| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huihui Li, Yichang Fan, Fan Yang, Lei Zhao, Bangwei Ca. The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells. Oncology letters. vol 16. issue 1. 2020-09-29. PMID:29928421. |
the combination of apatinib and tripterine significantly inhibited the proliferation, migration and invasion ability and promoted the apoptosis of hep3b cells by downregulating the expression of p-akt and p-erk, and upregulating the expression of caspase-3 and bax. |
2020-09-29 |
2023-08-13 |
human |
| Hai-Ying Cui, Xiang-Jian Zhang, Yi Yang, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Miao, Rong Che. Rosmarinic acid elicits neuroprotection in ischemic stroke Neural regeneration research. vol 13. issue 12. 2020-09-29. PMID:30323140. |
ra (20 and 40 mg/kg) greatly improved neurological function, reduced infarct volume, decreased cell apoptosis, upregulated bcl-2 protein and mrna expression, downregulated bax protein and mrna expression, increased ho-1 and nrf2 protein and mrna expression, increased superoxide dismutase activity, and decreased malondialdehyde levels in ischemic brain tissue of model mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Paul S Jeng, Akane Inoue-Yamauchi, James J Hsieh, Emily H Chen. BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis. Current opinion in physiology. vol 3. 2020-09-29. PMID:30334018. |
bh3-dependent and independent activation of bax and bak in mitochondrial apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Zhenbo Liu, Jun Xie, Kai Lin, Liguo Q. Influencing mechanism of magnolol on expression of BDNF and Bax in rats with cerebral ischemic stroke. Experimental and therapeutic medicine. vol 16. issue 6. 2020-09-29. PMID:30542392. |
in conclusion, magnolol can increase the expression of bdnf and decrease the expression of bax, thereby inhibiting apoptosis to protect the nerves, and magnolol can improve cerebral ischemic stroke in rats. |
2020-09-29 |
2023-08-13 |
rat |
| Yipu Fan, Weikang Xue, Melitta Schachner, Weijiang Zha. Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells Via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor. Cancers. vol 11. issue 1. 2020-09-29. PMID:30587839. |
in addition, honokiol promoted apoptosis and reduced bcl-2 expression, accompanied by increase in bax expression. |
2020-09-29 |
2023-08-13 |
mouse |
| Jinti Lin, Renjin Lin, Shihen Li, Hongqiang Wu, Jian Ding, Guangheng Xiang, Shi Li, Yiru Wang, Dingsheng Lin, Weiyang Gao, Jianzhong Kong, Huazi Xu, Kailiang Zho. Protective effects of resveratrol on random-pattern skin flap survival: an experimental study. American journal of translational research. vol 11. issue 1. 2020-09-29. PMID:30787995. |
moreover, rev decreased the levels of bax, cyc, and caspase3, suggesting that it inhibits apoptosis. |
2020-09-29 |
2023-08-13 |
rat |
| Chuang Yang, Bo Li, Yongsheng Liu, Yue Xin. Ginsenoside Rb1 protects cardiomyocytes from oxygen-glucose deprivation injuries by targeting microRNA-21. Experimental and therapeutic medicine. vol 17. issue 5. 2020-09-29. PMID:30988756. |
it was demonstrated that gs-rb1 could reduce intracellular ros content, and the expression of cytochrome c and the pro-apoptosis protein, apoptosis regulator b-cell lymphoma associated x (bax) protein while increasing the expression of the anti-apoptosis protein, apoptosis regulator bcl-2. |
2020-09-29 |
2023-08-13 |
rat |
| Boxue Ren, Lei Ye, Jianwei Gong, Huanhuan Ren, Yangfang Ding, Xiaoyu Chen, Xiaona Liu, Peng Lu, Fei Wei, Wenjuan Xu, Qiusheng Zheng, Defang L. Alteronol Enhances the Anti-tumor Activity and Reduces the Toxicity of High-Dose Adriamycin in Breast Cancer. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31001113. |
moreover, co-treatment of alteronol and adm (i) remarkably activated p38 and jnk kinases, (ii) elevated ros levels, (iii) triggered mitochondrial dysfunction, (iv) released cytochrome c into the cytoplasm, (v) upregulated apoptosis-related proteins, e.g., cleaved parp, bax, and cleaved caspase-3/9, and (vi) downregulated the expression of bcl-2, followed by apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hongwen Cao, Yigeng Feng, Lei Chen, Chao Y. Lobaplatin Inhibits Prostate Cancer Proliferation and Migration Through Regulation of BCL2 and BAX. Dose-response : a publication of International Hormesis Society. vol 17. issue 2. 2020-09-29. PMID:31217754. |
meanwhile, lobaplatin treatment regulates apoptosis by downregulation of bcl2 expression and upregulation of bax expression levels. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yang Xu, Shun Yao, Dongmei Gao, Wenhua Li, Di Zheng, Quan Zhan. Effect of astaxanthin on apoptosis of rat renal tubular epithelial cells induced by iohexol. American journal of translational research. vol 11. issue 5. 2020-09-29. PMID:31217873. |
subsequently, the nuclear morphology was observed by fluorescence staining of dapi dna, the apoptosis was detected by flow cytometry, the mitochondrial membrane potential was detected by jc-1 and the sirt1, p53, bax, bcl-2 protein expression level was detected by western blotting. |
2020-09-29 |
2023-08-13 |
rat |
| Shangli Ji, Jie Xiao, Jian Liu, Shibo Tan. Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway. Stem cells international. vol 2019. 2020-09-29. PMID:31737079. |
