| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammed A Ramadan, Alaa E Shawkey, Mohamed A Rabeh, Ashraf O Abdellati. Expression of P53, BAX, and BCL-2 in human malignant melanoma and squamous cell carcinoma cells after tea tree oil treatment in vitro. Cytotechnology. vol 71. issue 1. 2020-02-25. PMID:30599074. |
the present study aimed to investigate the cytotoxic effects of tto against two representative types of human skin cancer, namely malignant melanoma (a-375) and squamous cell carcinoma (hep-2).to outline the basic molecular mechanism involved in apoptosis induction in a-375 and hep-2 cell lines, annexin v/pi staining for apoptosis detection, cell cycle analysis were monitored using flow cytometry and mrna expression levels of the apoptosis-regulatory genes p53, bax, and bcl-2 were determined by real-time pcr and western blot after treatment with tto. |
2020-02-25 |
2023-08-13 |
human |
| Mohammed A Ramadan, Alaa E Shawkey, Mohamed A Rabeh, Ashraf O Abdellati. Expression of P53, BAX, and BCL-2 in human malignant melanoma and squamous cell carcinoma cells after tea tree oil treatment in vitro. Cytotechnology. vol 71. issue 1. 2020-02-25. PMID:30599074. |
this cytotoxicity resulted from tto induced apoptosis in both a-375 and hep-2 cell lines as evidenced by morphological features of apoptosis and annexin v/pi staining results in addition to the activation of caspase-3/7 and -9, upregulation of pro-apoptotic genes (p53 and bax) and downregulation of the anti-apoptotic gene bcl-2. |
2020-02-25 |
2023-08-13 |
human |
| Tomasz Kowalczyk, Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Dariusz Pytel, Joanna Wieczfińska, Janusz Szemraj, Tomasz Śliwińsk. Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells. Cytotechnology. vol 71. issue 1. 2020-02-25. PMID:30610508. |
the growth inhibition of human grade iv glioma cells mediated by mtrv extract appears to be associated with apoptosis and g2/m phase cell cycle arrest, and altered expression of the pro- and anti-apoptotic genes (bax, bcl-2, cas-3 and tp53) and proteins (bax, bcl-2, cas-3 and p53), as well as decreased mitochondrial membrane potential. |
2020-02-25 |
2023-08-13 |
human |
| Artur Beberok, Dorota Wrześniok, Jakub Rok, Zuzanna Rzepka, Michalina Respondek, Ewa Buszma. Ciprofloxacin triggers the apoptosis of human triple-negative breast cancer MDA-MB-231 cells via the p53/Bax/Bcl-2 signaling pathway. International journal of oncology. vol 52. issue 5. 2020-02-24. PMID:29532860. |
the aim of the present study was to examine the effect of ciprofloxacin on the viability, redox balance, apoptosis, expression of p53, bax and bcl-2, cell cycle distribution and dna fragmentation of triple-negative mda-mb-231 breast cancer cells. |
2020-02-24 |
2023-08-13 |
human |
| Hui Xu, Jie Cao, Jianguo Xu, Haiying Li, Haitao Shen, Xiang Li, Zhong Wang, Jiang Wu, Gang Che. GATA-4 regulates neuronal apoptosis after intracerebral hemorrhage via the NF-κB/Bax/Caspase-3 pathway both in vivo and in vitro. Experimental neurology. vol 315. 2020-02-24. PMID:30710529. |
moreover, gata-4 promoted the activation of nf-κb, and increased the expression of bax, and cysteine aspartate-specific protease 3 (caspase-3) in its cleaved form, causing neuronal apoptosis. |
2020-02-24 |
2023-08-13 |
rat |
| Xingmei Huang, Xiaobin Yu, Hongxia Li, Lianhua Han, Xiangjun Yan. Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway. Heart and vessels. vol 34. issue 12. 2020-02-24. PMID:31218464. |
