| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinshui He, Xu Zhang, Chaowei Lian, Jinzhi Wu, Yanling Fang, Xiaoling Y. Exendin-4 prevented pancreatic beta cells from apoptosis in (Type I) diabetic mouse via keap1-Nrf2 signaling. Experimental biology and medicine (Maywood, N.J.). vol 244. issue 1. 2020-05-29. PMID:30638057. |
moreover, sirna-mediated nrf2 down-regulation attenuated the suppressive effect of exendin-4 in pancreatic β-cell viability, via modulating apoptosis promoting- and counteracting-proteins, bax, and bcl-2. |
2020-05-29 |
2023-08-13 |
mouse |
| Dong-Wei Liu, Jia-Hui Zhang, Feng-Xun Liu, Xu-Tong Wang, Shao-Kang Pan, Deng-Ke Jiang, Zi-Hao Zhao, Zhang-Suo Li. Silencing of long noncoding RNA PVT1 inhibits podocyte damage and apoptosis in diabetic nephropathy by upregulating FOXA1. Experimental & molecular medicine. vol 51. issue 8. 2020-05-29. PMID:31371698. |
the silencing of pvt1 or the overexpression of foxa1 relieved the damage and inhibited the apoptosis of podocytes in dn, as was evidenced by the upregulated expression of synaptopodin and podocin, higher expression of bcl-2, and lower expression of bax and cleaved caspase-3. |
2020-05-29 |
2023-08-13 |
mouse |
| Alireza Heydarnejad, Somayyeh Ostadhosseini, Shiva Rouhollahi Varnosfaderani, Farnoosh Jafarpour, Ali Moghimi, Mohammad Hossein Nasr-Esfahan. Supplementation of maturation medium with CoQ10 enhances developmental competence of ovine oocytes through improvement of mitochondrial function. Molecular reproduction and development. vol 86. issue 7. 2020-05-27. PMID:31066163. |
the relative expression levels of apoptosis markers caspase3 and bax were significantly reduced in coq10-treated oocytes and cumulus cells whereas the relative expression level of gdf9, an oocyte-specific growth factor, significantly increased. |
2020-05-27 |
2023-08-13 |
Not clear |
| Tiechao Jiang, Fanglei Han, Guangyuan Gao, Miao Li. Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure induced rats. Life sciences. vol 249. 2020-05-27. PMID:32119962. |
hemodynamic parameters and body weight, heart weight and liver weight, apoptosis induction, and caspase-3, bax, and bcl-2 protein levels were measured, and a histopathological analysis of cardiomyocytes was performed. |
2020-05-27 |
2023-08-13 |
rat |
| Tiechao Jiang, Fanglei Han, Guangyuan Gao, Miao Li. Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure induced rats. Life sciences. vol 249. 2020-05-27. PMID:32119962. |
in addition, apoptosis and protein expression of caspase-3, cleaved caspase-3, bax, and bcl-2 were measured in cardiac h9c2 cells. |
2020-05-27 |
2023-08-13 |
rat |
| Tiechao Jiang, Fanglei Han, Guangyuan Gao, Miao Li. Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure induced rats. Life sciences. vol 249. 2020-05-27. PMID:32119962. |
mangiferin reduced inflammatory cell infiltration and the number of broken myocardial fibers, and decreased apoptosis in cardiomyocytes by reducing proteins levels of caspase-3 and bax and increasing those of bcl-2. |
2020-05-27 |
2023-08-13 |
rat |
| Pei Zhang, Surong Zhao, Xingyue Lu, Zongfen Shi, Hao Liu, Bing Zh. Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway. Gene. vol 745. 2020-05-27. PMID:32222530. |
furthermore, metformin combined with cisplatin obviously inhibited cell viability, decreased colony formation, induced apoptosis, mediated cleavage of caspase-9, caspase-3 and parp, activated mitochondrial membrane potential, downregulated mcl-1 and bcl-2 expression, upregulated bak and bax expression, and increased reactive oxygen species (ros) production, compared to the individual agent in sw480 and sw620 cells, which were attenuated by n-acetyl-l-cysteine (nac), a ros scavenger. |
2020-05-27 |
2023-08-13 |
Not clear |
| Yunyun Jin, Jian Wang, Meng Zhang, Sihuan Zhang, Chuzhao Lei, Hong Chen, Wei Guo, Xianyong La. Role of bta-miR-204 in the regulation of adipocyte proliferation, differentiation, and apoptosis. Journal of cellular physiology. vol 234. issue 7. 2020-05-20. PMID:30697738. |
meanwhile, overexpression of bta-mir-204 upregulated the expression of bax and downregulated the expression of bcl-2 both at messenger rna and protein levels, which suggested that bta-mir-204 can promote 3t3-l1 cell apoptosis. |
2020-05-20 |
2023-08-13 |
Not clear |
| Yuluo Rong, Wei Liu, Jiaxing Wang, Jin Fan, Yongjun Luo, Linwei Li, Fanqi Kong, Jian Chen, Pengyu Tang, Weihua Ca. Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy. Cell death & disease. vol 10. issue 5. 2020-05-19. PMID:31000697. |
following nsc-sev infusion, the sci area was significantly reduced, and the expression levels of the proapoptotic protein bax, the apoptosis effector cleaved caspase-3, and the pro-inflammatory cytokines tnf-α, il-1β, and il-6 were significantly reduced, whereas the expression level of the anti-apoptotic protein bcl-2 was upregulated. |
2020-05-19 |
2023-08-13 |
rat |
| Anran Xu, Jianye Wang, Haiyu Wang, Yanqing Sun, Tianyu Ha. Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats. Toxicology. vol 427. 2020-05-19. PMID:31568845. |
