang-Qiang Chen, Cai-Fei Ding, Jia Yu, Chen-Ye Wang, Ling-Yi Wan, Hui-Min Hu, Jian-Xiong M. Wuzi Yanzong Pill-Based on Network Pharmacology and Frontiers in pharmacology. vol 11. 2021-01-05. PMID:33390971. |
the results showed that wzyzp treatment improved rat sperm quality and attenuated serum hormone levels, reversed histopathological damage of the testis, reduced cell apoptosis in testis tissues, and ameliorated the expression of the predicted hub targets (tp53, tnf-α, akt1, nfκb, and iκba) and the apoptosis related proteins (bcl-xl, bcl-2, bax, caspase 3, and caspase 9). |
2021-01-05 |
2023-08-13 |
human |
| Guanghua Che, Hang Gao, Jing Tian, Qibo Hu, Hongchang Xie, Yunfeng Zhan. MicroRNA-483-3p Promotes Proliferation, Migration, and Invasion and Induces Chemoresistance of Wilms' Tumor Cells. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 23. issue 2. 2021-01-04. PMID:31498707. |
mir-483-3p inhibited the doxorubicin-induced apoptosis in wilms' tumor cells by the regulation of bax and bcl-2 expression. |
2021-01-04 |
2023-08-13 |
Not clear |
| Gong-En Tang, Yue-Xiang Niu, Yun Li, Chao-Yu Wu, Xiao-Ying Wang, Jian Zhan. Paris saponin VII enhanced the sensitivity of HepG2/ADR cells to ADR via modulation of PI3K/AKT/MAPK signaling pathway. The Kaohsiung journal of medical sciences. vol 36. issue 2. 2021-01-04. PMID:31688993. |
compared with hepg2/adr cells treated with adr (5 nm), those treated with ps vii (≤1.98 μm) and adr (5 nm) showed enhanced adr accumulation, decreased drug-resistant gene expressions, increased cell apoptosis with unregulated bax and cleaved caspase-3 and downregulated bcl-2, as well as the inhibition of pi3k/akt/mapk pathway. |
2021-01-04 |
2023-08-13 |
Not clear |
| Qin Zhao, Fei Lu, Qinglun Su, Zhen Liu, Xiaomei Xia, Zhenzhuang Yan, Fang Zhou, Rujie Qi. Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis. Neuroscience letters. vol 715. 2021-01-04. PMID:31778769. |
in vitro, lps induced sci microglia cells as described by decreased cell viability and b cell lymphoma 2 (bcl-2) expression, and increased cell apoptosis rate, bax and cleaved caspase 3 levels, and tumor necrosis factor α (tnf-α) and interleukin 6 (il-6) secretions. |
2021-01-04 |
2023-08-13 |
rat |
| Do Hyeong Gwon, Woo-Yong Lee, Nara Shin, Song I Kim, Kuhee Jeong, Won-Hyung Lee, Dong Woon Kim, Jinpyo Hong, Sun Yeul Le. International journal of molecular sciences. vol 21. issue 7. 2021-01-04. PMID:32231148. |
gain of function experiments revealed that adenovirus-mediated ectopic expression of bmal1 in u87mg cells resulted in a 19% (adenovirus (ad)-vector 0.94± 0.03 vs. ad-bmal1 0.76 ± 0.03) decrease in cell proliferation compared with the control via downregulation of cyclin b1 and increased early and late apoptosis due to changes in the levels of bcl2-associated x protein (bax), b-cell lymphoma 2 (bcl-2), and cleaved caspase-3. |
2021-01-04 |
2023-08-13 |
Not clear |