the mrna and protein expression levels of aqp9, erk1/2 phosphorylation and bax were significantly increased, as well as the myocardial infarct size, apoptosis index of myocardial tissue (all p < 0.05), the mrna and protein expression levels of bcl-2 were significantly decreased (all p < 0.05). |
2020-02-24 |
2023-08-13 |
rat |
| Kunal Kumar, Jai P N Mishra, Rana P Sing. Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and γ-H2A.X phosphorylation. Chemico-biological interactions. vol 315. 2020-02-21. PMID:31715134. |
apoptosis induction was accompanied by an increase in the ratio of bax:bcl-2 expression and cleaved-parp. |
2020-02-21 |
2023-08-13 |
mouse |
| Qing Xu, Haolin Fang, Liang Zhao, Cunxin Zhang, Luo Zhang, Baofang Tia. Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway. Bioscience reports. vol 39. issue 3. 2020-02-20. PMID:30858307. |
np cell apoptosis ratio, caspase-3 activity, gene expression of bcl-2, bax and caspase-3, protein expression of cleaved caspase-3, cleaved parp, bax and bcl-2 were analyzed to evaluate np cell apoptosis. |
2020-02-20 |
2023-08-13 |
rat |
| Yanhai Jiang, Zhijie Xie, Jinying Yu, Lianqiang F. Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway. Bioscience reports. vol 39. issue 3. 2020-02-20. PMID:30867252. |
np cell apoptosis was reflected by the caspase-3 activity, cell apoptosis ratio, and expression of apoptosis-related molecules (bcl-2, bax, caspase-3, cleaved caspase-3, and cleaved parp). |
2020-02-20 |
2023-08-13 |
rat |
| Yanhai Jiang, Zhijie Xie, Jinying Yu, Lianqiang F. Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway. Bioscience reports. vol 39. issue 3. 2020-02-20. PMID:30867252. |
compared with the control np cells, il-1β significantly increased caspase-3 activity, np cell apoptosis ratio and mrna/protein expression of bax, caspase-3, cleaved caspase-3 and cleaved parp, but decreased mrna expression of bcl-2. |
2020-02-20 |
2023-08-13 |
rat |
| N Saat, A Risvanli, H Dogan, E Onalan, N Akpolat, I Seker, E Sahn. Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 94. issue 7. 2020-02-20. PMID:31070494. |
we used bax, bcl-2 and caspase 3 staining to measure apoptosis in the uterine tissues. |
2020-02-20 |
2023-08-13 |
rat |
| Lauren L Haar, David S Lawrence, Robert M Hughe. Optogenetic perturbation of the biochemical pathways that control cell behavior. Methods in enzymology. vol 622. 2020-02-20. PMID:31155059. |
in this chapter we outline specific protocols for applying these tools to cell motility (optogenetic cofilin), apoptosis [optogenetic bcl-like protein 4 (bax)], and protein kinase-mediated signaling pathways [optogenetic camp-dependent protein kinase (pka)]. |
2020-02-20 |
2023-08-13 |
Not clear |
| Lauren L Haar, David S Lawrence, Robert M Hughe. Optogenetic perturbation of the biochemical pathways that control cell behavior. Methods in enzymology. vol 622. 2020-02-20. PMID:31155059. |
light-triggered migration of bax to the outer mitochondrial membrane induces cellular collapse and eventual apoptosis. |
2020-02-20 |
2023-08-13 |
Not clear |
| Yong Xiong, Yi-Jia Xiong, Dong-Yang Liu, Rong-Rong She. Pancratistatin Inhibits the Growth of Colorectal Cancer Cells by Inducing Apoptosis, Autophagy, and G2/M Cell Cycle Arrest. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31404056. |
growth inhibition due to pancratistatin was associated with morphological changes of hct-15 cells and included autophagy and apoptosis, and increased expression the autophagic proteins, lc3ii, beclin-1, and bax. |
