| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-Feng Li, Wei-Wei Xu, Ji-Dan Li, Feng-Ling Tao, Jian-Xin Chen, Jin-Hua X. Nucleotide exchange factor SIL1 promotes the progress of breast cancer cells via regulating the cell cycle and apoptosis. Science progress. vol 103. issue 1. 2020-04-01. PMID:31791191. |
sil1 knockdown induced apoptosis and also promoted the activity of caspase9 and bax. |
2020-04-01 |
2023-08-13 |
human |
| Chueh-Hsuan Lu, Yu-Yi Kuo, Guan-Bo Lin, Wei-Ting Chen, Chih-Yu Cha. Application of non-invasive low-intensity pulsed electric field with thermal cycling-hyperthermia for synergistically enhanced anticancer effect of chlorogenic acid on PANC-1 cells. PloS one. vol 15. issue 1. 2020-04-01. PMID:31995555. |
the synergistic activity against the panc-1 cells was achieved by inducing g2/m phase arrest and apoptosis, which were associated with up-regulation of p53 and coupled with increased expression of downstream proteins p21 and bax. |
2020-04-01 |
2023-08-13 |
human |
| K M Ahsanul Kabir, Ruhul Amin, Imtiaj Hasan, A K M Asaduzzaman, Hamida Khatun, Syed Rashel Kabi. Corrigendum to "Geodorum densiflorum rhizome lectin inhibits Ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of BAX, p53 and NF-κB genes expression"[Int. J. Biol. Macromol. 125 (2019) 92-98]. International journal of biological macromolecules. vol 150. 2020-03-31. PMID:32171584. |
corrigendum to "geodorum densiflorum rhizome lectin inhibits ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of bax, p53 and nf-κb genes expression"[int. |
2020-03-31 |
2023-08-13 |
Not clear |
| Haobin Zhao, Xiaoguang Xu, Shuzhen Lei, Dongyan Shao, Chunmei Jiang, Junling Shi, Yawen Zhang, Li Liu, Shuzhen Lei, Hui Sun, Qingsheng Huan. Iturin A-like lipopeptides from Bacillus subtilis trigger apoptosis, paraptosis, and autophagy in Caco-2 cells. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30238995. |
a western blot analysis showed that the lipopeptides induced apoptosis in caco-2 cells via a mitochondrial-dependent pathway, as indicated by upregulated expression of the apoptotic genes bax and bad and downregulated expression of the antiapoptotic gene bcl-2. |
2020-03-30 |
2023-08-13 |
human |
| Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O'Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, Rob Ramsay, Brian J Smith, Suresh Mathivanan, Thomas Kaufmann, Hamsa Puthalakat. BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 31. 2020-03-30. PMID:31311867. |
bok, a multidomain bcl-2 family protein, is generally believed to be an adaptor protein similar to bak and bax, regulating the mitochondrial permeability transition during apoptosis. |
2020-03-30 |
2023-08-13 |
Not clear |
| Zbigniew Wyżewski, Karolina P Gregorczyk-Zboroch, Matylda B Mielcarska, Magdalena Bossowska-Nowicka, Justyna Struzik, Joanna Szczepanowska, Felix N Toka, Marek G Niemiałtowski, Lidia Szulc-Dąbrowsk. Mitochondrial Heat Shock Response Induced by Ectromelia Virus is Accompanied by Reduced Apoptotic Potential in Murine L929 Fibroblasts. Archivum immunologiae et therapiae experimentalis. vol 67. issue 6. 2020-03-30. PMID:31324924. |
moreover, increase of mthsp amounts is accompanied by lack of apoptosis, and confirmed by reduced level of pro-apoptotic bax protein and elevated levels of anti-apoptotic bcl-2 and bcl-xl proteins. |
2020-03-30 |
2023-08-13 |
Not clear |
| Yi Ren, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Xin Chen, Shinan Ni. Curcumin relieves paraquat‑induced lung injury through inhibiting the thioredoxin interacting protein/NLR pyrin domain containing 3‑mediated inflammatory pathway. Molecular medicine reports. vol 20. issue 6. 2020-03-30. PMID:31485636. |
following treatment with curcumin, pq‑induced increases in ros levels and apoptosis were significantly attenuated, and bcl‑2 expression levels were upregulated, whereas those of bax were downregulated. |
2020-03-30 |
2023-08-13 |
human |
| Hassan Abbaszadeh, Armita Valizadeh, Masoud Mahdavinia, Ali Teimoori, Mohammad Hassan Pipelzadeh, Leila Zeidooni, Soheila Alboghobeis. 3-Bromopyruvate potentiates TRAIL-induced apoptosis in human colon cancer cells through a reactive oxygen species- and caspase-dependent mitochondrial pathway. Canadian journal of physiology and pharmacology. vol 97. issue 12. 2020-03-30. PMID:31491344. |
at a cellular mechanistic level, the present study showed that 3-bp sensitized human colon cancer cells to trail-induced apoptosis via reactive oxygen species generation, upregulation of bax, downregulation of bcl-2 and survivin, release of cytochrome c into the cytosol, and activation of caspase-3. |
2020-03-30 |
2023-08-13 |
human |
| Min-Young Kwon, Narae Hwang, Seon-Jin Lee, Su Wol Chun. Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells. BMB reports. vol 52. issue 11. 2020-03-30. PMID:31619316. |