besides, lyc ameliorated bap-mediated gap-junction dysfunction of sertoli cells, as shown by the inhibited sertoli cell death and apoptosis, the upregulation of bcl2 and cx43, the downregulation of cleaved caspase 3, bax and cam, and the decrease in ca |
2020-05-19 |
2023-08-13 |
rat |
| Andrew J McDonald, Katherine M Curt, Ruchi P Patel, Hanna Kozlowski, Dan L Sackett, Robert W Robey, Michael M Gottesman, Susan E Bate. Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models. Experimental cell research. vol 375. issue 2. 2020-05-18. PMID:30579954. |
a549 lung cancer cells or hct-116 cells deficient in bak and bax were also resistant to apoptosis with the combination implicating the intrinsic apoptotic pathway. |
2020-05-18 |
2023-08-13 |
Not clear |
| Maryam Vahdat-Lasemi, Sara Hosseini, Vahid Jajarmi, Bahram Kazemi, Mohammad Saleh. Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30605234. |
because patients with pcos have decreased numbers of follicular cells related to cell apoptosis, we also investigated two apoptotic genes, bax and bcl2. |
2020-05-18 |
2023-08-13 |
mouse |
| Maryam Vahdat-Lasemi, Sara Hosseini, Vahid Jajarmi, Bahram Kazemi, Mohammad Saleh. Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30605234. |
the changes in bcl2 and bax expression levels, as apoptosis biomarkers, showed that apoptosis was a secondary outcome of the effect of mir-224. |
2020-05-18 |
2023-08-13 |
mouse |
| He Ding, Jing Zhao, Hongyu Liu, Jun Wang, Wenfa L. BMAL1 knockdown promoted apoptosis and reduced testosterone secretion in TM3 Leydig cell line. Gene. vol 747. 2020-05-18. PMID:32305634. |
results showed that bmal1 knockdown promoted the apoptosis of leydig cells and expression of (bcl2 associated x) bax mrna and protein, and reduced the expression of (b-cell lymphoma-2) bcl-2 mrna and protein. |
2020-05-18 |
2023-08-13 |
mouse |
| Weiling Xu, Peihong Gao, Yan Zhang, Li Piao, Dong Don. microRNA-138 induces cell survival and reduces WNT/β-catenin signaling of osteoarthritis chondrocytes through NEK2. IUBMB life. vol 71. issue 9. 2020-05-15. PMID:31034758. |
the chondrocytes treated with mir-138 mimic and sirna-nek2 exhibited reduced expressions of nek2, β-catenin, mmp-13, bax, and p53 and elevated expressions of col2, aggrecan, and bcl-2 as well as phosphorylation levels of β-catenin along with enhanced chondrocytes' proliferation and suppressed cell apoptosis. |
2020-05-15 |
2023-08-13 |
mouse |
| Kunal Kumar, Akash Sabarwal, Rana P Sing. Mancozeb selectively induces mitochondrial-mediated apoptosis in human gastric carcinoma cells through ROS generation. Mitochondrion. vol 48. 2020-05-11. PMID:29902665. |
the results also showed that mancozeb-induced apoptosis was accompanied by up-regulation of bax and down-regulation of bcl-2 and bcl-xl. |
2020-05-11 |
2023-08-13 |
human |
| Jin-Lu Yu, Chao Li, Li-He Che, Yu-Hao Zhao, Yun-Bao Gu. Downregulation of long noncoding RNA H19 rescues hippocampal neurons from apoptosis and oxidative stress by inhibiting IGF2 methylation in mice with streptozotocin-induced diabetes mellitus. Journal of cellular physiology. vol 234. issue 7. 2020-05-11. PMID:30536889. |
upregulated lncrna h19 significantly increased the expression of bax and caspase-3 but decreased that of bcl-2, thus promoting the apoptosis of hippocampal neuron. |
2020-05-11 |
2023-08-13 |
mouse |
| Tara K Jalal, Al'aina Yuhanis Firus Khan, Hatim A Natto, Mohammad Syaiful Bahari Abdull Rasad, Mohd Arifin Kaderi, Mardhiah Mohammad, Muhammad Farid Johan, Muhammed Nor Omar, Ridhwan Abdul Waha. Identification and Quantification of Quercetin, A Major Constituent of Artocarpus altilis by Targeting Related Genes of Apoptosis and Cell Cycle: In Vitro Cytotoxic Activity Against Human Lung Carcinoma Cell Lines. Nutrition and cancer. vol 71. issue 5. 2020-05-11. PMID:30614285. |
taken together, these findings suggested that a. altilis induces apoptosis in a mitochondrial-dependent pathway by releasing and upregulating cytochrome c expression and regulates the expression of downstream apoptotic components, including bcl-2 and bax. |
2020-05-11 |
2023-08-13 |
human |
| Palani Dinesh, MahaboobKhan Rasoo. Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. Apoptosis : an international journal on programmed cell death. vol 24. issue 7-8. 2020-05-08. PMID:31111379. |
bbr inhibited the proliferation of aa-fls via promoting apoptosis through increased expression of bax and diminished bcl-2 transcription factor levels. |
2020-05-08 |
2023-08-13 |
Not clear |
| Xin Zhang, Yao Qin, Zhaohai Pan, Minjing Li, Xiaona Liu, Xiaoyu Chen, Guiwu Qu, Ling Zhou, Maolei Xu, Qiusheng Zheng, Defang L. Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. vol 9. issue 8. 2020-05-08. PMID:31349651. |
in addition, cbd significantly increased bax expression levels, decreased bcl-2 expression levels and mitochondrial membrane potential, and then upregulated the levels of cleaved caspase-3 and cleaved caspase-9, thereby inducing apoptosis in sgc-7901 cells. |
2020-05-08 |
2023-08-13 |
human |