| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shenglei Li, Feng Wang, Yunhui Qu, Xiaoqi Chen, Ming Gao, Jianping Yang, Dandan Zhang, Na Zhang, Wencai Li, Hongtao Li. HDAC2 regulates cell proliferation, cell cycle progression and cell apoptosis in esophageal squamous cell carcinoma EC9706 cells. Oncology letters. vol 13. issue 1. 2020-10-01. PMID:28123574. |
downregulation of hdac2 expression evidently inhibited cell proliferation, arrested cell cycle at the g0/g1 phase and induced cell apoptosis in escc ec9706 cells, coupled with increased expression of p21 and bax proteins and decreased expression of cyclin d1 and bcl-2 proteins. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ashish Kumar, T M Sivanandam, M K Thaku. Presenilin 2 overexpression is associated with apoptosis in Neuro2a cells. Translational neuroscience. vol 7. issue 1. 2020-10-01. PMID:28123824. |
to ascertain the role of ps2 in apoptosis, mouse neuroblastoma cells (neuro2a) were transfected with a cdna construct encoding full length mouse ps2 and analyzed for viability, expression of ps1, ps2, bax and p53, bax protein, and status of chromatin condensation. |
2020-10-01 |
2023-08-13 |
mouse |
| R Fardid, Zh Ghorbani, Gh Haddadi, A Behzad-Behbahani, R Arabsolghar, E Kazemi, M A Okhovat, S J Hosseinimeh. Effects of Hesperidin as a Radio-protector on Apoptosis in Rat Peripheral Blood Lymphocytes after Gamma Radiation. Journal of biomedical physics & engineering. vol 6. issue 4. 2020-10-01. PMID:28144590. |
this study aimed to evaluate the effects of hesperidin on the changes in the apoptosis level and expression of apoptotic genes target (bax, bcl-2 and ration of bax/bcl-2) in the peripheral blood lymphocytes of male rats after gamma radiation. |
2020-10-01 |
2023-08-13 |
human |
| Jie Lin, Li Jing, Hao Zhu, Fu-Sheng Don. Fundamental research on the action mechanism of the 800 nm semiconductor laser on skin blackheads and coarse pores. Experimental and therapeutic medicine. vol 13. issue 1. 2020-10-01. PMID:28428827. |
samples were extracted 1, 7 and 14 days after surgery and hematoxylin and eosin staining was used to identify the following: epidermis, dermis, sebaceous gland change and hair follicle damage; the expression of proliferating cell nuclear antigen (pcna) of sebaceous gland cells using immunohistochemistry; sebaceous gland cell apoptosis using tunel; and the protein expression of caspase-3, bax and bcl-2 using western blot analysis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhengfei Shan, Qingzuo Liu, Yuling Li, Jitao Wu, Dekang Sun, Zhenli Ga. PUMA decreases the growth of prostate cancer PC-3 cells independent of p53. Oncology letters. vol 13. issue 3. 2020-10-01. PMID:28454339. |
however, puma overexpression remained able to induce apoptosis in p53-silenced and control cells by increasing bax expression and decreasing bcl-2 expression, leading to the activation of caspase-3. |
2020-10-01 |
2023-08-13 |
human |
| Pengzhou Gai, Hongliang Sun, Guangda Wang, Qiang Xu, Xiaojun Qi, Zuofu Zhang, Lei Jian. miR-22 promotes apoptosis of osteosarcoma cells via inducing cell cycle arrest. Oncology letters. vol 13. issue 4. 2020-10-01. PMID:28454403. |
next, we found that overexpression of mir-22 remarkably increased the apoptosis of the mg-63 cells, evidenced from the flow cytometry results and elevated bax and reduced bcl-2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yali Song, Wei Cao, Xi Zhu, Zhuolin Qiu, Xiaoping Yang, Jing Liu, Ruoting Xu, Weizhuang Yuan, Song Qua. F10, a novel hydatidiform mole-associated gene, inhibits the paclitaxel sensitivity of A549 lung cancer cells by downregulating BAX and caspase-3. Oncology letters. vol 13. issue 4. 2020-10-01. PMID:28454434. |
the results of the current study demonstrate that f10 may inhibit the chemosensitivity of a549 cells to paclitaxel and that this inhibitory effect may be mediated by the downregulation of bax and caspase-3 expression, which subsequently inhibits cell apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ramu Venkatesan, Yong Un Park, Eunhee Ji, Eui-Ju Yeo, Sun Yeou Ki. Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer's disease. Cell death discovery. vol 3. 2020-10-01. PMID:28487766. |
malathion reduced cell viability mainly by apoptosis through mitochondrial dysfunction in n2a cells, as judged by an increase in the level of the pro-apoptotic protein bax and decrease in the levels of the anti-apoptotic proteins p-akt and bcl2, resulting in cytochrome |
2020-10-01 |
2023-08-13 |
mouse |
| Sukmin Kang, Eun-Ok Kim, Sung-Hoon Kim, Jun-Hee Lee, Kwang Seok Ahn, Miyong Yun, Seok-Geun Le. Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells. Oncology letters. vol 13. issue 6. 2020-10-01. PMID:28599457. |
morusin induces apoptosis by regulating expression of bax and survivin in human breast cancer cells. |
2020-10-01 |
2023-08-13 |
human |
| Deyou Wang, Sifeng Tang, Qiwen Zhan. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. Oncology letters. vol 13. issue 6. 2020-10-01. PMID:28599489. |