retinal cell apoptosis was examined by tunel staining and bax expression 14 days following huc-msc transplantation. |
2020-09-29 |
2023-08-13 |
human |
| Chong-Shan Shi, John H Kehr. Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL. Cell death discovery. vol 5. 2020-09-29. PMID:31839993. |
bcl-2 prevents apoptosis and promotes cellular survival by neutralizing bh3 domain-containing proteins, which directly activate the pore-forming proteins bax and bak. |
2020-09-29 |
2023-08-13 |
Not clear |
| Zhaohai Pan, Yongchuan Luo, Yuan Xia, Xin Zhang, Yao Qin, Wenjing Liu, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang L. Cinobufagin induces cell cycle arrest at the S phase and promotes apoptosis in nasopharyngeal carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 122. 2020-09-29. PMID:31918288. |
further analyses demonstrated that cinobufagin induces cell cycle arrest at the s phase in hk-1 cells through downregulating the levels of cdk2 and cyclin e. moreover, cinobufagin significantly downregulates the protein level of bcl-2 and upregulates the levels of bax, subsequently increasing the levels of cytoplasmic cytochrome c, apaf-1, cleaved parp1, cleaved caspase-3, and cleaved caspase-9, leading to hk-1 apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Muhammad Imran, Tanweer Aslam Gondal, Muhammad Atif, Muhammad Shahbaz, Tahira Batool Qaisarani, Muhammad Hanif Mughal, Bahare Salehi, Miquel Martorell, Javad Sharifi-Ra. Apigenin as an anticancer agent. Phytotherapy research : PTR. vol 34. issue 8. 2020-09-29. PMID:32059077. |
it induces intrinsic apoptosis pathway as evidenced by the induction of cytochrome c, bax, and caspase-3, while caspase-8, tnf-α, and b-cell lymphoma 2 levels remained unchanged in human prostate cancer pc-3 cells. |
2020-09-29 |
2023-08-13 |
human |
| Giovanna Priante, Monica Ceol, Lisa Gianesello, Claudio Furlan, Dorella Del Prete, Franca Anglan. Human proximal tubular cells can form calcium phosphate deposits in osteogenic culture: role of cell death and osteoblast-like transdifferentiation. Cell death discovery. vol 5. 2020-09-28. PMID:30701089. |
qrt/pcr, immunolabeling and cytochemistry were performed to assess osteogenic activation (runx2, osteonectin, osteopontin and alp), and early genes of apoptosis (bax, bcl-2). |
2020-09-28 |
2023-08-13 |
human |
| Giovanna Priante, Monica Ceol, Lisa Gianesello, Claudio Furlan, Dorella Del Prete, Franca Anglan. Human proximal tubular cells can form calcium phosphate deposits in osteogenic culture: role of cell death and osteoblast-like transdifferentiation. Cell death discovery. vol 5. 2020-09-28. PMID:30701089. |
the importance of apoptosis was reinforced by the time-dependent increase in bax expression, starting from day 1. |
2020-09-28 |
2023-08-13 |
human |
| Li Dong, Boris Reljic, Jen G Cheung, Elizabeth S Ng, Lisa M Lindqvist, Andrew G Elefanty, David L Vaux, Hoanh Tra. In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose. Cell death and differentiation. vol 26. issue 10. 2020-09-28. PMID:30770875. |
withdrawal of the growth factor interleukin-3 (il-3) from il-3-dependent myeloid cells causes them to undergo bax/bak1-dependent apoptosis, whereas factor-deprived bax |
2020-09-28 |
2023-08-13 |
Not clear |
| Daisuke Watanabe, Ayako Nogami, Keigo Okada, Hiroki Akiyama, Yoshihiro Umezawa, Osamu Miur. FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. Cancers. vol 11. issue 12. 2020-09-28. PMID:31756944. |
furthermore, inhibition of rsk1 increased sensitivities to bh3 mimetics inhibiting mcl-1 or bcl-2 and induced activation of bax, leading to apoptosis, as well as inhibition of proliferation synergistically with inhibition of pim or pi3k. |
2020-09-28 |
2023-08-13 |
Not clear |
| Pablo Parra-Flores, Jaime A Riquelme, Paula Valenzuela-Bustamante, Sebastian Leiva-Navarrete, Raúl Vivar, Jossete Cayupi-Vivanco, Esteban Castro, Claudio Espinoza-Pérez, Felipe Ruz-Cortés, Zully Pedrozo, Sergio Lavandero, Ramon Rodrigo, Guillermo Diaz-Aray. The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion. Antioxidants (Basel, Switzerland). vol 8. issue 12. 2020-09-28. PMID:31817022. |
moreover, treatment with a/d/n also reduced reperfusion-induced apoptosis, evidenced by a decrease in the sub-g1 population, lower fragmentation of pro-caspases 9 and 3, as well as increased b-cell lymphomaextra large protein (bcl-xl)/bcl-2-associated x protein (bax) ratio. |
2020-09-28 |
2023-08-13 |
rat |
| E A Braga, A M Burdennyy, I V Pronina, E A Filippova, T P Kazubskaya, M V Fridman, D S Khodyrev, A V Karpukhin, V I Loginov, N E Kushlinski. System of Markers Based on the Methylation of a Group of Proapoptotic Genes in Combination with MicroRNA in the Diagnosis of Breast Cancer. Bulletin of experimental biology and medicine. vol 168. issue 3. 2020-09-28. PMID:31938917. |
on a representative sample of 70 paired breast cancer specimens (tumor/normal), ms-pcr analysis revealed a significant increase in the methylation frequency of 5 protein-coding genes: rassf1a suppressor and apoptosis genes apaf1, bax, bim/bcl2l11, and dapk1 (34-61% vs. 4-24%) and 6 microrna genes: mirg124g1, mirg125bg1, mirg129g2, mirg148a, mirg34b/c, and mirg9g3 (36-76% vs. 6-27%). |
2020-09-28 |
2023-08-13 |
Not clear |