| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Honghai Wang, Jun Mao, Yuhong Huang, Jun Zhang, Lin Zhong, Ying Wu, He Huang, Jiayu Yang, Yuanyi Wei, Jianwu Tan. Prognostic roles of miR-124-3p and its target ANXA7 and their effects on cell migration and invasion in hepatocellular carcinoma. International journal of clinical and experimental pathology. vol 13. issue 3. 2020-04-11. PMID:32269673. |
in vitro, up-regulation of mir-124-3p promotes apoptosis and inhibits migration and invasion of hca-f. bcl-2 correlates x protein (bax) protein level was up-regulated, while anxa7, b-cell lymphoma-2 (bcl-2), matrix metalloproteinase (mmp-9) and c-x-c motif chemokine 12 (cxcl12) protein levels were suppressed relative to mir-124-3p over-expression. |
2020-04-11 |
2023-08-13 |
Not clear |
| Zhen Cheng, Weiwei Sun, Xiaohui Ni, Hua Xu, Youhua Wan. GAB2 inhibits chondrocyte apoptosis through PI3K-AKT signaling in osteoarthritis. International journal of clinical and experimental pathology. vol 13. issue 3. 2020-04-11. PMID:32269703. |
moreover, gab2 knockdown inhibited akt phosphorylation, increased bax expression, and decreased bcl2 expression, which indicated that gab2 regulates chondrocyte apoptosis through pi3k-akt signaling. |
2020-04-11 |
2023-08-13 |
Not clear |
| Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulsk. Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis. eLife. vol 8. 2020-04-10. PMID:30714902. |
during apoptosis, bcl-2 proteins such as bax and bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it. |
2020-04-10 |
2023-08-13 |
human |
| Defeng Guan, Chenyang Li, Xiao Lv, Yongxiu Yan. Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells. Journal of gynecologic oncology. vol 30. issue 5. 2020-04-10. PMID:31328459. |
pseudolaric acid b inhibits pax2 expression through wnt signaling and induces bax expression, therefore promoting apoptosis in hela cervical cancer cells. |
2020-04-10 |
2023-08-13 |
Not clear |
| Li-Ye Liang, Meng-Meng Wang, Ming Liu, Wei Zhao, Xin Wang, Lin Shi, Mei-Jia Zhu, Yuan-Ling Zhao, Lian Liu, Preeti Maurya, Yun Wan. Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries. Toxicology in vitro : an international journal published in association with BIBRA. vol 62. 2020-04-10. PMID:31629073. |
our cell culture study with pasmcs indicates that ma significantly induced the imbalance between proliferation and apoptosis by upregulating the level of pcna, bcl-2 and reduction in the expression of bax and caspase 3. |
2020-04-10 |
2023-08-13 |
rat |
| Yoshikazu Mikami, Motoki Senoo, Mio Lee, Kiyoshi Yamada, Kuniyasu Ochiai, Masaki J Honda, Eri Watanabe, Nobukazu Watanabe, Masanori Somei, Minoru Takag. Inhibitory Effects of a Tryptamine Derivative on Ultraviolet Radiation-Induced Apoptosis in MC3T3-E1 Mouse Osteoblasts. Journal of pharmacological sciences. vol 115. issue 2. 2020-04-10. PMID:32272539. |
we investigated the effect of ms-ipa1 on apoptosis by analyzing caspase3/7 activity, translocation of phosphatidylserine (ps), and mrna expression levels of bcl-2 and bax. |
2020-04-10 |
2023-08-13 |
mouse |
| Ziming Liu, Zhiwen Zhang, Ali Zhang, Fan Zhang, Wennan Du, Yongqiang Zhang, Rongfeng Zhang, Jiagang Xu, Xiangkun Wu, Chengmin Zhang, Ning Li, Qi Tan, Wei Huan. Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells. Bioscience reports. vol 39. issue 4. 2020-04-09. PMID:30872412. |
np cell apoptosis ratio, caspase-3/9 activity, expression of apoptosis-related molecules (bcl-2, bax, and caspase-3), matrix macromolecules (aggrecan and collagen ii), and matrix remodeling enzymes (mmp-3, mmp-13, and adamts-4), and immuno-staining of np matrix proteins (aggrecan and collagen ii) were evaluated. |
2020-04-09 |
2023-08-13 |
rat |
| Ziming Liu, Zhiwen Zhang, Ali Zhang, Fan Zhang, Wennan Du, Yongqiang Zhang, Rongfeng Zhang, Jiagang Xu, Xiangkun Wu, Chengmin Zhang, Ning Li, Qi Tan, Wei Huan. Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells. Bioscience reports. vol 39. issue 4. 2020-04-09. PMID:30872412. |
compared with the baseline culture, high glucose culture significantly increased np cell apoptosis ratio, caspase-3/9 activity, up-regulated expression of bax, caspase-3, mmp-3, mmp-13 and adamts-4, down-regulated expression of bcl-2, aggrecan and collagen ii, and decreased staining intensity of aggrecan and collagen ii. |
2020-04-09 |
2023-08-13 |
rat |
| Wei Zhang, Yangyang Zhang, Hengbing Zhang, Qian Zhao, Zheng Liu, Yawei X. USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling. Journal of cellular physiology. vol 234. issue 5. 2020-04-08. PMID:30246457. |
cell viability, apoptosis, the bax, bcl-2, and dusp1 expression, and the activity of mapks in ac16 cardiomyocytes following indicated treatment was measured by cck-8, flow cytometry, and western blot analysis. |
2020-04-08 |
2023-08-13 |
human |
| Raedeh Saraei, Faroogh Marofi, Adel Naimi, Mehdi Talebi, Mahnaz Ghaebi, Naser Javan, Omid Salimi, Ali Hassanzade. Leukemia therapy by flavonoids: Future and involved mechanisms. Journal of cellular physiology. vol 234. issue 6. 2020-04-08. PMID:30500074. |
based on the last decade reports, the most important acting mechanisms of these natural compounds in leukemia cells are stimulating of apoptosis pathways by upregulation of caspase 3, 8, 9 and poly adp-ribose polymerase (parp) and proapoptotic proteins, particularly bax activation. |
2020-04-08 |
2023-08-13 |
Not clear |
| Ming Guo, Yi Gu, Xiaoyue Fa. Chlorinated phosphorus flame retardants exert oxidative damage to SMMC-7721 human hepatocarcinoma cells. The Science of the total environment. vol 705. 2020-04-08. PMID:31972937. |
the expression of the bax apoptosis protein was up-regulated and the bcl-2 apoptosis protein was down-regulated, suggesting that the three chemicals may cause functional defects, damage the cell structure and promote apoptosis. |
2020-04-08 |
2023-08-13 |
human |
| Hu-Cheng Liu, Jin Zeng, Bin Zhang, Xu-Qiang Liu, Min Da. Inhibitory effect of MSH6 gene silencing in combination with cisplatin on cell proliferation of human osteosarcoma cell line MG63. Journal of cellular physiology. vol 234. issue 6. 2020-04-07. PMID:30456894. |
furthermore, silencing msh6 combined with ddp reduced expressions of c-myc, cyclin d1, bcl-2, stathmin, and pcna, and elevated bax expression, whereas inhibiting os cell viability, impeding cell cycle distribution, and inducing apoptosis. |
2020-04-07 |
2023-08-13 |
human |
| Zhenyan Jiang, Hansi Zhan. Curvature effect and stabilize ruptured membrane of BAX derived peptide studied by molecular dynamics simulations. Journal of molecular graphics & modelling. vol 88. 2020-04-06. PMID:30703689. |
bax protein plays a key role in mitochondrial membrane permeabilization and cytochrome c release upon apoptosis. |
2020-04-06 |
2023-08-13 |
Not clear |
| Yixin Zhang, Ningbo Xu, Yan Ding, Desislava Met Doycheva, Yiting Zhang, Qian Li, Jerry Flores, Mina Haghighiabyaneh, Jiping Tang, John H Zhan. Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30718467. |
here, we showed that rh-chemerin prevented the neuronal apoptosis and degeneration as evidenced by the decreased expression of the pro-apoptotic markers, cleaved caspase 3 and bax, as well as the numbers of fluoro-jade c and tunel-positive neurons. |