western blot analysis was performed in order to determine the differential expression levels of janus kinase (jak), signal transducer and activator of transcription 3 (stat3) and apoptosis associated proteins b-cell lymphoma 2 (bcl-2), bcl-2 associated x protein (bax) and bcl-2 associated agonist of cell death (bad). |
2020-10-01 |
2023-08-13 |
human |
| Deyou Wang, Sifeng Tang, Qiwen Zhan. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. Oncology letters. vol 13. issue 6. 2020-10-01. PMID:28599489. |
the results demonstrated that maslinic acid treatment significantly reduced cell proliferation, induced apoptosis and was accompanied by a significant decrease in bcl-2, bax and bad expression levels. |
2020-10-01 |
2023-08-13 |
human |
| Raquel Vinhas, Alexandra R Fernandes, Pedro V Baptist. Gold Nanoparticles for BCR-ABL1 Gene Silencing: Improving Tyrosine Kinase Inhibitor Efficacy in Chronic Myeloid Leukemia. Molecular therapy. Nucleic acids. vol 7. 2020-10-01. PMID:28624216. |
variation of bcl-2 and bax protein expression, an increase of caspase-3 activity, and apoptotic bodies in cells treated with the nanoconjugate demonstrate its aptitude for inducing apoptosis on k562 bcr-abl1-expressing cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hailiang Xu, Yunyun Feng, Zhankui Jia, Jinjian Yang, Xueren Lu, Jun Li, Mingliang Xia, Chunru Wu, Yonggang Zhang, Jianhua Che. AXIN1 protects against testicular germ cell tumors via the PI3K/AKT/mTOR signaling pathway. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693262. |
in addition, cell viability, apoptosis and the expression of apoptosis-associated proteins [apoptosis regulator bax (bax) and b-cell lymphoma (bcl)-2] and phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway proteins [phosphorylated (p)-mtor, mtor, p-akt, akt, p-70s ribosomal protein s6 (s6) and s6] were assessed. |
2020-10-01 |
2023-08-13 |
human |
| Hailiang Xu, Yunyun Feng, Zhankui Jia, Jinjian Yang, Xueren Lu, Jun Li, Mingliang Xia, Chunru Wu, Yonggang Zhang, Jianhua Che. AXIN1 protects against testicular germ cell tumors via the PI3K/AKT/mTOR signaling pathway. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693262. |
after overexpression of axin1, ntera2 cell viability and expression of bcl-2, p-mtor p-akt and p-s6 protein was decreased, while apoptosis and bax protein levels were increased, compared with the control group. |
2020-10-01 |
2023-08-13 |
human |
| Dafei Xie, Peiwen Yuan, Dong Wang, Hua Jin, Hui Che. Effects of naringin on the expression of miR-19b and cell apoptosis in human hepatocellular carcinoma. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28789364. |
the effects of naringin on the proliferation of hepg2 cells were observed by an mtt assay, morphological changes of cells were observed by an inverted microscope, cell apoptosis was detected by dapi staining, mir-19b mrna levels were determined with rt-pcr, and the expression of bax and bcl-2 proteins was examined by western blot assay. |
2020-10-01 |
2023-08-13 |
human |
| Dafei Xie, Peiwen Yuan, Dong Wang, Hua Jin, Hui Che. Effects of naringin on the expression of miR-19b and cell apoptosis in human hepatocellular carcinoma. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28789364. |
in addition, it can also upregulate the expression of bax protein and downregulate the expression of bcl-2 protein during the process of apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Claire Thornton, Bryan Leaw, Carina Mallard, Syam Nair, Masako Jinnai, Henrik Hagber. Cell Death in the Developing Brain after Hypoxia-Ischemia. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28878624. |
depending on several factors such as the metabolic situation, cell type, nature of the stress stimulus, and which intracellular organelle(s) are affected, the cell undergoes apoptosis (caspase activation) triggered by bax dependent mitochondrial permeabilzation, necroptosis (mixed lineage kinase domain-like activation), necrosis (via opening of the mitochondrial permeability transition pore), autophagic cell death (autophagy/na |
2020-10-01 |
2023-08-13 |
Not clear |
| Yang Geng, Yan Zhou, Sai Wu, Yabin Hu, Kai Lin, Yalin Wang, Zhongnan Zheng, Wei W. Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells. Journal of Cancer. vol 8. issue 13. 2020-10-01. PMID:28900483. |
sulforaphane induced apoptosis via promotion of mitochondrial fusion and erk1/2-mediated 26s proteasome degradation of novel pro-survival bim and upregulation of bax in human non-small cell lung cancer cells. |
2020-10-01 |
2023-08-13 |
human |
| Liya Su, Qimuge Suyila, Ling Yang, Hong Li, Yaguang Xi, Xiulan S. Bax is involved in the anticancer activity of Velcade in colorectal cancer. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:28912868. |
bcl-2-associated x protein (bax) is a proapoptotic protein that is an essential component of the intrinsic apoptosis signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Liya Su, Qimuge Suyila, Ling Yang, Hong Li, Yaguang Xi, Xiulan S. Bax is involved in the anticancer activity of Velcade in colorectal cancer. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:28912868. |
patients lacking bax may be less sensitive to chemotherapy due to an impaired intrinsic apoptosis signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |