| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wanhu Zhu, Qing Liang, Xu Yang, Yan Yu, Xiaoying Shen, Guangchun Su. Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt. American journal of cancer research. vol 7. issue 12. 2020-09-30. PMID:29312803. |
co-treatment of sorafenib and vpa synergistically inhibited hcc cell viability, induced cell apoptosis, along with the up-regulation of p21, bax, cleaved caspase9, cleaved caspase3, cleaved parp and down-regulation of bcl-xl, suggesting this combination activated intrinsic apoptotic pathway. |
2020-09-30 |
2023-08-13 |
mouse |
| Jian-Hong Dang, Zhi-Jun Jin, Xiao-Jun Liu, Dian Hu, Jing Wang, Yan Luo, Ling-Ling L. Metformin in combination with cisplatin inhibits cell viability and induces apoptosis of human ovarian cancer cells by inactivating ERK 1/2. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344202. |
flow cytometry was performed to examine cell apoptosis, and western blotting was used to measure the expression of extracellular signal-related kinase 1/2 (erk1/2) phosphorylated (p)-erk1/2, vascular endothelial growth factor (vegf), vegf receptor 2 (vegfr2), b-cell lymphoma 2 (bcl-2), bcl-2-associated x (bax) and caspase-3. |
2020-09-30 |
2023-08-13 |
human |
| Jian-Hong Dang, Zhi-Jun Jin, Xiao-Jun Liu, Dian Hu, Jing Wang, Yan Luo, Ling-Ling L. Metformin in combination with cisplatin inhibits cell viability and induces apoptosis of human ovarian cancer cells by inactivating ERK 1/2. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344202. |
in addition, erk1/2 and genes associated with apoptosis regulation, such as vegf, vegfr2, bcl-2, bax and caspase-3, exhibited differential expression in the ho-8910 cells. |
2020-09-30 |
2023-08-13 |
human |
| Ghada Hosny, Wesam Ismail, Rania Makboul, Fatma A M Badary, Thanaa M M Sotouh. Increased glomerular Bax/Bcl2 ratio is positively correlated with glomerular sclerosis in lupus nephritis. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 25. issue 2. 2020-09-30. PMID:29501391. |
we investigated the relation between the expression of two major proteins of the intrinsic pathway of apoptosis; bcl2 as an antiapoptotic protein and bax as a proapoptotic one; in renal tissue of ln. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kun Guo, Wei Wang, Weiwei Fan, Zhiying Wang, Manli Zhu, Xiaohan Tang, Wenting Wu, Xue Yang, Xinghua Shao, Yue Sun, Wei Zhang, Xiaofang L. Arabidopsis GAAP1 and GAAP3 Modulate the Unfolded Protein Response and the Onset of Cell Death in Response to ER Stress. Frontiers in plant science. vol 9. 2020-09-30. PMID:29616060. |
the function of human golgi antiapoptotic proteins (gaaps) resembles that of bax inhibitor-1, with apoptosis inhibition triggered by intrinsic and extrinsic stimuli. |
2020-09-30 |
2023-08-13 |
human |
| Jun-De Zhu, Jun-Jie Wang, Xian-Hu Zhang, Yan Yu, Zhao-Sheng Kan. Neural regeneration research. vol 13. issue 4. 2020-09-30. PMID:29722318. |
furthermore, panax ginseng extract reduced the number of glial fibrillary acidic protein-immunoreactive cells, and it decreased apoptosis by upregulating bcl-2 and downregulating bax protein expression. |
2020-09-30 |
2023-08-13 |
rat |
| Qian-Ming Qi, Yin-Cun Xue, Jian Lv, Di Sun, Jian-Xin Du, Sheng-Qiang Cai, Yun-He Li, Tian-Cun Gu, Mu-Bing Wan. Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29725398. |
ginkgolic acids may induce malignant cell death via the b-cell lymphoma 2 (bcl-2)-associated x protein (bax)/bcl-2 apoptosis pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Zhang, Hongmei Chen, Mingfei Wang, Xiaojing Song, Fanghui Ding, Jun Zhu, Xun L. Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29725429. |
these effects were accompanied by downregulation of p16, e-cadherin and apoptosis regulator bcl-2 protein, and upregulation of n-cadherin, apoptosis regulator bax and caspases 3, 8 and 9. |
2020-09-30 |
2023-08-13 |
human |
| Dong Chen, Junyi Chen, Yihong Guo, Yining L. Cinobufacini promotes apoptosis of bladder cancer cells by influencing the expression of autophagy-related genes. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29725433. |
flow cytometry and hoechst staining were used to detect the changes in the apoptosis of bladder cancer cells after being treated with cinobufacini; the changes in the expression levels of human bladder cancer cell apoptosis-related genes and proteins, cleaved caspase-3, bax, b-cell lymphoma-2 (bcl-2) and autophagy-related genes and proteins, p62, light chain 3 (lc3) and autophagy-related protein 7 (atg7) after treatment with cinobufacini were detected by western blot analysis and reverse transcription polymerase chain reaction (rt-pcr). |
2020-09-30 |
2023-08-13 |
human |
| Wei Li, Huiqin Chen, Hao Deng, Zhenzhan Kuang, Mingjian Long, Daxiang Chen, Xiaoqing Liao, Ming Li, Daniel L Rock, Shuhong Luo, Wenbo Ha. Orf Virus Encoded Protein ORFV119 Induces Cell Apoptosis Through the Extrinsic and Intrinsic Pathways. Frontiers in microbiology. vol 9. 2020-09-30. PMID:29896166. |