2020-04-06 |
2023-08-13 |
human |
| Ke Xu, Bin Han, Yang Bai, Xiu-Ying Ma, Zhen-Ni Ji, Yao Xiong, Shi-Kun Miao, Yuan-Yuan Zhang, Li-Ming Zho. MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer. Cell death & disease. vol 10. issue 3. 2020-04-06. PMID:30770794. |
over-expressing mir-451a or silencing bap31 suppressed the proliferation and apoptosis of crc cells by increasing the expressions of endoplasmic reticulum stress (ers)-associated proteins, including grp78/bip, bax, and perk/elf2α/atf4/chop, which resulted in increased ers, cytoplasmic calcium ion flowing, and apoptosis of crc cells. |
2020-04-06 |
2023-08-13 |
Not clear |
| Kpobari W Nkpaa, Benjamin A Amadi, Matthew O Wegwu, Ebenezer O Faromb. Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. Toxicology. vol 418. 2020-04-06. PMID:30844427. |
collectively, etoh increases mn - induced oxidative/nitrosative stress, neuro-inflammation and hippocampal apoptosis via mechanism involving oxidative damages of cellular constituents, neuronal inflammation and subsequent upregulation of bax and caspase-3 and downregulation of bcl-2 protein expression via p53 dependent/independent pathways to induced hippocampal apoptosis associated with impaired spatial learning and memory. |
2020-04-06 |
2023-08-13 |
rat |
| Yiyi Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Chuan Liu, Aijun Che. The effects of HSP27 against UVB-induced photoaging in rat skin. Biochemical and biophysical research communications. vol 512. issue 3. 2020-04-06. PMID:30902393. |
however, in hsp27 deletion group, the expression of antiapoptotic factor bcl-2 was decreased, while the apoptosis factor bax was increased after uvb irradiation. |
2020-04-06 |
2023-08-13 |
rat |
| Xiu-Mei Duan, Xiao-Na Liu, Yu-Xin Li, Yu-Qing Cao, Aidaeraili Silayiding, Rong-Kui Zhang, Ji-Ping Wan. MicroRNA-498 promotes proliferation, migration, and invasion of prostate cancer cells and decreases radiation sensitivity by targeting PTEN. The Kaohsiung journal of medical sciences. vol 35. issue 11. 2020-04-06. PMID:31332950. |
mir-498 reduced the radiation-induced apoptosis in pca cells by regulation of bax and bcl-2 expression. |
2020-04-06 |
2023-08-13 |
Not clear |
| Honglei Zhan, He Zhao, Nazim Muhammad, Tongtong Li, Yujia Liu, Jihui Wan. Lytic peptide-grafted beta-cyclodextrin polymer based nano-scaled drug delivery system with enhanced camptothecin anti-cancer efficacy. Nanotechnology. vol 31. issue 7. 2020-04-06. PMID:31665708. |
our results suggested zh-bcdp-cpt inclusion complex induced cell apoptosis by up-regulation of bax and p53 and down-regulation of bcl-2, primarily involved in the mitochondrial pathways. |
2020-04-06 |
2023-08-13 |
Not clear |
| Qiubo Chu, Yanfeng Zhu, Tianjiao Cao, Yi Zhang, Zecheng Chang, Yan Liu, Jiahui Lu, Yizhi Zhan. Studies on the Neuroprotection of Osthole on Glutamate-Induced Apoptotic Cells and an Alzheimer's Disease Mouse Model via Modulation Oxidative Stress. Applied biochemistry and biotechnology. vol 190. issue 2. 2020-04-02. PMID:31407160. |
in l-glutamic acid (l-glu)-damaged ht22 cells, a 3-h pre-incubation with ost-enhanced cell viability suppressed the apoptosis rate; inhibited the activities of caspase-3, caspase-8, and caspase-9; reduced the over-accumulation of intracellular reactive oxygen species; restored the dissipated mitochondrial membrane potential; and regulated the expression levels of b cell lymphoma-2 (bcl-2), bax, cleaved poly (adp-ribose) polymerase (parp), nf-e2p45-related factor 2 (nrf2), and its downstream proteins. |
2020-04-02 |
2023-08-13 |
mouse |