| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Li, M W Liu, W Yang, L J Wan, H L Yan, J C Li, S Y Tang, Y Q Wan. Naringenin induces neuroprotection against homocysteine-induced PC12 cells via the upregulation of superoxide dismutase 1 expression by decreasing miR-224-3p expression. Journal of biological regulators and homeostatic agents. vol 34. issue 2. 2020-09-16. PMID:32515177. |
the treatment also decreased the oxidative stress in the pc12 cells and the expressions of pro-apoptotic proteins bax, caspase-3, and caspase-9; increased the expression of anti-apoptotic protein bcl- 2; decreased the apoptosis of the pc12 cells; and increased the pc12 cells.the results suggest that naringenin can decrease the apoptosis and oxidative stress of pc12 cells induced by hcy and increase the activities and survival rates of pc12 cells. |
2020-09-16 |
2023-08-13 |
Not clear |
| Jianfeng Wang, Wan Wang, Haiyan Zha. MicroRNA-124 Enhances Dopamine Receptor Expression and Neuronal Proliferation in Mouse Models of Parkinson's Disease via the Hedgehog Signaling Pathway by Targeting EDN2. Neuroimmunomodulation. vol 26. issue 4. 2020-09-15. PMID:31454817. |
however, these treatments facilitated neuronal proliferation and suppressed neuronal apoptosis, corresponding to reduced expression of caspase-3 and bax, as well as increased levels of bcl-2 expression. |
2020-09-15 |
2023-08-13 |
mouse |
| Xiangyan Cui, Dong Xiao, Xin Wan. Inhibition of laryngeal cancer stem cells by tetrandrine. Anti-cancer drugs. vol 30. issue 9. 2020-09-15. PMID:31517730. |
at the molecular level, tetrandrine induced downregulation of bcl-2 and simultaneous upregulation of bax and caspase-3 as well as enhanced cell apoptosis.our results demonstrated that tetrandrine inhibited the cell viability and proliferation of cd133 hep-2 cells by reducing the number of cells in the s-phase of the cell cycle and enhancing cell apoptosis. |
2020-09-15 |
2023-08-13 |
Not clear |
| Cuiting Peng, Changzhen Sun, Ningyu Wang, Yuanmin He, Jixiang Xu, Yongqiong Deng, Lanyang Gao, Jianqiao Zhong, Xia Xiong, Li Li. A novel benzoxazinone derivative YLT-LL-11 inhibits diffuse large B-cell lymphoma growth via inducing cell cycle arrest and apoptosis. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31527063. |
furthermore, ylt-ll-11 facilitated oci-ly10 cell apoptosis by up-regulation of pro-apoptotic protein bax and down-regulation of anti-apoptotic protein bcl-2. |
2020-09-15 |
2023-08-13 |
human |
| Lingjuan Cui, Xiaoyan Jiang, Chengjun Zhang, Danxia Li, Shengqiang Yu, Fengchun Wan, Yue Ma, Wei Guo, Zhengfei Sha. Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31652453. |
we found that ketamine effectively damaged bladder tissues of rats and promoted apoptosis through regulating the expression levels of grp78, chop, bcl-2, bax and cleaved caspase-3 proteins in vivo and in vitro. |
2020-09-15 |
2023-08-13 |
human |
| Zhong-Wu Lu, Duo Wen, Wen-Jun Wei, Li-Tao Han, Jun Xiang, Yu-Long Wang, Yu Wang, Tian Liao, Qing-Hai J. Silencing of PPM1D inhibits cell proliferation and invasion through the p38 MAPK and p53 signaling pathway in papillary thyroid carcinoma. Oncology reports. vol 43. issue 3. 2020-09-15. PMID:31922231. |
the protein levels of phosphorylated p38 mitogen‑activated protein kinase (mapk), p53 and bax were increased in ppm1d‑knockdown cells, while inhibition of p38 phosphorylation restored cell migration, proliferation and cell apoptosis. |
2020-09-15 |
2023-08-13 |
human |
| Fengling Wang, Jinhui Wang, Zhaozhong Chong, Yanling M. A modified DAW-22 compound F-B1 inhibits Bcr/Abl and induces apoptosis in chronic myelogenous leukemia cells. Anti-cancer drugs. vol 30. issue 2. 2020-09-14. PMID:30422832. |