protein array data indicated that orfv119 could induce apoptosis via up-regulation of smac, bak, and bax and down-regulation of anti-apoptotic proteins bcl-2 and ciap-2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Meifen Chu, Tongtong Wang, Aihua Sun, Yu Che. Nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of PTEN. Experimental and therapeutic medicine. vol 16. issue 1. 2020-09-30. PMID:29896263. |
western blot analysis demonstrated that nimesulide increased expression of cleaved caspase-3 and apoptosis regulator bax (bcl-2 associated protein x), and decreased the expression of pro-caspase-3 and apoptosis regulator bcl-2 (b-cell lymphoma 2). |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiangrong Liu, Shaohong Wen, Shunying Zhao, Feng Yan, Shangfeng Zhao, Di Wu, Xunming J. Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP. Aging and disease. vol 9. issue 3. 2020-09-30. PMID:29896428. |
our results showed that mild therapeutic hypothermia increased the expression of iaspp and decreased the expression of its targets, puma and bax, and an apoptosis marker, cleaved caspase-3, in primary neurons under ogd/r. |
2020-09-30 |
2023-08-13 |
mouse |
| Kuai Zhou, Hai-Yuan Yang, Peng-Yu Tang, Wei Liu, Yong-Jun Luo, Bin Lv, Jian Yin, Tao Jiang, Jian Chen, Wei-Hua Cai, Jin Fa. Mitochondrial division inhibitor 1 protects cortical neurons from excitotoxicity: a mechanistic pathway. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127115. |
twenty-four hours after 10 mm glutamate treatment, drp1, bax and caspase-3 expression was upregulated, drp1 and bax were translocated to mitochondria, mitochondrial membrane potential was decreased and the rate of apoptosis was increased. |
2020-09-30 |
2023-08-13 |
rat |
| Xiaoxue Wu, Yundan Xu, Biran Zhu, Qiang Liu, Qunfeng Yao, Gang Zha. Resveratrol induces apoptosis in SGC-7901 gastric cancer cells. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127883. |
furthermore, cell cycle and apoptosis were detected using flow cytometry, and the expression levels of nuclear factor κb (nf-κb) as well as apoptosis-associated proteins [b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein (bax), cleaved caspase-3 and cleaved caspase-8] were analyzed by western blotting. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaolan Wang, Dianlong Zhang, Mingqian Cao, Jinling Ba, Bin Wu, Tao Liu, Chen Ni. A study on the biological function of heat shock factor 1 proteins in breast cancer. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127907. |
in conclusion, hsf1 protein, as a transcription factor, regulates the expression levels of hsp70, hsp90, mif, bcl-2 and bax, thus controlling the proliferation, apoptosis and invasion of cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shuna Yao, Yanyan Liu, Zhihua Yao, Yan Zhao, Haiying Wang, Yuanlin Xu, Jiuyang Zhang, Jing Li, Shujun Yan. MicroRNA-376a regulates cell proliferation and apoptosis by targeting forkhead box protein P2 in lymphoma. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127911. |
mir-376a overexpression inhibited lymphoma cell proliferation and induced apoptosis by regulating the expression levels of cyclin d2, cyclin a, bax and bcl-2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaolan Wang, Dianlong Zhang, Mingqian Cao, Jinling Ba, Bin Wu, Tao Liu, Chen Ni. A study on the biological function of heat shock factor 1 proteins in breast cancer. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127994. |
in conclusion, hsf1 protein, as a transcription factor, regulates the expression levels of hsp70, hsp90, mif, bcl-2 and bax, thus controlling the proliferation, apoptosis and invasion of cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zhong Wang, Feng Liu, Jian-Jun Yu, Ji-Zhong Ji. β-Bourbonene attenuates proliferation and induces apoptosis of prostate cancer cells. Oncology letters. vol 16. issue 4. 2020-09-30. PMID:30197674. |
taken together, β-bourbonene can inhibit the proliferation and simultaneously, induce apoptosis and g0/g1 arrest of prostate cancer pc-3m cells, which may be realized by upregulation of mrna expression of fas and fasl, increase of bax protein expression and decrease of bcl-2 protein expression. |
2020-09-30 |
2023-08-13 |
human |
| Mehdi Nikbakht Dastjerdi, Asaad Azarnezhad, Batool Hashemibeni, Mansour Salehi, Mohammad Kazemi, Zahra Babazade. An Effective Concentration of 5-Aza-CdR to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line through Reactivating RASSF1A and Up-Regulation of Bax Genes. Iranian journal of medical sciences. vol 43. issue 5. 2020-09-30. PMID:30214106. |
an effective concentration of 5-aza-cdr to induce cell death and apoptosis in human pancreatic cancer cell line through reactivating rassf1a and up-regulation of bax genes. |
2020-09-30 |
2023-08-13 |
human |
| Ying-Jie Hu, Jing-Ying Zhang, Qian Luo, Jia-Rui Xu, Yan Yan, Li-Min Mu, Jing Bai, Wan-Liang L. Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis. Nanomaterials (Basel, Switzerland). vol 8. issue 10. 2020-09-30. PMID:30304783. |
besides, bax activated apoptosis which led to the type i programmed death of breast cancer cells while beclin 1 initiated the excessive autophagy that resulted in the type ii programmed death of breast cancer cells. |
2020-09-30 |
2023-08-13 |
mouse |