nod2 deficiency increased er stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, bax, and bak) in vsmcs in the presence of tunicamycin (tm), an er stress inducer. |
2020-03-30 |
2023-08-13 |
mouse |
| Min-Young Kwon, Narae Hwang, Seon-Jin Lee, Su Wol Chun. Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells. BMB reports. vol 52. issue 11. 2020-03-30. PMID:31619316. |
in contrast, er stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, bax, and bak) were decreased in nod2-overexpressed vsmcs. |
2020-03-30 |
2023-08-13 |
mouse |
| Hui Han, Daopeng Dai, Jinquan Hu, Jinzhou Zhu, Lin Lu, Guorong Tao, Ruiyan Zhan. Dexmedetomidine improves cardiac function and protects against maladaptive remodeling following myocardial infarction. Molecular medicine reports. vol 20. issue 6. 2020-03-30. PMID:31661145. |
apoptosis was determined by the relative expression levels of bax and bcl‑2 and the myocardial caspase‑3 activity. |
2020-03-30 |
2023-08-13 |
mouse |
| Ramakrishnan Sabitha, Kumari Nishi, Vinoth Prasanna Gunasekaran, Balupillai Agilan, Ernest David, Govindhan Annamalai, Rajamanickam Vinothkumar, Malliga Perumal, Latha Subbiah, Mathan Ganesha. p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models. Chemico-biological interactions. vol 321. 2020-03-30. PMID:32151596. |
we also noticed that the pca protected ethanol induced apoptosis and liver markers by inhibiting the expression of bax, caspases; ast, alt, als, and ldh in liver tissue. |
2020-03-30 |
2023-08-13 |
rat |
| Pei-Jun Chen, An-Quan Shang, Jian-Ping Yang, Wei-Wei Wan. microRNA-874 inhibition targeting STAT3 protects the heart from ischemia-reperfusion injury by attenuating cardiomyocyte apoptosis in a mouse model. Journal of cellular physiology. vol 234. issue 5. 2020-03-27. PMID:30370578. |
then, mir-874 inhibition improved cardiac function of i/r mice, inhibited cardiomyocyte apoptosis (also shown as decreased bcl-2 associated x protein b [bax] and increased b-cell lymphoma-2 [bcl-2]), and activated the jak2/stat3 signaling pathway. |
2020-03-27 |
2023-08-13 |
mouse |
| Haoliang Ni, Yuejun Han, Xihan Ji. Celastrol inhibits colon cancer cell proliferation by downregulating miR-21 and PI3K/AKT/GSK-3β pathway. International journal of clinical and experimental pathology. vol 12. issue 3. 2020-03-25. PMID:31933888. |
mir-21 mimic overexpression could enhance the cell viability, inhibit the apoptosis, decrease bcl-2 expression, increase bax and induce caspase-3 activity to some extent which were reversed by celastrol. |
2020-03-25 |
2023-08-13 |
Not clear |
| Jinghua Jiao, Yuheng Wang, Xiaofeng Sun, Xiaojing Jian. Midazolam induces A549 cell apoptosis International journal of clinical and experimental pathology. vol 11. issue 3. 2020-03-25. PMID:31938232. |
midazolam significantly induced a549 cell apoptosis and modulated expression of bcl-2, bax, and caspase-3. |
2020-03-25 |
2023-08-13 |
Not clear |
| Danyang Li, Pengyan Song, Liantao Liu, Xiaodan Wan. Perfluorooctanoic acid exposure during pregnancy alters the apoptosis of uterine cells in pregnant mice. International journal of clinical and experimental pathology. vol 11. issue 12. 2020-03-25. PMID:31949647. |
the results indicated that pfoa could accelerate the apoptosis of uterine cells, and lead to slow embryo development or abortion by regulating the expression of fas, fasl, bax, bcl-2 and caspase-3 in uterine cells. |
2020-03-25 |
2023-08-13 |
mouse |
| Hui Bi, Gui Wang, Zhiying Li, Lin Zhou, Ming Zhang, Jiru Ye, Zhigang Wan. Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-03-24. PMID:32201430. |
results our results indicated that various concentrations of cse (0%, 0.1%, 1%, and 10%) significantly promoted cell apoptosis, augmented caspase-3 activity, upregulated bax expression, decreased bcl-2 expression, and enhanced lncrna meg3 level in hpmecs. |
2020-03-24 |
2023-08-13 |
human |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
building on previous models (chong et al., 2015; zhang et al., 2009a), we developed a mathematical model that incorporated the molecular interactions in the core regulation of p53 and the apoptosis initiation module involving puma, bcl2 and bax. |
2020-03-23 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
activation of bax was assumed to be an indicator of apoptosis initiation. |
2020-03-23 |
2023-08-13 |
Not clear |
| Mariana Franzoni Maioral, Natália Marceli Stefanes, Álisson Bigolin, Gabriele Andressa Zatelli, Ana Cláudia Philippus, Miriam de Barcellos Falkenberg, Maria Cláudia Santos-Silv. MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Investigational new drugs. vol 37. issue 5. 2020-03-23. PMID:30569243. |
the compound also triggered intrinsic and extrinsic apoptosis by modulating bax, fasr and survivin expression. |
2020-03-23 |
2023-08-13 |
Not clear |