in addition, f-b1 also induced cell apoptosis by impairing the balance between proapoptotic protein bax and antiapoptotic proteins bcl-2 and bcl-xl and increased the activity of mitochondrial-dependent apoptosis in nude mouse xenografts. |
2020-09-14 |
2023-08-13 |
mouse |
| Yong Ling, Yangyang Li, Rui Zhu, Jianqiang Qian, Ji Liu, Weijie Gao, Chi Meng, Jiefei Miao, Biao Xiong, Xiaodong Qiu, Changchun Ling, Hong Dai, Yanan Zhan. Hydroxamic Acid Derivatives of β-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways. Journal of natural products. vol 82. issue 6. 2020-09-14. PMID:31120744. |
compound 12b enhanced the acetylation levels of histone h3 and α-tubulin and induced greater cancer cell apoptosis than the fda-approved hdac inhibitor saha by regulating expression of apoptotic proteins bax, bcl-2, and caspase 3. |
2020-09-14 |
2023-08-13 |
human |
| Youbo Zuo, Xingping Hu, Qiuyan Yang, Lei Zhao, Xueli Chen, Jiangtao Lin, Tiande Yan. Preoperative vitamin-rich carbohydrate loading alleviates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 373. 2020-09-14. PMID:31340174. |
furthermore, preoperative cho loading reduced er stress and neuronal apoptosis in the hippocampus of aged rats, as indicated by the protein biomarkers of grp78, eif2a, beclin1, bax, and bcl-2. |
2020-09-14 |
2023-08-13 |
rat |
| Yu-Jing Lan, Yu-Ting Wang, Chien-Lun Hung, Yun-Wei Chian. PEGylation-based strategy to identify pathways involved in the activation of apoptotic BAX protein. Biochimica et biophysica acta. General subjects. vol 1864. issue 4. 2020-09-14. PMID:31987956. |
bax activation is a crucial step for commitment to apoptosis. |
2020-09-14 |
2023-08-13 |
Not clear |
| Christian Bogner, Justin Kale, Justin Pogmore, Xiaoke Chi, Aisha Shamas-Din, Cécile Fradin, Brian Leber, David W Andrew. Allosteric Regulation of BH3 Proteins in Bcl-x Molecular cell. vol 77. issue 4. 2020-09-14. PMID:32001105. |
allosteric regulation of bh3 proteins in bcl-x current models of apoptosis regulation by the bcl-2 family of proteins postulate that heterodimeric interactions between family members determine whether bax and bak are activated to trigger cell death. |
2020-09-14 |
2023-08-13 |
Not clear |
| Jiongrui Cao, Jian Geng, Xiaoyuan Chu, Rui Wang, Guichun Huang, Longbang Che. miRNA‑885‑3p inhibits docetaxel chemoresistance in lung adenocarcinoma by downregulating Aurora A. Oncology reports. vol 41. issue 2. 2020-09-11. PMID:30431113. |
higher levels of aurora a expression were significantly correlated with higher chemoresistance and proliferation in lad cells, while silencing aurora a promoted caspase‑3‑dependent cell apoptosis by downregulating nf‑κb and bcl‑2 and upregulating bax expression. |
2020-09-11 |
2023-08-13 |
Not clear |
| Jianhong Qiang, Tingting Lv, Zhenbiao Wu, Xichao Yan. Down-regulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting nuclear factor-κB signaling. Bioscience reports. vol 39. issue 7. 2020-09-11. PMID:31239367. |
mir-142-3p inhibitor significantly decreased the cell viability, the number of cell clones, the migration rate, the number of invasive cells, the contents and expression of il-6 and mmp-3, and increased the apoptosis rate and the expressions of bax and bad, and decreased bcl-2 expression of tnf-α-treated ra-hflss. |
2020-09-11 |
2023-08-13 |
human |
| Tingting Wang, Lin Zhu, Hongling Liu, Guoyi Yu, Yunliang Gu. Picroside II Protects SH-SY5Y Cells From Autophagy and Apoptosis Following Oxygen Glucose Deprivation/Reoxygen Injury by Inhibiting JNK Signal Pathway. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 12. 2020-09-11. PMID:31251836. |