2020-02-20 |
2023-08-13 |
human |
| Gaowu Hu, Huajiang Liu, Ming Wang, Wei Pen. IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31605603. |
upregulation of iqgap3 inhibited apoptosis in bc cells, along with increased expression of phosphorylated extracellular signal-regulated kinases 1/2 (p-erk1/2) and b cell lymphoma 2 (bcl2) and decreased bcl-2-associated x protein (bax) expression, which was counteracted by kaempferol treatment. |
2020-02-20 |
2023-08-13 |
Not clear |
| Jianlou Zhang, Jinghui Fan, Yan Li, Shuang Liang, Shanshan Huo, Xing Wang, Yuzhu Zuo, Dan Cui, Wenyan Li, Zhenyu Zhong, Fei Zhon. Porcine Parvovirus Infection Causes Pig Placenta Tissue Damage Involving Nonstructural Protein 1 (NS1)-Induced Intrinsic ROS/Mitochondria-Mediated Apoptosis. Viruses. vol 11. issue 4. 2020-02-19. PMID:31027293. |
we have found that ns1-induced apoptosis was significantly inhibited by caspase 9 inhibitor, but not caspase 8 inhibitor, and transfection of ns1 gene into pk-15 cells significantly inhibited mitochondria-associated antiapoptotic molecules bcl-2 and mcl-1 expressions and enhanced proapoptotic molecules bax, p21, and p53 expressions, suggesting that ns1-induced apoptosis is mainly through the mitochondria-mediated intrinsic apoptosis pathway. |
2020-02-19 |
2023-08-13 |
Not clear |
| Bo Li, Junkai Zhang, Ya Su, Yiling Hou, Zhenguo Wang, Lin Zhao, Shengkai Sun, Hao F. Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism. Molecular medicine reports. vol 20. issue 4. 2020-02-19. PMID:31485626. |
result from the present study demonstrated that treatment with pemetrexed suppressed lung cancer cell proliferation, inhibited mrna and protein expression levels of anti‑apoptotic bcl2, and increased the mrna and the protein expression levels of pro‑apoptotic p53 and apoptosis regulator bax. |
2020-02-19 |
2023-08-13 |
Not clear |
| Xiaoliang Mei, Jian Tong, Wei Zhu, Yongliang Zh. lncRNA‑NR024118 overexpression reverses LPS‑induced inflammatory injury and apoptosis via NF‑κB/Nrf2 signaling in ATDC5 chondrocytes. Molecular medicine reports. vol 20. issue 4. 2020-02-19. PMID:31485657. |
expression of the cell apoptosis markers bcl‑2, bax, bcl‑2‑like protein 11, nf‑κb, phosphorylated (p)‑nf‑κb inhibitor β (iκbβ), iκbβ, p‑transcription factor p65 (p65) and p65, and nuclear factor erythroid‑2 related factor 2 (nrf2) signaling pathways‑associated proteins, nrf2, ho‑1 and quinone oxidoreductase‑1 were detected by western blot analysis and rt‑qpcr. |
2020-02-19 |
2023-08-13 |
cat |
| Weiqi Wang, Ping Han, Rongxia Xie, Mingfeng Yang, Cheng Zhang, Qiongjie Mi, Baoliang Sun, Zongyong Zhan. TAT-mGluR1 Attenuation of Neuronal Apoptosis through Prevention of MGluR1α Truncation after Experimental Subarachnoid Hemorrhage. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30339347. |
furthermore, tat-mglur1 significantly improved the neurological deficit, increased p-pi3k, p-akt, and p-gsk3β, downregulated bax, upregulated bcl-2, and reduced cortical apoptosis in the basal cortex at 24 h after sah. |
2020-02-18 |
2023-08-13 |
rat |
| Yan Wang, Zhong He, Qiu Yang, Guangju Zho. XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy. FEBS open bio. vol 9. issue 7. 2020-02-18. PMID:31077568. |
treatment of xbp1-overexpressing cells with hg resulted in a decrease of reactive oxygen species (ros) and a suppression of cell apoptosis, concomitant with decreases in cleaved caspase-3 and bax. |
2020-02-18 |
2023-08-13 |
Not clear |