after ogd/r, the cellular viability of sh-sy5y cells was reduced, whereas the cytotoxicity, apoptosis, and autophagy were increased, accompanied with an increase of phospho-mkk4, phospho-jnk, phospho-c-jun, phospho-bcl-2, lc3 ii, beclin-1, and bax. |
2020-09-11 |
2023-08-13 |
Not clear |
| Wenmei Zhang, Yanna Li, Xin Xi, Guangfa Zhu, Shenghao Wang, Yan Liu, Man Son. MicroRNA‑15a‑5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP‑2 signaling pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894295. |
in addition, the overexpression of mir‑15a‑5p reduced pasmc proliferation, induced apoptosis, promoted the activity of caspase‑3/9, induced the protein expression of b‑cell lymphoma 2‑associated x protein (bax), decreased the expression of b‑cell lymphoma 2 (bcl‑2), increased inflammation, as indicated by the expression of tumor necrosis factor‑α (tnf)‑α and interleukin (il)‑1β, il‑6 and il‑18, suppressed the protein expression of vascular endothelial growth factor (vegf), and promoted the protein expression levels of phosphorylated (p)‑p38 mitogen‑activated protein kinase (p38) and matrix metalloproteinase (mmp)‑2 in the pasmcs of rats with mct‑induced pah. |
2020-09-11 |
2023-08-13 |
rat |
| Wenmei Zhang, Yanna Li, Xin Xi, Guangfa Zhu, Shenghao Wang, Yan Liu, Man Son. MicroRNA‑15a‑5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP‑2 signaling pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894295. |
by contrast, the downregulation of mir‑15a‑5p increased cell proliferation, decreased apoptosis, reduced the activity of caspase‑3/9 and the protein expression of bax, increased the expression of bcl‑2, inhibited inflammation (as suggested by the expression of tnf‑α, il‑1β, il‑6 and il‑18), induced the protein expression of vegf, and suppressed the protein expression of p‑p38 and mmp‑2 in the pasmcs of rats with mct‑induced pah. |
2020-09-11 |
2023-08-13 |
rat |
| Kun Xia, Yong Zhang, Dongming Su. miR‑217 and miR‑543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF‑κB signaling pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894309. |
cell viability was detected using cell counting kit‑8 assay, and cell apoptosis was measured by analyzing the expression levels of bcl‑2 and bax, and by flow cytometry. |
2020-09-11 |
2023-08-13 |
mouse |
| Ling Li, Jingjun Cheng, Dedong Zhu, Xiaojun Shi, Yongning Wei, Sihan Chen, Zhe Wang, Denggao Yua. The effects of Alisol B 23-acetate in hepatocellular carcinoma via inducing cell apoptosis and inhibiting cell migration and invasion. General physiology and biophysics. vol 39. issue 3. 2020-09-11. PMID:32525815. |
ab23a suppressed cell viability in a concentration-dependent manner, blocked cell cycle, and induced apoptosis via up-regulating bax, caspase-3 and caspase-9, and down-regulating bcl-2 in hcc cells both in vitro and in vivo. |
2020-09-11 |
2023-08-13 |
Not clear |
| Yi Qin, Guizhen Wang, Zhiyong Pen. MicroRNA-191-5p diminished sepsis-induced acute kidney injury through targeting oxidative stress responsive 1 in rat models. Bioscience reports. vol 39. issue 8. 2020-09-09. PMID:31362998. |
after being transfected with oxsr1, the apoptosis rates and expressions of b-cell lymphoma-2 (bcl-2), down-regulated bax and cleaved caspase-3 (c caspase-3) indicated overexpressed oxsr1 contributed to cell apoptosis. |
2020-09-09 |
2023-08-13 |
rat |
| Fatih Kar, Ceyhan Hacioglu, Sedat Kacar, Varol Sahinturk, Gungor Kanba. Betaine suppresses cell proliferation by increasing oxidative stress-mediated apoptosis and inflammation in DU-145 human prostate cancer cell line. Cell stress & chaperones. vol 24. issue 5. 2020-09-09. PMID:31368044. |
morphological changes and apoptosis were evaluated using h&e technique, bax and bcl-2 immunohistochemistry. |
2020-09-09 |
2023-08-13 |
human |